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Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133+ cells in clear cell renal carcinoma.
Clear cell renal cell carcinoma (ccRCC) contains cancer stem-like cells (CSCs) that express CD133 (ccRCC-CD133+). CSCs are rarely in cell cycle and, as nonproliferating cells, resist most chemotherapeutic agents. Previously, we...
Novel Heating-Induced Reversion during Crystallization of Al-based Glassy Alloys.
Thermal stability and crystallization of three multicomponent glassy alloys, Al86Y7Ni5Co1Fe0.5Pd0.5, Al85Y8Ni5Co1Fe0.5Pd0.5 and Al84Y9Ni4Co1.5Fe0.5Pd1, were examined to assess the ability to form the mixture of amorphous (am)...
TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway.
Jun Wang, Ricardo Ferreira, Wanhua Lu, Samatha Farrow, Kate Downes, Lutz Jermutus, Ralph Minter, Rafia S Al-Lamki, Jordan S Pober, John R Bradley
Sep 08, 2018
Human T regulatory cells (T regs) express high levels of TNF receptor 2 (TNFR2). Ligation of TNFR2 with TNF, which can recognise both TNFR1 and TNFR2, or with a TNFR2-selective binding molecule, DARPin 18 (D18) activates...
Cell Nucleus Cell Proliferation Cells Cultured Gene Expression Regulation Healthy Volunteers Humans Interleukin-2 NF-KappaB Inhibitor alpha NF-kappa B p52 Subunit Primary Cell Culture Proteolysis Receptors Tumor Necrosis Factor Type II Recombinant Fusion Proteins Signal Transduction T-Lymphocytes Regulatory Transcription Factor RelB
ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.
Haibin Jiang, Mingxia Du, Yaning Li, Tengfei Zhou, Jia Lei, Hongqing Liang, Zhen Zhong, Rafia S Al-Lamki, Ming Jiang, Jun Yang
Jul 15, 2022
Inhibition of DNA binding proteins 1 and 3 (ID1 and ID3) are important downstream targets of BMP signalling that are necessary for embryonic development. However, their specific roles in regulating the pluripotency of human...
The Efficacy of Sunitinib Treatment of Renal Cancer Cells Is Associated with the Protein PHAX In Vitro
Rafia S. Al-Lamki, Nicholas J. Hudson, John R. Bradley, Anne Y. Warren, Tim Eisen, Sarah J. Welsh, Antony C. P. Riddick, Fiach C. O’Mahony, Arran Turnbull, Thomas Powles, SCOTRRCC Collaborative SCOTRRCC Collaborative, Antonio Reverter, David J. Harrison, Grant D. Stewart
Apr 08, 2020
Anti-angiogenic agents, such as the multi-tyrosine kinase inhibitor sunitinib, are key first line therapies for metastatic clear cell renal cell carcinoma (ccRCC), but their mechanism of action is not fully understood. Here, we...
The Efficacy of Sunitinib Treatment of Renal Cancer Cells Is Associated with the Protein PHAX In Vitro.
Rafia S Al-Lamki, Nicholas J Hudson, John R Bradley, Anne Y Warren, Tim Eisen, Sarah J Welsh, Antony CP Riddick, Fiach C O'Mahony, Arran Turnbull, Thomas Powles, Scotrrcc Collaborative, Antonio Reverter, David J Harrison, Grant D Stewart
Apr 03, 2020
Anti-angiogenic agents, such as the multi-tyrosine kinase inhibitor sunitinib, are key first line therapies for metastatic clear cell renal cell carcinoma (ccRCC), but their mechanism of action is not fully understood. Here, we...
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Geoffrey S Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S Al-Lamki, Andrew J Leishman, Steven J Rust, Ross Stewart, Lutz Jermutus, John R Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter, Robert W Wilkinson
Jul 20, 2018
TNFR2 cancer immunotherapy Drug Discovery phenotypic screening Regulatory T cell Animals Antineoplastic Agents Cell Line Tumor Drug Screening Assays Antitumor Female HEK293 Cells Humans Immunotherapy Jurkat Cells Mice Inbred BALB C NF-kappa B Neoplasms Neoplasms Experimental Phenotype Receptors Tumor Necrosis Factor Type II Signal Transduction T-Lymphocytes Regulatory
Possible mechanism and mode of action of Al-Hijama (Wet Cupping Therapy) to Manage Non Communicable Lifestyle Diseases–An appraisal
Lifestyle diseases or diseases of longevity has reached alarming proportions among Indians in recent era due to rapid economic development, stress full life and increasing westernization of lifestyle. There is an extensive...
Published by: IJHS Medical Association
Estimating the total prevalence of PTSD among the UK police force
Two recent surveys have reported widely differing prevalence rates for posttraumatic stress disorder (PTSD) within the U.K. police force. Stevelink et al. (2020) reported a rate of 3.9% whereas a survey conducted for the charity...
Humans prevalence Stress Disorders Post-Traumatic Police Diagnostic and Statistical Manual of Mental Disorders United Kingdom
Published by: PLOS ONE
Possible mechanism and mode of action of Al-Hijama (Wet Cupping Therapy) to Manage Non Communicable Lifestyle Diseases–An appraisal
Lifestyle diseases or diseases of longevity has reached alarming proportions among Indians in recent era due to rapid economic development, stress full life and increasing westernization of lifestyle. There is an extensive...
Published by: IJHS Medical Association
Barnes et al. Reply
A C Barnes, L B Skinner, Philip S Salmon, A Bytchkov, I Pozdnyakova, T O Farmer, H E Fischer
Jan 01, 0001
A Reply to the Comment by G. N. Greaves et al.
Barnes et al. Reply
A C Barnes, L B Skinner, Philip S Salmon, A Bytchkov, I Pozdnyakova, T O Farmer, H E Fischer
Jan 01, 0001
A Reply to the Comment by G. N. Greaves et al.
Synthesis, Structures and Properties of Novel Platinum(II) Acetylide Complexes and Polymers with Tri(tolyl)phosphine as the Auxiliary Ligand
Abu Ali Ibn Sina, S. M. Ibrahim Al-rafia, Md. Faruak Ahmad, Ratan Kumar Paul, S. M. Saiful Islam, Muhammad Younus, Paul R. Raithby, Cheuk-lam Ho, Yih Hsing Lo, Li Liu, Hua Li, Wai-Yeung Wong
May 01, 2015
A new family of luminescent platinum(II) acetylide complexes and polymers were formed by the copper(I) catalyzed reaction of cis-[PtCl2(PR3)2] (R=C6H5–p-CH3) with appropriate acetylide ligands. The reaction of metal precursors...
Synthesis, Structures and Properties of Novel Platinum(II) Acetylide Complexes and Polymers with Tri(tolyl)phosphine as the Auxiliary Ligand
Abu Ali Ibn Sina, S. M. Ibrahim Al-rafia, Md. Faruak Ahmad, Ratan Kumar Paul, S. M. Saiful Islam, Muhammad Younus, Paul R. Raithby, Cheuk-lam Ho, Yih Hsing Lo, Li Liu, Hua Li, Wai-Yeung Wong
May 01, 2015
A new family of luminescent platinum(II) acetylide complexes and polymers were formed by the copper(I) catalyzed reaction of cis-[PtCl2(PR3)2] (R=C6H5–p-CH3) with appropriate acetylide ligands. The reaction of metal precursors...
Ambiphilic Al‐Cu Bonding
Michael Hill, Han-Ying Dennis Liu, Ryan Schwamm, Mary Mahon, Claire McMullin, Nasir Rajabi
Jun 21, 2021
Copper‐alumanyl complexes, [LCu‐Al(SiN Dipp )], where L = carbene = NHC iPr (N,Nʹ‐di‐isopropyl‐4,5‐dimethyl‐2‐ylidene) and Me2 CAAC (1‐(2,6‐di‐isopropylphenyl)‐3,3,5,5‐tetramethyl‐pyrrolidin‐2‐ylidene) and featuring unsupported...
Ambiphilic Al‐Cu Bonding
Michael Hill, Han-Ying Dennis Liu, Ryan Schwamm, Mary Mahon, Claire McMullin, Nasir Rajabi
Jun 21, 2021
Copper‐alumanyl complexes, [LCu‐Al(SiN Dipp )], where L = carbene = NHC iPr (N,Nʹ‐di‐isopropyl‐4,5‐dimethyl‐2‐ylidene) and Me2 CAAC (1‐(2,6‐di‐isopropylphenyl)‐3,3,5,5‐tetramethyl‐pyrrolidin‐2‐ylidene) and featuring unsupported...
Structure and triclustering in Ba-Al-O glass
Glass-forming ability in the (BaO) x(Al 2O 3) 1-x system (0≤x≤1) was investigated by using the containerless aerodynamic levitation and laser-heating method. The main glass-forming region was found to occur for 0.40(2) ≤x≤...
Structure and triclustering in Ba-Al-O glass
Glass-forming ability in the (BaO) x(Al 2O 3) 1-x system (0≤x≤1) was investigated by using the containerless aerodynamic levitation and laser-heating method. The main glass-forming region was found to occur for 0.40(2) ≤x≤...
A Socioeconomic Study of the Coastal Fishing Fleet in the Al Hoceima Port (Moroccan Mediterranean)
Mohamed Keznine, Soufiane Hasni, Sara Al Mabruk, Manal Demiathi, Mohamed Analla, Mustapha Aksissou
Jan 01, 2023
Coastal fishing in the Moroccan Mediterranean plays a key role in the fishing industry's economy. This activity is an important source of jobs and income for many coastal communities in the Al Hoceima region of the north-western...
Published by: IGI Global Scientific Publishing
Azimuthal correlations of high transverse momentum jets at next-to-leading order in the parton branching method
Abstract The azimuthal correlation, $$\Delta \phi _{12}$$
MI Abdulhamid, MA Al-Mashad, AB Martinez, G Bonomelli, I Bubanja, N Crnković, F Colombina, B D’Anzi, S Cerci, M Davydov, LIE Banos, N Forzano, F Hautmann, H Jung, S Kim, AL Quirós, DE Martins, M Mendizabal, KM Figueroa, S Prestel, ST Monfared, C Süslü, DS Cerci, AM van Kampen, P Van Mechelen, A Verbytskyi, Q Wang, H Yang, Y Zhou
Mar 01, 2022
Consumer Legal Protection On The Implementation Of E-Commerce Using Instagram With A Pre-Order System During The Covid-19 Pandemic
The implementation of e-commerce in Indonesia is growing rapidly and has its own online sales place, which is commonly called a marketplace. However, the current rapid technological developments that are used to promote not only...
Published by: Indonesia Strategic Sustainability
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