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Strategies for overcoming aversion to unnaturalness
Clean meat (grown from animal cells rather than rearing animals) has the potential to address many concerns associated with meat production. However, research suggests that the perceived unnaturalness of clean meat could be a...
Strategies for overcoming aversion to unnaturalness
Clean meat (grown from animal cells rather than rearing animals) has the potential to address many concerns associated with meat production. However, research suggests that the perceived unnaturalness of clean meat could be a...
Quenching of excited triplet states by dissolved natural organic matter
Excited triplet states of aromatic ketones and quinones are used as proxies to assess the reactivity of excited triplet states of the dissolved organic matter (3DOM*) in natural waters. 3DOM* are crucial...
Quenching of excited triplet states by dissolved natural organic matter
Excited triplet states of aromatic ketones and quinones are used as proxies to assess the reactivity of excited triplet states of the dissolved organic matter (3DOM*) in natural waters. 3DOM* are crucial...
A frontal attention mechanism in the visual mismatch negativity
Craig Hedge, George Stothart, Jenna Todd Jones, Priscila Rojas Frías, Kristopher Lundy Magee, Jonathan C W Brooks
Oct 15, 2015
Automatic detection of environmental change is a core component of attention. The mismatch negativity (MMN), an electrophysiological marker of this mechanism, has been studied prominently in the auditory domain, with cortical...
Complete Ichthyornis skull illuminates mosaic assembly of the avian head
Daniel Field, Michael Hanson, David Burnham, Laura Wilson, Kristopher Super, Dana Ehret, Jun Ebersole, Bhart-Anjan S Bhullar
May 03, 2018
The skull of living birds is greatly modified from the condition found in their dinosaurian antecedents. Bird skulls have an enlarged, toothless premaxillary beak and an intricate kinetic system that includes a mobile palate...
Photooxidation-induced changes in optical, electrochemical, and photochemical properties of humic substances
Charles M. Sharpless, Michael Aeschbacher, Sarah E. Page, Jannis Wenk, Michael Sander, Kristopher McNeill
Mar 04, 2014
Two aquatic fulvic acids and one soil humic acid were irradiated to examine the resulting changes in the redox and photochemical properties of the humic substances (HS), the relationship between these changes, and their...
Photooxidation-induced changes in optical, electrochemical, and photochemical properties of humic substances
Charles M. Sharpless, Michael Aeschbacher, Sarah E. Page, Jannis Wenk, Michael Sander, Kristopher McNeill
Mar 04, 2014
Two aquatic fulvic acids and one soil humic acid were irradiated to examine the resulting changes in the redox and photochemical properties of the humic substances (HS), the relationship between these changes, and their...
A frontal attention mechanism in the visual mismatch negativity
Craig Hedge, George Stothart, Jenna Todd Jones, Priscila Rojas Frías, Kristopher Lundy Magee, Jonathan C W Brooks
Oct 15, 2015
Automatic detection of environmental change is a core component of attention. The mismatch negativity (MMN), an electrophysiological marker of this mechanism, has been studied prominently in the auditory domain, with cortical...
Complete Ichthyornis skull illuminates mosaic assembly of the avian head
Daniel Field, Michael Hanson, David Burnham, Laura Wilson, Kristopher Super, Dana Ehret, Jun Ebersole, Bhart-Anjan S Bhullar
May 03, 2018
The skull of living birds is greatly modified from the condition found in their dinosaurian antecedents. Bird skulls have an enlarged, toothless premaxillary beak and an intricate kinetic system that includes a mobile palate...
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma.
Natalie Cook, Kristopher K Frese, Tashinga E Bapiro, Michael A Jacobetz, Aarthi Gopinathan, Jodi L Miller, Sudhir S Rao, Tim Demuth, William J Howat, Duncan I Jodrell, David A Tuveson
Sep 03, 2020
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical intervention. Notch pathway antagonism has been shown to prevent pancreatic preneoplasia progression in mouse models, but potential...
Amyloid Precursor Protein Secretases Animals Carcinoma Pancreatic Ductal Cell Line Tumor Cell Proliferation Cyclic S-Oxides Deoxycytidine Drug Synergism Drug Therapy Combination Endothelial Cells Humans Hypoxia Mice Mice Mutant Strains Necrosis Pancreatic Neoplasms Protease Inhibitors Receptors Notch Signal Transduction Thiadiazoles Translational Research Biomedical Gemcitabine
SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice.
Albrecht Neesse, Kristopher K Frese, Derek S Chan, Tashinga E Bapiro, William J Howat, Frances M Richards, Volker Ellenrieder, Duncan I Jodrell, David A Tuveson
Feb 12, 2020
DESIGN: Pharmacokinetic and pharmacodynamic parameters of cremophor-paclitaxel, nab-paclitaxel (human-albumin-bound paclitaxel, Abraxane) and a novel mouse-albumin-bound paclitaxel (m-nab-paclitaxel) were evaluated in...
pancreatic cancer Adenocarcinoma Albumin-Bound Paclitaxel Albumins Animals Animals Genetically Modified Antineoplastic Agents Phytogenic Collagen Dose-Response Relationship Drug Mice Osteonectin Paclitaxel Pancreatic Neoplasms Pharmaceutical Vehicles Polyethylene Glycols Xenograft Model Antitumor Assays
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS
Tashinga E Bapiro, Frances M Richards, Mae A Goldgraben, Kenneth P Olive, Basetti Madhu, Kristopher K Frese, Natalie Cook, Michael A Jacobetz, Donna-Michelle Smith, David A Tuveson, John R Griffiths, Duncan I Jodrell
Nov 30, 2017
PURPOSE: To develop a sensitive analytical method to quantify gemcitabine (2',2'-difluorodeoxycytidine, dFdC) and its metabolites 2',2'-difluorodeoxyuridine (dFdU) and 2',2'-difluorodeoxycytidine-5'-triphosphate (dFdCTP)...
A Case for Electron-Astrophysics.
Daniel Verscharen, Robert T Wicks, Olga Alexandrova, Roberto Bruno, David Burgess, Christopher HK Chen, Raffaella D'Amicis, Johan De Keyser, Thierry Dudok de Wit, Luca Franci, Jiansen He, Pierre Henri, Satoshi Kasahara, Yuri Khotyaintsev, Kristopher G Klein, Benoit Lavraud, Bennett A Maruca, Milan Maksimovic, Ferdinand Plaschke, Stefaan Poedts, Christopher S Reynolds, Owen Roberts, Fouad Sahraoui, Shinji Saito, Chadi S Salem, Joachim Saur, Sergio Servidio, Julia E Stawarz, Štěpán Štverák, Daniel Told
Mar 09, 2023
The smallest characteristic scales, at which electron dynamics determines the plasma behaviour, are the next frontier in space and astrophysical plasma research. The analysis of astrophysical processes at these scales lies at...
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.
Michael A Jacobetz, Derek S Chan, Albrecht Neesse, Tashinga E Bapiro, Natalie Cook, Kristopher K Frese, Christine Feig, Tomoaki Nakagawa, Meredith E Caldwell, Heather I Zecchini, Martijn P Lolkema, Ping Jiang, Anne Kultti, Curtis B Thompson, Daniel C Maneval, Duncan I Jodrell, Gregory I Frost, HM Shepard, Jeremy N Skepper, David A Tuveson
Sep 03, 2020
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix...
Animals Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Carcinoma Pancreatic Ductal Cell Adhesion Molecules Deoxycytidine Doxorubicin Drug Delivery Systems Drug Resistance Neoplasm Hyaluronic Acid Hyaluronoglucosaminidase Immunohistochemistry Kaplan-Meier Estimate Mice Mice Transgenic Pancreatic Neoplasms Recombinant Proteins Tissue Array Analysis Treatment Outcome Gemcitabine
A Case for Electron-Astrophysics.
Daniel Verscharen, Robert T Wicks, Olga Alexandrova, Roberto Bruno, David Burgess, Christopher HK Chen, Raffaella D'Amicis, Johan De Keyser, Thierry Dudok de Wit, Luca Franci, Jiansen He, Pierre Henri, Satoshi Kasahara, Yuri Khotyaintsev, Kristopher G Klein, Benoit Lavraud, Bennett A Maruca, Milan Maksimovic, Ferdinand Plaschke, Stefaan Poedts, Christopher S Reynolds, Owen Roberts, Fouad Sahraoui, Shinji Saito, Chadi S Salem, Joachim Saur, Sergio Servidio, Julia E Stawarz, Štěpán Štverák, Daniel Told
Apr 13, 2023
The smallest characteristic scales, at which electron dynamics determines the plasma behaviour, are the next frontier in space and astrophysical plasma research. The analysis of astrophysical processes at these scales lies at...
Making the invisible enemy visible.
Tristan I Croll, Kay Diederichs, Florens Fischer, Cameron D Fyfe, Yunyun Gao, Sam Horrell, Agnel Praveen Joseph, Luise Kandler, Oliver Kippes, Ferdinand Kirsten, Konstantin Müller, Kristopher Nolte, Alexander M Payne, Matthew Reeves, Jane S Richardson, Gianluca Santoni, Sabrina Stäb, Dale E Tronrud, Lea C von Soosten, Christopher J Williams, Andrea Thorn
May 24, 2021
Structural biology plays a crucial role in the fight against COVID-19, permitting us to ‘see’ and understand SARS-CoV-2. However, the macromolecular structures of SARS-CoV-2 proteins that were solved with great speed and urgency...
Apoptotic cell death in disease-Current understanding of the NCCD 2023
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami I. Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. Bazan, Christoph Becker, Francesca Bernassola, Mathieu J.M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K.M. Chan, Guo Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D’Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Häcker, György Hajnóczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jäättelä, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri V. Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos López-Otín, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean Christophe Marine, Seamus J. Martin, Jean Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Muñoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Núñez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H.M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M.P. Rodrigues, Barak Rotblat, Carla V. Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W.G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi
May 30, 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key...
Apoptotic cell death in disease-Current understanding of the NCCD 2023
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami I. Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. Bazan, Christoph Becker, Francesca Bernassola, Mathieu J.M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K.M. Chan, Guo Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D’Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Häcker, György Hajnóczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jäättelä, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri V. Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos López-Otín, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean Christophe Marine, Seamus J. Martin, Jean Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Muñoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Núñez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H.M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M.P. Rodrigues, Barak Rotblat, Carla V. Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W.G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi
May 30, 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key...