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Interview with Mark Cooke
Mark Cooke
Jan 01, 0001
In his March 25, 2015 interview with Jenna Kasmarik, Mark Cooke details the role Title IX has played in athletics at Winthrop. Cooke details changes in recruitment and facilities. He also shares why he's stayed at Winthrop for...
Published by: Winthrop University
BMP9 Morphs into a Potential Player in Portopulmonary Hypertension.
Mark Toshner
Mar 26, 2019
The last 30 years of pulmonary hypertension research is a qualified translational success story. Patients with portopulmonary hypertension (PoPH) have benefitted from inclusion in the licensed indications for novel therapies...
Mark Twain Circle of America Welcomes Winthrop Professor as President
Winthrop University
Jan 01, 0001
The Mark Twain Circle is the most important academic association of Twain scholars and enthusiasts with more than 200 members internationally. Bird's first book on Twain, "Mark Twain and Metaphor," published in 2007.
Published by: Winthrop University
English Professor John Bird Discovers Never-Before-Published Mark Twain Children's Story
Winthrop University
Jan 01, 0001
Called "The Purloining of Prince Oleomargarine," it is the story of a young boy who eats a flower sprouted by a magical seed and gains the ability to talk to animals. Bird said he spotted Twain's notes on the story while...
Published by: Winthrop University
One-Room Schoolhouse Scholar Mark Dewalt Appears in Documentary
Winthrop University
Jan 01, 0001
"Country School: One Room - One Nation," written and produced by award-winning filmmakers Tammy and Kelly Rundle ("Villisca: Living with a Mystery" and "Lost Nation: The Ioway"), will be screened Nov. 19-21 at the State...
Published by: Winthrop University
Approaches to treat pulmonary arterial hypertension by targeting BMPR2
Pulmonary arterial hypertension (PAH) is estimated to affect between 10 and 50 people per million worldwide. The lack of cure and devastating nature of the disease means that treatment is crucial to arrest rapid clinical...
Mark Evans '06 Offers Incoming Students Good Advice at Convocation Ceremony
Winthrop University
Jan 01, 0001
Mark Evans '06, the supply chain manager for the Americas division of BSN Medical, delivered the Aug. 22 Convocation keynote address. Convocation serves as an official welcome to freshmen and their induction into the Winthrop...
Published by: Winthrop University
Repurposing of medications for pulmonary arterial hypertension.
Mark Toshner, Edda Spiekerkoetter, Harm Bogaard, Georg Hansmann, Sylvia Nikkho, Kurt W Prins
Dec 07, 2020
This manuscript on drug repurposing incorporates the broad experience of members of the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical...
Decoding 5HMC as an Active Chromatin Mark in the Brain and its Link to Rett Syndrome
Pinar Ayata
Jan 01, 0001
Functions of the nervous system are accompanied at the cellular level by changes in gene expression, regulated by transcription factors and epigenetic mechanisms, such as histone modifications and DNA methylation, that are...
Published by: Rockefeller University
The resistance-compliance product of the pulmonary circulation varies in health and pulmonary vascular disease.
Pulmonary vascular resistance (PVR) is traditionally used to describe pulmonary hemodynamic characteristics. However, it does not take into account pulmonary artery compliance (Ca) or pulsatile flow. The product of PVR and Ca is...
Repurposing of medications for pulmonary arterial hypertension
Mark Toshner, Edda Spiekerkoetter, Harm Bogaard, Georg Hansmann, Sylvia Nikkho, Kurt W. Prins
Nov 19, 2020
This manuscript on drug repurposing incorporates the broad experience of members of the Pulmonary Vascular Research Institute’s Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical...
Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood.
Mark L Ormiston, Mark R Toshner, Fedir N Kiskin, Christopher JZ Huang, Emily Groves, Nicholas W Morrell, Amer A Rana
Jun 14, 2018
Historically, the limited availability of primary endothelial cells from patients with vascular disorders has hindered the study of the molecular mechanisms underlying endothelial dysfunction in these individuals. However, the...
Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.
Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso, Paul D Upton, John P Waters, Mark L Ormiston, Jeremy N Skepper, Gerard Nash, Amer A Rana, Nicholas W Morrell
Jun 14, 2018
The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming versus the tissue contextual environment for this specialization is...
Adult Animals Cell Differentiation Cell Line Cluster Analysis Embryonic Stem Cells Endothelial Cells Fetus Gene Expression Profiling Gene Ontology Genes Homeobox Homeodomain Proteins Humans Lung Mice Neovascularization Physiologic Oligonucleotide Array Sequence Analysis Organ Specificity Phenotype Pulmonary Artery RNA Messenger Rats Real-Time Polymerase Chain Reaction Reproducibility of Results
Increased Antielastase Activity in Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.
Jingxu Guo, Katharine Lodge, Michael Newnham, Katherine Bunclark, Mark Toshner, Nicholas W Morrell, Wei Li
Sep 29, 2018
Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling and occlusion of pre-capillary arterioles in the lung with a subsequent increase in pulmonary vascular resistance. This can lead to right ventricular...
‘The real life of language’
Mark Wormald and Mick Gowar both teach in universities in the city of Cambridge – Mark at Pembroke College, and the Faculty of English, University of Cambridge; Mick at the Cambridge School of Art, and Faculty of Arts, Law and...
The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations.
Benjamin J Dunmore, Kylie M Drake, Paul D Upton, Mark R Toshner, Micheala A Aldred, Nicholas W Morrell
Apr 06, 2020
Pulmonary arterial hypertension (PAH) is characterized by dysregulated pulmonary artery endothelial cell (PAEC) proliferation, apoptosis and permeability. Loss-of-function mutations in the bone morphogenetic protein receptor...
Bone Morphogenetic Protein Receptors Type II Cell Line Cell Membrane Cells Cultured Chloroquine Endothelial Cells Familial Primary Pulmonary Hypertension Growth Differentiation Factor 2 Growth Differentiation Factors Humans Hypertension Pulmonary Lysosomes Mutation Pulmonary Artery RNA Small Interfering Signal Transduction Smad Proteins Transcription Genetic
Arrhythmic Burden and Outcomes in Pulmonary Arterial Hypertension.
Jennifer T Middleton, Angshuman Maulik, Robert Lewis, David G Kiely, Mark Toshner, Athanasios Charalampopoulos, Andreas Kyriacou, Alexander Rothman
Sep 25, 2019
Pulmonary arterial hypertension (PAH) is a devastating, life-limiting disease driven by small vessel vascular remodeling leading to a rise in pulmonary vascular resistance (PVR). Patients present with a range of symptoms...
Site-Specific Cleavage by Topoisomerase 2
In addition to its roles in transcription and replication, topoisomerase 2 (topo 2) is crucial in shaping mitotic chromosomes and in ensuring the orderly separation of sister chromatids. As well as its recruitment throughout the...
Pulmonary thromboembolic events in COVID-19 - a systematic literature review.
Paul M Overton, Mark Toshner, Claire Mulligan, Pareen Vora, Sylvia Nikkho, Jan de Backer, Ben R Lavon, Frederikus A Klok
Sep 09, 2022
Pulmonary thromboembolic events (TE) have been linked to coronavirus disease 2019 (COVID-19), but their incidence and long-term sequelae remain unclear. We performed a systematic literature review to investigate the incidence of...
Published by: Pulmonary circulation
Asymptotically cylindrical Calabi-Yau manifolds
Let M be a complete Ricci-flat Kähler manifold with one end and assume that this end converges at an exponential rate to [0, ∞) x X for some compact connected Ricci-flat manifold X. We begin by proving general structure...
Thromboembolic Risk in Hospitalized and Nonhospitalized COVID-19 Patients
Frederick K Ho, Kenneth KC Man, Mark Toshner, Colin Church, Carlos Celis-Morales, Ian CK Wong, Colin Berry, Naveed Sattar, Jill P Pell
Nov 25, 2021
OBJECTIVE: To assess the associations between coronavirus disease 2019 (COVID-19) infection and thromboembolism including myocardial infarction (MI), ischemic stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE)....
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