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Structure and stability of symptoms in first episode psychosis
Attoliter protein nanogels from droplet nanofluidics for intracellular delivery.
Microscale hydrogels consisting of macromolecular networks in aqueous continuous phases have received increasing attention because of their potential use in tissue engineering, cell encapsulation and for the storage and release...
Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems.
Tadas Kartanas, Victor Ostanin, Pavan Kumar Challa, Ronan Daly, Jerome Charmet, Tuomas PJ Knowles
Jun 11, 2018
Microelectromechanical systems (MEMS) have enabled the development of a new generation of sensor platforms. Acoustic sensor operation in liquid, the native environment of biomolecules, causes, however, significant degradation of...
Structure and stability of symptoms in first episode psychosis
Siân Lowri Griffiths, Samuel P Leighton, Pavan Kumar Mallikarjun, Georgina Blake, Linda Everard, Peter B Jones, David Fowler, Joanne Hodgekins, Tim Amos, Nick Freemantle, Vimal Sharma, Max Marshall, Paul McCrone, Swaran P Singh, Max Birchwood, Rachel Upthegrove
Jan 07, 2022
Early psychosis is characterised by heterogeneity in illness trajectories, where outcomes remain poor for many. Understanding psychosis symptoms and their relation to illness outcomes, from a novel network perspective, may help...
Attoliter protein nanogels from droplet nanofluidics for intracellular delivery.
Microscale hydrogels consisting of macromolecular networks in aqueous continuous phases have received increasing attention because of their potential use in tissue engineering, cell encapsulation and for the storage and release...
Published by: Science advances
Low-Cost Microfabrication Tool Box.
Jérôme Charmet, Rui Rodrigues, Ender Yildirim, Pavan Kumar Challa, Benjamin Roberts, Robert Dallmann, Yudan Whulanza
Apr 14, 2020
Microsystems are key enabling technologies, with applications found in almost every industrial field, including in vitro diagnostic, energy harvesting, automotive, telecommunication, drug screening, etc. Microsystems, such as...
Predicting treatment resistance from first-episode psychosis using routinely collected clinical information
Prediction of Piezoelectric Tile Performance in Flat and Mountainous Terrains Through Deep Neural Network
Jitendra Adhikari, Kamalpreet Singh, Anjani Kumar Sagar, Vikki Kumar Sharma, Rajeev Kumar, Satish Chandra Jain
Sep 13, 2023
Piezoelectric tiles harvest mechanical vibrations and convert them into electrical energy, making them an attractive energy-harvesting technology. However, their performance is heavily influenced by the terrain where they are...
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.
Pavan Kumar Challa, Quentin Peter, Maya A Wright, Yuewen Zhang, Kadi L Saar, Jacqueline A Carozza, Justin LP Benesch, Tuomas PJ Knowles
Aug 18, 2020
Optical detection has become a convenient and scalable approach to read out information from microfluidic systems. For the study of many key biomolecules, however, including peptides and proteins, which have low fluorescence...
PSK Method for Solving Mixed and Type-4 Intuitionistic Fuzzy Solid Transportation Problems
P. Kumar
Apr 01, 2019
In this article, the author categorises the solid transportation problem (STP) under uncertain environments. He formulates the mixed and fully intuitionistic fuzzy solid transportation problems (FIFSTPs) and utilizes the...
Published by: IGI Global Scientific Publishing
Prediction of Piezoelectric Tile Performance in Flat and Mountainous Terrains Through Deep Neural Network
Jitendra Adhikari, Kamalpreet Singh, Anjani Kumar Sagar, Vikki Kumar Sharma, Rajeev Kumar, Satish Chandra Jain
Sep 13, 2023
Piezoelectric tiles harvest mechanical vibrations and convert them into electrical energy, making them an attractive energy-harvesting technology. However, their performance is heavily influenced by the terrain where they are...
Development and external validation of the Psychosis Metabolic Risk Calculator (PsyMetRiC)
Benjamin I Perry, Emanuele F Osimo, Rachel Upthegrove, Pavan K Mallikarjun, Jessica Yorke, Jan Stochl, Jesus Perez, Stan Zammit, Oliver Howes, Peter B Jones, Golam M Khandaker
Mar 12, 2021
BACKGROUND: Young people with psychosis are at high risk of developing cardiometabolic disorders; however, there is no suitable cardiometabolic risk prediction algorithm for this group. We aimed to develop and externally...
Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis
Abstract Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, resistance to which occurs primarily due to mutations in pncA ...
Ramani Baddam, Narender Kumar, Lothar H Wieler, Aditya Kumar Lankapalli, Niyaz Ahmed, Sharon J Peacock, Torsten Semmler
May 30, 2018
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes.
Anti-thrombotic efficacy of S007-867
Ankita Misra, Prem Prakash, Hobby Aggarwal, Priyanka Dhankani, Sachin Kumar, Chandra Prakash Pandey, Nicholas Pugh, Dominique Bihan, Manoj Kumar Barthwal, Richard W Farndale, Dinesh Kumar Dikshit, Madhu Dikshit
Mar 15, 2018
Pharmacological inhibition of platelet collagen interaction is a promising therapeutic strategy to treat intra-vascular thrombosis. S007-867 is a novel synthetic inhibitor of collagen-induced platelet aggregation. It has shown...
Blood Flow Velocity Collagen Hemostasis Platelet Activation Thrombosis Animals Aspirin Blood Coagulation Chlorides Clopidogrel Dose-Response Relationship Drug Ferric Compounds Fibrinolytic Agents Male Mice Piperidines Platelet Adhesiveness Platelet Aggregation Pyrrolidines Rats Rats Sprague-Dawley Thrombosis
Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis.
Ramani Baddam, Narender Kumar, Lothar H Wieler, Aditya Kumar Lankapalli, Niyaz Ahmed, Sharon J Peacock, Torsten Semmler
Sep 26, 2018
Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, resistance to which occurs primarily due to mutations in pncA (Rv2043c) that encodes the pyrazinamidase enzyme responsible for conversion of pro-drug PZA into...
Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites
Nalinee Kanth Kadiyala, Badal Kumar Mandal, L Vinod Kumar Reddy, Crispin HW Barnes, Luis De Los Santos Valladares, Dwaipayan Sen
Feb 23, 2023
This study mainly deals with an effective one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed zirconium oxide nanoparticles on the flattened rough surface of reduced graphene oxide (ZrO2/rGO NCs)...
Nanobubbles in water and wastewater treatment systems
Mingyi Jia, Muhammad Usman Farid, Jehad A. Kharraz, Nallapaneni Manoj Kumar, Shauhrat S. Chopra, Am Jang, John Chew, Samir Kumar Khanal, Guanghao Chen, Alicia An
Oct 15, 2023
Since the discovery of nanobubbles (NBs) in 1994, NBs have been attracting growing attention for their fascinating properties and have been studied for application in various environmental fields, including water and wastewater...
Linker Histone Medicated Regulation of Mitotic Chromosome Compaction and Individualization
Pavan Choppakatla
Jan 01, 0001
Mitotic chromosomes are scaled to the cell size to ensure effective chromosome segregation. Recent studies have shown how condensins and DNA topoisomerase II organize the mitotic chromosome. However, the regulation of these...
Published by: Rockefeller University
Biogenic Photo-Catalyst TiO2 Nanoparticles for Remediation of Environment Pollutants.
Boya Palajonnala Narasaiah, Pravallika Banoth, Angel Guillermo Bustamante Dominguez, Badal Kumar Mandal, Challa Kiran Kumar, Crispin HW Barnes, Luis De Los Santos Valladares, Pratap Kollu
Sep 07, 2022
This article reports a benign environmentally friendly fabrication method of titanium dioxide (TDO) nanoparticles (named TDO NPs3, TDO NPs5, and TDO NPs8) using aqueous extract of durva herb waste. This synthesis process avoids...
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes.
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Michele Vendruscolo, Rajanish Giri
Mar 24, 2023
The phenomenon of protein aggregation is associated with a wide range of human diseases. Our knowledge of the aggregation behaviour of viral proteins, however, is still rather limited. Here, we investigated this behaviour in the...
Animals Mammals Humans Proteome Amyloidogenic Proteins covid-19 SARS-CoV-2 Severe acute respiratory syndrome-related coronavirus
Published by: Nature Communications
Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites
Nalinee Kanth Kadiyala, Badal Kumar Mandal, L Vinod Kumar Reddy, Crispin HW Barnes, Luis De Los Santos Valladares, Dwaipayan Sen
Jan 18, 2023
This study mainly deals with an effective one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed zirconium oxide nanoparticles on the flattened rough surface of reduced graphene oxide (ZrO2/rGO NCs)...
Nanobubbles in water and wastewater treatment systems
Mingyi Jia, Muhammad Usman Farid, Jehad A. Kharraz, Nallapaneni Manoj Kumar, Shauhrat S. Chopra, Am Jang, John Chew, Samir Kumar Khanal, Guanghao Chen, Alicia An
Oct 15, 2023
Since the discovery of nanobubbles (NBs) in 1994, NBs have been attracting growing attention for their fascinating properties and have been studied for application in various environmental fields, including water and wastewater...
Functional balance between Tcf21-Slug defines cellular plasticity and migratory modalities in high grade serous ovarian cancer cell lines.
Sagar S Varankar, Madhuri More, Ancy Abraham, Kshama Pansare, Brijesh Kumar, Nivedhitha J Narayanan, Mohit Kumar Jolly, Avinash M Mali, Sharmila A Bapat
Dec 19, 2019
Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis that can be initiated by single cell epithelial to mesenchymal transition (EMT) or cooperative cell migration (CCM). Our study identifies...
Development and Validation of a Nonremission Risk Prediction Model in First-Episode Psychosis
Samuel P Leighton, Rajeev Krishnadas, Rachel Upthegrove, Steven Marwaha, Ewout W Steyerberg, Georgios V Gkoutos, Matthew R Broome, Peter F Liddle, Linda Everard, Swaran P Singh, Nicholas Freemantle, David Fowler, Peter B Jones, Vimal Sharma, Robin Murray, Til Wykes, Richard J Drake, Iain Buchan, Simon Rogers, Jonathan Cavanagh, Shon W Lewis, Max Birchwood, Pavan K Mallikarjun
Oct 28, 2021
Psychosis is a major mental illness with first onset in young adults. The prognosis is poor in around half of the people affected, and difficult to predict. The few tools available to predict prognosis have major weaknesses...
Schizophrenia Prognosis logistic regression Early intervention Psychotic Disorders Precision Medicine
Published by: Schizophrenia bulletin open
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