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Viral Metagenomic Analysis of Cerebrospinal Fluid from Patients with Acute Central Nervous System Infections of Unknown Origin, Vietnam.
Nguyen To Anh, Le Nguyen Truc Nhu, Nguyen Thi Thu Hong, Tran My Phuc, Pham Thi Thanh Tam, Dang Thao Huong, Tran Tuan Anh, Xutao Deng, Ho Dang Trung Nghia, Tran Thua Nguyen, Nguyen Van Hung, Nguyen Dac Thuan, Pham Thi Hong Phuong, Nguyen Van Vinh Chau, Stephen Baker, Eric Delwart, Guy Thwaites, Le Van Tan, VIZIONS Consortium1
May 17, 2021
Central nervous system (CNS) infection is a serious neurologic condition, although the etiology remains unknown in >50% of patients. We used metagenomic next-generation sequencing to detect viruses in 204 cerebrospinal fluid...
Pathogenic Escherichia coli Possess Elevated Growth Rates under Exposure to Sub-Inhibitory Concentrations of Azithromycin
Tran Tuan-Anh, Ha Thanh Tuyen, Nguyen Ngoc Minh Chau, Nguyen Duc Toan, Tran Hanh Triet, Le Minh Triet, Nguyen Hoang Thu Trang, Nguyen Thi Nguyen To, Josefin Bartholdson Scott, Hao Chung The, Duy Pham Thanh, Hannah Clapham, Stephen Baker
Oct 29, 2020
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of the ten major threats to global health. Advances in technology, including whole-genome sequencing, have provided new insights...
Pathogenic Escherichia coli Possess Elevated Growth Rates under Exposure to Sub-Inhibitory Concentrations of Azithromycin.
Tran Tuan-Anh, Ha Thanh Tuyen, Nguyen Ngoc Minh Chau, Nguyen Duc Toan, Tran Hanh Triet, Le Minh Triet, Nguyen Hoang Thu Trang, Nguyen Thi Nguyen To, Josefin Bartholdson Scott, Hao Chung The, Duy Pham Thanh, Hannah Clapham, Stephen Baker
Dec 07, 2020
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of the ten major threats to global health. Advances in technology, including whole-genome sequencing, have provided new insights...
The emergence of azithromycin-resistant Salmonella Typhi in Nepal.
Pham Thanh Duy, Sabina Dongol, Abhishek Giri, Nguyen Thi Nguyen To, Ho Ngoc Dan Thanh, Nguyen Pham Nhu Quynh, Pham Duc Trung, Guy E Thwaites, Buddha Basnyat, Stephen Baker, Maia A Rabaa, Abhilasha Karkey
May 17, 2021
BACKGROUND: Typhoid fever remains a significant cause of morbidity and mortality in Asia and Africa. The emergence of azithromycin resistance in South Asia is concerning, as azithromycin is one of the last effective oral drugs...
Genetic diversity of Salmonella Paratyphi A isolated from enteric fever patients in Bangladesh from 2008 to 2018.
Sadia Isfat Ara Rahman, To Nguyen Thi Nguyen, Farhana Khanam, Nicholas R Thomson, Zoe A Dyson, Alyce Taylor-Brown, Emran Kabir Chowdhury, Gordon Dougan, Stephen Baker, Firdausi Qadri
Nov 12, 2021
BACKGROUND: The proportion of enteric fever cases caused by Salmonella Paratyphi A is increasing and may increase further as we begin to introduce typhoid conjugate vaccines (TCVs). While numerous epidemiological and genomic...
Structure of general-population antibody titer distributions to influenza A virus.
Nguyen Thi Duy Nhat, Stacy Todd, Erwin de Bruin, Tran Thi Nhu Thao, Nguyen Ha Thao Vy, Tran Minh Quan, Dao Nguyen Vinh, Janko van Beek, Pham Hong Anh, Ha Minh Lam, Nguyen Thanh Hung, Nguyen Thi Le Thanh, Huynh Le Anh Huy, Vo Thi Hong Ha, Stephen Baker, Guy E Thwaites, Nguyen Thi Nam Lien, Tran Thi Kim Hong, Jeremy Farrar, Cameron P Simmons, Nguyen Van Vinh Chau, Marion Koopmans, Maciej F Boni
Apr 10, 2019
Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific...
Genetic diversity of Salmonella Paratyphi A isolated from enteric fever patients in Bangladesh from 2008 to 2018
Genetic diversity of Salmonella Paratyphi A isolated from enteric fever patients in Bangladesh from 2008 to 2018.
Sadia Isfat Ara Rahman, To Nguyen Thi Nguyen, Farhana Khanam, Nicholas R Thomson, Zoe A Dyson, Alyce Taylor-Brown, Emran Kabir Chowdhury, Gordon Dougan, Stephen Baker, Firdausi Qadri
Nov 22, 2021
Background
The proportion of enteric fever cases caused by Salmonella Paratyphi A is increasing and may increase further as we begin to introduce typhoid conjugate vaccines (TCVs). While numerous epidemiological and...
Published by: PLoS neglected tropical diseases
Outbreaks of Serratia marcescens and Serratia rubidaea bacteremia in a central Kathmandu hospital following the 2015 earthquakes.
Abhilasha Karkey, Niva Joshi, Shiva Chalise, Suchita Joshi, Shrijana Shrestha, To Nguyen Thi Nguyen, Sabina Dongol, Buddha Basnyat, Stephen Baker, Christine J Boinett
Apr 10, 2019
BACKGROUND: Human infections with Serratia spp. are generally limited to Serratia marcescens and the Serratia liquefaciens complex. There is little data regarding the infections caused by the remaining Serratia spp., as they are...
Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients.
Hoang NH Tran, Trang Nguyen Hoang Thu, Phu Huu Nguyen, Chi Nguyen Vo, Khanh Van Doan, Chau Nguyen Ngoc Minh, Ngoc Tuan Nguyen, Van Ngoc Duc Ta, Khuong An Vu, Thanh Danh Hua, To Nguyen Thi Nguyen, Tan Trinh Van, Trung Pham Duc, Ba Lap Duong, Phuc Minh Nguyen, Vinh Chuc Hoang, Duy Thanh Pham, Guy E Thwaites, Lindsay J Hall, Daniel J Slade, Stephen Baker, Vinh Hung Tran, Hao Chung The
Nov 28, 2022
Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker. Despite its significance in the promotion of...
A model immunization programme to control Japanese encephalitis in Viet Nam.
Nguyen Thu Yen, Wei Liu, Hoang Duc Hanh, Na Yoon Chang, Tran Nhu Duong, Robert V Gibbons, Florian Marks, Nghiem Anh Thu, Nguyen Minh Hong, Jin Kyung Park, Pham Anh Tuan, Ananda Nisalak, John D Clemens, Zhi-Yi Xu
Aug 01, 2019
In Viet Nam, an inactivated, mouse brain-derived vaccine for Japanese encephalitis (JE) has been given exclusively to ≤ 5 years old children in 3 paediatric doses since 1997. However, JE incidence remained high, especially among...
Demonstration project Effectiveness study Immunization Japanese encephalitis vaccines Child Child Preschool Encephalitis Japanese Feasibility Studies Female Humans Immunization Programs Incidence Infant Japanese Encephalitis Vaccines Male vaccines Inactivated Vietnam
Published by: J Health Popul Nutr
Formal Analysis of Database Trigger Systems Using Event-B
Most modern relational database systems use triggers to implement automatic tasks in response to specific events happening inside or outside a system. A database trigger is a human readable block code without any formal...
Systems & Software Design Computer Science and Information Technology Systems and Software Engineering
Published by: IGI Global Scientific Publishing
A Double-blind, Randomized, Placebo-controlled Trial of Lactobacillus acidophilus for the Treatment of Acute Watery Diarrhea in Vietnamese Children.
Tran Thi Hong Chau, Nguyen Ngoc Minh Chau, Nhat Thanh Hoang Le, Hao Chung The, Phat Voong Vinh, Nguyen Thi Nguyen To, Nguyen Minh Ngoc, Ha Manh Tuan, Tang Le Chau Ngoc, Marion-Eliette Kolader, Jeremy J Farrar, Marcel Wolbers, Guy E Thwaites, Stephen Baker, Oxford-Vietnam Probiotics Study Group
Aug 02, 2019
Antigenic characterization of highly pathogenic avian influenza A(H5N1) viruses with chicken and ferret antisera reveals clade-dependent variation in hemagglutination inhibition profiles.
Diep Thi Nguyen, Samuel S Shepard, David Francis Burke, Joyce Jones, Sharmi Thor, Long Van Nguyen, Tho Dang Nguyen, Amanda Balish, Dang Nguyen Hoang, Thanh Long To, Munir Iqbal, David E Wentworth, Erica Spackman, H Rogier van Doorn, C Todd Davis, Juliet E Bryant
Oct 10, 2018
Highly pathogenic avian influenza (HPAI) A(H5N1) viruses pose a significant economic burden to the poultry industry worldwide and have pandemic potential. Poultry vaccination against HPAI A(H5N1) viruses has been an important...
Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients.
Hoang NH Tran, Trang Nguyen Hoang Thu, Phu Huu Nguyen, Chi Nguyen Vo, Khanh Van Doan, Chau Nguyen Ngoc Minh, Ngoc Tuan Nguyen, Van Ngoc Duc Ta, Khuong An Vu, Thanh Danh Hua, To Nguyen Thi Nguyen, Tan Trinh Van, Trung Pham Duc, Ba Lap Duong, Phuc Minh Nguyen, Vinh Chuc Hoang, Duy Thanh Pham, Guy E Thwaites, Lindsay J Hall, Daniel J Slade, Stephen Baker, Vinh Hung Tran, Hao Chung The
Oct 29, 2022
Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker. Despite its significance in the promotion of...
Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children's hospital.
Nguyen Duc Toan, Thomas C Darton, Nguyen Hoang Thien Huong, Le Thanh Hoang Nhat, To Nguyen Thi Nguyen, Ha Thanh Tuyen, Le Quoc Thinh, Nguyen Kien Mau, Pham Thi Thanh Tam, Cam Ngoc Phuong, Le Nguyen Thanh Nhan, Ngo Ngoc Quang Minh, Ngo Minh Xuan, Tang Chi Thuong, Nguyen Thanh Hung, Christine Boinett, Stephen Reece, Abhilasha Karkey, Jeremy N Day, Stephen Baker
Apr 17, 2023
Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there...
Published by: PLOS global public health
A genomic snapshot of Salmonella enterica serovar Typhi in Colombia.
Paula Diaz Guevara, Mailis Maes, Duy Pham Thanh, Carolina Duarte, Edna Catering Rodriguez, Lucy Angeline Montaño, Thanh Ho Ngoc Dan, To Nguyen Thi Nguyen, Megan E Carey, Josefina Campos, Isabel Chinen, Enrique Perez, Stephen Baker
Oct 18, 2021
Published by: PLoS neglected tropical diseases
Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children's hospital.
Nguyen Duc Toan, Thomas C Darton, Nguyen Hoang Thien Huong, Le Thanh Hoang Nhat, To Nguyen Thi Nguyen, Ha Thanh Tuyen, Le Quoc Thinh, Nguyen Kien Mau, Pham Thi Thanh Tam, Cam Ngoc Phuong, Le Nguyen Thanh Nhan, Ngo Ngoc Quang Minh, Ngo Minh Xuan, Tang Chi Thuong, Nguyen Thanh Hung, Christine Boinett, Stephen Reece, Abhilasha Karkey, Jeremy N Day, Stephen Baker
Sep 02, 2022
Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there...
Patient Safety Infant Mortality Hematology Sepsis Pediatric Clinical Research Infectious Diseases Perinatal Period - Conditions Originating in Perinatal Period 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis Infection Inflammatory and immune system 3 Good Health and Well Being
A genomic snapshot of Salmonella enterica serovar Typhi in Colombia.
Paula Diaz Guevara, Mailis Maes, Duy Pham Thanh, Carolina Duarte, Edna Catering Rodriguez, Lucy Angeline Montaño, Thanh Ho Ngoc Dan, To Nguyen Thi Nguyen, Megan E Carey, Josefina Campos, Isabel Chinen, Enrique Perez, Stephen Baker
Nov 15, 2021
Little is known about the genetic diversity of Salmonella enterica serovar Typhi (S. Typhi) circulating in Latin America. It has been observed that typhoid fever is still endemic in this part of the world; however, a lack of...
Filtered Reaction Rate Modelling in Moderate and High Karlovitz Number Flames
Thommie Nilsson, Rixin Yu, Nguyen Anh Khoa Doan, Ivan Langella, Nedunchezhian Swaminathan, Xue-Song Bai
Jun 16, 2020
Abstract: Direct numerical simulations (DNS) of statistically planar flames at moderate and high Karlovitz number (Ka) have been used to perform an a priori evaluation of a presumed-PDF model approach for filtered reaction rate...
article Turbulent premixed flame Direct Numerical Simulation Combustion model High Karlovitz number Probability density function
Published by: Springer Netherlands
Dynamic Prediction of Death in Patients With Tuberculous Meningitis Using Time-updated Glasgow Coma Scale and Plasma Sodium Measurements.
Le Thi Phuong Thao, Marcel Wolbers, A Dorothee Heemskerk, Nguyen Thi Hoang Mai, Dang Thi Minh Ha, Tran Thi Hong Chau, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Maxine Caws, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Thuy Thuong Thuong, Jeremy Day, M Estee Torok, Nguyen Duc Bang, Guy E Thwaites, Ronald B Geskus
Apr 16, 2019
Genomic epidemiology, antimicrobial resistance and virulence factors of Enterobacter cloacae complex causing potential community-onset bloodstream infections in a tertiary care hospital of Nepal.
Sulochana Manandhar, Quynh Nguyen, To Nguyen Thi Nguyen, Duy Thanh Pham, Maia A Rabaa, Sabina Dongol, Buddha Basnyat, Sameer M Dixit, Stephen Baker, Abhilasha Karkey
Jul 07, 2022
OBJECTIVES: Community-onset bloodstream infections (BSIs) caused by carbapenemase-producing Enterobacter cloacae complex (ECC) species are increasing internationally. This observation suggests that ECC are emerging pathogens...
A universal genome sequencing method for rotavirus A from human fecal samples which identifies segment reassortment and multi-genotype mixed infection.
Tran Thi Ngoc Dung, Pham Thanh Duy, October M Sessions, Uma K Sangumathi, Voong Vinh Phat, Pham Thi Thanh Tam, Nguyen Thi Nguyen To, Tran My Phuc, Tran Thi Hong Chau, Nguyen Ngoc Minh Chau, Ngoc Nguyen Minh, Guy E Thwaites, Maia A Rabaa, Stephen Baker
Apr 10, 2019
BACKGROUND: Genomic characterization of rotavirus (RoV) has not been adopted at large-scale due to the complexity of obtaining sequences for all 11 segments, particularly when feces are used as starting material. METHODS: To...
Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia.
Kelly L Wyres, To NT Nguyen, Margaret MC Lam, Louise M Judd, Nguyen Van Vinh Chau, David AB Dance, Margaret Ip, Abhilasha Karkey, Clare L Ling, Thyl Miliya, Paul N Newton, Nguyen Phu Huong Lan, Amphone Sengduangphachanh, Paul Turner, Balaji Veeraraghavan, Phat Voong Vinh, Manivanh Vongsouvath, Nicholas R Thomson, Stephen Baker, Kathryn E Holt
Mar 02, 2020
BACKGROUND: Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI). Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new treatment...
Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi.
Pham Thanh Duy, Nga Tran Vu Thieu, To Nguyen Thi Nguyen, Ho Ngoc Dan Thanh, Sabina Dongol, Abhilasha Karkey, Megan Carey, Buddha Basnyat, Gordon Dougan, Maia A Rabaa, Stephen Baker
Oct 27, 2020
Despite recent advances in typhoid fever control, asymptomatic carriage of Salmonella Typhi in the gallbladder remains poorly understood. Aiming to understand if S. Typhi becomes genetically adapted for long-term colonisation in...
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