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Results: 434
The Amyloid-β Pathway in Alzheimer's Disease.
Harald Hampel, John Hardy, Kaj Blennow, Christopher Chen, George Perry, Seung Hyun Kim, Victor L Villemagne, Paul Aisen, Michele Vendruscolo, Takeshi Iwatsubo, Colin L Masters, Min Cho, Lars Lannfelt, Jeffrey L Cummings, Andrea Vergallo
Jan 28, 2022
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular mechanisms of the pathway and the spatial-temporal dynamics...
The amyloid-β pathway in Alzheimer's disease
Harald Hampel, Yan Hu, John Hardy, Kaj Blennow, Christopher Chen, George Perry, Seung Hyun Kim, Victor L Villemagne, Paul Aisen, Michele Vendruscolo, Takeshi Iwatsubo, Colin L Masters, Min Cho, Lars Lannfelt, Jeffrey L Cummings, Andrea Vergallo
Mar 30, 2023
WHAT IS THIS SUMMARY ABOUT?: This plain language summary of an article published in Molecular Psychiatry, reviews the evidence supporting the role of the amyloid-β (Aβ) pathway and its dysregulation in Alzheimer's disease (AD)...
Tumor Suppression by a TRNA Synthetase
Maria Passarelli
Jan 01, 0001
Despite substantial progress in treatment, breast cancer remains a leading cause of cancer mortality among women. During malignant transformation, healthy mammary cells must bypass tumor suppressive checkpoints and activate...
Published by: Rockefeller University
Democratic equality and militant democracy
Lars Vinx
Dec 17, 2019
The practice of militant democracy reacts to a perceived weakness of democratic political systems: a democracy seems to allow for the abolition of democracy by democratic means. To counter this threat, some democratic political...
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.
Rona J Strawbridge, Angela Silveira, Marcel den Hoed, Stefan Gustafsson, Jian'an Luan, Denis Rybin, Josée Dupuis, Ruifang Li-Gao, Maryam Kavousi, Abbas Dehghan, Kadri Haljas, Jari Lahti, Jesper R Gådin, Alexandra Bäcklund, Ulf de Faire, Karl Gertow, Phillipe Giral, Anuj Goel, Steve E Humphries, Sudhir Kurl, Claudia Langenberg, Lars L Lannfelt, Lars Lind, Cecilia CM Lindgren, Elmo Mannarino, Dennis O Mook-Kanamori, Andrew P Morris, Renée de Mutsert, Rainer Rauramaa, Peter Saliba-Gustafsson, Bengt Sennblad, Andries J Smit, Ann-Christine Syvänen, Elena Tremoli, Fabrizio Veglia, Björn Zethelius, Hanna M Björck, Johan G Eriksson, Albert Hofman, Oscar H Franco, Hugh Watkins, J Wouter Jukema, Jose C Florez, Nicholas J Wareham, James B Meigs, Erik Ingelsson, Damiano Baldassarre, Anders Hamsten, IMPROVE study group
Feb 02, 2018
BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease...
Atherosclerosis Genetic variants Intima-media-thickness Mendelian randomisation Proinsulin SINGLE NUCLEOTIDE POLYMORPHISMS Asymptomatic Diseases Carotid Artery Diseases Carotid Intima-Media Thickness Chromosomes Human Pair 15 Europe Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Linear Models Male Mendelian Randomization Analysis Phenotype Polymorphism Single Nucleotide Proinsulin Quantitative Trait Loci Risk Factors Vascular Remodeling
Procuring complex performance
Purpose: The paper analyses how public buyers transition from procuring single products and services to procuring complex performance (PCP). The aim is to examine the change in the interactions between buyer and supplier, the...
Management innovation in complex products and systems
This paper examines the process of a management innovation in complex products and systems (CoPS). Prior literature offers limited theoretical and empirical insights into how an inter-organizational relationship delivers CoPS by...
Procuring complex performance
Purpose: The paper analyses how public buyers transition from procuring single products and services to procuring complex performance (PCP). The aim is to examine the change in the interactions between buyer and supplier, the...
Hermitian Yang–Mills Connections on Blowups
Consider a vector bundle over a Kähler manifold which admits a Hermitian Yang-Mills connection. We show that the pullback bundle on the blowup of the Kähler manifold at a collection of points also admits a Hermitian Yang-Mills...
Size Dependent Plasmonic Effect on BiVO4 Photoanodes for Solar Water Splitting.
Plasmonic nanostructures show great promise in enhancing the solar water splitting efficiency due to their ability to confine light to extremely small volumes inside semiconductors. While size plays a critical role in the...
Competing models of organizational form
Mutual and stock insurers have coexisted and competed against each other in insurance markets for centuries. In this article, we examine the risk management strategies and underwriting profitability of the different...
How to test for phasic modulation of neural and behavioural responses.
Research on whether perception or other processes depend on the phase of neural oscillations is rapidly gaining popularity. However, it is unknown which methods are optimally suited to evaluate the hypothesized phase effect....
Management innovation in complex products and systems
This paper examines the process of a management innovation in complex products and systems (CoPS). Prior literature offers limited theoretical and empirical insights into how an inter-organizational relationship delivers CoPS by...
Optimal Symplectic Connections on Holomorphic Submersions
The main result of this paper gives a new construction of extremal Kähler metrics on the total space of certain holomorphic submersions, giving a vast generalisation and unification of results of Hong, Fine and others. The...
Rank Bounds for Approximating Gaussian Densities in the Tensor-Train Format
Low-rank tensor approximations have shown great potential for uncertainty quantification in high dimensions, for example, to build surrogate models that can be used to speed up large-scale inference problems [M. Eigel, M....
“What Utopia Would Feel Like”
E Talijan
Nov 22, 2016
Underwater acoustic emission monitoring – Experimental investigations and acoustic signature recognition of synthetic mooring ropes
Mooring ropes are essential components of offshore installations, and synthetic ropes are increasingly preferred because of their favourable cost to weight ratios. In-service condition of these materials is traditionally...
Coping with the climate
Terrestrial arthropods achieve waterproofing by a layer of cuticular hydrocarbons (CHCs). At the same time, CHCs also serve as communication signals. To maintain waterproofing under different climate conditions, insects adjust...
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