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Stiffness and Strength of Stabilized Organic Soils—Part II/II
Predicting the range of achievable strength and stiffness from stabilized soil mixtures is critical for engineering design and construction, especially for organic soils, which are often considered “unsuitable” due to their high...
The role of noradrenaline in cognition and cognitive disorders.
Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha and beta adrenoreceptors. Loss of these projections is common in...
Progressive supranuclear palsy
Treating patients with progressive supranuclear palsy (PSP) is both effective and rewarding. This review aims to share our experience in the proactive management of PSP, considering the patient, the family and the medical...
Stiffness and strength of stabilized organic soils—part i/ii
This paper presents the experimental database and corresponding statistical analysis (Part I), which serves as a basis to perform the corresponding parametric analysis and machine learning modelling (Part II) of a...
Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.
[<sup>18</sup>F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.
Elijah Mak, Antonina Kouli, Negin Holland, Nicolas Nicastro, George Savulich, Ajenthan Surendranathan, Maura Malpetti, Roido Manavaki, Young T Hong, Tim D Fryer, Franklin Aigbirhio, James B Rowe, John T O'Brien, Caroline H Williams-Gray
Oct 07, 2021
Published by: Brain communications
11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.
Nicolas Nicastro, Negin Holland, George Savulich, Stephen F Carter, Elijah Mak, Young T Hong, Selena Milicevic Sephton, Tim D Fryer, Franklin I Aigbirhio, James B Rowe, John T O'Brien
Nov 10, 2020
OBJECTIVE: Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer's disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in...
Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features.
In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.
[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.
Elijah Mak, Antonina Kouli, Negin Holland, Nicolas Nicastro, George Savulich, Ajenthan Surendranathan, Maura Malpetti, Roido Manavaki, Young T Hong, Tim D Fryer, Franklin Aigbirhio, James B Rowe, John T O'Brien, Caroline H Williams-Gray
Sep 05, 2021
While [18F]-AV-1451 was developed as a PET radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of 'off-target' [18F]-AV-1451 binding to neuromelanin in the substantia nigra could be a...
Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.
Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.
Elijah Mak, Nicolas Nicastro, Maura Malpetti, George Savulich, Ajenthan Surendranathan, Negin Holland, Luca Passamonti, P Simon Jones, Stephen F Carter, Li Su, Young T Hong, Tim D Fryer, Guy B Williams, Franklin Aigbirhio, James B Rowe, John T O'Brien
Nov 17, 2020
Alzheimer's disease (AD) pathology is frequently observed as a comorbidity in people with dementia with Lewy bodies (DLB). Here, we evaluated the in vivo distribution of tau burden and its influence on the clinical phenotype of...
Amyloid Dementia Lewy Bodies Neuroinflammation Tau Aged Aged 80 and over Carbolines Female Fluorine Radioisotopes Humans Inflammation Lewy Body Disease Male Microglia Middle Aged Phenotype Positron-Emission Tomography Radioisotopes Radiopharmaceuticals Severity of Illness Index Temporal Lobe tau Proteins
Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.
Negin Holland, P Simon Jones, George Savulich, Julie K Wiggins, Young T Hong, Tim D Fryer, Roido Manavaki, Selena Milicevic Sephton, Istvan Boros, Maura Malpetti, Frank H Hezemans, Franklin I Aigbirhio, Jonathan P Coles, John O'Brien, James B Rowe
Jun 11, 2020
BACKGROUND: Synaptic loss is a prominent and early feature of many neurodegenerative diseases. OBJECTIVES: We tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy...
GABAergic cortical network physiology in frontotemporal lobar degeneration.
Natalie E Adams, Laura E Hughes, Matthew A Rouse, Holly N Phillips, Alexander D Shaw, Alexander G Murley, Thomas E Cope, W Richard Bevan-Jones, Luca Passamonti, Duncan Street, Negin Holland, David Nesbitt, Karl Friston, James B Rowe
Apr 06, 2021
The clinical syndromes caused by frontotemporal lobar degeneration are heterogeneous, including the behavioural variant frontotemporal dementia (bvFTD) and progressive supranuclear palsy. Although pathologically distinct, they...
GABA conductance-based modelling Dynamic causal modelling frontotemporal dementia progressive supranuclear palsy Aged Cerebral Cortex Cross-Over Studies Double-Blind Method Female frontotemporal dementia GABA Uptake Inhibitors Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Magnetoencephalography Male Models Neurological Nerve Net Supranuclear Palsy Progressive Synaptic Transmission Tiagabine gamma-Aminobutyric Acid
Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.
Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson's disease.
Claire O'Callaghan, Frank H Hezemans, Rong Ye, Catarina Rua, P Simon Jones, Alexander G Murley, Negin Holland, Ralf Regenthal, Kamen A Tsvetanov, Noham Wolpe, Roger A Barker, Caroline H Williams-Gray, Trevor W Robbins, Luca Passamonti, James B Rowe
Mar 24, 2021
Parkinson’s disease atomoxetine Locus Coeruleus neuromelanin imaging Noradrenaline Adrenergic Uptake Inhibitors Aged Atomoxetine Hydrochloride Double-Blind Method Female Humans INHIBITION Psychological Locus Coeruleus Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Parkinson Disease Reaction Time
In vivo 18F-flortaucipir PET does not accurately support the staging of progressive supranuclear palsy
Maura Malpetti, Sanne Kaalund, Kamen Tsvetanov, Timothy Rittman, Mayen Briggs, Kieren SJ Allinson, Luca Passamonti, Negin Holland, P Simon Jones, Tim Fryer, Young Hong, Antonina Kouli, W Richard Bevan-Jones, Elijah Mak, George Savulich, Maria Grazia Spillantini, Franklin I Aigbirhio, Caroline Williams-Gray, John T O'Brien, James B Rowe
Oct 12, 2021
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome.
Edwin Jabbari, Negin Holland, Viorica Chelban, P Simon Jones, Ruth Lamb, Charlotte Rawlinson, Tong Guo, Alyssa A Costantini, Manuela MX Tan, Amanda J Heslegrave, Federico Roncaroli, Johannes C Klein, Olaf Ansorge, Kieren SJ Allinson, Zane Jaunmuktane, Janice L Holton, Tamas Revesz, Thomas T Warner, Andrew J Lees, Henrik Zetterberg, Lucy L Russell, Martina Bocchetta, Jonathan D Rohrer, Nigel M Williams, Donald G Grosset, David J Burn, Nicola Pavese, Alexander Gerhard, Christopher Kobylecki, P Nigel Leigh, Alistair Church, Michele Tm Hu, John Woodside, Henry Houlden, James B Rowe, Huw R Morris
Feb 26, 2020
IMPORTANCE: Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be difficult to distinguish in early stages and are often...