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Results: 265
Ancestry-related distribution of Runs of homozygosity and functional variants in Qatari population.
Massimo Mezzavilla, Massimiliano Cocca, Pierpaolo Maisano Delser, Ramin Badii, Fatemeh Abbaszadeh, Khalid Abdul Hadi, Girotto Giorgia, Paolo Gasparini
Sep 21, 2022
BACKGROUND: Describing how genetic history shapes the pattern of medically relevant variants could improve the understanding of how specific loci interact with each other and affect diseases and traits prevalence. The Qatari...
Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations.
Yali Xue, Massimo Mezzavilla, Marc Haber, Shane McCarthy, Yuan Chen, Vagheesh Narasimhan, Arthur Gilly, Qasim Ayub, Vincenza Colonna, Lorraine Southam, Christopher Finan, Andrea Massaia, Himanshu Chheda, Priit Palta, Graham Ritchie, Jennifer Asimit, George Dedoussis, Paolo Gasparini, Aarno Palotie, Samuli Ripatti, Nicole Soranzo, Daniela Toniolo, James F Wilson, Richard Durbin, Chris Tyler-Smith, Eleftheria Zeggini
Aug 15, 2018
The genetic features of isolated populations can boost power in complex-trait association studies, and an in-depth understanding of how their genetic variation has been shaped by their demographic history can help leverage these...
"Like sugar in milk"
Gyaneshwer Chaubey, Qasim Ayub, Niraj Rai, Satya Prakash, Veena Mushrif-Tripathy, Massimo Mezzavilla, Ajai Kumar Pathak, Rakesh Tamang, Sadaf Firasat, Maere Reidla, Monika Karmin, Deepa Selvi Rani, Alla G Reddy, Jüri Parik, Ene Metspalu, Siiri Rootsi, Kurush Dalal, Shagufta Khaliq, Syed Qasim Mehdi, Lalji Singh, Mait Metspalu, Toomas Kivisild, Chris Tyler-Smith, Richard Villems, Kumarasamy Thangaraj
Nov 21, 2018
BACKGROUND: The Parsis are one of the smallest religious communities in the world. To understand the population structure and demographic history of this group in detail, we analyzed Indian and Pakistani Parsi populations using...
A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans.
Luis R Saraiva, Fernando Riveros-McKay, Massimo Mezzavilla, Eman H Abou-Moussa, Charles J Arayata, Melanie Makhlouf, Casey Trimmer, Ximena Ibarra-Soria, Mona Khan, Laura Van Gerven, Mark Jorissen, Matthew Gibbs, Ciaran O'Flynn, Scott McGrane, Peter Mombaerts, John C Marioni, Joel D Mainland, Darren W Logan
Dec 19, 2019
The mammalian olfactory system displays species-specific adaptations to different ecological niches. To investigate the evolutionary dynamics of olfactory sensory neuron (OSN) subtypes across mammalian evolution, we applied RNA...
Mitochondrial complex III Rieske Fe-S protein processing and assembly.
Regulation of the mitochondrial respiratory chain biogenesis is a matter of great interest because of its implications for mitochondrial disease. One of the mitochondrial disease genes recently discovered associated to...
mitochondrial respiratory chain OXPHOS Rieske Fe-S protein TTC19 UQCRFS1 Mitochondria mitochondrial complex III mitochondrial disease Animals Cattle Chickens Electron Transport Complex III Membrane Proteins Mice Mice Knockout Mitochondria Mitochondrial Proteins Protein Binding Protein Structure Quaternary Protein Subunits
On the relationship between firms and their legal environment
In this study we seek to reconcile diverging dominant views on the relationship between firms and their legal environment by offering a cultural contingency perspective.
We begin by accepting the notion that a new law will...
We begin by accepting the notion that a new law will...
Introduction
Funder: Università degli Studi Roma Tre
Information theory analysis of cascading process in a synthetic model of fluid turbulence
The use of transfer entropy has proven to be helpful in detecting which is the verse of dynamical driving in the interaction of two processes, X and Y . In this paper, we present a different normalization for the transfer...
Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions.
Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and involved in various aspects of cellular life, with a primary role in energy production. The interest in this organelle has grown stronger...
On the relationship between firms and their legal environment
In this study we seek to reconcile diverging dominant views on the relationship between firms and their legal environment by offering a cultural contingency perspective.
We begin by accepting the notion that a new law will...
We begin by accepting the notion that a new law will...
An adaptive guidance meta-heuristic for the vehicle routing problem with splits and clustered backhauls
This paper presents the case study of an Italian carrier, Grendi Trasporti Marittimi, which provides freight transportation services by trucks and containers. Its trucks deliver container loads from a port to import customers...
Macromolecular ab initio phasing enforcing secondary and tertiary structure.
Ab initio phasing of macromolecular structures, from the native intensities alone with no experimental phase information or previous particular structural knowledge, has been the object of a long quest, limited by two main...
An adaptive guidance meta-heuristic for the vehicle routing problem with splits and clustered backhauls
This paper presents the case study of an Italian carrier, Grendi Trasporti Marittimi, which provides freight transportation services by trucks and containers. Its trucks deliver container loads from a port to import customers...
RNase H1 Regulates Mitochondrial Transcription and Translation via the Degradation of 7S RNA
RNase H1 is able to recognize DNA/RNA heteroduplexes and to degrade their RNA component. As a consequence, it has been implicated in different aspects of mtDNA replication such as primer formation, primer removal, and...
RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases.
Mitochondrial translation defects can be due to mutations affecting mitochondrial- or nuclear-encoded components. The number of known nuclear genes involved in mitochondrial translation has significantly increased in the past...
Implications of AlphaFold2 for crystallographic phasing by molecular replacement.
The AlphaFold2 results in the 14th edition of Critical Assessment of Structure Prediction (CASP14) showed that accurate (low root-mean-square deviation) in silico models of protein structure domains are on the horizon, whether...
Carbon/hemp bio-hybrid composites
Fulvio Pinto, Luca Boccarusso, Dario De Fazio, Stefano Cuomo, Massimo Durante, Michele Meo
Jun 15, 2020
This work is focused on the design and production of hybrid laminates in which the reinforcement is a combination of carbon and hemp fibres. Four different stacking sequences were considered and pure hemp and pure carbon...
Structure of a 13-fold superhelix (almost) determined from first principles.
Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex with a co-activator such as TIF2 (transcriptional intermediary factor...
RNase H1 Regulates Mitochondrial Transcription and Translation via the Degradation of 7S RNA.
RNase H1 is able to recognize DNA/RNA heteroduplexes and to degrade their RNA component. As a consequence, it has been implicated in different aspects of mtDNA replication such as primer formation, primer removal, and...
Published by: Frontiers in genetics
New models to study vascular mural cell embryonic origin
A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells (SMCs) and pericytes influences vessel properties, in particular the regional propensity to vascular diseases....
Information theory analysis of cascading process in a synthetic model of fluid turbulence
The use of transfer entropy has proven to be helpful in detecting which is the verse of dynamical driving in the interaction of two processes, X and Y . In this paper, we present a different normalization for the transfer...
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