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Whole Genome Sequencing of Giant Schnauzer Dogs with Progressive Retinal Atrophy Establishes NECAP1 as a Novel Candidate Gene for Retinal Degeneration.
Rebekkah J Hitti, James AC Oliver, Ellen C Schofield, Anina Bauer, Maria Kaukonen, Oliver P Forman, Tosso Leeb, Hannes Lohi, Louise M Burmeister, David Sargan, Cathryn S Mellersh
Aug 21, 2019
Canine progressive retinal atrophies (PRA) are genetically heterogeneous diseases characterized by retinal degeneration and subsequent blindness. PRAs are untreatable and affect multiple dog breeds, significantly impacting...
Defining the ABC of gene essentiality in streptococci.
Amelia RL Charbonneau, Oliver P Forman, Amy K Cain, Graham Newland, Carl Robinson, Mike Boursnell, Julian Parkhill, James A Leigh, Duncan J Maskell, Andrew S Waller
Jun 01, 2017
BACKGROUND: Utilising next generation sequencing to interrogate saturated bacterial mutant libraries provides unprecedented information for the assignment of genome-wide gene essentiality. Exposure of saturated mutant libraries...
Non-invasive technical investigation of english portrait miniatures attributed to Nicholas Hilliard and Isaac Oliver
This study presents the results of the technical investigation carried out on several English portrait miniatures painted in the 16th and 17th century by Nicholas Hilliard and Isaac Oliver, two of the most famous limners...
Oliver Cromwell and the People of God
DL Smith
Jul 01, 2019
On 21 April 1657, in one of the speeches to Parliament’s representatives in which he meditated on their offer of the kingship, Oliver Cromwell offered these words of praise for those who had framed the Humble Petition and...
Defining the ABC of gene essentiality in streptococci
Amelia RL Charbonneau, Oliver P Forman, Amy K Cain, Graham Newland, Carl Robinson, Mike Boursnell, Julian Parkhill, James A Leigh, Duncan John Maskell, Andrew S Waller
Aug 17, 2017
Background
Utilising next generation sequencing to interrogate saturated bacterial mutant libraries provides unprecedented information for the assignment of genome-wide gene essentiality. Exposure of saturated mutant libraries...
Problem formulation for theorizing at the frontier
Ostensibly, the evolving science of strategic management is geared towards addressing vexing
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
Interview with Gwen P. Howell
Gwen P. Howell
Jan 01, 0001
Interview with Gwen P. Howell, member of the South Carolina Mothers Association.
Published by: Winthrop University
Problem formulation for theorizing at the frontier
Ostensibly, the evolving science of strategic management is geared towards addressing vexing
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
managerial problems. In practice, however, scholars in the field have a marked tendency to formulate problems to fit existing...
PSK Method for Solving Mixed and Type-4 Intuitionistic Fuzzy Solid Transportation Problems
P. Kumar
Apr 01, 2019
In this article, the author categorises the solid transportation problem (STP) under uncertain environments. He formulates the mixed and fully intuitionistic fuzzy solid transportation problems (FIFSTPs) and utilizes the...
Published by: IGI Global Scientific Publishing
Crystalline Interlayers for Reducing the Effective Thermal Boundary Resistance in GaN-on-Diamond.
Daniel E Field, Jerome A Cuenca, Matthew Smith, Simon M Fairclough, Fabien C-P Massabuau, James W Pomeroy, Oliver Williams, Rachel A Oliver, Iain Thayne, Martin Kuball
Nov 25, 2020
Integrating diamond with GaN high electron mobility transistors (HEMTs) improves thermal management, ultimately increasing the reliability and performance of high-power high-frequency radio frequency amplifiers. Conventionally...
Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.
Robert Lowe, Carl Barton, Christopher A Jenkins, Christina Ernst, Oliver Forman, Denise Sylvia Fernandez-Twinn, Christoph Bock, Stephen J Rossiter, Chris G Faulkes, Susan Ozanne, Lutz Walter, Duncan Odom, Cathryn Mellersh, Vardhman K Rakyan
Apr 26, 2018
Mammalian species exhibit a wide range of lifespans. To date, a robust and dynamic molecular readout of these lifespan differences has not yet been identified. Recent studies have established the existence of ageing-associated...
B Cell Activation: The Regulation by T Cells and the Induction of the Protein Tyrosine Kinase SYK
Mark S Forman
Jan 01, 0001
During the activation and differentiation of B cells, there are critical stages of regulation which determine the fate of the B cell. Resting B cells are initially stimulated by either native antigen or T cells via...
Published by: Rockefeller University
Identifying risk factors for L'Hermitte's sign after IMRT for head and neck cancer.
Hannah M Laidley, David Noble, Gill C Barnett, Julia R Forman, Amy M Bates, Richard J Benson, Sarah J Jefferies, Rajesh Jena, Neil Burnet
Jul 03, 2018
BACKGROUND
L’Hermitte’s sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high.
METHODS
117 patients...
Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.
Robert Lowe, Carl Barton, Christopher A Jenkins, Christina Ernst, Oliver Forman, Denise S Fernandez-Twinn, Christoph Bock, Stephen J Rossiter, Chris G Faulkes, Susan E Ozanne, Lutz Walter, Duncan T Odom, Cathryn Mellersh, Vardhman K Rakyan
Apr 26, 2018
BACKGROUND: Mammalian species exhibit a wide range of lifespans. To date, a robust and dynamic molecular readout of these lifespan differences has not yet been identified. Recent studies have established the existence of...
Measurement of the η<inf>c</inf>(1 S) production cross-section in p p collisions at √s=13TeV
R Aaij, CA Beteta, T Ackernley, B Adeva, M Adinolfi, H Afsharnia, CA Aidala, S Aiola, Z Ajaltouni, S Akar, P Albicocco, J Albrecht, F Alessio, M Alexander, AA Albero, G Alkhazov, PA Cartelle, AA Alves, S Amato, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, F Archilli, P d’Argent, JA Romeu, A Artamonov, M Artuso, K Arzymatov, E Aslanides, M Atzeni, B Audurier, S Bachmann, JJ Back, S Baker, V Balagura, W Baldini, A Baranov, RJ Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, G Bassi, V Batozskaya, B Batsukh, A Battig, V Battista, A Bay, M Becker, F Bedeschi, I Bediaga, A Beiter, LJ Bel, V Belavin, S Belin, N Beliy, V Bellee, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, S Beranek, A Berezhnoy, R Bernet, D Berninghoff, HC Bernstein, E Bertholet, A Bertolin, C Betancourt, F Betti, MO Bettler, MV Beuzekom, I Bezshyiko, S Bhasin, J Bhom, MS Bieker, S Bifani, P Billoir, A Birnkraut, A Bizzeti, M Bjørn, MP Blago, T Blake, F Blanc, S Blusk, D Bobulska, V Bocci, OB Garcia, T Boettcher, A Boldyrev, A Bondar, N Bondar, S Borghi, M Borisyak, M Borsato, JT Borsuk, M Boubdir
Mar 02, 2021
Using a data sample corresponding to an integrated luminosity of
$2.0\,fb^{-1}$, collected by the LHCb experiment, the production of the
$\eta_c(1S)$ state in proton-proton collisions at a centre-of-mass energy of
$\sqrt{s}=13...
Performance Characteristics of Discrete-Time Queue With Variant Working Vacations
This article analyzes an infinite buffer discrete-time single server queueing system with variant working vacations in which customers arrive according to a geometric process. As soon as the system becomes empty, the server...
Published by: IGI Global Scientific Publishing
Axonal Transport of Glycoproteins and Glycolipids in the Goldfish Optic System
David Sholem Forman
Jan 01, 0001
The goldfish retino-tectal pathway is a convenient experimental system for studying axonal transport. Radioactive precursors are injected into the eye, and radioactivity which is transported in the axons of the retinal ganglion...
Published by: Rockefeller University
Research Inefficiency in Degenerative Cervical Myelopathy
STUDY DESIGN: Scoping review. OBJECTIVE: To describe activity, themes and trends in degenerative cervical myelopathy (DCM) research over the past 20 years with a view to considering DCM research inefficiency. METHODS: A...
Intrinsically p-biharmonic maps
For a compact Riemannian manifold $N$, a domain $\Omega \subset \mathbb{R}^m$ and for $p \in (1,\infty)$, we introduce an intrinsic version $E_p$ of the $p$-biharmonic energy functional for maps $u : \Omega \to N$. This requires...
The Synthetic Chemistry of Carboxyalkyl-P, P-Diphenyl Phosphines
Larry S. Andrews
Jan 01, 0001
This 55 page thesis examines the preparation of carboxyalkyl-P and P-diphenyl phosphines to determine their acidity characteristics as a function of structure and to characterize their ability to function as chelating agents.
potassium diphenylphosphine sodium liquid ammonia Acidity Synthesis Chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Ratiometric electrochemical detection of Pd•••π interactions
The widespread and large scale use of platinum group metals, especially palladium, in a wide variety of industrial applications has seen their levels in wastewater streams, roadside dust and even pharmaceuticals significantly...
Recycling thermal insulation materials
The limits to linear models of production based on material extraction, manufacture, use, and disposal are becoming increasingly apparent across the global economy. The Circular Economy (CE) describes an alternative to...
Application of fluid dynamic gauging in the characterization and removal of biofouling deposits
Green cleaning is generally defined as cleaning of a surface by consuming minimal resources in order to lessen the impact on human health and environmental quality. The main aim of this study is to perform cleaning studies of...
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