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Results: 42
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.
Dimitris Karamitros, Bilyana Stoilova, Zahra Aboukhalil, Fiona Hamey, Andreas Reinisch, Marina Samitsch, Lynn Quek, Georg Otto, Emmanouela Repapi, Jessica Doondeea, Batchimeg Usukhbayar, Julien Calvo, Stephen Taylor, Nicolas Goardon, Emmanuelle Six, Francoise Pflumio, Catherine Porcher, Ravindra Majeti, Berthold Göttgens, Paresh Vyas
Nov 06, 2017
Torsion, torsion length and finitely presented groups
Abstract
We show that a construction by Aanderaa and Cohen used in their proof of the Higman Embedding Theorem preserves torsion length. We give a new construction showing that...
COVID-19 Crisis
Yui-yip Lau, Yuk Ming Tang, Ka Yin Chau, Lina Vyas, Andrés Sandoval-Hernández, Simon Wong
Jul 22, 2021
The COVID-19 pandemic has brought a tremendous impact on the pedagogy and learning experience of students in sub-degree education sector of Hong Kong. Online learning has become the “sole” solution to deal with student learning...
Impact of spliceosome mutations on RNA splicing in myelodysplasia
Andrea Pellagatti, Richard N Armstrong, Violetta Steeples, Eshita Sharma, Emmanouela Repapi, Shalini Singh, Andrea Sanchi, Aleksandar Radujkovic, Patrick Horn, Hamid Dolatshad, Swagata Roy, John Broxholme, Helen Lockstone, Stephen Taylor, Aristoteles Giagounidis, Paresh Vyas, Anna Schuh, Angela Hamblin, Elli Papaemmanuil, Sally Killick, Luca Malcovati, Marco L Hennrich, Anne-Claude Gavin, Anthony D Ho, Thomas Luft, Eva Hellström-Lindberg, Mario Cazzola, Christopher WJ Smith, Stephen Smith, Jacqueline Boultwood
Mar 19, 2019
SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in the myelodysplastic syndromes (MDS). We have performed a comprehensive and systematic analysis to determine the effect of these commonly mutated...
A combination of soft X-ray and laser light sources offer 3D high content information on the native state of the cellular environment
Abstract
Beamline B24 is a life sciences correlative cryo-imaging beamline at Diamond Light Source. B24 uses a combination of conventional and super-resolution visible-light...
COVID-19 Crisis
Yui-yip Lau, Yuk Ming Tang, Ka Yin Chau, Lina Vyas, Andrés Sandoval-Hernández, Simon Wong
Jul 22, 2021
The COVID-19 pandemic has brought a tremendous impact on the pedagogy and learning experience of students in sub-degree education sector of Hong Kong. Online learning has become the “sole” solution to deal with student learning...
Impact of the announcement and implementation of the UK Soft Drinks Industry Levy on sugar content, price, product size and number of available soft drinks in the UK, 2015-19
Peter Scarborough, Vyas Adhikari, Richard A. Harrington, Ahmed Elhussein, Adam Briggs, Mike Rayner, Jean Adams, Steven Cummins, Tarra Penney, Martin White
Feb 11, 2020
Background: Dietary sugar, especially in liquid form, increases risk of dental caries, adiposity, and type 2 diabetes. The United Kingdom Soft Drinks Industry Levy (SDIL) was announced in March 2016 and implemented in April 2018...
CD82 controls CpG-dependent TLR9 signaling.
Nida S Khan, Daniel P Lukason, Marianela Feliu, Rebecca A Ward, Allison K Lord, Jennifer L Reedy, Zaida G Ramirez-Ortiz, Jenny M Tam, Pia V Kasperkovitz, Paige E Negoro, Tammy D Vyas, Shuying Xu, Melanie M Brinkmann, Mridu Acharaya, Katerina Artavanis-Tsakonas, Eva-Maria Frickel, Christine E Becker, Zeina Dagher, You-Me Kim, Eicke Latz, Hidde L Ploegh, Michael K Mansour, Cindy K Miranti, Stuart M Levitz, Jatin M Vyas
Oct 03, 2019
The Scanning TMR Microscope for Biosensor Applications.
Kunal N Vyas, David M Love, Adrian Ionescu, Justin Llandro, Pratap Kollu, Thanos Mitrelias, Stuart Holmes, Crispin HW Barnes
Sep 28, 2021
We present a novel tunnel magnetoresistance (TMR) scanning microscope set-up capable of quantitatively imaging the magnetic stray field patterns of micron-sized elements in 3D. By incorporating an Anderson loop measurement...
Impact of the announcement and implementation of the UK Soft Drinks Industry Levy on sugar content, price, product size and number of available soft drinks in the UK, 2015-19
Peter Scarborough, Vyas Adhikari, Richard A Harrington, Ahmed Elhussein, Adam Briggs, Mike Rayner, Jean Adams, Steven Cummins, Tarra Penney, Martin White
Jan 09, 2020
BACKGROUND: Dietary sugar, especially in liquid form, increases risk of dental caries, adiposity, and type 2 diabetes. The United Kingdom Soft Drinks Industry Levy (SDIL) was announced in March 2016 and implemented in April 2018...
Impact of the announcement and implementation of the UK Soft Drinks Industry Levy on sugar content, price, product size and number of available soft drinks in the UK, 2015-19
Peter Scarborough, Vyas Adhikari, Richard A Harrington, Ahmed Elhussein, Adam Briggs, Mike Rayner, Jean Adams, Steven Cummins, Tarra Penney, Martin White
Mar 13, 2020
BACKGROUND:Dietary sugar, especially in liquid form, increases risk of dental caries, adiposity, and type 2 diabetes. The United Kingdom Soft Drinks Industry Levy (SDIL) was announced in March 2016 and implemented in April 2018...
Published by: PLoS Medicine
Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer's disease
Michael CB David, Martina Del Giovane, Kathy Y Liu, Benjamin Gostick, James Rowe, Imafidon Oboh, Robert Howard, Paresh A Malhotra
Jul 19, 2022
BACKGROUND: Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some patients. This system offers a potential therapeutic...
Aβ42/Aβ40 and Aβ42/Aβ38 Ratios Are Associated with Measures of Gait Variability and Activities of Daily Living in Mild Alzheimer's Disease
Ivan Koychev, Brook Galna, Henrik Zetterberg, Jennifer Lawson, Giovanna Zamboni, Basil H Ridha, James B Rowe, Alan Thomas, Robert Howard, Paresh Malhotra, Craig Ritchie, Simon Lovestone, Lynn Rochester
Dec 20, 2018
Gait disturbances are some of the earliest changes in dementia and their monitoring presents an opportunity for early diagnosis. The exact relationship between gait and well-established biomarkers of Alzheimer's disease (AD)...
Intelligent Fog Computing Surveillance System for Crime and Vulnerability Identification and Tracing
Ranjana Sikarwar, Romil Rawat, Rajesh Chakrawarti, José Gonzáles, Ramakant Bhardwaj, Piyush Vyas
Jan 01, 2023
IoT devices generate enormous amounts of data, which deep learning algorithms can learn from more effectively than shallow learning algorithms. The approach for threat detection may ultimately benefit fog computing or fog...
Published by: IGI Global Scientific Publishing
Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program.
Ranna El-Khairi, Evelyn Olszanowski, Daniele Muraro, Pedro Madrigal, Katarzyna Tilgner, Mariya Chhatriwala, Sapna Vyas, Crystal Y Chia, Ludovic Vallier, Santiago A Rodríguez-Seguí
Sep 07, 2021
HNF1B MODY5 Diabetes DIFFERENTIATION Human induced pluripotent stem cells iPSC in vitro monogenic Pancreas β cell Biomarkers CRISPR-Cas Systems Cell Differentiation Cell Lineage Diabetes mellitus Disease Susceptibility Fluorescent Antibody Technique Gene Editing Gene Expression Profiling Gene Expression Regulation Developmental Haploinsufficiency Hepatocyte Nuclear Factor 1-beta Humans Immunophenotyping Induced Pluripotent Stem Cells Insulin-Secreting Cells Models Biological Organogenesis Pancreas Signal Transduction
Visualizing Magnetic Structure in 3D Nanoscale Ni-Fe Gyroid Networks.
Justin Llandro, David M Love, András Kovács, Jan Caron, Kunal N Vyas, Attila Kákay, Ruslan Salikhov, Kilian Lenz, Jürgen Fassbender, Maik RJ Scherer, Christian Cimorra, Ullrich Steiner, Crispin HW Barnes, Rafal E Dunin-Borkowski, Shunsuke Fukami, Hideo Ohno
Apr 27, 2020
Arrays of interacting 2D nanomagnets display unprecedented electromagnetic properties via collective effects, demonstrated in artificial spin ices and magnonic crystals. Progress toward 3D magnetic metamaterials is hampered by...
Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer's disease
Michael CB David, Martina Del Giovane, Kathy Y Liu, Benjamin Gostick, James Benedict Rowe, Imafidon Oboh, Robert Howard, Paresh A Malhotra
Jul 25, 2022
BACKGROUND: Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some patients. This system offers a potential therapeutic...
Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults
Abstract
Background
Considerable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD)....
Audrey Low, Maria A Prats-Sedano, Elizabeth McKiernan, Stephen F Carter, James D Stefaniak, Stefania Nannoni, Li Su, Maria-Eleni Dounavi, Graciela Muniz-Terrera, Karen Ritchie, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare Mackay, Ivan Koychev, Craig W Ritchie, Hugh S Markus, John T O’Brien
Oct 12, 2022
Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.
Cécile K Lopez, Esteve Noguera, Vaia Stavropoulou, Elie Robert, Zakia Aid, Paola Ballerini, Chrystèle Bilhou-Nabera, Hélène Lapillonne, Fabien Boudia, Cécile Thirant, Alexandre Fagnan, Marie-Laure Arcangeli, Sarah J Kinston, M'Boyba Diop, Bastien Job, Yann Lecluse, Erika Brunet, Loélia Babin, Jean Luc Villeval, Eric Delabesse, Antoine HFM Peters, William Vainchenker, Muriel Gaudry, Riccardo Masetti, Franco Locatelli, Sébastien Malinge, Claus Nerlov, Nathalie Droin, Camille Lobry, Isabelle Godin, Olivier A Bernard, Berthold Göttgens, Arnaud Petit, Françoise Pflumio, Juerg Schwaller, Thomas Mercher
Nov 25, 2019
Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the specific associations between age and phenotype. We observed that fusion oncogenes, such as ETO2-GLIS2, are associated with acute...
Deep and Frequent Phenotyping study protocol
Ivan Koychev, Jennifer Lawson, Tharani Chessell, Clare Mackay, Roger Gunn, Barbara Sahakian, James B Rowe, Alan J Thomas, Lynn Rochester, Dennis Chan, Brian Tom, Paresh Malhotra, Clive Ballard, Iain Chessell, Craig W Ritchie, Vanessa Raymont, Iracema Leroi, Imre Lengyel, Matt Murray, David L Thomas, John Gallacher, Simon Lovestone
Feb 11, 2019
Alzheimer’s disease Amyloid Biomarkers prodromal dementia Tau Aged Alzheimer Disease Amyloid beta-Peptides Biomarkers Case-Control Studies Cognition Disease Progression Female Gait analysis Humans Magnetic Resonance Imaging Male Mental Status and Dementia Tests Multicenter Studies as Topic Neuroimaging Observational Studies as Topic Phenotype Positron Emission Tomography Computed Tomography
Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs
Anton M Sholukh, Jennifer D Watkins, Hemant K Vyas, Sandeep Gupta, Samir K Lakhashe, Swati Thorat, Mingkui Zhou, Girish Hemashettar, Barbara C Bachler, Donald N Forthal, Francois Villinger, Quentin J Sattentau, Robin A Weiss, Gloria Agatic, Davide Corti, Antonio Lanzavecchia, Jonathan L Heeney, Ruth M Ruprecht
Jun 12, 2015
(6 max) Complete protection IgA IgG Passive immunization Rhesus monkey SHIV-C mucosal challenge Administration Intravenous Administration mucosal Animals Antibodies Monoclonal Antibodies Neutralizing HIV Antibodies HIV-1 Humans Immunity Cellular Immunity mucosal Immunization Passive Immunoglobulin A Immunoglobulin G Macaca mulatta Mucous Membrane RNA Viral Simian Acquired Immunodeficiency Syndrome Simian Immunodeficiency Virus T-Lymphocytes
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.
Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean Teh, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher S Foster, Anne Y Warren, Hayley C Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Patrick F Chinnery, Ultan McDermott, Michael R Stratton, Peter J Campbell
Nov 01, 2018
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated...
cancer genome evolution evolutionary biology Genomics human Mitochondrial DNA mutational signature SEQUENCING Somatic mutation Animals Base Composition DNA DNA Replication DNA Mitochondrial DNA Neoplasm Data Mining evolution Molecular Genome Mitochondrial High-Throughput Nucleotide Sequencing Humans Mitochondria Mutation Neoplasms Polymorphism Single Nucleotide
Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia
Maria-Eleni Dounavi, Coco Newton, Natalie Jenkins, Elijah Mak, Audrey Low, Graciela Muniz-Terrera, Guy B Williams, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare E Mackay, Ivan Koychev, Karen Ritchie, Craig W Ritchie, Li Su, John T O'Brien
Jul 19, 2022
BACKGROUND: Macrostructural brain alterations in the form of brain atrophy or cortical thinning typically occur during the prodromal Alzheimer's disease stage. Mixed findings largely dependent on the age of the examined cohorts...
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