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Case Study of a Blind Computer Graphics Student's Online Interactions
Previous research points that computer-supported collaborative learning is an educational approach that suits blind students, because they have high verbal capacity. The authors believe that both sighted and blind students may...
Published by: IGI Global Scientific Publishing
Monitoring Practitioner's Skills in Pure-Tone Audiometry
So far, there exists no standard, to evaluate a practitioner's skills in pure-tone audiometry. To narrow the gap, this article presents an artificial patient (AP) emulating various types of hearing impairment. In contrast to...
Published by: IGI Global Scientific Publishing
TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.
Margaret E Harley, Olga Murina, Andrea Leitch, Martin R Higgs, Louise S Bicknell, Gökhan Yigit, Andrew N Blackford, Anastasia Zlatanou, Karen J Mackenzie, Kaalak Reddy, Mihail Halachev, Sarah McGlasson, Martin AM Reijns, Adeline Fluteau, Carol-Anne Martin, Simone Sabbioneda, Nursel H Elcioglu, Janine Altmüller, Holger Thiele, Lynn Greenhalgh, Luciana Chessa, Mohamad Maghnie, Mahmoud Salim, Michael B Bober, Peter Nürnberg, Stephen P Jackson, Matthew E Hurles, Bernd Wollnik, Grant S Stewart, Andrew P Jackson
Oct 28, 2015
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
The societal burden of chronic liver diseases
Luciana Scalone, Stefano Fagiuoli, Roberta Ciampichini, Ivan Gardini, Raffaele Bruno, Luisa Pasulo, Maria Grazia Lucà, Francesco Fusco, Laura Gaeta, Anna Del Prete, Giancarlo Cesana, Lorenzo Giovanni Mantovani
Jan 22, 2020
OBJECTIVE: Chronic liver diseases (CLDs) impose a significant socioeconomic burden on patients and the healthcare system, but to what extent remains underexplored. We estimated costs and health-related-quality-of-life (HRQoL)...
Perinatal and sociodemographic factors at birth predicting conduct problems and violence to age 18 years
Joseph Murray, Barbara Maughan, Ana MB Menezes, Matthew Hickman, John Macleod, Alicia Matijasevich, Helen Gonçalves, Luciana Anselmi, Erika AG Gallo, Fernando C Barros
Dec 18, 2014
ALSPAC Conduct problems cohort study middle-income country Risk Factors violence Adolescent Adult Age Distribution Brazil Child Cohort Studies Conduct Disorder Cross-Cultural Comparison Female Humans Infant Newborn Male Mothers Poverty Pregnancy Prospective Studies Risk Factors Self Report Sex Distribution Socioeconomic Factors Surveys and Questionnaires United Kingdom violence Young Adult
90K immunostimulatory glycoprotein in children with juvenile idiopathic arthritis.
Cristina Cecamore, Manuela Marsili, Roberta Salvatore, Roberto Troiani, Maurizia D'Egidio, Nicola Tinari, Piernicola Pelliccia, Francesco Chiarelli, M Loredana Marcovecchio, Luciana Breda
Nov 23, 2018
OBJECTIVES: To assess whether circulating levels of 90K glycoprotein are increased in children with juvenile idiopathic arthritis (JIA) at different stages of the disease, compared to healthy controls and to evaluate potential...
Relationship Between Learning Styles and Learning Objects
Luciana Assis, Ana Rodrigues, Alessandro Vivas, Cristiano Pitangui, Cristiano Silva, Fabiano Dorça
Jan 01, 2022
The automation of learning object recommendation and learning styles detection processes has attracted the interest of many researchers. Some works consider Learning Styles to recommend Learning Objects. On the other hand, other...
Published by: IGI Global Scientific Publishing
Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring.
Josca M Schoonejans, Heather L Blackmore, Thomas J Ashmore, Lucas C Pantaleão, Luciana Pellegrini Pisani, Laura Dearden, John A Tadross, Catherine E Aiken, Denise S Fernandez-Twinn, Susan E Ozanne
Nov 02, 2022
developmental programming Fatty Liver Gestational diabetes Inflammation Maternal obesity Metformin White adipose tissue Humans Pregnancy Animals Mice Child Male Female Adult Infant Metformin Glucose Diabetes mellitus Type 2 Mice Inbred C57BL obesity Body composition Diabetes Gestational Fatty Liver Inflammation Lipids prenatal exposure delayed effects Diet High-Fat
Childhood behaviour problems predict crime and violence in late adolescence
Frontal-subcortical behaviors during Alzheimer's disease in individuals with Down syndrome.
Luciana Mascarenhas Fonseca, Guilherme Prado Mattar, Glenda Guerra Haddad, Aline Souza Gonçalves, André de Queiroz Constantino Miguel, Laura Maria Guilhoto, Shahid Zaman, Anthony J Holland, Cassio Machado de Campos Bottino, Marcelo Queiroz Hoexter
Apr 03, 2019
There is evidence that frontal-subcortical circuits play an important role in the initial presentation of dementia in Down syndrome (DS), including changes in behavior, a decline in working memory and executive dysfunction. We...
Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.
Hashem Koohy, Daniel J Bolland, Louise S Matheson, Stefan Schoenfelder, Claudia Stellato, Andrew Dimond, Csilla Várnai, Peter Chovanec, Tamara Chessa, Jeremy Denizot, Raquel Manzano Garcia, Steven W Wingett, Paula Freire-Pritchett, Takashi Nagano, Phillip Hawkins, Len Stephens, Sarah Elderkin, Mikhail Spivakov, Peter Fraser, Anne E Corcoran, Patrick D Varga-Weisz
Jun 24, 2019
BACKGROUND: Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression...
European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial).
Peter JD Andrews, Helen Louise Sinclair, Claire G Battison, Kees H Polderman, Giuseppe Citerio, Luciana Mascia, Bridget A Harris, Gordon D Murray, Nino Stocchetti, David K Menon, Haleema Shakur, Daniel De Backer, Eurotherm3235Trial collaborators
Jun 16, 2011
BACKGROUND: Traumatic brain injury is a major cause of death and severe disability worldwide with 1,000,000 hospital admissions per annum throughout the European Union.Therapeutic hypothermia to reduce intracranial hypertension...
Physical, ecological and human dimensions of environmental change in Brazil's Pantanal wetland
Christopher Schulz, Bronwen S Whitney, Onélia Carmem Rossetto, Danilo M Neves, Lauren Crabb, Emiliano Castro de Oliveira, Pedro Luiz Terra Lima, Muhammad Afzal, Anna F Laing, Luciana C de Souza Fernandes, Charlei Aparecido da Silva, Valdir Adilson Steinke, Ercília Torres Steinke, Carlos Hiroo Saito
Jun 17, 2019
The Pantanal is the world's largest freshwater wetland, located in the geographical centre of South America. It is relatively well conserved, and features unique landscapes, ecosystems, and traditional cultural practices, shaped...
Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring.
Laís Vales Mennitti, Asha AM Carpenter, Elena Loche, Lucas C Pantaleão, Denise S Fernandez-Twinn, Josca M Schoonejans, Heather L Blackmore, Thomas J Ashmore, Luciana Pellegrini Pisani, John A Tadross, Iain Hargreaves, Susan E Ozanne
Jan 28, 2022
OBJECTIVE: This study investigated the effect of maternal obesity on aged-male offspring liver phenotype and hepatic expression of a programmed miRNA. METHODS: A mouse model (C57BL/6 J) of maternal diet-induced obesity was used...
The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil.
Luciana M Fonseca, Glenda G Haddad, Guilherme P Mattar, Melaine C de Oliveira, Sharon S Simon, Laura M Guilhoto, Geraldo F Busatto, Shahid Zaman, Anthony J Holland, Marcelo Q Hoexter, Cassio M Bottino
Jul 06, 2020
OBJECTIVE: Alzheimer's disease occurs at a higher prevalence and an earlier age in individuals with Down syndrome (DS) than typically developing individuals. However, diagnosing dementia in individuals with intellectual...
Mechanical ventilation in patients with acute brain injury
Chiara Robba, Daniele Poole, Molly McNett, Karim Asehnoune, Julian Bösel, Nicolas Bruder, Arturo Chieregato, Raphael Cinotti, Jacques Duranteau, Sharon Einav, Ari Ercole, Niall Ferguson, Claude Guerin, Ilias I Siempos, Pedro Kurtz, Nicole P Juffermans, Jordi Mancebo, Luciana Mascia, Victoria McCredie, Nicolas Nin, Mauro Oddo, Paolo Pelosi, Alejandro A Rabinstein, Ary Serpa Neto, David B Seder, Markus B Skrifvars, Jose I Suarez, Fabio Silvio Taccone, Mathieu van der Jagt, Giuseppe Citerio, Robert D Stevens
Oct 06, 2020
PURPOSE: To provide clinical practice recommendations and generate a research agenda on mechanical ventilation and respiratory support in patients with acute brain injury (ABI). METHODS: An international consensus panel was...
Global benchmarking of children's exposure to television advertising of unhealthy foods and beverages across 22 countries.
Bridget Kelly, Stefanie Vandevijvere, SeeHoe Ng, Jean Adams, Lorena Allemandi, Liliana Bahena-Espina, Simon Barquera, Emma Boyland, Paul Calleja, Isabel Cristina Carmona-Garcés, Luciana Castronuovo, Daniel Cauchi, Teresa Correa, Camila Corvalán, Emma Lucia Cosenza-Quintana, Carlos Fernández-Escobar, Laura I González-Zapata, Jason Halford, Nongnuch Jaichuen, Melissa L Jensen, Tilakavati Karupaiah, Asha Kaur, María F Kroker-Lobos, Zandile Mchiza, Krista Miklavec, Whadi-Ah Parker, Monique Potvin Kent, Igor Pravst, Manuel Ramírez-Zea, Sascha Reiff, Marcela Reyes, Miguel Ángel Royo-Bordonada, Putthipanya Rueangsom, Peter Scarborough, Maria Victoria Tiscornia, Lizbeth Tolentino-Mayo, Jillian Wate, Martin White, Irina Zamora-Corrales, Lingxia Zeng, Boyd Swinburn
Feb 08, 2019
Restricting children's exposures to marketing of unhealthy foods and beverages is a global obesity prevention priority. Monitoring marketing exposures supports informed policymaking. This study presents a global overview of...
Birth cohort-specific trends of sun-related behaviors among individuals from an international consortium of melanoma-prone families.
John Charles A Lacson, Shawn A Zamani, Luis Alberto Ribeiro Froes, Nandita Mitra, Lu Qian, Scarlet H Doyle, Esther Azizi, Claudia Balestrini, D Timothy Bishop, William Bruno, Blanca Carlos-Ortega, Francisco Cuellar, Anne E Cust, David E Elder, Anne-Marie Gerdes, Paola Ghiorzo, Thais C Grazziotin, Nelleke A Gruis, Johan Hansson, Marko Hočevar, Veronica Höiom, Elizabeth A Holland, Christian Ingvar, Gilles Landman, Alejandra Larre-Borges, Graham J Mann, Montserrat Molgo, Luciana Facure Moredo, Håkan Olsson, Jacoba J Out-Luiting, Barbara Perić, Dace Pjanova, Susana Puig, Julio Salas-Alanis, Helen Schmid, Karin AW Wadt, Julia A Newton-Bishop, Peter A Kanetsky, GenoMEL Study Group
Apr 23, 2021
Quantifying and addressing the prevalence and bias of study designs in the environmental and social sciences.
Alec P Christie, David Abecasis, Mehdi Adjeroud, Juan C Alonso, Tatsuya Amano, Alvaro Anton, Barry P Baldigo, Rafael Barrientos, Jake E Bicknell, Deborah A Buhl, Just Cebrian, Ricardo S Ceia, Luciana Cibils-Martina, Sarah Clarke, Joachim Claudet, Michael D Craig, Dominique Davoult, Annelies De Backer, Mary K Donovan, Tyler D Eddy, Filipe M França, Jonathan PA Gardner, Bradley P Harris, Ari Huusko, Ian L Jones, Brendan P Kelaher, Janne S Kotiaho, Adrià López-Baucells, Heather L Major, Aki Mäki-Petäys, Beatriz Martín, Carlos A Martín, Philip A Martin, Daniel Mateos-Molina, Robert A McConnaughey, Michele Meroni, Christoph FJ Meyer, Kade Mills, Monica Montefalcone, Norbertas Noreika, Carlos Palacín, Anjali Pande, C Roland Pitcher, Carlos Ponce, Matt Rinella, Ricardo Rocha, María C Ruiz-Delgado, Juan J Schmitter-Soto, Jill A Shaffer, Shailesh Sharma, Anna A Sher, Doriane Stagnol, Thomas R Stanley, Kevin DE Stokesbury, Aurora Torres, Oliver Tully, Teppo Vehanen, Corinne Watts, Qingyuan Zhao, William J Sutherland
Nov 16, 2020
Building trust in science and evidence-based decision-making depends heavily on the credibility of studies and their findings. Researchers employ many different study designs that vary in their risk of bias to evaluate the true...
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