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Results: 66
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Oct 16, 2020
Abstract: Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and biological mechanisms underlying mLOY are not fully understood. In a cohort of 95,380...
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Elucidating the genetic architecture of reproductive ageing in the Japanese population.
Momoko Horikoshi, Felix R Day, Masato Akiyama, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kazuyoshi Ishigaki, Masahiro Kanai, Hollis Wright, Carlos A Toro, Sergio R Ojeda, Alejandro Lomniczi, Michiaki Kubo, Ken K Ong, John RB Perry
Aug 16, 2018
Population studies elucidating the genetic architecture of reproductive ageing have been largely limited to European ancestries, restricting the generalizability of the findings and overlooking possible key genes poorly captured...
Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
Masato Ogishi
Jan 01, 0001
Tuberculosis (TB), a multi-organ infectious disease caused by virulent mycobacteria, most predominantly M. tuberculosis,remains one of the deadliest infectious diseases in human history.Bacillus Calmette-Guérin (BCG)...
Published by: Rockefeller University
The ecology of medical care on an isolated island in Okinawa, Japan
BACKGROUND: We aimed to describe the ecology of medical care on an isolated island with limited access to secondary care, and to evaluate the gatekeeping function of the island's primary care clinic through comparison with a...
Ecology General Practice Medical care Physician visit Primary Health Care Adolescent Adult Ambulatory Care Facilities Emergency Service hospital Female Health Services Accessibility Humans Japan Male Medically Underserved Area Middle Aged Primary Health Care Referral and Consultation Retrospective Studies Young Adult
The unusual case of plastic deformation and high dislocation densities with the cold sintering of the piezoelectric ceramic K0.5Na0.5NbO3
K0.5Na0.5NbO3 (KNN) can be readily densified using the cold sintering process, but despite observing high relative permittivity, the ferroelectric hysteresis is strongly suppressed along with a major suppression in the...
The unusual case of plastic deformation and high dislocation densities with the cold sintering of the piezoelectric ceramic K0.5Na0.5NbO3
K0.5Na0.5NbO3 (KNN) can be readily densified using the cold sintering process, but despite observing high relative permittivity, the ferroelectric hysteresis is strongly suppressed along with a major suppression in the...
Epoxy-functionalised 4-vinylguaiacol for the synthesis of bio-based, degradable star polymers via a RAFT/ROCOP strategy
An epoxy derivative of a naturally occuring vinylphenolic compound, 4-vinylguaiacol (4VGEP), was used for the synthesis of a well-defined (Mw/Mn = 1.08–1.14), bio-based styrene-type polymer. Block copolymers of 4VGEP with...
Dissecting Nearby Galaxies with piXedfit. II. Spatially Resolved Scaling Relations among Stars, Dust, and Gas
Abstract
We study spatially resolved scaling relations among stars, dust, and gas in ten nearby spiral galaxies. In a preceding paper, we have derived spatially resolved properties...
Abdurro'Uf, YT Lin, H Hirashita, T Morishita, S Tacchella, PF Wu, M Akiyama, TT Takeuchi
Aug 19, 2022
Epoxy-functionalised 4-vinylguaiacol for the synthesis of bio-based, degradable star polymers via a RAFT/ROCOP strategy
An epoxy derivative of a naturally occuring vinylphenolic compound, 4-vinylguaiacol (4VGEP), was used for the synthesis of a well-defined (Mw/Mn = 1.08–1.14), bio-based styrene-type polymer. Block copolymers of 4VGEP with...
Insights into gene expression profiles induced by Socs3 depletion in keratinocytes.
Archana Bajpai, Takashi Ishii, Kosuke Miyauchi, Vipul Gupta, Yuka Nishio-Masaike, Yuki Shimizu-Yoshida, Masato Kubo, Hiroaki Kitano
Jul 11, 2019
Specific deletion of suppressor of cytokine signaling 3 (Socs3) in keratinocytes can cause severe skin inflammation with infiltration of immune cells. The molecular mechanisms and key regulatory pathways involved in these...
VISUAL-CC system uncovers the role of GSK3 as an orchestrator of vascular cell type ratio in plants
Takayuki Tamaki, Satoyo Oya, Makiko Naito, Yasuko Ozawa, Tomoyuki Furuya, Masato Saito, Mayuko Sato, Mayumi Wakazaki, Kiminori Toyooka, Hiroo Fukuda, Ykä Helariutta, Yuki Kondo
Apr 22, 2021
Abstract: The phloem transports photosynthetic assimilates and signalling molecules. It mainly consists of sieve elements (SEs), which act as “highways” for transport, and companion cells (CCs), which serve as “gates” to...
Reassessment of the phylogenetic relationships of the late Miocene apes Hispanopithecus and Rudapithecus based on vestibular morphology.
Alessandro Urciuoli, Clément Zanolli, Sergio Almécija, Amélie Beaudet, Jean Dumoncel, Naoki Morimoto, Masato Nakatsukasa, Salvador Moyà-Solà, David R Begun, David M Alba
May 24, 2021
Late Miocene great apes are key to reconstructing the ancestral morphotype from which earliest hominins evolved. Despite consensus that the late Miocene dryopith great apes Hispanopithecus laietanus (Spain) and Rudapithecus...
VISUAL-CC system uncovers the role of GSK3 as an orchestrator of vascular cell type ratio in plants
Takayuki Tamaki, Satoyo Oya, Makiko Naito, Yasuko Ozawa, Tomoyuki Furuya, Masato Saito, Mayuko Sato, Mayumi Wakazaki, Kiminori Toyooka, Hiroo Fukuda, Ykä Helariutta, Yuki Kondo
Feb 18, 2021
Abstract: The phloem transports photosynthetic assimilates and signalling molecules. It mainly consists of sieve elements (SEs), which act as “highways” for transport, and companion cells (CCs), which serve as “gates” to...
Faint Quasars Live in the Same Number Density Environments as Lyman Break Galaxies at z∼4
Hisakazu Uchiyama, Masayuki Akiyama, Jun Toshikawa, Nobunari Kashikawa, Roderik Overzier, Tohru Nagao, Kohei Ichikawa, Murilo Marinello, Masatoshi Imanishi, Masayuki Tanaka, Yoshiki Matsuoka, Yutaka Komiyama, Shogo Ishikawa, Masafusa Onoue, Mariko Kubo, Yuichi Harikane, Kei Ito, Shigeru Namiki, Yongming Liang
Dec 21, 2020
Characterizing high-z quasar environments is key to understanding the coevolution of quasars and the surrounding galaxies. To restrict their global picture, we statistically examine the g-dropout galaxy overdensity distribution...
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi, Masahide Takahashi
May 28, 2019
In clathrin-mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo-specific adaptors for distinct cellular functions. Here, we show that the actin-binding protein girdin...
VISUAL-CC system uncovers the role of GSK3 as an orchestrator of vascular cell type ratio in plants.
Takayuki Tamaki, Satoyo Oya, Makiko Naito, Yasuko Ozawa, Tomoyuki Furuya, Masato Saito, Mayuko Sato, Mayumi Wakazaki, Kiminori Toyooka, Hiroo Fukuda, Ykä Helariutta, Yuki Kondo
Jun 05, 2020
The phloem transports photosynthetic assimilates and signalling molecules. It mainly consists of sieve elements (SEs), which act as "highways" for transport, and companion cells (CCs), which serve as "gates" to load/unload...
Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.
Jie Zheng, Yuemiao Zhang, Humaira Rasheed, Venexia Walker, Yuka Sugawara, Jiachen Li, Yue Leng, Benjamin Elsworth, Robyn E Wootton, Si Fang, Qian Yang, Stephen Burgess, Philip C Haycock, Maria Carolina Borges, Yoonsu Cho, Rebecca Carnegie, Amy Howell, Jamie Robinson, Laurent F Thomas, Ben Michael Brumpton, Kristian Hveem, Stein Hallan, Nora Franceschini, Andrew P Morris, Anna Köttgen, Cristian Pattaro, Matthias Wuttke, Masayuki Yamamoto, Naoki Kashihara, Masato Akiyama, Masahiro Kanai, Koichi Matsuda, Yoichiro Kamatani, Yukinori Okada, Robin Walters, Iona Y Millwood, Zhengming Chen, George Davey Smith, Sean Barbour, Canqing Yu, Bjørn Olav Åsvold, Hong Zhang, Tom R Gaunt
Feb 10, 2022
Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.
Jie Zheng, Yuemiao Zhang, Humaira Rasheed, Venexia Walker, Yuka Sugawara, Jiachen Li, Yue Leng, Benjamin Elsworth, Robyn E Wootton, Si Fang, Qian Yang, Stephen Burgess, Philip C Haycock, Maria Carolina Borges, Yoonsu Cho, Rebecca Carnegie, Amy Howell, Jamie Robinson, Laurent F Thomas, Ben Michael Brumpton, Kristian Hveem, Stein Hallan, Nora Franceschini, Andrew P Morris, Anna Köttgen, Cristian Pattaro, Matthias Wuttke, Masayuki Yamamoto, Naoki Kashihara, Masato Akiyama, Masahiro Kanai, Koichi Matsuda, Yoichiro Kamatani, Yukinori Okada, Robin Walters, Iona Y Millwood, Zhengming Chen, George Davey Smith, Sean Barbour, Canqing Yu, Bjørn Olav Åsvold, Hong Zhang, Tom R Gaunt
Oct 25, 2021
Human artificial chromosome with a conditional centromere for gene delivery and gene expression.
Yuichi Iida, Jung-Hyun Kim, Yasuhiro Kazuki, Hidetoshi Hoshiya, Masato Takiguchi, Masahiro Hayashi, Indri Erliandri, Hee-Sheung Lee, Alex Samoshkin, Hiroshi Masumoto, William C Earnshaw, Natalay Kouprina, Vladimir Larionov, Mitsuo Oshimura
Dec 18, 2020
Human artificial chromosomes (HACs), which carry a fully functional centromere and are maintained as a single-copy episome, are not associated with random mutagenesis and offer greater control over expression of ectopic genes on...
Animals CHO Cells Cell Line Centromere Chickens Chromosomes Artificial Human Cricetinae Cricetulus Gene Expression Gene Targeting Gene Transfer Techniques Genetic Therapy Genetic Vectors Green Fluorescent Proteins Humans In Situ Hybridization Fluorescence Operator Regions Genetic Plasmids Polymerase Chain Reaction Recombination Genetic Tetracyclines Transgenes
Chiral Phosphoric Acid Catalysis
Matthew N. Grayson
Oct 01, 2021
Since Akiyama and Terada independently reported the introduction of chiral phosphoric acids (CPAs) as effective catalysts for Mannich-type reactions in 2004, the field of CPA catalysis has grown immensely. Terada reported in...
Chiral Phosphoric Acid Catalysis
Matthew N. Grayson
Oct 01, 2021
Since Akiyama and Terada independently reported the introduction of chiral phosphoric acids (CPAs) as effective catalysts for Mannich-type reactions in 2004, the field of CPA catalysis has grown immensely. Terada reported in...
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