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Results: 532
Diagnostic interpretation of non-contrast qualitative MR imaging features for characterisation of uterine leiomyosarcoma.
Hilal Sahin, Janette Smith, Jeries Paolo Zawaideh, Amreen Shakur, Luca Carmisciano, Iztok Caglic, Annemarie Bruining, Mercedes Jimenez-Linan, Sue Freeman, Helen Addley
May 31, 2021
OBJECTIVE: To assess the value of non-contrast MRI features for characterisation of uterine leiomyosarcoma (LMS) and differentiation from atypical benign leiomyomas. METHODS: This study included 57 atypical leiomyomas and 16 LMS...
Epirubicin, Cisplatin, and Capecitabine for Primary Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer
Karen Sayal, Ioannis Gounaris, Bristi Basu, Sue Freeman, Penny Moyle, Karen Hosking, Mahesh Iddawela, Mercedes Jimenez-Linan, Jean Abraham, James Brenton, Helen Hatcher, Helena Earl, Christine Parkinson
Oct 26, 2020
OBJECTIVE: Primary platinum-resistant epithelial ovarian cancer (EOC) is an area of unmet medical need. There is limited evidence from small studies that platinum-based combinations can overcome "resistance" in a proportion of...
Adenocarcinoma Clear Cell Adult Aged Antineoplastic Combined Chemotherapy Protocols Capecitabine cisplatin Cystadenocarcinoma Serous Drug Resistance Neoplasm Endometrial Neoplasms Epirubicin Female Follow-Up Studies Humans Middle Aged Neoplasm Grading Neoplasm Invasiveness Neoplasm Staging Ovarian Neoplasms Prognosis Retrospective Studies Survival Rate
Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier.
Non-contrast MRI can accurately characterize adnexal masses
Hilal Sahin, Camilla Panico, Stephan Ursprung, Vittorio Simeon, Paolo Chiodini, Amy Frary, Bruno Carmo, Janette Smith, Sue Freeman, Mercedes Jimenez-Linan, Helen Bolton, Krishnayan Haldar, Joo Ern Ang, Caroline Reinhold, Evis Sala, Helen Addley
Aug 26, 2021
Abstract: Objective: To determine the accuracy of interpretation of a non-contrast MRI protocol in characterizing adnexal masses. Methods and materials: Two hundred ninety-one patients (350 adnexal masses) who underwent...
The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population.
Lesion-specific 3D-printed moulds for image-guided tissue multi-sampling of ovarian tumours
Maria Delgado-Ortet, Marika Av Reinius, Cathal McCague, Vlad Bura, Ramona Woitek, Leonardo Rundo, Andrew B Gill, Marcel Gehrung, Stephan Ursprung, Helen Bolton, Krishnayan Haldar, Pubudu Pathiraja, James D Brenton, Mireia Crispin-Ortuzar, Mercedes Jimenez-Linan, Lorena Escudero Sanchez, Evis Sala
Feb 27, 2023
Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene.
Lorenza Mittempergher, Anna M Piskorz, Astrid J Bosma, Magali Michaut, G Bea A Wisman, Roelof JC Kluin, Marja Nieuwland, Wim Brugman, Kevin JW van der Ven, Francesco Marass, James Morris, Nitzan Rosenfeld, Mercedes Jimenez-Linan, Steven de Jong, Ate GJ van der Zee, James D Brenton, René Bernards
Sep 15, 2020
High-grade serous ovarian carcinoma (HGSOC) remains the deadliest form of epithelial ovarian cancer and despite major efforts little improvement in overall survival has been achieved. Identification of recurring "driver" genetic...
Non-contrast MRI can accurately characterize adnexal masses
Hilal Sahin, Camilla Panico, Stephan Ursprung, Vittorio Simeon, Paolo Chiodini, Amy Frary, Bruno Carmo, Janette Smith, Sue Freeman, Mercedes Jimenez-Linan, Helen Bolton, Krishnayan Haldar, Joo Ern Ang, Caroline Reinhold, Evis Sala, Helen Addley
Jan 15, 2021
OBJECTIVE: To determine the accuracy of interpretation of a non-contrast MRI protocol in characterizing adnexal masses. METHODS AND MATERIALS: Two hundred ninety-one patients (350 adnexal masses) who underwent gynecological MRI...
Ultrasound-guided targeted biopsies of CT-based radiomic tumour habitats
Lucian Beer, Paula Martin-Gonzalez, Maria Delgado-Ortet, Marika Reinius, Leonardo Rundo, Ramona Woitek, Stephan Ursprung, Lorena Escudero, Hilal Sahin, Ionut-Gabriel Funingana, Joo-Ern Ang, Mercedes Jimenez-Linan, Tristan Lawton, Gaurav Phadke, Sally Davey, Nghia Q. Nguyen, Florian Markowetz, James D. Brenton, Mireia Crispin-Ortuzar, Helen Addley, Evis Sala
May 20, 2021
Ultrasound-guided targeted biopsies of CT-based radiomic tumour habitats
Lucian Beer, Paula Martin-Gonzalez, Maria Delgado-Ortet, Marika Reinius, Leonardo Rundo, Ramona Woitek, Stephan Ursprung, Lorena Escudero, Hilal Sahin, Ionut-Gabriel Funingana, Joo-Ern Ang, Mercedes Jimenez-Linan, Tristan Lawton, Gaurav Phadke, Sally Davey, Nghia Q Nguyen, Florian Markowetz, James D Brenton, Mireia Crispin-Ortuzar, Helen Addley, Evis Sala
Dec 02, 2020
Kinome capture sequencing of high-grade serous ovarian carcinoma reveals novel mutations in the JAK3 gene
Lorenza Mittempergher, Anna M. Piskorz, Astrid J. Bosma, Magali Michaut, G. Bea A. Wisman, Roelof J. C. Kluin, Marja Nieuwland, Wim Brugman, Kevin J. W. van der Ven, Francesco Marass, James Morris, Nitzan Rosenfeld, Mercedes Jimenez-Linan, Steven de Jong, Ate G. J. van der Zee, James D. Brenton, René Bernards
Jul 08, 2020
High-grade serous ovarian carcinoma (HGSOC) remains the deadliest form of epithelial ovarian cancer and despite major efforts little improvement in overall survival has been achieved. Identification of recurring “driver” genetic...
PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma.
Concetta D'Ambrosio, Jessica Erriquez, Maddalena Arigoni, Sonia Capellero, Gloria Mittica, Eleonora Ghisoni, Fulvio Borella, Dionyssios Katsaros, Silvana Privitera, Marisa Ribotta, Elena Maldi, Giovanna Di Nardo, Enrico Berrino, Tiziana Venesio, Riccardo Ponzone, Marco Vaira, Douglas Hall, Mercedes Jimenez-Linan, Anna L Paterson, Raffaele A Calogero, James D Brenton, Giorgio Valabrega, Maria Flavia Di Renzo, Martina Olivero
Mar 10, 2020
Identifying cancer drivers and actionable mutations is critical for precision oncology. In epithelial ovarian cancer (EOC) the majority of mutations lack biological or clinical validation. We fully characterized 43 lines of...
PDX derived tumour cells PI3K PIK3R1 Patient-Derived xenografts ovarian cancer Animals Carcinoma Ovarian Epithelial Cell Line Tumor Class Ia Phosphatidylinositol 3-Kinase Cystadenocarcinoma Serous Female Heterografts Humans Mice Mice Inbred NOD Mice SCID Molecular Targeted Therapy Mutation Neoplasm Grading Ovarian Neoplasms Random Allocation
Spatial and temporal heterogeneity in high-grade serous ovarian cancer
Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer
Surrin S. Deen, Andrew N. Priest, Mary A. McLean, Andrew B. Gill, Cara Brodie, Robin Crawford, John Latimer, Peter Baldwin, Helena M. Earl, Christine Parkinson, Sarah Smith, Charlotte Hodgkin, Ilse Patterson, Helen Addley, Susan Freeman, Penny Moyle, Mercedes Jimenez-Linan, Martin J. Graves, Evis Sala, James D. Brenton, Ferdia A. Gallagher
Jul 23, 2020
Abstract: This study assessed the feasibility of using diffusion kurtosis imaging (DKI) as a measure of tissue heterogeneity and proliferation to predict the response of high grade serous ovarian cancer (HGSOC) to neoadjuvant...
Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer
Fiona R James, Mercedes Jiminez-Linan, Jennifer Alsop, Marie Mack, Honglin Song, James D Brenton, Paul D P Pharoah, H. R Ali
Sep 21, 2017
Abstract
Background
There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of...
Clinically Interpretable Radiomics-Based Prediction of Histopathologic Response to Neoadjuvant Chemotherapy in High-Grade Serous Ovarian Carcinoma.
Leonardo Rundo, Lucian Beer, Lorena Escudero Sanchez, Mireia Crispin-Ortuzar, Marika Reinius, Cathal McCague, Hilal Sahin, Vlad Bura, Roxana Pintican, Marta Zerunian, Stephan Ursprung, Iris Allajbeu, Helen Addley, Paula Martin-Gonzalez, Thomas Buddenkotte, Naveena Singh, Anju Sahdev, Ionut-Gabriel Funingana, Mercedes Jimenez-Linan, Florian Markowetz, James D Brenton, Evis Sala, Ramona Woitek
Jun 30, 2022
BACKGROUND: Pathological response to neoadjuvant treatment for patients with high-grade serous ovarian carcinoma (HGSOC) is assessed using the chemotherapy response score (CRS) for omental tumor deposits. The main limitation of...
Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer.
Fiona R James, Mercedes Jiminez-Linan, Jennifer Alsop, Marie Mack, Honglin Song, James D Brenton, Paul DP Pharoah, H Raza Ali
Nov 29, 2018
BACKGROUND: There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption of TILs as a clinical biomarker, a standardised method for...
Methanol-based fixation is superior to buffered formalin for next-generation sequencing of DNA from clinical cancer samples.
AM Piskorz, D Ennis, G Macintyre, TE Goranova, M Eldridge, N Segui-Gracia, M Valganon, A Hoyle, C Orange, L Moore, M Jimenez-Linan, D Millan, IA McNeish, JD Brenton
Jan 04, 2016
Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.
Surrin S Deen, Frank Riemer, Mary A McLean, Andrew B Gill, Joshua D Kaggie, James T Grist, Robin Crawford, John Latimer, Peter Baldwin, Helena M Earl, Christine A Parkinson, Sarah A Smith, Charlotte Hodgkin, Elizabeth Moore, Mercedes Jimenez-Linan, Cara R Brodie, Helen C Addley, Susan J Freeman, Penelope L Moyle, Evis Sala, Martin J Graves, James D Brenton, Ferdia A Gallagher
Apr 26, 2019
Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer.
Surrin S Deen, Andrew N Priest, Mary A McLean, Andrew B Gill, Cara Brodie, Robin Crawford, John Latimer, Peter Baldwin, Helena M Earl, Christine Parkinson, Sarah Smith, Charlotte Hodgkin, Ilse Patterson, Helen Addley, Susan Freeman, Penny Moyle, Mercedes Jimenez-Linan, Martin J Graves, Evis Sala, James D Brenton, Ferdia A Gallagher
Jul 15, 2019
This study assessed the feasibility of using diffusion kurtosis imaging (DKI) as a measure of tissue heterogeneity and proliferation to predict the response of high grade serous ovarian cancer (HGSOC) to neoadjuvant chemotherapy...
Magnetization transfer imaging of ovarian cancer
Surrin S Deen, Mary A McLean, Andrew B Gill, Robin AF Crawford, John Latimer, Peter Baldwin, Helena M Earl, Christine A Parkinson, Sarah Smith, Charlotte Hodgkin, Mercedes Jimenez-Linan, Cara R Brodie, Ilse Patterson, Helen C Addley, Susan J Freeman, Penelope M Moyle, Martin J Graves, Evis Sala, James D Brenton, Ferdia A Gallagher
Oct 15, 2022
OBJECTIVES: To investigate the relationship between magnetization transfer (MT) imaging and tissue macromolecules in high-grade serous ovarian cancer (HGSOC) and whether MT ratio (MTR) changes following neoadjuvant chemotherapy...
Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer.
Filipe Correia Martins, Dominique-Laurent Couturier, Ines de Santiago, Carolin Margarethe Sauer, Maria Vias, Mihaela Angelova, Deborah Sanders, Anna Piskorz, James Hall, Karen Hosking, Anumithra Amirthanayagam, Sabina Cosulich, Larissa Carnevalli, Barry Davies, Thomas BK Watkins, Ionut G Funingana, Helen Bolton, Krishnayan Haldar, John Latimer, Peter Baldwin, Robin Crawford, Matthew Eldridge, Bristi Basu, Mercedes Jimenez-Linan, Andrew W Mcpherson, Nicholas McGranahan, Kevin Litchfield, Sohrab P Shah, Iain McNeish, Carlos Caldas, Gerard Evan, Charles Swanton, James D Brenton
Nov 26, 2022
New paradigms for BRCA1/BRCA2 testing in women with ovarian cancer
Inga Plaskocinska, Hannah Shipman, James Drummond, Edward Thompson, Vanessa Buchanan, Barbara Newcombe, Charlotte Hodgkin, Elisa Barter, Paul Ridley, Rita Ng, Suzanne Miller, Adela Dann, Victoria Licence, Hayley Webb, Li Tee Tan, Margaret Daly, Sarah Ayers, Barnaby Rufford, Helena Earl, Christine Parkinson, Timothy Duncan, Mercedes Jimenez-Linan, Gurdeep S Sagoo, Stephen Abbs, Nicholas Hulbert-Williams, Paul Pharoah, Robin Crawford, James D Brenton, Marc Tischkowitz
Apr 28, 2016
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