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Results: 78889
Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα.
James A Horscroft, Katie A O'Brien, Anna D Clark, Ross T Lindsay, Alice Strang Steel, Nathan EK Procter, Jules Devaux, Michael Frenneaux, Stephen DR Harridge, Andrew J Murray
Feb 27, 2019
Dietary inorganic nitrate prevents aspects of cardiac mitochondrial dysfunction induced by hypoxia, although the mechanism is not completely understood. In both heart and skeletal muscle, nitrate increases fatty acid oxidation...
Spiking computation and stochastic amplification in a neuron-like semiconductor microstructure
We have demonstrated the proof of principle of a semiconductor neuron, which has dendrites, axon, and a soma and computes information encoded in electrical pulses in the same way as biological neurons. Electrical impulses...
A model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolites.
Ross T Lindsay, Demetris Demetriou, Dominic Manetta-Jones, James A West, Andrew J Murray, Julian L Griffin
Jan 03, 2020
INTRODUCTION:Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates have become...
Using false discovery rates to benchmark SNP-callers in next-generation sequencing projects
Sequence alignments form the basis for many comparative and population genomic studies. Alignment
tools provide a range of accuracies dependent on the divergence between the sequences and the alignment
methods. Despite...
tools provide a range of accuracies dependent on the divergence between the sequences and the alignment
methods. Despite...
LincRNA signatures in human lymphocytes
Sequencing studies have provided a comprehensive catalog of the expression of intergenic long noncoding RNAs (lincRNAs) in 13 subsets of human T cells and B cells. Subtype-selective lincRNAs are among those identified, including...
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.
Seema Qamar, GuoZhen Wang, Suzanne J Randle, Francesco Simone Ruggeri, Juan A Varela, Julie Qiaojin Lin, Emma C Phillips, Akinori Miyashita, Declan Williams, Florian Ströhl, William Meadows, Rodylyn Ferry, Victoria J Dardov, Gian G Tartaglia, Lindsay A Farrer, Gabriele S Kaminski Schierle, Clemens F Kaminski, Christine E Holt, Paul E Fraser, Gerold Schmitt-Ulms, David Klenerman, Tuomas Knowles, Michele Vendruscolo, Peter St George-Hyslop
Sep 05, 2018
Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report...
AFM-IR arginine methylation cation-π citrullination frontotemporal dementia membraneless organelle neuronal ribonucleoprotein granule phase separation phase-sensitive fluorescent dyes synaptic new protein synthesis Amyotrophic Lateral Sclerosis Animals Arginine cations DNA Methylation frontotemporal dementia Frontotemporal Lobar Degeneration Humans Microscopy Atomic Force Microscopy Fluorescence Molecular Chaperones Protein Binding Protein Domains Protein Processing Post-Translational Protein Structure Secondary RNA-Binding Protein FUS Tyrosine Xenopus laevis
LincRNA signatures in human lymphocytes
Sequencing studies have provided a comprehensive catalog of the expression of intergenic long noncoding RNAs (lincRNAs) in 13 subsets of human T cells and B cells. Subtype-selective lincRNAs are among those identified, including...
A model for determining cardiac mitochondrial substrate utilisation using stable 13 C-labelled metabolites
Ross T. Lindsay, Demetris Demetriou, Dominic Manetta-Jones, James A. West, Andrew J. Murray, Julian L. Griffin
Nov 25, 2020
Abstract: Introduction: Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates...
Spiking computation and stochastic amplification in a neuron-like semiconductor microstructure
We have demonstrated the proof of principle of a semiconductor neuron, which has dendrites, axon, and a soma and computes information encoded in electrical pulses in the same way as biological neurons. Electrical impulses...
Clinical potential of oligonucleotide-based therapeutics in the respiratory system
The discovery of an ever-expanding plethora of coding and non-coding RNAs with nodal and causal roles in the regulation of lung physiology and disease is reinvigorating interest in the clinical utility of the oligonucleotide...
Clinical potential of oligonucleotide-based therapeutics in the respiratory system
The discovery of an ever-expanding plethora of coding and non-coding RNAs with nodal and causal roles in the regulation of lung physiology and disease is reinvigorating interest in the clinical utility of the oligonucleotide...
Sexually selected sentinels? Evidence of a role for intrasexual competition in sentinel behavior.
Although the evolutionary mechanisms that favor investment in cooperative behaviors have long been a focus of research, comparatively few studies have considered the role that sexual selection may play. For example, evolutionary...
Using false discovery rates to benchmark SNP-callers in next-generation sequencing projects
Sequence alignments form the basis for many comparative and population genomic studies. Alignment
tools provide a range of accuracies dependent on the divergence between the sequences and the alignment
methods. Despite...
tools provide a range of accuracies dependent on the divergence between the sequences and the alignment
methods. Despite...
Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells
Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs...
Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts
Marina R. Hadjicharalambous, Benoît Roux, Carol A. Feghali-Bostwick, Lynne A. Murray, Deborah L. Clarke, Mark Lindsay
Dec 11, 2018
There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are...
From Pencils to Podcasts: COE Professor Promotes Technology in Literacy
Winthrop University
Jan 01, 0001
Lindsay Yearta and Katie Stover got the idea after a reading project with students and pre-service teachers. "From Pencils to Podcasts" is available on Amazon for $34.95.
Published by: Winthrop University
Mapping human development at single-cell resolution.
Human development is regulated by spatiotemporally restricted molecular programmes and is pertinent to many areas of basic biology and human medicine, such as stem cell biology, reproductive medicine and childhood cancer....
Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells
Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs...
Single-photon emission from single-electron transport in a SAW-driven lateral light-emitting diode.
Tzu-Kan Hsiao, Antonio Rubino, Yousun Chung, Seok-Kyun Son, Hangtian Hou, Jorge Pedrós, Ateeq Nasir, Gabriel Éthier-Majcher, Megan J Stanley, Richard T Phillips, Thomas A Mitchell, Jonathan P Griffiths, Ian Farrer, David A Ritchie, Christopher J B Ford
Mar 17, 2020
The long-distance quantum transfer between electron-spin qubits in semiconductors is important for realising large-scale quantum computing circuits. Electron-spin to photon-polarisation conversion is a promising technology for...
Published by: Nature Communications
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