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Results: 47
Statistical reanalysis of vascular event outcomes in primary and secondary vascular prevention trials.
Lisa J Woodhouse, Alan A Montgomery, Jonathan Mant, Barry R Davis, Ale Algra, Jean-Louis Mas, Jan A Staessen, Lutgarde Thijs, Andrew Tonkin, Adrienne Kirby, Stuart J Pocock, John Chalmers, Graeme J Hankey, J David Spence, Peter Sandercock, Hans-Christoph Diener, Shinichiro Uchiyama, Nikola Sprigg, Philip M Bath
Oct 18, 2021
BACKGROUND: Vascular prevention trials typically use dichotomous event outcomes although this may be inefficient statistically and gives no indication of event severity. We assessed whether ordinal outcomes would be more...
Comprehensive field study of swash-zone processes, part 2
Thijs Lanckriet, Jack A. Puleo, Gerd Masselink, Ian L. Turner, Daniel Conley, C Blenkinsopp, Paul Russell
Jan 01, 2014
Sheet flow sediment concentration profiles were measured in natural conditions for the first time as part of a comprehensive field study on swash-zone hydrodynamics and sediment transport. Three conductivity concentration...
3D-to-2D Transition of Anion Vacancy Mobility in CsPbBr<sub>3</sub>under Hydrostatic Pressure
Anion vacancy migration in the orthorhombic Pnma phase of the lead-halide perovskite CsPbBr3 under hydrostatic pressure is studied computationally. Density functional theory calculations are used to determine transition...
3D-to-2D Transition of Anion Vacancy Mobility in CsPbBr<sub>3</sub>under Hydrostatic Pressure
Anion vacancy migration in the orthorhombic Pnma phase of the lead-halide perovskite CsPbBr3 under hydrostatic pressure is studied computationally. Density functional theory calculations are used to determine transition...
Comprehensive field study of swash-zone processes, part 2
Thijs Lanckriet, Jack A. Puleo, Gerd Masselink, Ian L. Turner, Daniel Conley, C Blenkinsopp, Paul Russell
Jan 01, 2014
Sheet flow sediment concentration profiles were measured in natural conditions for the first time as part of a comprehensive field study on swash-zone hydrodynamics and sediment transport. Three conductivity concentration...
Factors determining human-to-human transmissibility of zoonotic pathogens via contact.
Mathilde Richard, Sascha Knauf, Philip Lawrence, Alison E Mather, Vincent J Munster, Marcel A Müller, Derek Smith, Thijs Kuiken
Jun 12, 2020
The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and...
Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.
Matthew Traylor, Loes CA Rutten-Jacobs, Vincent Thijs, Elizabeth G Holliday, Chris Levi, Steve Bevan, Rainer Malik, Giorgio Boncoraglio, Cathie Sudlow, Peter M Rothwell, Martin Dichgans, Hugh S Markus
Mar 22, 2016
cerebral small vessel diseases Genetic Association Studies Genetics leukoencephalopathies stroke lacunar Adult Aged Aged 80 and over Female Genetic Association Studies Genetic Predisposition to Disease Humans Leukoaraiosis Magnetic Resonance Imaging Male Middle Aged Polymorphism Single Nucleotide Registries risk stroke lacunar
Mesoporous silica formation mechanisms probed using combined Spin-Echo Modulated Small Angle Neutron Scattering (SEMSANS) and Small Angle Neutron Scattering (SANS)
Julien Schmitt, Jan Joost Zeeuw, Jeroen Plomp, Wim G. Bouwman, Adam Washington, Robert Malcolm Dalgliesh, Chris Duif, Michel A. Thijs, Fankang Li, Roger Pynn, Steven R. Parnell, Karen J. Edler
Jun 24, 2020
The initial formation stages of surfactant-templated silica thin films which grow at the air-water interface were studied using combined spin-echo modulated small-angle neutron scattering (SEMSANS) and small-angle neutron...
Effect of filgotinib on health-related quality of life in active psoriatic arthritis
Ana-Maria Orbai, Alexis Ogdie, Laure Gossec, William Tillett, Ying Ying Leung, Jingjing Gao, Mona Trivedi, Chantal Tasset, Luc Meuleners, Robin Besuyen, Thijs Hendrikx, Laura C Coates
Jul 01, 2020
To examine the effects of filgotinib, an oral, selective Janus kinase 1 inhibitor, on health-related quality of life (HRQoL) using the Psoriatic Arthritis Impact of Disease (PsAID)9 questionnaire in active PsA. Methods...
Effect of filgotinib on health-related quality of life in active psoriatic arthritis
Ana-Maria Orbai, Alexis Ogdie, Laure Gossec, William Tillett, Ying Ying Leung, Jingjing Gao, Mona Trivedi, Chantal Tasset, Luc Meuleners, Robin Besuyen, Thijs Hendrikx, Laura C Coates
Jul 01, 2020
To examine the effects of filgotinib, an oral, selective Janus kinase 1 inhibitor, on health-related quality of life (HRQoL) using the Psoriatic Arthritis Impact of Disease (PsAID)9 questionnaire in active PsA. Methods...
Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon.
Rory Hennell James, Eva F Caceres, Alex Escasinas, Haya Alhasan, Julie A Howard, Michael J Deery, Thijs JG Ettema, Nicholas P Robinson
Jan 24, 2018
The covalent modification of protein substrates by ubiquitin regulates a diverse range of critical biological functions. Although it has been established that ubiquitin-like modifiers evolved from prokaryotic sulphur transfer...
Mesoporous silica formation mechanisms probed using combined Spin-Echo Modulated Small Angle Neutron Scattering (SEMSANS) and Small Angle Neutron Scattering (SANS)
Julien Schmitt, Jan Joost Zeeuw, Jeroen Plomp, Wim G. Bouwman, Adam Washington, Robert Malcolm Dalgliesh, Chris Duif, Michel A. Thijs, Fankang Li, Roger Pynn, Steven R. Parnell, Karen J. Edler
Jun 24, 2020
The initial formation stages of surfactant-templated silica thin films which grow at the air-water interface were studied using combined spin-echo modulated small-angle neutron scattering (SEMSANS) and small-angle neutron...
Blood biomarkers on admission in acute traumatic brain injury
Endre Czeiter, Krisztina Amrein, Benjamin Y Gravesteijn, Fiona Lecky, David K Menon, Stefania Mondello, Virginia FJ Newcombe, Sophie Richter, Ewout W Steyerberg, Thijs Vande Vyvere, Jan Verheyden, Haiyan Xu, Zhihui Yang, Andrew IR Maas, Kevin KW Wang, András Büki, CENTER-TBI Participants and Investigators
May 06, 2020
Biomarkers clinical decision rule Computerized tomography Diagnostic GFAP Injury severity serum Traumatic brain injury Aged Aged 80 and over Area Under Curve Biomarkers Brain Injuries Traumatic Female Glial Fibrillary Acidic Protein Humans Male Neurofilament Proteins Patient Admission Patient Care Planning Prospective Studies ROC Curve S100 Calcium Binding Protein beta Subunit Severity of Illness Index Tomography X-Ray Computed Ubiquitin Thiolesterase tau Proteins
Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery.
Tomoyuki Hatano, Saravanan Palani, Dimitra Papatziamou, Ralf Salzer, Diorge P Souza, Daniel Tamarit, Mehul Makwana, Antonia Potter, Alexandra Haig, Wenjue Xu, David Townsend, David Rochester, Dom Bellini, Hamdi MA Hussain, Thijs JG Ettema, Jan Löwe, Buzz Baum, Nicholas P Robinson, Mohan Balasubramanian
Jul 14, 2022
The ESCRT machinery, comprising of multiple proteins and subcomplexes, is crucial for membrane remodelling in eukaryotic cells, in processes that include ubiquitin-mediated multivesicular body formation, membrane repair...
Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).
Matthew Traylor, Daniel J Tozer, Iain D Croall, Danuta M Lisiecka-Ford, Abiodun Olubunmi Olorunda, Giorgio Boncoraglio, Martin Dichgans, Robin Lemmens, Jonathan Rosand, Natalia S Rost, Peter M Rothwell, Cathie LM Sudlow, Vincent Thijs, Loes Rutten-Jacobs, Hugh S Markus, International Stroke Genetics Consortium
Jan 15, 2019
Experimental Lagos bat virus infection in straw-colored fruit bats
Lineke Begeman, Richard Suu-Ire, Ashley C Banyard, Christian Drosten, Elisa Eggerbauer, Conrad M Freuling, Louise Gibson, Hooman Goharriz, Daniel L Horton, Daisy Jennings, Denise A Marston, Yaa Ntiamoa-Baidu, Silke Riesle Sbarbaro, David Selden, Emma L Wise, Thijs Kuiken, Anthony R Fooks, Thomas Müller, James LN Wood, Andrew A Cunningham
Feb 01, 2021
Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are...
Limited airborne transmission of H7N9 influenza A virus between ferrets.
Mathilde Richard, Eefje JA Schrauwen, Miranda de Graaf, Theo M Bestebroer, Monique IJ Spronken, Sander van Boheemen, Dennis de Meulder, Pascal Lexmond, Martin Linster, Sander Herfst, Derek J Smith, Judith M van den Brand, David F Burke, Thijs Kuiken, Guus F Rimmelzwaan, Albert DME Osterhaus, Ron AM Fouchier
Jun 12, 2020
Wild waterfowl form the main reservoir of influenza A viruses, from which transmission occurs directly or indirectly to various secondary hosts, including humans. Direct avian-to-human transmission has been observed for viruses...
Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens
Guus A M Kortman, Michelle L. M Mulder, Thijs J W Richters, Nanda K N Shanmugam, Estela Trebicka, Jos Boekhorst, Harro M. Timmerman, Rian Roelofs, Erwin T. Wiegerinck, Coby M. Laarakkers, Dorine W. Swinkels, Albert Bolhuis, Bobby J. Cherayil, Harold Tjalsma
Sep 01, 2015
Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses...
Common NOTCH3 Variants and Cerebral Small-Vessel Disease.
Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens
Guus A M Kortman, Michelle L. M Mulder, Thijs J W Richters, Nanda K N Shanmugam, Estela Trebicka, Jos Boekhorst, Harro M. Timmerman, Rian Roelofs, Erwin T. Wiegerinck, Coby M. Laarakkers, Dorine W. Swinkels, Albert Bolhuis, Bobby J. Cherayil, Harold Tjalsma
Sep 01, 2015
Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses...
Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI
Ewout W Steyerberg, Eveline Wiegers, Charlie Sewalt, Andras Buki, Giuseppe Citerio, Véronique De Keyser, Ari Ercole, Kevin Kunzmann, Linda Lanyon, Fiona Lecky, Hester Lingsma, Geoffrey Manley, David Nelson, Wilco Peul, Nino Stocchetti, Nicole von Steinbüchel, Thijs Vande Vyvere, Jan Verheyden, Lindsay Wilson, Andrew IR Maas, David K Menon, CENTER-TBI Participants and Investigators
May 29, 2019
Adult Aged Brain Injuries Traumatic Cohort Studies Critical Care Outcomes Critical Pathways Diagnosis-Related Groups Europe Female Glasgow Coma Scale Glasgow Outcome Scale Humans Intensive Care Units Israel Longitudinal Studies Male Middle Aged Patient Admission Prognosis Prospective Studies Registries
Investigation of antihypertensive class, dementia, and cognitive decline
Ruth Peters, Sevil Yasar, Craig S Anderson, Shea Andrews, Riitta Antikainen, Hisatomi Arima, Nigel Beckett, Joanne C Beer, Anne Suzanne Bertens, Andrew Booth, Martin van Boxtel, Carol Brayne, Henry Brodaty, Michelle C Carlson, John Chalmers, Maria Corrada, Steven DeKosky, Carol Derby, Roger A Dixon, Françoise Forette, Mary Ganguli, Willem A van Gool, Antonio Guaita, Ann M Hever, David B Hogan, Carol Jagger, Mindy Katz, Claudia Kawas, Patrick G Kehoe, Sirkka Keinanen-Kiukaanniemi, Rose Ann Kenny, Sebastian Köhler, Setor K Kunutsor, Jari Laukkanen, Colleen Maxwell, G Peggy McFall, Tessa van Middelaar, Eric P Moll van Charante, Tze-Pin Ng, Jean Peters, Iris Rawtaer, Edo Richard, Kenneth Rockwood, Lina Rydén, Perminder S Sachdev, Ingmar Skoog, Johan Skoog, Jan A Staessen, Blossom CM Stephan, Sylvain Sebert, Lutgarde Thijs, Stella Trompet, Phillip J Tully, Christophe Tzourio, Roberta Vaccaro, Eeva Vaaramo, Erin Walsh, Jane Warwick, Kaarin J Anstey
Sep 03, 2019
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