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Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.
Belinda M Kumpel, Radka Saldova, Carolien A M Koeleman, Jodie L Abrahams, Agnes Hipgrave Ederveen, Kathryn L Armour, Natalia I Olovnikova, Gestur Vidarsson, Rick Kapur, Pauline M Rudd, Manfred Wuhrer
Mar 02, 2020
Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays...
Published by: Scientific reports
Systematic Review
Chrissy Bolton, Yifan Chen, Rachel Hawthorne, Ianthe R. M. Schepel, Elinor Harriss, Silke C. Hofmann, Spencer Ellis, Alexander Clarke, Helena Wace, Blanca Martin, Joel Smith
Nov 26, 2020
Abstract: Background: Subacute cutaneous lupus erythematosus (SCLE) lacks consensus diagnostic criteria and the pathogenesis is poorly understood. There are increasing reports of SCLE induced by monoclonal antibodies (mAbs), but...
Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.
Christopher J Lelliott, Andrea Ahnmark, Therese Admyre, Ingela Ahlstedt, Lorraine Irving, Feenagh Keyes, Laurel Patterson, Michael B Mumphrey, Mikael Bjursell, Tracy Gorman, Mohammad Bohlooly-Y, Andrew Buchanan, Paula Harrison, Tristan Vaughan, Hans-Rudolf Berthoud, Daniel Lindén
Feb 18, 2021
We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in...
Animals Antibodies Monoclonal Arcuate Nucleus of Hypothalamus Chemokine CCL2 Chemokine CCL7 Circumventricular Organs Eating Energy Metabolism Female Gene Expression Regulation Glucose Intolerance Humans Hypothalamus Leptin Mice Mice Knockout Mice Obese Mitogen-Activated Protein Kinases obesity Receptor Fibroblast Growth Factor Type 1 Receptor Melanocortin Type 4 Receptors Somatostatin Ribosomal Protein S6 Kinases 70-kDa Serum Response Factor Signal Transduction
First do no harm
Timo Kivimaki
Dec 01, 2015
A recent revelation by President and Nobel Peace Prize laureate Martti Ahtisaari suggests that the large scale destruction of Syria could perhaps have been avoided by diplomacy. However, the negotiated solution was not accepted...
First do no harm
Timo Kivimaki
Dec 01, 2015
A recent revelation by President and Nobel Peace Prize laureate Martti Ahtisaari suggests that the large scale destruction of Syria could perhaps have been avoided by diplomacy. However, the negotiated solution was not accepted...
What Do Academic Library Deans Do?
Mark Y. Herring
Jan 01, 0001
A recent discussion apropos of nothing set me to a thought-experiment: what is it deans of library services (or, as it often the case when I'm introduced, deans of library sciences) do? If one were to write up a short list of...
Published by: Winthrop University
Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy.
Belinda M Kumpel, Radka Saldova, Carolien AM Koeleman, Jodie L Abrahams, Agnes Hipgrave Ederveen, Kathryn L Armour, Natalia I Olovnikova, Gestur Vidarsson, Rick Kapur, Pauline M Rudd, Manfred Wuhrer
Jan 29, 2021
Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays...
Tarsila do Amaral
Sofia Gotti
Feb 18, 2020
Tarsila do Amaral: Inventing Modern Art in Brazil sets out to confront "the issues of race, class, and gender in Brazil . . . as well as larger matters of nationalism and internationalism, primitivism and colonial history and...
An antigen-independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells
Dendritic cells bearing antigen efficiently aggregate and stimulate antigen-specific T cells. We describe an experimental model in which an initial, apparently antigen-independent binding step is followed by ligation of the TCR....
Published by: Rockefeller University
Considering planned change anew
Large Group Interventions, methods for involving “the whole system” in a change process, are important contemporary planned organizational change approaches. They are well known to practitioners but unfamiliar to many...
SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies.
MacGregor Cox, Thomas P Peacock, William T Harvey, Joseph Hughes, Derek W Wright, COVID-19 Genomics UK (COG-UK) Consortium, Brian J Willett, Emma Thomson, Ravindra K Gupta, Sharon J Peacock, David L Robertson, Alessandro M Carabelli
Nov 28, 2022
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19 and are especially important in high-risk individuals where vaccination is not an option. Given the importance of understanding the...
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131.
Mailis Maes, Zoe A Dyson, Sarah E Smith, David A Goulding, Catherine Ludden, Stephen Baker, Paul Kellam, Stephen T Reece, Gordon Dougan, Josefin Bartholdson Scott
Sep 21, 2020
The increase of antimicrobial resistance (AMR), and lack of new classes of licensed antimicrobials, have made alternative treatment options for AMR pathogens increasingly attractive. Recent studies have demonstrated...
Anti-Bacterial Agents Antibodies Monoclonal Humanized Drug Resistance Bacterial Escherichia coli Escherichia coli Infections Feasibility Studies High-Throughput Screening Assays Humans Interspersed Repetitive Sequences Microbial Sensitivity Tests Microscopy Electron O Antigens Phylogeny Polymorphism Single Nucleotide Virulence
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
Andrew J Whitehouse, Sherine E Thomas, Karen P Brown, Alexander Fanourakis, Daniel S-H Chan, M Daben J Libardo, Vitor Mendes, Helena IM Boshoff, R Andres Floto, Chris Abell, Tom L Blundell, Anthony G Coyne
Jul 19, 2019
Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous mycobacteria that has emerged as a growing threat to individuals with cystic fibrosis and other pre-existing chronic lung diseases....
Systematic Review
Chrissy Bolton, Yifan Chen, Rachel Hawthorne, Ianthe R. M. Schepel, Elinor Harriss, Silke C. Hofmann, Spencer Ellis, Alexander Clarke, Helena Wace, Blanca Martin, Joel Smith
Dec 22, 2020
Abstract: Background: Subacute cutaneous lupus erythematosus (SCLE) lacks consensus diagnostic criteria and the pathogenesis is poorly understood. There are increasing reports of SCLE induced by monoclonal antibodies (mAbs), but...
Rapid Isolation of Rare Isotype-Switched Hybridoma Variants
Stéphanie Charrin, Roberta Palmulli, Martine Billard, Denis Clay, Claude Boucheix, Guillaume Van Niel, Eric Rubinstein
Jul 04, 2020
CD63, a member of the tetraspanin superfamily, is used as a marker of late endosomes and lysosome-related organelles, as well as a marker of exosomes. Here, we selected rare isotype variants of TS63 by sorting hybridoma cells on...
Considering planned change anew
Large Group Interventions, methods for involving “the whole system” in a change process, are important contemporary planned organizational change approaches. They are well known to practitioners but unfamiliar to many...
Why do People Blame Others?
According to Amanda Watson when the situation is "someone else's fault", then there's little reason to do anything further about it, let alone seek to understand the role that one's own behaviour, feelings or assumptions might...
Published by: Department of History, University of Karachi
The Ursinus Weekly, December 4, 1911
Alumni notes The last game: Ursinus held to tie score by Bucknell at Reading, on Thanksgiving Day Oratorical union meets English-Historical group meets Mathematical groups hold meeting Senate meeting The Vale of Perkiomen
Ursinus College Collegeville Pennsylvania newspaper Football YWCA student government cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Ursinus Weekly, June 4, 1909
Ernest C. Wagner, Dorothy Latshaw, Morvin Wanner Godshall, Wesley Reiff Gerges, Helen Neff, Theodore Henckels
Jan 01, 0001
Recital by pupils of school of music Vale 1909! Track team Baseball Tennis tournament Work on field house begun Society notes Alumni notes Personals Another Ph.D. in the faculty Orators for junior contest selected ...
Ursinus College Collegeville Pennsylvania newspaper baseball track team tennis YMCA YWCA Zwinglian literary society Schaff literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Identification of immunostimulatory dendritic cells in the synovial effusions of patients with rheumatoid arthritis
Dendritic cells in the circulation are leukocytes that are rich in Ia antigens and that actively stimulate T cell replication. We have identified dendritic cells in the joint effusions of patients with rheumatoid arthritis. By...
Published by: Rockefeller University
A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes
Resting T cells enter cell cycle when challenged with anti-CD3 mAb and accessory cells that bear required Fc receptor (FcR). Presentation of anti-CD3 is though to be a model for antigens presented by accessory cells to the TCR...
Published by: Rockefeller University
In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Hanne Kinnunen Bown, Catherine Bonn, Stefan T. Yohe, Daniela Bumbaca Yadav, Thomas W. Patapoff, Ann L. Daugherty, Randall J. Mrsny
Mar 10, 2018
Monoclonal antibodies (mAbs), which are now more frequently administered by subcutaneous (SC) injection rather than intravenously, have become a tremendously successful drug format across a wide range of therapeutic areas....
In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Hanne Kinnunen Bown, Catherine Bonn, Stefan T. Yohe, Daniela Bumbaca Yadav, Thomas W. Patapoff, Ann L. Daugherty, Randall J. Mrsny
Mar 10, 2018
Monoclonal antibodies (mAbs), which are now more frequently administered by subcutaneous (SC) injection rather than intravenously, have become a tremendously successful drug format across a wide range of therapeutic areas....
Systematic Review
Chrissy Bolton, Yifan Chen, Rachel Hawthorne, Ianthe RM Schepel, Elinor Harriss, Silke C Hofmann, Spencer Ellis, Alexander Clarke, Helena Wace, Blanca Martin, Joel Smith
Sep 22, 2021
BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE) lacks consensus diagnostic criteria and the pathogenesis is poorly understood. There are increasing reports of SCLE induced by monoclonal antibodies (mAbs), but there are...
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