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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
Teachers as Augmented Reality Designers
Martina Manna
Feb 02, 2023
As an emergent technology augmented reality (AR) demonstrated a plethora of advantages in foreign language education, promoting motivation, memorization of contents, as well as contextualized learning. However, the majority of...
Published by: IGI Global Scientific Publishing
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
CT colonography
Christian Bräuer, Philippe Lefere, Stefaan Gryspeerdt, Helmut Ringl, Ali Al-Mukhtar, Paul Apfaltrer, Dominik Berzaczy, Barbara Füger, Julia Furtner, Christina Müller-Mang, Matthias Pones, Martina Scharitzer, Ramona Woitek, Anno Graser, Michael Weber, Thomas Mang
Dec 20, 2018
OBJECTIVES: To assess whether electronic cleansing (EC) of tagged residue and different computed tomography (CT) windows influence the size of colorectal polyps in CT colonography (CTC). METHODS: A database of 894...
CT colonography Cancer screening Colonic Polyps Neoplasms colorectal Virtual colonoscopy Aged Algorithms Analysis of Variance Colonic Polyps Colonography Computed Tomographic Female Humans Image Processing Computer-Assisted Male Middle Aged Reference Standards Retrospective Studies Sensitivity and Specificity
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
Using Naturalistic Vehicle-Based Data to Predict Distraction and Environmental Demand
This research utilized vehicle-based measures from a naturalistic driving dataset to detect distraction as indicated by long off-path glances (≥ 2 s) and whether the driver was engaged in a secondary (non-driving) task or not...
Published by: IGI Global Scientific Publishing
Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals.
Ching-Ti Liu, Jordi Merino, Denis Rybin, Daniel DiCorpo, Kelly S Benke, Jennifer L Bragg-Gresham, Mickaël Canouil, Tanguy Corre, Harald Grallert, Aaron Isaacs, Zoltan Kutalik, Jari Lahti, Letizia Marullo, Carola Marzi, Laura J Rasmussen-Torvik, Ghislain Rocheleau, Rico Rueedi, Chiara Scapoli, Niek Verweij, Nicole Vogelzangs, Sara M Willems, Loïc Yengo, Stephan JL Bakker, John Beilby, Jennie Hui, Eero Kajantie, Martina Müller-Nurasyid, Wolfgang Rathmann, Beverley Balkau, Sven Bergmann, Johan G Eriksson, Jose C Florez, Philippe Froguel, Tamara Harris, Joseph Hung, Alan L James, Maryam Kavousi, Iva Miljkovic, Arthur W Musk, Lyle J Palmer, Annette Peters, Ronan Roussel, Pim van der Harst, Cornelia M van Duijn, Peter Vollenweider, Inês Barroso, Inga Prokopenko, Josée Dupuis, James B Meigs, Nabila Bouatia-Naji
Jul 18, 2019
Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development...
Approaches to Alternative Energy Policy: A Comparison of the United States and Germany
Martina Dzuna
Jan 01, 0001
This paper will examine the types of alternative energies that are available at this point, focus on the formation of markets for alternative energy and discuss how new energy technology enters and then diffuses into the...
alternative energies energy markets Green Party Stromeinspeisungsgesetz EEG Energy Policy Act Energy policy Environmental Sciences Environmental Studies Natural Resources Management and Policy Oil, Gas, and Energy Policy Design, Analysis, and Evaluation sustainability
Published by: Ursinus College
Analysis of responder-based endpoints
Abstract: Background: Clinical trials and other studies commonly assess the effectiveness of an intervention through the use of responder-based endpoints. These classify patients based on whether they meet a number of criteria...
The Emotional Facet of Subjective and Neural Indices of Similarity.
Emotional similarity refers to the tendency to group stimuli together because they evoke the same feelings in us. The majority of research on similarity perception that has been conducted to date has focused on non-emotional...
Analysis of responder-based endpoints
BACKGROUND: Clinical trials and other studies commonly assess the effectiveness of an intervention through the use of responder-based endpoints. These classify patients based on whether they meet a number of criteria which often...
COVID-19, Societalization and the Future of Business in Society
COVID-19 is profoundly affecting almost all aspects of economic and social life globally. Governments have closed borders, banned mass gatherings, and enforced social distancing, generating a new normal for businesses and...
Employing a latent variable framework to improve efficiency in composite endpoint analysis.
Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in...
Alzheimer's disease
OBJECTIVE: Peripheral protein biomarkers of Alzheimer's disease (AD) may help identify novel treatment avenues by allowing early diagnosis, recruitment to clinical trials, and treatment initiation. The purpose of this review was...
Daily stressors and Food Choices
We investigate experimentally the effects of daily-like stressors on immediate and planned food choices, in a sample of low socioeconomic status (SES) mothers. We design a novel stress protocol that aims to mimic everyday...
Small-Molecule Activation of YAP for Inner-Ear Regeneration and Beyond
Nathaniel Kastan
Jan 01, 0001
Hippo signaling is an evolutionarily conserved pathway that restricts organ growth during development and suppresses regeneration in mature organs. Using a highthroughput phenotypic screen, we have identified a potent...
Published by: Rockefeller University
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