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SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Petra Mlcochova, Steven A Kemp, Mahesh Shanker Dhar, Guido Papa, Bo Meng, Isabella ATM Ferreira, Rawlings Datir, Dami A Collier, Anna Albecka, Sujeet Singh, Rajesh Pandey, Jonathan Brown, Jie Zhou, Niluka Goonawardane, Swapnil Mishra, Charles Whittaker, Thomas Mellan, Robin Marwal, Meena Datta, Shantanu Sengupta, Kalaiarasan Ponnusamy, Venkatraman Srinivasan Radhakrishnan, Adam Abdullahi, Oscar Charles, Partha Chattopadhyay, Priti Devi, Daniela Caputo, Tom Peacock, Chand Wattal, Neeraj Goel, Ambrish Satwik, Raju Vaishya, Meenakshi Agarwal, Indian SARS-CoV-2 Genomics Consortium (INSACOG), Genotype to Phenotype Japan (G2P-Japan) Consortium, CITIID-NIHR BioResource COVID-19 Collaboration, Antranik Mavousian, Joo Hyeon Lee, Jessica Bassi, Chiara Silacci-Fegni, Christian Saliba, Dora Pinto, Takashi Irie, Isao Yoshida, William L Hamilton, Kei Sato, Samir Bhatt, Seth Flaxman, Leo C James, Davide Corti, Luca Piccoli, Wendy S Barclay, Partha Rakshit, Anurag Agrawal, Ravindra K Gupta
Sep 10, 2021
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages...
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity.
Bo Meng, Adam Abdullahi, Isabella ATM Ferreira, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuén Pereyra Gerber, Saman Fatihi, Surabhi Rathore, Samantha K Zepeda, Guido Papa, Steven A Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L Mallery, Oscar J Charles, CITIID-NIHR BioResource COVID-19 Collaboration, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, John E Bowen, Anshu Joshi, Alexandra C Walls, Laurelle Jackson, Darren Martin, Kenneth GC Smith, John Bradley, John AG Briggs, Jinwook Choi, Elo Madissoon, Kerstin B Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah A Teichmann, Andrew J Fisher, Matteo S Pizzuto, Anna de Marco, Davide Corti, Myra Hosmillo, Joo Hyeon Lee, Leo C James, Lipi Thukral, David Veesler, Alex Sigal, Fotios Sampaziotis, Ian G Goodfellow, Nicholas J Matheson, Kei Sato, Ravindra K Gupta
Mar 31, 2022
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its...
Adult Aged Aged 80 and over Angiotensin-Converting Enzyme 2 Animals Antibodies Neutralizing Antibodies Viral covid-19 COVID-19 Vaccines Cell Line Cell Membrane Chlorocebus aethiops Convalescence Female Humans Immune Sera Intestines Lung Male Membrane Fusion Middle Aged Mutation Nasal Mucosa SARS-CoV-2 Serine Endopeptidases Spike Glycoprotein Coronavirus Tissue Culture Techniques Virulence Virus Internalization Virus Replication
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
Petra Mlcochova, Steven A. Kemp, Mahesh Shanker Dhar, Guido Papa, Bo Meng, Isabella A. T. M. Ferreira, Rawlings Datir, Dami A. Collier, Anna Albecka, Sujeet Singh, Rajesh Pandey, Jonathan Brown, Jie Zhou, Niluka Goonawardane, Swapnil Mishra, Charles Whittaker, Thomas Mellan, Robin Marwal, Meena Datta, Shantanu Sengupta, Kalaiarasan Ponnusamy, Venkatraman Srinivasan Radhakrishnan, Adam Abdullahi, Oscar Charles, Partha Chattopadhyay, Priti Devi, Daniela Caputo, Tom Peacock, Chand Wattal, Neeraj Goel, Ambrish Satwik, Raju Vaishya, Meenakshi Agarwal, Antranik Mavousian, Joo Hyeon Lee, Jessica Bassi, Chiara Silacci-Fegni, Christian Saliba, Dora Pinto, Takashi Irie, Isao Yoshida, William L. Hamilton, Kei Sato, Samir Bhatt, Seth Flaxman, Leo C. James, Davide Corti, Luca Piccoli, Wendy S. Barclay, Partha Rakshit, Anurag Agrawal, Ravindra K. Gupta, Himanshu Chauhan, Tanzin Dikid, Hema Gogia, Hemlata Lall, Kaptan Verma, Manoj K. Singh, Namita Soni, Namonarayan Meena, Preeti Madan, Priyanka Singh, Ramesh Sharma, Rajeev Sharma, Sandhya Kabra, Sattender Kumar, Swati Kumari, Uma Sharma, Urmila Chaudhary, Sridhar Sivasubbu, Vinod Scaria, J. K. Oberoi, Reena Raveendran, S. Datta, Saumitra Das, Arindam Maitra, Sreedhar Chinnaswamy, Nidhan Kumar Biswas, Ajay Parida, Sunil K. Raghav, Punit Prasad, Apurva Sarin, Satyajit Mayor, Uma Ramakrishnan, Dasaradhi Palakodeti, Aswin Sai Narain Seshasayee, K. Thangaraj, Murali Dharan Bashyam, Ashwin Dalal, Manoj Bhat, Yogesh Shouche, Ajay Pillai, Priya Abraham, Varsha Atul Potdar, Sarah S. Cherian, Anita Sudhir Desai, Chitra Pattabiraman, M. V. Manjunatha, Reeta S. Mani, Gautam Arunachal Udupi, Vinay Nandicoori, Karthik Bharadwaj Tallapaka, Divya Tej Sowpati, Ryoko Kawabata, Nanami Morizako, Kenji Sadamasu, Hiroyuki Asakura, Mami Nagashima, Kazuhisa Yoshimura, Jumpei Ito, Izumi Kimura, Keiya Uriu, Yusuke Kosugi, Mai Suganami, Akiko Oide, Miyabishara Yokoyama, Mika Chiba, Akatsuki Saito, Erika P. Butlertanaka, Yuri L. Tanaka, Terumasa Ikeda, Chihiro Motozono, Hesham Nasser, Ryo Shimizu, Yue Yuan, Kazuko Kitazato, Haruyo Hasebe, So Nakagawa, Jiaqi Wu, Miyoko Takahashi, Takasuke Fukuhara, Kenta Shimizu, Kana Tsushima, Haruko Kubo, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Akifumi Takaori-Kondo, Kenzo Tokunaga, Seiya Ozono, Stephen Baker, Gordon Dougan, Christoph Hess, Nathalie Kingston, Paul J. Lehner, Paul A. Lyons, Nicholas J. Matheson, Willem H. Owehand, Caroline Saunders, Charlotte Summers, James E. D. Thaventhiran, Mark Toshner, Michael P. Weekes, Patrick Maxwell, Ashley Shaw, Ashlea Bucke, Jo Calder, Laura Canna, Jason Domingo, Anne Elmer, Stewart Fuller, Julie Harris, Sarah Hewitt, Jane Kennet, Sherly Jose, Jenny Kourampa, Anne Meadows, Criona O’Brien, Jane Price, Cherry Publico, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Ben Bullman, Benjamin J. Dunmore, Stuart Fawke, Stefan Gräf, Josh Hodgson, Christopher Huang, Kelvin Hunter, Emma Jones, Ekaterina Legchenko, Cecilia Matara, Jennifer Martin, Federica Mescia, Ciara O’Donnell, Linda Pointon, Nicole Pond, Joy Shih, Rachel Sutcliffe, Tobias Tilly, Carmen Treacy, Zhen Tong, Jennifer Wood, Marta Wylot, Laura Bergamaschi, Ariana Betancourt, Georgie Bower, Chiara Cossetti, Aloka De Sa, Madeline Epping, Nick Gleadall, Richard Grenfell, Andrew Hinch, Oisin Huhn, Sarah Jackson, Isobel Jarvis, Ben Krishna, Daniel Lewis, Joe Marsden, Francesca Nice, Georgina Okecha, Ommar Omarjee, Marianne Perera, Martin Potts, Nathan Richoz, Veronika Romashova, Natalia Savinykh Yarkoni, Rahul Sharma, Luca Stefanucci, Jonathan Stephens, Mateusz Strezlecki, Lori Turner, Eckart M. D. D. De Bie, Katherine Bunclark, Masa Josipovic, Michael Mackay, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, John Allison, Helen Butcher, Debbie Clapham-Riley, Eleanor Dewhurst, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Mary Kasanicki, Emma Le Gresley, Rachel Linger, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Isabel Phelan, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Neil Walker, Jennifer Webster, Ingrid Scholtes, Sabine Hein, Rebecca King
Nov 03, 2021
Abstract: The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing...