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Results: 891
Alemtuzumab CARE-MS II 5-year follow-up
Alasdair J Coles, Jeffrey A Cohen, Edward J Fox, Gavin Giovannoni, Hans-Peter Hartung, Eva Havrdova, Sven Schippling, Krzysztof W Selmaj, Anthony Traboulsee, D Alastair S Compston, David H Margolin, Karthinathan Thangavelu, Madalina C Chirieac, Darlene Jody, Panos Xenopoulos, Richard J Hogan, Michael A Panzara, Douglas L Arnold, CARE-MS II and CAMMS03409 Investigators
Dec 11, 2017
OBJECTIVE: To evaluate 5-year efficacy and safety of alemtuzumab in patients with active relapsing-remitting multiple sclerosis and inadequate response to prior therapy. METHODS: In the 2-year Comparison of Alemtuzumab and Rebif...
Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS.
Lina A Dahabiyeh, David Tooth, Robin W Carrell, Randy J Read, Yahui Yan, Fiona Broughton Pipkin, David A Barrett
Dec 11, 2018
Angiotensinogen (AGT) is a critical protein in the renin-angiotensin-aldosterone system and may have an important role in the pathogenesis of pre-eclampsia. The disulphide linkage between cysteines 18 and 138 has a key role in...
MS in South Asians in England
Richard S Nicholas, Vassiliki Kostadima, Maya Hanspal, Benjamin R Wakerley, Ruhena Sergeant, Saskia Decuypere, Omar Malik, Rosemary J Boyton, Daniel M Altmann
Sep 29, 2016
BACKGROUND: Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals. However, individuals from other ethnic backgrounds and low-risk regions can...
LC–MS Lipidomics
Typical lipidomics methods incorporate a liquid−liquid extraction with LC−MS quantitation; however, the classic sample extraction methods are not high-throughput and do not perform well at extracting the full range of lipids...
Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC-MS/MS approach
Job Tchoumtchoua, Maria Halabalaki, Evangelos Gikas, Anthony Tsarbopoulos, Nikoletta Fotaki, Lucy Liu, Sangkil Nam, Richard Jove, Leandros A. Skaltsounis
Feb 05, 2019
Indirubins represent a group of natural and synthetic products with bio-activities against numerous human cancer cell lines acting by inhibiting protein kinases. The natural sources of indirubins are plants of Isatis sp....
Functionalized graphene oxide tablets for sample preparation of drugs in biological fluids
Zeynab Zohdijamil, Mahdi Hashemi, Abbi Abdel-Rehim, Karthik Laxman, Abdusalam Uheida, Joydeep Dutta, Mohamed Abdel-Rehim
Jun 04, 2021
In this work, graphene oxide-based tablets (GO-Tabs) were prepared by applying a thin layer of functionalized GO on a polyethylene substrate. The GO was functionalized with amine groups (-NH2 ) by poly(ethylene...
Organoid Sample Preparation and Extraction for LC-MS Peptidomics.
Emily L Miedzybrodzka, Rachel E Foreman, Sam G Galvin, Pierre Larraufie, Amy L George, Deborah A Goldspink, Frank Reimann, Fiona M Gribble, Richard G Kay
Mar 18, 2021
This protocol describes the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry (LC-MS). Currently, most peptides are quantified by ELISA...
Determination of CSF GFAP, CCN5, and vWF Levels Enhances the Diagnostic Accuracy of Clinically Defined MS From Non-MS Patients With CSF Oligoclonal Bands.
Fay Probert, Tianrong Yeo, Yifan Zhou, Megan Sealey, Siddharth Arora, Jacqueline Palace, Timothy DW Claridge, Rainer Hillenbrand, Johanna Oechtering, Jens Kuhle, David Leppert, Daniel C Anthony
Feb 18, 2022
BACKGROUND: Inclusion of cerebrospinal fluid (CSF) oligoclonal IgG bands (OCGB) in the revised McDonald criteria increases the sensitivity of diagnosis when dissemination in time (DIT) cannot be proven. While OCGB negative...
Alemtuzumab improves preexisting disability in active relapsing-remitting MS patients
G Giovannoni, JA Cohen, AJ Coles, H-P Hartung, E Havrdova, KW Selmaj, DH Margolin, SL Lake, SM Kaup, MA Panzara, DAS Compston, CARE-MS II Investigators
Jan 11, 2017
Adjuvants Immunologic Alemtuzumab Analysis of Variance Antibodies Monoclonal Humanized Antineoplastic Agents Disability Evaluation Disabled Persons Female Humans Interferon-beta Kaplan-Meier Estimate Longitudinal Studies Male Multiple Sclerosis Relapsing-Remitting Severity of Illness Index Treatment Outcome
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Duuamene Nyimanu, Richard G Kay, Petra Sulentic, Rhoda E Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M Gribble, Joseph Cheriyan, Janet J Maguire, Anthony P Davenport
Dec 05, 2019
[Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its stability...
Preliminary pharmacokinetic study of the anticancer 6BIO in mice using an UHPLC-MS/MS approach
Job Tchoumtchoua, Maria Halabalaki, Evangelos Gikas, Anthony Tsarbopoulos, Nikoletta Fotaki, Lucy Liu, Sangkil Nam, Richard Jove, Leandros A. Skaltsounis
Feb 05, 2019
Indirubins represent a group of natural and synthetic products with bio-activities against numerous human cancer cell lines acting by inhibiting protein kinases. The natural sources of indirubins are plants of Isatis sp....
Superior MRI outcomes with alemtuzumab compared with subcutaneous interferon β-1a in MS
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr 1 ]apelin-13 in humans
Duuamene Nyimanu, Richard G. Kay, Petra Sulentic, Rhoda E. Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M. Gribble, Joseph Cheriyan, Janet J. Maguire, Anthony P. Davenport
Dec 26, 2020
Abstract: [Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its...
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS
Tashinga E Bapiro, Frances M Richards, Mae A Goldgraben, Kenneth P Olive, Basetti Madhu, Kristopher K Frese, Natalie Cook, Michael A Jacobetz, Donna-Michelle Smith, David A Tuveson, John R Griffiths, Duncan I Jodrell
Nov 30, 2017
PURPOSE: To develop a sensitive analytical method to quantify gemcitabine (2',2'-difluorodeoxycytidine, dFdC) and its metabolites 2',2'-difluorodeoxyuridine (dFdU) and 2',2'-difluorodeoxycytidine-5'-triphosphate (dFdCTP)...
Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS.
Nunzia La Maida, Manuela Pellegrini, Esther Papaseit, Clara Pérez-Mañá, Lourdes Poyatos, Mireia Ventura, Liliana Galindo, Francesco Paolo Busardò, Simona Pichini, Magí Farré, Emilia Marchei
Dec 11, 2020
The consumption of synthetic cannabinoids (SCs) has significantly increased in the last decade and the analysis of SCs and their metabolites in human specimens is gaining interest in clinical and forensic toxicology. A pilot...
Spectral Libraries for SWATH-MS Assays for Drosophila melanogaster and Solanum lycopersicum.
Bertrand Fabre, Dagmara Korona, Clara I Mata, Harriet T Parsons, Michael J Deery, Maarten LATM Hertog, Bart M Nicolaï, Steven Russell, Kathryn S Lilley
Apr 04, 2018
Quantitative proteomics methods have emerged as powerful tools for measuring protein expression changes at the proteome level. Using MS-based approaches, it is now possible to routinely quantify thousands of proteins. However...
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Duuamene Nyimanu, Richard G Kay, Petra Sulentic, Rhoda E Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M Gribble, Joseph Cheriyan, Janet J Maguire, Anthony P Davenport
Jan 29, 2020
[Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its stability...
A Sample of Understudied Works in Aberdeen MS 123
Bailey Ludwig
Jan 01, 0001
This project examines and transcribes various understudied texts from the University of Aberdeen's MS 123 in order to create a more complete picture of this manuscript. Chapter one looks at the "Sultan Letters" and "List of...
aberdeen ms 123 middle english miscellany crusades Medicine Gender Arts and Humanities English Language and Literature Medieval Studies
Published by: Ursinus College
Efficacy and safety of alemtuzumab over 6 years
Alasdair J Coles, Douglas L Arnold, Ann D Bass, Aaron L Boster, D Alastair S Compston, Óscar Fernández, Eva Kubala Havrdová, Kunio Nakamura, Anthony Traboulsee, Tjalf Ziemssen, Alan Jacobs, David H Margolin, Xiaobi Huang, Nadia Daizadeh, Madalina C Chirieac, Krzysztof W Selmaj
Jun 27, 2021
BACKGROUND: In the 2-year CARE-MS I and II trials, alemtuzumab 12 mg administered on 5 consecutive days at core study baseline and on 3 consecutive days 12 months later significantly improved outcomes versus subcutaneous...
Organizing the Online Course
Kathleen A Burke, Ms.
Jan 01, 0001
If you are new to online instruction or are a veteran looking for fresh ideas for designing your online courses, this presentation will demonstrate user-friendly design for online courses, including course menu links...
Redundancy Orientation communications discussion organization Arts and Humanities Education Higher Education and Teaching Scholarship of Teaching and Learning
Published by: Winthrop University
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.
Glenn R Masson, John E Burke, Natalie G Ahn, Ganesh S Anand, Christoph Borchers, Sébastien Brier, George M Bou-Assaf, John R Engen, S Walter Englander, Johan Faber, Rachel Garlish, Patrick R Griffin, Michael L Gross, Miklos Guttman, Yoshitomo Hamuro, Albert JR Heck, Damian Houde, Roxana E Iacob, Thomas JD Jørgensen, Igor A Kaltashov, Judith P Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S Strutzenberg, Eric S Underbakke, Cornelia Wagner, Thomas E Wales, Benjamin T Walters, David D Weis, Derek J Wilson, Patrick L Wintrode, Zhongqi Zhang, Jie Zheng, David C Schriemer, Kasper D Rand
Jun 26, 2020
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data...
From the Farm to the Clinic
Oral presentation describing the need and development of a "farm to clinic" program to address chronic disease and food insecurity in Eastern North Carolina by connecting local NC agriculture to community-based health clinics.
Published by: Winthrop University
Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale.
Martin Steger, Vadim Demichev, Mattias Backman, Uli Ohmayer, Phillip Ihmor, Stefan Müller, Markus Ralser, Henrik Daub
Oct 18, 2021
Mass spectrometry (MS)-based ubiquitinomics provides system-level understanding of ubiquitin signaling. Here we present a scalable workflow for deep and precise in vivo ubiquitinome profiling, coupling an improved sample...
Developing a Yeast Model System to Study the Human Orthologs of the Ribosome-Associated Complex
Amanda Marley
Jan 01, 0001
Prions are a class of misfolded proteins that are infectious due to their ability to self-propagate and form protein aggregates, which are associated with diseases like Mad-Cow Disease and Creutzfeldt-Jakob. Fortunately, our...
Proteins protein misfolding chaperones Prions prion suppression Neurodegenerative Diseases Biochemistry Biochemistry, Biophysics, and Structural Biology Biology Cell Biology
Published by: Ursinus College
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