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The Meaningfulness of Knowledge for the Design of Sustainable AI
A growing number of business processes can be characterized as knowledge-intensive. The ability to speed up the necessary transfer of knowledge between individuals in business processes can lead to a huge competitive advantage...
Published by: IGI Global Scientific Publishing
Addressing Sustainability of Sanitation Systems
Recently, a technical draft of the international standard ISO/DIS 30500 for non-sewered sanitation systems has been developed (publication expected for 2018). Its innovative feature is the inclusion of sustainable aspects. This...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
Biocompatible, Crystalline, and Amorphous Bismuth-Based Metal-Organic Frameworks for Drug Delivery.
The synthetic flexibility of metal-organic frameworks (MOFs) with high loading capacities and biocompatibility makes them ideal candidates as drug delivery systems (DDSs). Here, we report the use of CAU-7, a biocompatible...
In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer.
Fluorescent transcriptional reporters are widely used as signaling reporters and biomarkers to monitor pathway activities and determine cell type identities. However, a large amount of dynamic information is lost due to the long...
D. melanogaster developmental biology fluorescent reporter transcriptional dynamics transcriptional timer Animals Drosophila melanogaster Embryo Nonmammalian Enhancer Elements Genetic Fluorescence Gene Expression Regulation Green Fluorescent Proteins Intestines Protein Biosynthesis Receptors Notch STAT Transcription Factors Stem Cells Transcription Genetic
Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations.
Balázs Göcz, Szabolcs Takács, Katalin Skrapits, Éva Rumpler, Norbert Solymosi, Szilárd Póliska, William H Colledge, Erik Hrabovszky, Miklós Sárvári
Sep 08, 2022
Kisspeptin neurons residing in the rostral periventricular area of the third ventricle (KPRP3V) and the arcuate nucleus (KPARC) mediate positive and negative estrogen feedback, respectively. Here, we aim to compare...
Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.
Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that...
Design and development of a nozzle-free electrospinning device for the high-throughput production of biomaterial nanofibers
Muhammad Waqas, Antonios Keirouz, Maria Kana Sanira Putri, Faraz Fazal, Francisco Javier Diaz Sanchez, Dipa Ray, Vasileios Koutsos, Norbert Radacsi
Jun 30, 2021
This technical note provides a step-by-step guide for the design and construction of a temperature-controlled nozzle-free electrospinning device. The equipment uses a rotating mandrel partially immersed within a polymer...
Direct and Indirect Determinants of Body Mass Index in Both Major Ethnic Groups Experiencing the Nutritional Transition in Cameroon.
Emmanuel Cohen, Norbert Amougou, Amandine Ponty, Margaux Guerrien, Wakilongo Wakenge, Glory Chidumwa, Rihlat Said-Mohamed, Léopold K Fezeu, Patrick Pasquet
Jun 29, 2022
In the context of rapid nutritional transitions in Africa, few studies have analyzed the etiology of obesity by considering the driver pathways that predict body mass index (BMI). The aim of this study is to innovatively...
Direct and Indirect Determinants of Body Mass Index in Both Major Ethnic Groups Experiencing the Nutritional Transition in Cameroon.
Emmanuel Cohen, Norbert Amougou, Amandine Ponty, Margaux Guerrien, Wakilongo Wakenge, Glory Chidumwa, Rihlat Said-Mohamed, Léopold K Fezeu, Patrick Pasquet
May 19, 2022
In the context of rapid nutritional transitions in Africa, few studies have analyzed the etiology of obesity by considering the driver pathways that predict body mass index (BMI). The aim of this study is to innovatively...
An Octanuclear Metallosupramolecular Cage Designed To Exhibit Spin-Crossover Behavior.
Niklas Struch, Christoph Bannwarth, Tanya K Ronson, Yvonne Lorenz, Bernd Mienert, Norbert Wagner, Marianne Engeser, Eckhard Bill, Rakesh Puttreddy, Kari Rissanen, Johannes Beck, Stefan Grimme, Jonathan R Nitschke, Arne Lützen
Mar 29, 2018
By employing the subcomponent self-assembly approach utilizing 5,10,15,20-tetrakis(4-aminophenyl)porphyrin or its zinc(II) complex, 1H-4-imidazolecarbaldehyde, and either zinc(II) or iron(II) salts, we were able to prepare...
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.
Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Jan 02, 2019
UNLABELLED: Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation....
E3 ubiquitin ligase ER associated degradation HMGCR RNF145 Cell Biology Cholesterol gp78 human Animals CRISPR-Cas Systems Cholesterol Humans Hydroxymethylglutaryl CoA Reductases Membrane Proteins Mice Proteolysis Receptors Autocrine Motility Factor Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination
Response of the human gut and saliva microbiome to urbanization in Cameroon.
Ana Lokmer, Sophie Aflalo, Norbert Amougou, Sophie Lafosse, Alain Froment, Francis Ekwin Tabe, Mathilde Poyet, Mathieu Groussin, Rihlat Said-Mohamed, Laure Ségurel
May 18, 2020
Urban populations from highly industrialized countries are characterized by a lower gut bacterial diversity as well as by changes in composition compared to rural populations from less industrialized countries. To unveil the...
The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region.
Bismark Osei Sarfo, Andreas Hahn, Norbert Georg Schwarz, Anna Jaeger, Nimako Sarpong, Florian Marks, Yaw Adu-Sarkodie, Thalea Tamminga, Juergen May
Feb 19, 2019
BACKGROUND: Malaria remains a leading cause of childhood mortality in sub-Saharan Africa. Identifying patients who are at risk for severe manifestations at presentation still remains challenging. This study examines whether a...
Design and development of a nozzle-free electrospinning device for the high-throughput production of biomaterial nanofibers
Muhammad Waqas, Antonios Keirouz, Maria Kana Sanira Putri, Faraz Fazal, Francisco Javier Diaz Sanchez, Dipa Ray, Vasileios Koutsos, Norbert Radacsi
Jun 30, 2021
This technical note provides a step-by-step guide for the design and construction of a temperature-controlled nozzle-free electrospinning device. The equipment uses a rotating mandrel partially immersed within a polymer...
Pharmacological characterisation of novel adenosine A3 receptor antagonists.
Kerry Barkan, Panagiotis Lagarias, Margarita Stampelou, Dimitrios Stamatis, Sam Hoare, Dewi Safitri, Karl-Norbert Klotz, Eleni Vrontaki, Antonios Kolocouris, Graham Ladds
Sep 22, 2020
Adenosine A3 Receptor Antagonists Animals Binding Sites Binding Competitive CHO Cells Cricetulus Cyclic AMP Drug Evaluation Preclinical Humans Kinetics Molecular Dynamics Simulation Mutagenesis Site-Directed Radioligand Assay Rats Receptor Adenosine A3 Receptors Purinergic P1 Recombinant Proteins Species Specificity Structure-Activity Relationship
Enisamium Reduces Influenza Virus Shedding and Improves Patient Recovery by Inhibiting Viral RNA Polymerase Activity.
Aartjan JW Te Velthuis, Tatiana G Zubkova, Megan Shaw, Andrew Mehle, David Boltz, Norbert Gmeinwieser, Holger Stammer, Jens Milde, Lutz Müller, Victor Margitich
Jan 27, 2021
FAV00A RNA polymerase RNA synthesis Adenovirus Adenoviruses enisamium iodide influenza A and B influenza A and B viruses respiratory syncytial virus respiratory viruses Treatment Adolescent Adult Humans Influenza Human Middle Aged Orthomyxoviridae Pyridinium Compounds RNA Viral Respiratory Tract Infections Viral Replicase Complex Proteins Virus Shedding Young Adult
Very Large Array Radio Study of a Sample of Nearby X-Ray and Optically Bright Early-type Galaxies
Abstract
Many massive early-type galaxies host central radio sources and hot X-ray atmospheres indicating the presence of radio-mechanical active galactic nucleus (AGN) feedback....
Romana Grossová, Norbert Werner, Francesco Massaro, Kiran Lakhchaura, Tomáš Plšek, Krisztina Gabányi, Kamlesh Rajpurohit, Rebecca EA Canning, Paul Nulsen, Ewan O’Sullivan, Steven W Allen, Andrew Fabian
Jan 28, 2022
Nutrition Transition and Biocultural Determinants of Obesity among Cameroonian Migrants in Urban Cameroon and France.
Emmanuel Cohen, Norbert Amougou, Amandine Ponty, Juliette Loinger-Beck, Téodyl Nkuintchua, Nicolas Monteillet, Jonathan Y Bernard, Rihlat Saïd-Mohamed, Michelle Holdsworth, Patrick Pasquet
Jan 21, 2020
Native of rural West Cameroon, the Bamiléké population is traditionally predisposed to obesity. Bamiléké who migrated to urban areas additionally experience the nutrition transition. We investigated the biocultural determinants...
Very Large Array Radio Study of a Sample of Nearby X-Ray and Optically Bright Early-type Galaxies
Abstract
Many massive early-type galaxies host central radio sources and hot X-ray atmospheres indicating the presence of radio-mechanical active galactic nucleus (AGN) feedback....
Romana Grossová, Norbert Werner, Francesco Massaro, Kiran Lakhchaura, Tomáš Plšek, Krisztina Gabányi, Kamlesh Rajpurohit, Rebecca EA Canning, Paul Nulsen, Ewan O’Sullivan, Steven W Allen, Andrew Fabian
Feb 09, 2022
Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.
Harm J Bogaard, Ekaterina Legchenko, Ketul R Chaudhary, Xiao-Qing Sun, Duncan J Stewart, Georg Hansmann
Nov 20, 2019
Translational research is essential to develop strategies for the treatment of pulmonary arterial hypertension (PAH) using animal models which reproduce the severity, the progressive nature and resistance to...
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