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K Garwood, T McLaughlin, C Garwood, S Joens, N Morrison, CF Taylor, K Carroll, C Evans, AD Whetton, S Hart, D Stead, Z Yin, AJP Brown, A Hesketh, K Chater, L Hansson, M Mewissen, P Ghazal, J Howard, KS Lilley, SJ Gaskell, A Brass, SJ Hubbard, SG Oliver, NW Paton
Jun 16, 2011
Abstract Background Proteomics is rapidly evolving into a high-throughput technology, in which substantial and systematic studies are conducted on samples from a wide range of physiological, developmental, or pathological...
Animals Arabidopsis Proteins Bacterial Proteins Candida albicans Candida glabrata Computational Biology Database Management Systems Databases Protein Fungal Proteins Helminth Proteins Jejunal Diseases Mice Proteins Proteomics Saccharomyces cerevisiae Proteins Software Design Streptomyces coelicolor Trichinella spiralis Trichinellosis
Prospective association between adherence to the Mediterranean diet and hepatic steatosis
Objective: The Mediterranean diet has been promoted as a healthy dietary pattern, but whether the Mediterranean diet may help to prevent hepatic steatosis is not clear. This study aimed to evaluate the prospective association...
Development and multi-cohort validation of a clinical score for predicting type 2 diabetes mellitus.
Vanessa Kraege, Peter Vollenweider, Gérard Waeber, Stephen J Sharp, Maite Vallejo, Oscar Infante, Mohammad Reza Mirjalili, Fatemeh Ezoddini-Ardakani, Hassan Mozaffari-Khosravi, Mohammad Hasan Lotfi, Masoud Mirzaei, Marie Méan, Pedro Marques-Vidal
Dec 18, 2019
BACKGROUND AND AIMS: Many countries lack resources to identify patients at risk of developing Type 2 diabetes mellitus (diabetes). We aimed to develop and validate a diabetes risk score based on easily accessible clinical data....
The association between adherence to the Mediterranean diet and hepatic steatosis
Saman Khalatbari-Soltani, Fumiaki Imamura, Soren Brage, Emanuella De Lucia Rolfe, Simon J Griffin, Nicholas J Wareham, Pedro Marques-Vidal, Nita G Forouhi
Feb 11, 2019
BACKGROUND AND AIMS: The risk of hepatic steatosis may be reduced through changes to dietary intakes, but evidence is sparse, especially for dietary patterns including the Mediterranean diet. We investigated the association...
Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure
Laura Mele, Guillaume Bidault, Pedro Mena, Alan Crozier, Furio Brighenti, Antonio Vidal-Puig, Daniele Del Rio
Nov 19, 2020
The incidence of overweight and obesity has reached epidemic proportions, making the control of body weight and its complications a primary health problem. Diet has long played a first-line role in preventing and managing...
brown adipose tissue dietary (poly)phenols energy expenditure Flavan-3-ols obesity resveratrol uncoupled protein 1 Adipose Tissue Brown Adrenergic Agonists Animals Anti-Obesity Agents Body Weight Diet Disease Models Animal Energy Metabolism Flavonoids Humans obesity Polyphenols resveratrol Stilbenes Tea Thermogenesis Uncoupling Protein 1
A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening.
Bárbara B Sousa, Marcos FQ Sousa, Marta C Marques, João D Seixas, José A Brito, Pedro M Matias, Gonçalo JL Bernardes, António Roldão
Sep 15, 2020
Bone Marrow Tyrosine kinase in the chromosome X (BMX) is a TEC family kinase associated with numerous pathological pathways in cancer cells. Covalent inhibition of BMX activity holds promise as a therapeutic approach against...
Sensitive and robust chemical detection using an olfactory brain-computer interface.
Erez Shor, Pedro Herrero-Vidal, Adam Dewan, Ilke Uguz, Vincenzo F Curto, George G Malliaras, Cristina Savin, Thomas Bozza, Dmitry Rinberg
Sep 27, 2021
When it comes to detecting volatile chemicals, biological olfactory systems far outperform all artificial chemical detection devices in their versatility, speed, and specificity. Consequently, the use of trained animals for...
Spanish Professor Selected as Thompson Scholar
Winthrop University
Jan 01, 0001
Spanish professor Pedro Muñoz has been chosen as the new Thompson Scholar. Muñoz, a native of Spain, will spend a year researching service learning courses for at-risk Hispanic students.
Published by: Winthrop University
Comparative genomic survey of Bacillus cereus sensu stricto isolates from the dairy production chain in Brazil
Gabriel Augusto Marques Rossi, Higor Oliveira Silva, Carlos Eduardo Gamero Aguilar, Arina Lázaro Rochetti, Ben Pascoe, Guillaume Méric, Evangelos Mourkas, Matthew D. Hitchings, Luis Antonio Mathias, Vera Letticie De Azevedo Ruiz, Heidge Fukumasu, Samuel K. Sheppard, Ana Maria Centola Vidal
Feb 01, 2018
The genomes of 262 Bacillus cereus isolates were analyzed including 69 isolates sampled from equipment, raw milk and dairy products from Brazil. The population structure of isolates showed strains belonging to known...
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.
João D Seixas, Bárbara B Sousa, Marta C Marques, Ana Guerreiro, Rui Traquete, Tiago Rodrigues, Inês S Albuquerque, Marcos FQ Sousa, Ana R Lemos, Pedro MF Sousa, Tiago M Bandeiras, Di Wu, Shelby K Doyle, Carol V Robinson, Angela N Koehler, Francisco Corzana, Pedro M Matias, Gonçalo JL Bernardes
Oct 01, 2021
The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with...
Comparative genomic survey of Bacillus cereus sensu stricto isolates from the dairy production chain in Brazil
Gabriel Augusto Marques Rossi, Higor Oliveira Silva, Carlos Eduardo Gamero Aguilar, Arina Lázaro Rochetti, Ben Pascoe, Guillaume Méric, Evangelos Mourkas, Matthew D. Hitchings, Luis Antonio Mathias, Vera Letticie De Azevedo Ruiz, Heidge Fukumasu, Samuel K. Sheppard, Ana Maria Centola Vidal
Feb 01, 2018
The genomes of 262 Bacillus cereus isolates were analyzed including 69 isolates sampled from equipment, raw milk and dairy products from Brazil. The population structure of isolates showed strains belonging to known...
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Massimo F Piepoli, Arno W Hoes, Stefan Agewall, Christian Albus, Carlos Brotons, Alberico L Catapano, Marie-Therese Cooney, Ugo Corrà, Bernard Cosyns, Christi Deaton, Ian Graham, Michael Stephen Hall, FD Richard Hobbs, Maja-Lisa Løchen, Herbert Löllgen, Pedro Marques-Vidal, Joep Perk, Eva Prescott, Josep Redon, Dimitrios J Richter, Naveed Sattar, Yvo Smulders, Monica Tiberi, H Bart van der Worp, Ineke van Dis, WM Monique Verschuren, Simone Binno, ESC Scientific Document Group
May 24, 2016
blood pressure Clinical settings Diabetes Guidelines Healthy lifestyle Lipid Nutrition physical activity POPULATION Prevention PRIMARY CARE Psychosocial factors Rehabilitation Risk Assessment risk management Smoking Stakeholder Adult Age Factors Aged Antihypertensive Agents Biomarkers Cardiac Rehabilitation Cardiovascular Diseases Cost-Benefit Analysis Diabetic Angiopathies Diagnostic Imaging Diet Healthy Exercise General Practice Health Promotion Healthy Lifestyle Humans Hyperlipidemias Hypertension Middle Aged Multiple Chronic Conditions Pedigree Practice Patterns Physicians' Risk Assessment Sex Factors Smoking Cessation Socioeconomic Factors
Impact of the geometry of inclusions at the micro-scale on the overall stochastic properties
In this contribution, the establishment of relationships between the microstructure of the material and the macroscopic properties is numerically investigated. The material under study is composed by inclusions randomly...
The need for widely available genomic testing in rare eye diseases
Graeme C Black, Panagiotis Sergouniotis, Andrea Sodi, Bart P Leroy, Caroline Van Cauwenbergh, Petra Liskova, Karen Grønskov, Artur Klett, Susanne Kohl, Gita Taurina, Marius Sukys, Lonneke Haer-Wigman, Katarzyna Nowomiejska, João Pedro Marques, Dorothée Leroux, Frans PM Cremers, Elfride De Baere, Hélène Dollfus, ERN-EYE study group
May 17, 2021
BACKGROUND: Rare Eye Diseases (RED) are the leading cause of visual impairment and blindness for children and young adults in Europe. This heterogeneous group of conditions includes over 900 disorders ranging from relatively...
Biology and pathology of the uterine microenvironment and its natural killer cells.
Tissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity. Determining how immune cells inhabit, housekeep, and defend gut, lung, brain, liver...
A Novel Multi-Criteria Local Latin Hypercube Refinement System for Commutation Angle Improvement in IPMSMs
The commutation angle, γ, of an interior permanent magnet synchronous motor's (IPMSM) vector diagram, plays an important role in compensating the back electromotive force (back-EMF); both under phase current variations and an...
Genomics of Parallel Ecological Speciation in Lake Victoria Cichlids.
Joana Isabel Meier, David Alexander Marques, Catherine Elise Wagner, Laurent Excoffier, Ole Seehausen
Nov 27, 2019
The genetic basis of parallel evolution of similar species is of great interest in evolutionary biology. In the adaptive radiation of Lake Victoria cichlid fishes, sister species with either blue or red-back male nuptial...
A Novel Multi-Criteria Local Latin Hypercube Refinement System for Commutation Angle Improvement in IPMSMs
The commutation angle, γ, of an interior permanent magnet synchronous motor's (IPMSM) vector diagram, plays an important role in compensating the back electromotive force (back-EMF); both under phase current variations and an...
Demographic modelling with whole-genome data reveals parallel origin of similar Pundamilia cichlid species after hybridization.
Joana I Meier, Vitor C Sousa, David A Marques, Oliver M Selz, Catherine E Wagner, Laurent Excoffier, Ole Seehausen
Nov 27, 2019
Modes and mechanisms of speciation are best studied in young species pairs. In older taxa, it is increasingly difficult to distinguish what happened during speciation from what happened after speciation. Lake Victoria cichlids...
Communication Overload in Online Communities in Higher Education
This paper presents part of a research project on the use of information technology by students and teachers to communicate with each other in online community contexts of higher education institutions. The part of this project...
Published by: IGI Global Scientific Publishing
Impact of the geometry of inclusions at the micro-scale on the overall stochastic properties
In this contribution, the establishment of relationships between the microstructure of the material and the macroscopic properties is numerically investigated. The material under study is composed by inclusions randomly...
A Combinatorial View on Speciation and Adaptive Radiation.
Speciation is often thought of as a slow process due to the waiting times for mutations that cause incompatibilities, and permit ecological differentiation or assortative mating. Cases of rapid speciation and particularly cases...
Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging.
Negative symptoms, such as amotivation and anhedonia, are a major cause of functional impairment in schizophrenia. There are currently no licensed treatments for negative symptoms, highlighting the need to understand the...
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