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Molecular Landscape of Acute Myeloid Leukemia
PURPOSE OF REVIEW: The field of acute myeloid leukemia (AML) has been revolutionized in recent years by the advent of high-throughput techniques, such as next-generation sequencing. In this review, we will discuss some of the...
Why do users trust algorithms? A review and conceptualization of initial trust and trust over time
Algorithms are increasingly playing a pivotal role in organizations' day-to-day operations; however, a general distrust of artificial intelligence-based algorithms and automated processes persists. This aversion to algorithms...
Play ''Kiss Me Kate'' is Challenging Production for Department
Winthrop University
Jan 01, 0001
"Kiss Me Kate" is based on a book by Sam and Bella Spewack, with Broadway composer Cole Porter providing music and lyrics. The play was first presented at Winthrop in 1963 when it was directed by Chris Reynolds.
Published by: Winthrop University
Why do users trust algorithms? A review and conceptualization of initial trust and trust over time
Algorithms are increasingly playing a pivotal role in organizations' day-to-day operations; however, a general distrust of artificial intelligence-based algorithms and automated processes persists. This aversion to algorithms...
Engaging the Crowd
In this article, the challenges of realising e-participatory projects in urban planning are described. A participatory case study in Singapore serves as the basis for their presented conclusions. The researchers used a map-based...
Published by: IGI Global Scientific Publishing
Sociology Professor Jennifer Solomon Reflects on Women's Equality Day
Winthrop University
Jan 01, 0001
In 1971, Rep. Bella Abzug (D-NY) requested that the U.S. Congress designate the day of Aug. 26 as Women's Equality Day. Women's Equality Day not only commemorates the passage of the 19th Amendment, but also calls attention to...
Published by: Winthrop University
Hematopoietic stem cells made BETter by inhibition.
Bromodomain and extra terminal (BET) proteins comprise the ubiquitously expressed BRD2, BRD3, BRD4 and the testes specific BRDT. These multipurpose proteins contain tandem N-terminal bromodomains that bind acetylated lysine...
The Resilient Organisation
The Input-Process-Output framework is adopted to examine the impact of diversity attributes (the input) on communication (the process) and their influence on performance (the output), to understand the internal group/team...
The Resilient Organisation
The Input-Process-Output framework is adopted to examine the impact of diversity attributes (the input) on communication (the process) and their influence on performance (the output), to understand the internal group/team...
Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease.
Campbell Le Heron, Sanjay Manohar, Olivia Plant, Kinan Muhammed, Ludovica Griffanti, Andrea Nemeth, Gwenaëlle Douaud, Hugh S Markus, Masud Husain
Dec 11, 2018
Apathy is a syndrome of reduced motivation that commonly occurs in patients with cerebral small vessel disease, including those with the early onset form, CADASIL (cerebral autosomal dominant arteriopathy with subcortical...
Mindfulness-Based Interventions for University Students
Anna F Dawson, William W Brown, Joanna Anderson, Bella Datta, James N Donald, Karen Hong, Sophie Allan, Tom B Mole, Peter B Jones, Julieta Galante
Oct 29, 2019
BACKGROUND: University students are expressing an increased need for mental health support. Mindfulness-based interventions (MBIs) are being integrated into university stress-reduction programmes globally. We conducted a...
Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
Camille Martin-Gallausiaux, Pierre Larraufie, Anne Jarry, Fabienne Béguet-Crespel, Ludovica Marinelli, Florence Ledue, Frank Reimann, Hervé M Blottière, Nicolas Lapaque
Dec 20, 2018
Commensal bacteria are crucial for the development and maintenance of a healthy immune system therefore contributing to the global well-being of their host. A wide variety of metabolites produced by commensal bacteria are...
IDO-1 butyrate Gut microbiota immune gene regulation intestinal epithelial cells Bacteria Butyric Acid Caco-2 Cells Down-Regulation Epithelial Cells Female Gastrointestinal Microbiome Gene Expression Regulation Developmental Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Interferon-gamma Intestinal Mucosa Male Middle Aged Receptors G-Protein-Coupled Transcription Factors
Cell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints.
Bella B Manshian, Stefaan J Soenen, Abdullah Al-Ali, Andy Brown, Nicole Hondow, John Wills, Gareth JS Jenkins, Shareen H Doak
May 13, 2020
Toxicity of nanoparticles (NPs) is often correlated with the physicochemical characteristics of the materials. However, some discrepancies are noted in in-vitro studies on quantum dots (QDs) with similar physicochemical...
Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries.
Bella B Manshian, Stefaan J Soenen, Andy Brown, Nicole Hondow, John Wills, Gareth JS Jenkins, Shareen H Doak
May 13, 2020
Quantum dots (QD) have unique electronic and optical properties promoting biotechnological advances. However, our understanding of the toxicological structure-activity relationships remains limited. This study aimed to determine...
Persistence of haemostatic response following gene therapy with valoctocogene roxaparvovec in severe haemophilia A.
K John Pasi, Michael Laffan, Savita Rangarajan, Tara M Robinson, Nina Mitchell, Will Lester, Emily Symington, Bella Madan, Xinqun Yang, Benjamin Kim, Glenn F Pierce, Wing Yen Wong
Nov 08, 2021
INTRODUCTION: Valoctocogene roxaparvovec is an investigational AAV5-based factor VIII (FVIII) gene therapy that has demonstrated sustained clinical benefit in people with severe haemophilia A. AIM: To report safety...
A systematic review on the impact of commercially available hybrid closed loop systems on psychological outcomes in youths with type 1 diabetes and their parents
Roberto Franceschi, Enza Mozzillo, Francesca Di Candia, Evelina Maines, Letizia Leonardi, Martina Girardi, Ludovica Fedi, Francesco Maria Rosanio, M. Loredana Marcovecchio
Apr 17, 2023
Aim: To systematically assess the impact of commercially available hybrid closed loop (HCL) systems on psychological outcomes in youths with type 1 diabetes and their parents. Methods: We performed a systematic review including...
The Genetic Origin of Daunians and the Pan-Mediterranean Southern Italian Iron Age Context.
Serena Aneli, Tina Saupe, Francesco Montinaro, Anu Solnik, Ludovica Molinaro, Cinzia Scaggion, Nicola Carrara, Alessandro Raveane, Toomas Kivisild, Mait Metspalu, Christiana L Scheib, Luca Pagani
Feb 17, 2022
The geographical location and shape of Apulia, a narrow land stretching out in the sea at the South of Italy, made this region a Mediterranean crossroads connecting Western Europe and the Balkans. Such movements culminated at...
Longitudinal In Vivo Assessment of Host-Microbe Interactions in a Murine Model of Pulmonary Aspergillosis.
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.
Mathew Van de Pette, Allifia Abbas, Amelie Feytout, Gráinne McNamara, Ludovica Bruno, Wilson K To, Andrew Dimond, Alessandro Sardini, Zoe Webster, James McGinty, Eleanor J Paul, Mark A Ungless, Paul MW French, Dominic J Withers, Anthony Uren, Anne C Ferguson-Smith, Matthias Merkenschlager, Rosalind M John, Amanda G Fisher
Mar 11, 2020
Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-specific reporters to non-invasively monitor...
Automated Detection of Candidate Subjects With Cerebral Microbleeds Using Machine Learning.
Vaanathi Sundaresan, Christoph Arthofer, Giovanna Zamboni, Robert A Dineen, Peter M Rothwell, Stamatios N Sotiropoulos, Dorothee P Auer, Daniel J Tozer, Hugh Markus, Karla L Miller, Iulius Dragonu, Nikola Sprigg, Fidel Alfaro-Almagro, Mark Jenkinson, Ludovica Griffanti
Feb 03, 2022
Cerebral microbleeds (CMBs) appear as small, circular, well defined hypointense lesions of a few mm in size on T2*-weighted gradient recalled echo (T2*-GRE) images and appear enhanced on susceptibility weighted images (SWI). Due...
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