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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
STRING FEVER
The Rockefeller University
Jan 01, 0001
String Fever: a new play by Jacquelyn Reingold
Followed by Q&A led by professor and physicist Konstantin A. Goulianos, Ph.D.
Published by: The Rockefeller University
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
Rather doomed than uncertain
We analyze the relation between individuals' risk aversion and their willingness to expose themselves to infection when faced with an asymptomatic infectious disease. We show that in a high prevalence environment, increasing...
Predicting Pathways between Distant Configurations for Biomolecules.
Many of the most interesting rearrangements associated with function and dysfunction of biomolecules involve complex, highly nonlinear pathways. Predicting these convoluted changes in structure is an important research...
Mutational Basin-Hopping
The study of energy landscapes has led to a good understanding of how and why proteins and nucleic acids adopt their native structure. Through evolution, sequences have adapted until they exhibit a strongly funneled energy...
Energy Landscapes for the Aggregation of Aβ17-42.
The aggregation of the Aβ peptide (Aβ1-42) to form fibrils is a key feature of Alzheimer's disease. The mechanism is thought to be a nucleation stage followed by an elongation process. The elongation stage involves the...
Evolved Minimal Frustration in Multifunctional Biomolecules.
Protein folding is often viewed in terms of a funneled potential or free energy landscape. A variety of experiments now indicate the existence of multifunnel landscapes, associated with multifunctional biomolecules. Here, we...
Implementation of Text Mining in Socio-Economic Research
This work aims to analyze insights from social networks for identification of population satisfaction with pay level in Russia using the text mining approach. For this, a sentiment analysis framework was developed, which...
Published by: IGI Global Scientific Publishing
Fast Track Physics: [Dr. Konstantin Goulianos]
M. S. Kaplan
Jan 01, 0001
Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual...
Goulianos Konstantin Rockefeller University Scientists PARTICLE PHYSICS drift chamber particle collisions small angle physics Fermi National Accelerator Laboratory Cool Rodney CDF (Collider Detector at Fermilab) Tevatron Life Sciences
Published by: The Rockefeller University
Experimentally revealed stochastic preferences for multicomponent choice options.
Alexandre Pastor-Bernier, Konstantin Volkmann, Arkadiusz Stasiak, Fabian Grabenhorst, Wolfram Schultz
Jul 27, 2020
Realistic, everyday rewards contain multiple components. An apple has taste and size. However, we choose in single dimensions, simply preferring some apples to others. How can such single-dimensional preference relationships...
Energy Landscapes of Deoxyxylo- and Xylo-Nucleic Acid Octamers.
Artificial analogues of the natural nucleic acids have attracted interest as a diverse class of information storage molecules capable of self-replication. In this study, we use the computational potential energy landscape...
Structural transitions in the RNA 7SK 5' hairpin and their effect on HEXIM binding.
Konstantin Röder, Guillaume Stirnemann, Anne-Catherine Dock-Bregeon, David J Wales, Samuela Pasquali
Oct 31, 2019
7SK RNA, as part of the 7SK ribonucleoprotein complex, is crucial to the regulation of transcription by RNA-polymerase II, via its interaction with the positive transcription elongation factor P-TEFb. The interaction is induced...
Binding Sites Humans Molecular Dynamics Simulation Nucleic Acid Conformation Nucleotide Motifs Peptides Positive Transcriptional Elongation Factor B Protein Binding RNA Polymerase II RNA Small Cytoplasmic RNA-Binding Proteins Ribonucleoproteins Thermodynamics Transcription Factors Transcription Genetic
Speech Intelligibility and Spatial Release From Masking Improvements Using Spatial Noise Reduction Algorithms in Bimodal Cochlear Implant Users.
Ayham Zedan, Tim Jürgens, Ben Williges, Birger Kollmeier, Konstantin Wiebe, Julio Galindo, Thomas Wesarg
May 10, 2021
This study investigated the speech intelligibility benefit of using two different spatial noise reduction algorithms in cochlear implant (CI) users who use a hearing aid (HA) on the contralateral side (bimodal CI users). The...
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