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Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.
Michela Mazzon, Cecilia Castro, Bastian Thaa, Lifeng Liu, Margit Mutso, Xiang Liu, Suresh Mahalingam, Julian L Griffin, Mark Marsh, Gerald M McInerney
May 23, 2018
Virus reprogramming of cellular metabolism is recognised as a critical determinant for viral growth. While most viruses appear to activate central energy metabolism, different viruses have been shown to rely on alternative...
Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophages
Soluble products from antigen stimulated Trypanosoma cruzi-immune spleen cells enhanced the expression of Ia antigens on proteose-peptone-elicited mouse peritoneal macrophages (Mphi). Acquisition of Ia paralleled Mphi...
Published by: Rockefeller University
Lymphokine enhances the expression and synthesis of Ia antigen on cultured mouse peritoneal macrophages
Steinman, R.M., Nogueira, N., Witmer, M.D., Tydings, J.D., and Mellman, I.S. Lymphokine enhances the expression and synthesis of Ia antigen on cultured mouse peritoneal macrophages. J. Exp. Med. 152: 1248-1261, 1980
Published by: The Rockefeller University Press
Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells during primary antibody responses in vitro
[No abstract available]
Published by: Rockefeller University
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro
Inaba, K., Witmer-Pack, M., Inaba, M., Sakuta, H., Hathcock, K.S., Azuma, M., Yagita, H., Okumura, K., Linsley, P.S., Ikehara, S., Muramatsu, S., Hodes, R.J., and Steinman, R.M. The tissue distribution of the B7-2 costimulator...
Published by: The Rockefeller University Press
Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction
The C-type lectin dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN)/CD209 efficiently binds several pathogens, including HIV-1. DC-SIGN is expressed on monocyte-derived DCs in culture, and importantly, it is able to...
Published by: Rockefeller University
Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice
Dendritic cells (DCs) are a new cell type initially identified in mouse lymphoid organs. Recently, DCs have been purified from mouse spleen. This paper demonstrates a functional role of DCs: they are potent stimulators of the...
Published by: Rockefeller University
Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β.
After its uptake into the cytosol, intracellular glucose is phosphorylated to glucose-6-phosphate (G6P), trapping it within the cell and preparing it for metabolism. In glucose-exporting tissues, like liver, G6P is transported...
Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells, during primary antibody responses in vitro
Inaba, K., Witmer, M.D., and Steinman, R.M. Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells, during primary antibody responses in vitro. J. Exp. Med. 160: 858-876, 1984
Published by: The Rockefeller University Press
Influence of delayed immune reactions on human epidermal keratinocytes
The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous leishmaniasis. In each situation...
delayed hypersensitivity epidermis Histopathology immunopathology keratinocyte lepromatous leprosy skin leishmaniasis uberculin test
Published by: Rockefeller University
HIV-1 selectively infects a subset of nonmaturing BDCA1-positive dendritic cells in human blood
The infection of cultured monocyte-derived dendritic cells (DCs) with HIV-1 involves CD4 and CCR5 receptors, while transmission to T cells is enhanced at least in part by the lectin DC-SIGN/CD209. In the present study, we...
Published by: Rockefeller University
The function of Ia+ dendritic cells and ia dendritic cell precursors in thymocyte mitogenesis to lectin and lectin plus interleukin i
[No abstract available]
Published by: Rockefeller University
Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice
Steinman, R.M., and Witmer, M.D. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc. Natl. Acad. Sci. USA 75: 5132-5136, 1978
Published by: The National Academy of Sciences
Immunologic properties of purified epidermal Langerhans cells: Distinct requirements for stimulation of unprimed and sensitized T lymphocytes
Inaba, K., Schuler, G., Witmer, M., Valinsky, J., Atassi, B., and Steinman, R.M. Immunologic properties of purified epidermal Langerhans cells: Distinct requirements for stimulation of unprimed and sensitized T lymphocytes. J....
Published by: The Rockefeller University Press
Identification of proliferating dendritic cell precursors in mouse blood
Inaba, K., Steinman, R.M., Witmer-Pack, M., Aya, H., Inaba, M., Sudo, T., Wolpe, S., and Schuler, G. Identification of proliferating dendritic cell precursors in mouse blood. J. Exp. Med. 175: 1157-1167, 1992
Autoradiography blood culture Cell Aggregation dendritic cell immunoperoxidase staining mixed lymphocyte reaction t lymphocyte activation stem cell
Published by: The Rockefeller University Press
High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes
T lymphocytes recirculate continually through the T cell areas of peripheral lymph nodes. During each passage, the T cells survey the surface of large dendritic cells (DCs), also known as interdigitating cells. However, these...
Published by: Rockefeller University
Migration and maturation of Langerhans cells in skin transplants and explants
Larsen, C.P., Steinman, R.M., Witmer-Pack, M.D., Hankins, D.F., Morris, P.J., and Austyn, J.M. Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. 172: 1483-1493, 1990
Published by: The Rockefeller University Press
Role of the deubiquitylating enzyme DmUsp5 in coupling ubiquitin equilibrium to development and apoptosis in Drosophila melanogaster.
Protein ubiquitylation is a dynamic process that affects the function and stability of proteins and controls essential cellular processes ranging from cell proliferation to cell death. This process is regulated through the...
A monoclonal antibody specific for mouse dendritic cells
Nussenzweig, M.C., Steinman, R.M., Witmer, M.D., and Gutchinov, B. A monoclonal antibody specific for mouse dendritic cells. Proc. Natl. Acad. Sci. USA 79: 161-165, 1982
Published by: The National Academy of Sciences
The Tissue Distribution of the B7-2 Costimulator in Mice: Abundant Expression on Dendritic Cells In Situ and During Maturation In Vitro
B7-2 is a recently discovered, second ligand for the CTLA-4/CD28, T cell signaling system. Using the GL-1 rat monoclonal antibody (mAb), we monitored expression of B7-2 on mouse leukocytes with an emphasis on dendritic cells. By...
Published by: Rockefeller University
Longitudinal Risk Factors of Selling and Buying Sexual Services Among Youths in Switzerland.
The aim of this study was to examine the longitudinal predictors of buying and selling sexual services among youths in a high-income country. We used data from Switzerland (target sample: N = 1675 children, 52% male), where no...
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