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Results: 170
Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer
IMPORTANCE: The age-based or "one-size-fits-all" breast screening approach does not take into account the individual variation in risk. Mammography screening reduces death from breast cancer at the cost of overdiagnosis....
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Ros Eeles, Zsofia Kote-Jarai, Paul D P Pharoah, Nora Pashayan
Jan 27, 2020
BACKGROUND:The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69. Knowing how the potential benefits and harms of screening...
Potential of polygenic risk scores for improving population estimates of women's breast cancer genetic risks.
Michael Wolfson, Steve Gribble, Nora Pashayan, Douglas F Easton, Antonis C Antoniou, Andrew Lee, Sasha van Katwyk, Jacques Simard
Jul 09, 2021
PURPOSE: Breast cancer risk has conventionally been assessed using family history (FH) and rare high/moderate penetrance pathogenic variants (PVs), notably in BRCA1/2, and more recently PALB2, CHEK2, and ATM. In addition to...
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Zsofia Kote-Jarai, Paul DP Pharoah, Nora Pashayan
Feb 07, 2020
BACKGROUND: The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69. Knowing how the potential benefits and harms of...
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Zsofia Kote-Jarai, Paul D. P. Pharoah, Nora Pashayan
Dec 20, 2019
Background: The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55–69. Knowing how the potential benefits and harms of...
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Nora Pashayan, Antonis C Antoniou, Andrew Lee, Michael Wolfson, Jocelyne Chiquette, Laurence Eloy, Andrea Eisen, Tracy L Stockley, Hermann Nabi, Jennifer D Brooks, Michel Dorval, Douglas F Easton, Bartha Maria Knoppers, Anna M Chiarelli, Jacques Simard
Oct 29, 2021
In risk-stratified cancer screening, multiple risk factors are incorporated into the risk assessment. An individual's estimated absolute cancer risk is linked to risk categories with tailored screening recommendations for each...
Published by: Journal of personalized medicine
Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.
Chey Loveday, Kevin Litchfield, Max Levy, Amy Holroyd, Peter Broderick, Zsofia Kote-Jarai, Alison M Dunning, Kenneth Muir, Julian Peto, Rosalind Eeles, Douglas F Easton, Darshna Dudakia, Nick Orr, Nora Pashayan, Alison Reid, Robert A Huddart, Richard S Houlston, Clare Turnbull
Feb 23, 2018
Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number of loci...
Population-Based Precision Cancer Screening
Pamela M Marcus, Nora Pashayan, Timothy R Church, V Paul Doria-Rose, Michael K Gould, Rebecca A Hubbard, Michael Marrone, Diana L Miglioretti, Paul D Pharoah, Paul F Pinsky, Katherine A Rendle, Hilary A Robbins, Megan C Roberts, Betsy Rolland, Mark Schiffman, Jasmin A Tiro, Ann G Zauber, Deborah M Winn, Muin J Khoury
Sep 29, 2016
Should Age-Dependent Absolute Risk Thresholds Be Used for Risk Stratification in Risk-Stratified Breast Cancer Screening?
Nora Pashayan, Antonis C. Antoniou, Andrew Lee, Michael Wolfson, Jocelyne Chiquette, Laurence Eloy, Andrea Eisen, Tracy L. Stockley, Hermann Nabi, Jennifer D. Brooks, Michel Dorval, Douglas F. Easton, Bartha Maria Knoppers, Anna M. Chiarelli, Jacques Simard
Sep 17, 2021
In risk-stratified cancer screening, multiple risk factors are incorporated into the risk assessment. An individual’s estimated absolute cancer risk is linked to risk categories with tailored screening recommendations for each...
When Emotions Rule Knowledge
Although emotions play an important role in human behavior and knowledge studies, knowledge management (KM) research considers them from specific angles and, to date, has lacked a comprehensive understanding of the emotions...
Published by: IGI Global Scientific Publishing
Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology.
Chey Loveday, Philip Law, Kevin Litchfield, Max Levy, Amy Holroyd, Peter Broderick, Zsofia Kote-Jarai, Alison M Dunning, Kenneth Muir, Julian Peto, Rosalind Eeles, Douglas F Easton, Darshna Dudakia, Nick Orr, Nora Pashayan, The PRACTICAL Consortium UK Testicular Cancer Collaboration, Alison Reid, Robert A Huddart, Richard S Houlston, Clare Turnbull
Sep 21, 2018
UNLABELLED: Testicular germ cell tumour (TGCT) is the most common cancer in young men. Multiplex TGCT families have been well reported and analyses of population cancer registries have demonstrated a four- to eightfold risk to...
Familial GWAS Genetics polygenic risk score Testicular germ cell tumour Biomarkers Tumor Case-Control Studies Environment Genetic Predisposition to Disease Genome-Wide Association Study Heredity Humans Life Style Male Multifactorial Inheritance Neoplasms Germ Cell and Embryonal Pedigree Phenotype Polymorphism Single Nucleotide Risk Assessment Risk Factors Testicular Neoplasms
Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis.
The Ursinus Weekly, October 8, 1970
Alan Gold, Bob Swarr, Candy Silver, Marc Hauser, Charles Chambers, Cris Crane, Peter von Sothen
Jan 01, 0001
Pettit inauguration scheduled; Appointments still undetermined Ursinus institutes security measures to protect students Obituaries: Dr. Paul R. Wagner; Nora Shuler Helfferich Ashley Montagu appears in first Forum program ...
Ursinus College Collegeville Pennsylvania newspaper William Schuyler Pettit Donald L. Helfferich security Miley Detective Agency identification cards Paul R. Wagner Nora Shuler Helfferich Ashley Montagu Art Severance field hockey Football cross country Bruce Albert cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Identification of a Microrna Network that Regulates Melanoma Metastasis and Angiogenesis by Targeting Apoe
Nora Pencheva
Jan 01, 0001
Metastatic melanoma, a prevalent and deadly form of skin cancer, remains an aggressive clinical outcome that lacks effective preventative and/or curative therapeutics. Patients diagnosed with advanced metastatic melanoma face a...
Published by: Rockefeller University
Personalized early detection and prevention of breast cancer
Nora Pashayan, Antonis C. Antoniou, Urska Ivanus, Laura J. Esserman, Douglas F. Easton, David French, Gaby Sroczynski, Per Hall, Jack Cuzick, D. Gareth Evans, Jacques Simard, Montserrat Garcia-Closas, Rita Schmutzler, Odette Wegwarth, Paul Pharoah, Sowmiya Moorthie, Sandrine De Montgolfier, Camille Baron, Zdenko Herceg, Clare Turnbull, Corinne Balleyguier, Paolo Giorgi Rossi, Jelle Wesseling, David Ritchie, Marc Tischkowitz, Mireille Broeders, Dan Reisel, Andres Metspalu, Thomas Callender, Harry de Koning, Peter Devilee, Suzette Delaloge, Marjanka K. Schmidt, Martin Widschwendter
Feb 16, 2021
Abstract: The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early...
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