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Combined Learning Models Based on Constructionism Applied in Modern Learning of Biology
Iancu Mariana
Jan 01, 2019
The purpose of this research has been to identify modern and effective learning models, based on constructionism, in learning biological concepts. The author shows that the cognitive, formative, and emotional benefits, of...
Published by: IGI Global Scientific Publishing
Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.
Kornelia Johann, Anna Lena Cremer, Alexander W Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel López, Joerg Heeren, Jeffrey W Dalley, Heiko Backes, Jens Mittag
Oct 09, 2020
Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and...
beige adipose tissue beta3-adrenergic receptor Body Temperature brown adipose tissue glucose tolerance hyperthermia metabolism Norepinephrine pyrexia sympathetic nervous system thyroid hormone receptor Uncoupling Protein 1 Adipose Tissue Beige Adipose Tissue Brown Adipose Tissue White Animals Glucose Male Mice Mice Inbred C57BL Muscle Skeletal Receptors Adrenergic beta-3 Thermogenesis Thyroid Hormones Uncoupling Protein 1
Design Thinking and Compliance as Drivers for Decision Support System Adoption in Agriculture
To respond to increasing demands for good agricultural practices (GAP) and food safety, governments globally are introducing stringent regulations to govern agricultural compliance that affect production, storage, and sales...
Published by: IGI Global Scientific Publishing
From Face Perception to Individual Recognition: The Missing Link
Sofia Mariana Landi
Jan 01, 0001
Recognizing other individuals is a key social aspect of our everyday lives. To recognize a familiar individual, we must establish a link between sensory inputs and a representation of that individual held in memory. In primates...
Published by: Rockefeller University
The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life
The use of assisted reproductive technologies (ART) worldwide has led to the conception and birth of over eight million babies since being implemented in 1978. ART use is currently on the rise, given growing infertility and the...
Self-conscious emotions in patients suffering from chronic musculoskeletal pain
Objective: The role of self-conscious emotions (SCEs) including shame, guilt, humiliation and embarrassment are of increasing interest within health. Yet, little is known about SCEs in the experience of chronic pain. This...
Investigating the critical variables of azithromycin oral absorption using <i>in vitro </i>tests and PBPK Modeling
Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics. Conflicting evidence has been found regarding azithromycin classification according to the Biopharmaceutics classification system...
Mammalian autophagy and the plasma membrane.
Autophagy (literally 'self-eating') is an evolutionarily conserved degradation process where cytoplasmic components are engulfed by vesicles called autophagosomes, which are then delivered to lysosomes, where their contents are...
Investigating the critical variables of azithromycin oral absorption using <i>in vitro </i>tests and PBPK Modeling
Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics. Conflicting evidence has been found regarding azithromycin classification according to the Biopharmaceutics classification system...
Self-conscious emotions in patients suffering from chronic musculoskeletal pain
Objective: The role of self-conscious emotions (SCEs) including shame, guilt, humiliation and embarrassment are of increasing interest within health. Yet, little is known about SCEs in the experience of chronic pain. This...
The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life
The use of assisted reproductive technologies (ART) worldwide has led to the conception and birth of over eight million babies since being implemented in 1978. ART use is currently on the rise, given growing infertility...
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases.
Alvin Djajadikerta, Swati Keshri, Mariana Pavel, Ryan Prestil, Laura Ryan, David C Rubinsztein
Dec 11, 2019
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links between autophagy and neurodegenerative disease, and...
Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review.
Mariana Guimarães, Marina Statelova, René Holm, Christos Reppas, Moira Symilllides, Maria Vertzoni, Nikoletta Fotaki
Apr 30, 2019
Objectives: In this review, the current biopharmaceutical approaches for evaluation of oral formulation performance in paediatrics are discussed. Key findings: The paediatric gastrointestinal (GI) tract undergoes numerous...
Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review.
Mariana Guimarães, Marina Statelova, René Holm, Christos Reppas, Moira Symilllides, Maria Vertzoni, Nikoletta Fotaki
Apr 30, 2019
Objectives: In this review, the current biopharmaceutical approaches for evaluation of oral formulation performance in paediatrics are discussed. Key findings: The paediatric gastrointestinal (GI) tract undergoes numerous...
Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster.
Heiko Meyer, Annika Buhr, Patrick Callaerts, Ronja Schiemann, Mariana F Wolfner, Steven J Marygold
Jul 08, 2021
The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is...
Published by: MicroPubl Biol
Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ
Abstract: Amyloid-beta (Aβ) and tau protein are both involved in the pathogenesis of Alzheimer’s disease. Aβ produces synaptic deficits in wild-type mice that are not seen in Mapt−/− mice, suggesting that tau protein is required...
Auxin-degron system identifies immediate mechanisms of OCT4.
The pluripotency factor OCT4 is essential for the maintenance of naive pluripotent stem cells in vitro and in vivo. However, the specific role of OCT4 in this process remains unknown. Here, we developed a rapid protein-level...
High-pressure synthesis and storage of solid organic compounds in active subduction zones.
Baptiste Debret, Bénédicte Ménez, Bastien Walter, Hélène Bouquerel, Pierre Bouilhol, Nadine Mattielli, Céline Pisapia, Thomas Rigaudier, Helen Myfanwy Williams
Oct 18, 2022
Recent thermodynamic and experimental studies have suggested that volatile organic compounds (e.g., methane, formate, and acetate) can be produced and stabilized in subduction zones, potentially playing an important role in the...
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture
Abstract Tailoring of the activity and specificity of proteases is critical for their utility across industrial, medical and research purposes. However, engineering or evolving protease catalysts...
Philipp Knyphausen, Mariana Rangel Pereira, Paul Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Feb 11, 2023
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