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A Conversation with Ha-Joon Chang
Maha Abdelrahman
Aug 01, 2019
Ha‐Joon Chang is the Director of the Centre of Development Studies and a Reader in the Political Economy of Development in the Faculty of Economics at the University of Cambridge. He grew up in South Korea where he completed his...
Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling.
To progress towards differentiation, progeny of stem cells need to extinguish expression of stem-cell maintenance genes. Failures in such mechanisms can drive tumorigenesis. In Drosophila neural stem cell (NSC) lineages...
D. melanogaster Notch NuRD Complex Chromosomes developmental biology Gene Expression Stem Cells Adenosine Triphosphatases Animals Autoantigens Basic Helix-Loop-Helix Transcription Factors Carcinogenesis Cell Differentiation Cell Lineage Cell Proliferation Drosophila Proteins Drosophila melanogaster Gene Expression Regulation Developmental Humans Hyperplasia Models Biological Neural Stem Cells Neurons Protein Binding Receptors Notch Repressor Proteins Signal Transduction
Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure.
Iyas Daghlas, Ville Karhunen, Devleena Ray, Verena Zuber, Stephen Burgess, Philip S Tsao, Julie A Lynch, Kyung Min Lee, Benjamin F Voight, Kyong-Mi Chang, Emma H Baker, Scott M Damrauer, Joanna MM Howson, Marijana Vujkovic, Dipender Gill
May 27, 2021
Background This study was designed to investigate the genetic evidence for repurposing of GLP1R (glucagon-like peptide-1 receptor) agonists to prevent heart failure (HF) and whether the potential benefit exceeds the benefit...
GLP1R Mendelian randomization Diabetes mellitus ejection fraction Heart Failure Biomarkers Blood Glucose Diabetes mellitus Type 2 Drug Repositioning genetic variation Genome-Wide Association Study Glucagon-Like Peptide-1 Receptor Glycated Hemoglobin Heart Failure Humans Hypoglycemic Agents Incretins Mendelian Randomization Analysis Risk Assessment Risk Factors Stroke Volume Treatment Outcome Ventricular Function Left
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease.
Michael G Levin, Verena Zuber, Venexia M Walker, Derek Klarin, Julie Lynch, Rainer Malik, Aaron W Aday, Leonardo Bottolo, Aruna D Pradhan, Martin Dichgans, Kyong-Mi Chang, Daniel J Rader, Philip S Tsao, Benjamin F Voight, Dipender Gill, Stephen Burgess, Scott M Damrauer
Jul 05, 2021
BACKGROUND: Lipoprotein-related traits have been consistently identified as risk factors for atherosclerotic cardiovascular disease, largely on the basis of studies of coronary artery disease (CAD). The relative contributions of...
Atherosclerosis Coronary Artery Disease Genomics Lipoproteins Peripheral Arterial Disease Alleles Apolipoproteins Biomarkers Disease Susceptibility Gene Expression Profiling Genetic Predisposition to Disease Genome-Wide Association Study Humans Lipid Metabolism Peripheral Arterial Disease Public Health Surveillance Quantitative Trait Heritable Risk Assessment Risk Factors Transcriptome United Kingdom
On the Shores of Politics
RORY O'BRYEN
Apr 20, 2018
This article explores discourses surrounding the modernisation of the state and the formation of national literature in nineteenth‐century Colombia, examining the racism at the heart of both, particularly in their representation...
M2 Do patients and informal carers agree on symptom burden in advanced copd?
Objective: Accurate informal carer assessment of patient symptoms is likely to be valuable for decision-making in managing the high symptom burden of chronic obstructive pulmonary disease (COPD) in the home setting. Few studies...
Do patients and carers agree on symptom burden in advanced COPD?
Emma Mi, Ella Mi, Gail Ewing, Patrick White, Ravi Mahadeva, A Carole Gardener, Morag Farquhar
Apr 16, 2019
OBJECTIVE: Accurate informal carer assessment of patient symptoms is likely to be valuable for decision making in managing the high symptom burden of COPD in the home setting. Few studies have investigated agreement between...
COPD agreement Informal carers symptom Adaptation Psychological Aged Caregivers Cost of Illness Cross-Sectional Studies Female Health Knowledge Attitudes practice health status Humans Male Mental Health Middle Aged Patients Prognosis Prospective Studies Pulmonary Disease Chronic Obstructive Quality of life Risk Factors Severity of Illness Index
Deepwater Horizon oil spill exposures and nonfatal myocardial infarction in the GuLF STUDY.
Jean Strelitz, Lawrence S Engel, Richard K Kwok, Aubrey K Miller, Aaron Blair, Dale P Sandler
Jul 17, 2019
BACKGROUND: Workers involved in the response and clean-up of the 2010 Deepwater Horizon oil spill faced possible exposures to crude oil, burning oil, dispersants and other pollutants in addition to physical and emotional stress....
Deepwater Horizon Disaster epidemiology Myocardial Infarction Oil spill Adult Aged Cohort Studies Female Gulf of Mexico Humans Incidence Male Middle Aged Myocardial Infarction occupational exposure Petroleum Petroleum Pollution Prospective Studies Self Report Southeastern United States Water Pollutants Chemical Young Adult
A Hox-Embedded Long Noncoding RNA
Licia Selleri, Marisa S Bartolomei, Wendy A Bickmore, Lin He, Lisa Stubbs, Wolf Reik, Gregory S Barsh
Jun 24, 2019
Over 20 years ago, the discovery of Xist as a critical component of X chromosome inactivation revealed a fundamental role for long noncoding RNAs (lncRNAs) in epigenetic regulation during mammalian development and foreshadowed a...
Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction.
Ting-Ting Tang, Yuan-Yuan Li, Jing-Jing Li, Ke Wang, Yue Han, Wen-Yong Dong, Zheng-Feng Zhu, Ni Xia, Shao-Fang Nie, Min Zhang, Zhi-Peng Zeng, Bing-Jie Lv, Jiao Jiao, Heng Liu, Zong-Shu Xian, Xiang-Ping Yang, Yu Hu, Yu-Hua Liao, Qing Wang, Xin Tu, Ziad Mallat, Yu Huang, Guo-Ping Shi, Xiang Cheng
Nov 22, 2018
Interleukin (IL)-22 regulates tissue inflammation and repair. Here we report participation of the liver in IL-22-mediated cardiac repair after acute myocardial infarction (MI). Methods: We induced experimental MI in mice by...
Rejection of harsh pH saline solutions using graphene membranes
Dong Han Seo, Ming Xie, Adrian T. Murdock, Timothy van der Laan, Malcolm Lawn, Myoung Jun Park, Yun Chul Woo, Shafique Pineda, Jung Mi Hong, Mihaela Grigore, Samuel Yick, Zhaojun Han, Graeme Millar, Stephen Gray, Kostya Ostrikov, Ho Kyong Shon, Avi Bendavid
Jan 31, 2021
Water security is a pressing issue for global citizens in the 21st century. Concerns over clean water supply, and the environmental impact of industrial waste water, make water treatment a world-wide problem requiring a...
Handling missing data in matched case-control studies using multiple imputation.
Analysis of matched case-control studies is often complicated by missing data on covariates. Analysis can be restricted to individuals with complete data, but this is inefficient and may be biased. Multiple imputation (MI) is an...
Motivational interviewing competencies among UK family nurse partnership nurses
Sue Channon, Marie Jet Bekkers, Julia Sanders, Rebecca Cannings-John, Laura Robertson, Kristina Bennert, Christopher Butler, Kerenza Hood, Michael Robling
Sep 20, 2016
Background: Motivational Interviewing (MI) is a person-centred counselling approach to behaviour change which is increasingly being used in public health settings, either as a stand-alone approach or in combination with other...
Encompassing new use cases - level 3.0 of the HUPO-PSI format for molecular interactions.
M Sivade Dumousseau, D Alonso-López, M Ammari, G Bradley, NH Campbell, A Ceol, G Cesareni, C Combe, J De Las Rivas, N Del-Toro, J Heimbach, H Hermjakob, I Jurisica, M Koch, L Licata, RC Lovering, DJ Lynn, BHM Meldal, G Micklem, S Panni, P Porras, S Ricard-Blum, B Roechert, L Salwinski, A Shrivastava, J Sullivan, N Thierry-Mieg, Y Yehudi, K Van Roey, S Orchard
Sep 08, 2018
BACKGROUND: Systems biologists study interaction data to understand the behaviour of whole cell systems, and their environment, at a molecular level. In order to effectively achieve this goal, it is critical that researchers...
Almost global convergence to practical synchronization in the generalized Kuramoto model on networks over the n-sphere
Abstract From the flashing of fireflies to autonomous robot swarms, synchronization phenomena are ubiquitous in nature and technology. They are commonly described by the Kuramoto model that, in...
English Article Style Recognition and Matching by Using Web Semantics
With the explosion of internet information, people feel helpless and difficult to choose in the face of massive information. However, the traditional method to organize a huge set of original documents is not only time-consuming...
Published by: IGI Global Scientific Publishing
Understanding the organic micropollutants transport mechanisms in the fertilizer-drawn forward osmosis process
We systematically investigated the transport mechanisms of organic micropollutants (OMPs) in a fertilizer-drawn forward osmosis (FDFO) membrane process. Four representative OMPs, i.e., atenolol, atrazine, primidone, and...
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model.
DS Mansell, VD Bruno, E Sammut, A Chiribiri, T Johnson, I Khaliulin, D Baz Lopez, HS Gill, KH Fraser, M Murphy, T Krieg, MS Suleiman, S George, R Ascione, AN Cookson
Oct 08, 2021
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance...
Animals Biomarkers Computational Biology Data analysis Data Interpretation Statistical Disease Models Animal Disease Susceptibility Female Image Processing Computer-Assisted Magnetic Resonance Imaging Myocardial Infarction Myocardium Proteome Proteomics Reproducibility of Results Swine Translational Research Biomedical Ventricular Function Left Ventricular Remodeling
Understanding the organic micropollutants transport mechanisms in the fertilizer-drawn forward osmosis process
We systematically investigated the transport mechanisms of organic micropollutants (OMPs) in a fertilizer-drawn forward osmosis (FDFO) membrane process. Four representative OMPs, i.e., atenolol, atrazine, primidone, and...
Multiple imputation of missing data in nested case-control and case-cohort studies.
The nested case-control and case-cohort designs are two main approaches for carrying out a substudy within a prospective cohort. This article adapts multiple imputation (MI) methods for handling missing covariates in full-cohort...
Predicting risk of cardiovascular events 1 to 3 years post-myocardial infarction using a global registry.
Stuart J Pocock, David Brieger, John Gregson, Ji Y Chen, Mauricio G Cohen, Shaun G Goodman, Christopher B Granger, Richard Grieve, Jose C Nicolau, Tabassome Simon, Dirk Westermann, Satoshi Yasuda, Katarina Hedman, Kirsten L Rennie, Karolina Andersson Sundell, TIGRIS Study Investigators
Jan 16, 2020
BACKGROUND: Risk prediction tools are lacking for patients with stable disease some years after myocardial infarction (MI). HYPOTHESIS: A practical long-term cardiovascular risk index can be developed. METHODS: The long-Term...
Non-destructive testing and evaluation of composite materials/structures
Composite materials/structures are advancing in product efficiency,
cost-effectiveness and the development of superior specific properties. There
are increasing demands in their applications to load-carrying structures...
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