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In Vitro Influence of Mycophenolic Acid on Selected Parameters of Stimulated Peripheral Canine Lymphocytes.
Mycophenolic acid (MPA) is an active metabolite of mycophenolate mofetil, a new immunosuppressive drug effective in the treatment of canine autoimmune diseases. The impact of MPA on immunity is ambiguous and its influence on the...
Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation.
Autophagy is a conserved intracellular degradation pathway essential for protein homeostasis, survival and development. Defects in autophagic pathways have been connected to a variety of human diseases, including cancer and...
Female university students' preferences for different types of sexual relationships
BACKGROUND: Gender-based violence among young women is a growing problem worldwide. The consequences of this victimization have been well reported in the scientific literature, among which negative health outcomes stand out. The...
Chronic Illnesses, Vulnerability, and Uncertainty
The goal of this chapter is to describe some of the recent challenges that modern medicine is facing using patient-centered medicine as a theoretical frame of reference. First, the work will describe the origin, the development...
Published by: IGI Global Scientific Publishing
Symptom appraisal in uncertainty
Lauren C. Heathcote, Nele Loecher, Pamela Simon, Sheri Spunt, Abbie Jordan, Perri Tutelman, Sarah Cunningham, Lidia Schapira, Laura Simons
Dec 31, 2021
Objective: Somatic symptoms capture attention, demand interpretation, and promote health behaviors. Symptom appraisal is particularly impactful within uncertain health contexts such as cancer survivorship. Yet, little is known...
Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.
Regulated phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) by the endoplasmic reticulum (ER) stress-activated protein kinase PERK modulates protein synthesis and couples the...
Nest desertion is not predicted by cuckoldry in the Eurasian penduline tit
Rene E Van Dijk, Lidia A Mészáros, Marco Velde, T Székely, A Pogány, J Szabad, Jan Komdeur
Sep 01, 2010
Engagement in extra-pair copulations is an example of the abundant conflicting interests between males and females over reproduction. Potential benefits for females and the risk of cuckoldry for males are expected to have...
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer.
Rachael E Clifford, Naren Govindarajah, David Bowden, Paul Sutton, Mark Glenn, Mahnaz Darvish-Damavandi, Simon Buczacki, Ultan McDermott, Zdzislaw Szulc, Besim Ogretmen, Jason L Parsons, Dale Vimalachandran
Jan 05, 2021
Previous work utilizing proteomic and immunohistochemical analyses has identified that high levels of acid ceramidase (AC) expression confers a poorer response to neoadjuvant treatment in locally advanced rectal cancer. We aimed...
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer
Rachael E. Clifford, Naren Govindarajah, David Bowden, Paul Sutton, Mark Glenn, Mahnaz Darvish-Damavandi, Simon Buczacki, Ultan McDermott, Zdzislaw Szulc, Besim Ogretmen, Jason L. Parsons, Dale Vimalachandran
Dec 22, 2020
Previous work utilizing proteomic and immunohistochemical analyses has identified that high levels of acid ceramidase (AC) expression confers a poorer response to neoadjuvant treatment in locally advanced rectal cancer. We aimed...
Nest desertion is not predicted by cuckoldry in the Eurasian penduline tit
Rene E Van Dijk, Lidia A Mészáros, Marco Velde, T Székely, A Pogány, J Szabad, Jan Komdeur
Sep 01, 2010
Engagement in extra-pair copulations is an example of the abundant conflicting interests between males and females over reproduction. Potential benefits for females and the risk of cuckoldry for males are expected to have...
Symptom appraisal in uncertainty
Lauren C. Heathcote, Nele Loecher, Pamela Simon, Sheri Spunt, Abbie Jordan, Perri Tutelman, Sarah Cunningham, Lidia Schapira, Laura Simons
Dec 31, 2021
Objective: Somatic symptoms capture attention, demand interpretation, and promote health behaviors. Symptom appraisal is particularly impactful within uncertain health contexts such as cancer survivorship. Yet, little is known...
GPVI surface expression and signalling pathway activation are increased in platelets from obese patients
María N Barrachina, Aurelio M Sueiro, Irene Izquierdo, Lidia Hermida-Nogueira, Esteban Guitián, Felipe F Casanueva, Richard W Farndale, Masaaki Moroi, Stephanie M Jung, María Pardo, Ángel García
Jan 30, 2019
Drug targets GPVI signalling obesity platelets Proteomics SFK-Mediated signalling pathways Adolescent Adult Blood Platelets Body Mass Index Case-Control Studies Female Humans Male obesity Phospholipase C gamma Phosphorylation Platelet Activation Platelet Aggregation Platelet Membrane Glycoproteins Signal Transduction Up-Regulation Young Adult
Breaking the electrical barrier between copper and carbon nanotubes.
Karolina Z Milowska, Mahdi Ghorbani-Asl, Marek Burda, Lidia Wolanicka, Nordin Ćatić, Paul D Bristowe, Krzysztof KK Koziol
Nov 20, 2018
Improving the interface between copper and carbon nanotubes (CNTs) offers a straightforward strategy for the effective manufacturing and utilisation of Cu-CNT composite material that could be used in various industries including...
Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an "HHT-like" syndrome in children.
Joshua Hodgson, Lidia Ruiz-Llorente, Jamie McDonald, Oliver Quarrell, Kelechi Ugonna, James Bentham, Rebecca Mason, Jennifer Martin, David Moore, Katie Bergstrom, Pinar Bayrak-Toydemir, Whitney Wooderchak-Donahue, Nicholas Morrell, Robin Condliffe, Carmelo Bernabeu, Paul Upton
Mar 23, 2021
BACKGROUND: Disrupted endothelial BMP9/10 signaling may contribute to the pathophysiology of both hereditary hemorrhagic telangiectasia (HHT) and pulmonary arterial hypertension (PAH), yet loss of circulating BMP9 has not been...
Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein.
Lidia Ruiz-Llorente, M Cristina Vega, Francisco J Fernández, Carmen Langa, Nicholas Morrell, Paul Upton, Carmelo Bernabeu
Oct 20, 2021
Endoglin (Eng, CD105) is a type I membrane glycoprotein that functions in endothelial cells as an auxiliary receptor for transforming growth factor β (TGF-β)/bone morphogenetic protein (BMP) family members and as an integrin...
Chronic exposure to glucocorticoids induces suboptimal decision-making in mice.
Lidia Cabeza, Bahrie Ramadan, Julie Giustiniani, Christophe Houdayer, Yann Pellequer, Damien Gabriel, Sylvie Fauconnet, Emmanuel Haffen, Pierre-Yves Risold, Dominique Fellmann, David Belin, Yvan Peterschmitt
Feb 02, 2021
Anxio-depressive symptoms as well as severe cognitive dysfunction including aberrant decision-making (DM) are documented in neuropsychiatric patients with hypercortisolaemia. Yet, the influence of the...
Digital transformation, for better or worse
J Dąbrowska, A Almpanopoulou, A Brem, H Chesbrough, V Cucino, A Di Minin, F Giones, H Hakala, C Marullo, AL Mention, L Mortara, S Nørskov, PA Nylund, CM Oddo, A Radziwon, P Ritala
Mar 17, 2022
For better or worse, digital technologies are reshaping everything, from customer behaviors and expectations to organizational and manufacturing systems, business models, markets, and ultimately society. To understand this...
Generation of a Soluble Form of Human Endoglin Fused to Green Fluorescent Protein.
Lidia Ruiz-Llorente, M Cristina Vega, Francisco J Fernández, Carmen Langa, Nicholas W Morrell, Paul D Upton, Carmelo Bernabeu
Jan 05, 2022
Endoglin (Eng, CD105) is a type I membrane glycoprotein that functions in endothelial cells as an auxiliary receptor for transforming growth factor β (TGF-β)/bone morphogenetic protein (BMP) family members and as an integrin...
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain.
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