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Imprinted <i>Grb10,</i> encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (<i>Igf1r</i>) and insulin receptor (<i>Insr</i>) genes
Background
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Sukru Anil Dogan, Raffaele Cerutti, Cristiane Benincá, Gloria Brea-Calvo, Howard Trevor Jacobs, Massimo Zeviani, Marten Szibor, Carlo Viscomi
Sep 08, 2018
Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring electrons from coenzyme Q directly to O2. They have therefore been proposed as a potential therapeutic tool for mitochondrial diseases. We...
ROS alternative oxidase antioxidant Autophagy mitochondrial biogenesis mitochondrial disease redox signaling satellite cells stress responses Animals Autophagy Female Male Mice Mice Inbred C57BL Mice Knockout Mitochondrial Myopathies Mitochondrial Proteins Muscle Skeletal Organelle Biogenesis Oxidation-Reduction Oxidoreductases Plant Proteins Reactive Oxygen Species Signal Transduction
Imprinted <i>Grb10,</i> encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (<i>Igf1r</i>) and insulin receptor (<i>Insr</i>) genes
Background
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling...
High-resolution label-free mapping of murine kidney vasculature by raster-scanning optoacoustic mesoscopy
Colin A Goebel, Emma Brown, Fabian B Fahlbusch, Alexandra L Wagner, Adrian Buehler, Thomas Raupach, Martin Hohmann, Moritz Späth, Neal Burton, Joachim Woelfle, Michael Schmidt, Andrea Hartner, Adrian P Regensburger, Ferdinand Knieling
Aug 06, 2022
BACKGROUND: Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The aim of...
Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids
Amelia Lane, Katarina Jovanovic, Ciara Shortall, Daniele Ottaviani, Anna Brugulat-Panes, Nele Schwarz, Rosellina Guarascio, Matthew J Hayes, Arpad Palfi, Naomi Chadderton, G Jane Farrar, Alison J Hardcastle, Michael E Cheetham
Jul 07, 2020
RP2 mutations cause a severe form of X-linked retinitis pigmentosa (XLRP). The mechanism of RP2-associated retinal degeneration in humans is unclear, and animal models of RP2 XLRP do not recapitulate this severe phenotype. Here...
AAV CRISPR gene editing Cell Death Disease Modeling gene therapy Genetic inherited disease Retinal Degeneration retinal organoid stem cell Cell Death Cell Survival Dependovirus GTP-Binding Proteins Gene Expression Regulation Gene Knockdown Techniques Humans Induced Pluripotent Stem Cells Membrane Proteins Models Biological Organoids Retina Retinal Rod Photoreceptor Cells Retinitis Pigmentosa
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice.
Denise van Uden, Thomas Koudstaal, Jennifer AC van Hulst, Ingrid M Bergen, Chelsea Gootjes, Nicholas W Morrell, Geert van Loo, Jan H von der Thüsen, Thierry PP van den Bosch, Maria-Rosa Ghigna, Frédéric Perros, David Montani, Mirjam Kool, Karin A Boomars, Rudi W Hendriks
Apr 26, 2021
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a significant role. We previously reported that 31-week-old...
BMPR2 Tnfaip3 Toll-like receptor Dendritic Cells Inflammation pulmonary arterial hypertension Animals Bone Morphogenetic Protein Receptors Type II Dendritic Cells Familial Primary Pulmonary Hypertension Gene Deletion Heart Ventricles Humans Immunity Innate Mice Mutation Toll-Like Receptor 4 Tumor Necrosis Factor alpha-Induced Protein 3
p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons.
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R Merlo
Feb 28, 2022
p140Cap, encoded by the gene SRCIN1 (SRC kinase signaling inhibitor 1), is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms. p140Cap knock-out (KO)...
Charity retailing in the United Kingdom
Nonprofit organizations are venturing into commercial activities due to the intense competition for the limited government funds and declining availability of donor funds for third-sector organizations that address social...
An integrated model of cause-related marketing strategy development
Researchers in the fields of marketing and corporate social responsibility have suggested that cause-related marketing (CRM) can provide firms with opportunities for managing their community relationships and for enhancing their...
A typology of Guanxi-based governance mechanisms for knowledge transfer in business networks of Chinese small- and medium-sized enterrpises
Guanxi has strong implications for interactions among individuals in Chinese society. This study investigates guanxi-based governance mechanisms in the context of knowledge transfer among Chinese small and medium-sized...
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice
Denise van Uden, Thomas Koudstaal, Jennifer A. C. van Hulst, Ingrid M. Bergen, Chelsea Gootjes, Nicholas W. Morrell, Geert van Loo, Jan H. von der Thüsen, Thierry P. P. van den Bosch, Maria-Rosa Ghigna, Frédéric Perros, David Montani, Mirjam Kool, Karin A. Boomars, Rudi W. Hendriks
Feb 11, 2021
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a significant role. We previously reported that 31-week-old...
Understanding the process of knowledge spillover
Through analyzing in-depth interview data obtained from representatives of U.K.-based social enterprises, we explore how traditional third-sector organizations acquire entrepreneurial knowledge via knowledge spillover and use...
ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.
Haibin Jiang, Mingxia Du, Yaning Li, Tengfei Zhou, Jia Lei, Hongqing Liang, Zhen Zhong, Rafia S Al-Lamki, Ming Jiang, Jun Yang
Jul 15, 2022
Inhibition of DNA binding proteins 1 and 3 (ID1 and ID3) are important downstream targets of BMP signalling that are necessary for embryonic development. However, their specific roles in regulating the pluripotency of human...
How and when socially entrepreneurial nonprofit organizations benefit from adopting social alliance management routines to manage social alliances
Social alliance is defined as the collaboration between for-profit and nonprofit organizations. Building on the insights derived from the resource-based theory, we develop a conceptual framework to explain how socially...
Harmonious Workplace Climate and Employee Altruistic Behavior
Purpose
Drawing on the social exchange perspective, the authors explore the roles of satisfaction over material rewards, perceived organizational politics and career ambition in the relationship between harmonious...
Purpose
Drawing on the social exchange perspective, the authors explore the roles of satisfaction over material rewards, perceived organizational politics and career ambition in the relationship between harmonious...
Managing employee attention and internal branding
We extend the marketing literature on internal branding by developing a theoretical framework to explain the processes whereby brand orientation affects in- and extra-role employee brand-building behavior from the theoretical...
Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.
Aldosterone is released from adrenal zona glomerulosa (ZG) cells and plays an important role in Na and K homoeostasis. Mutations in the human inwardly rectifying K channel CNJ type (KCNJ) 5 (KCNJ5) gene encoding the G-coupled...
GIRK4 K channel KCNJ5 gene RNASeq aldosterone knockout mice aldosterone Angiotensin II Animals Cell Line Tumor Cytochrome P-450 CYP11B2 Female G Protein-Coupled Inwardly-Rectifying Potassium Channels Gene Expression Profiling Humans Male Mice Inbred C57BL Mice Knockout Sex Factors Vasoconstrictor Agents zona glomerulosa
Charity retailing in the United Kingdom
Nonprofit organizations are venturing into commercial activities due to the intense competition for the limited government funds and declining availability of donor funds for third-sector organizations that address social...
An integrated model of cause-related marketing strategy development
Researchers in the fields of marketing and corporate social responsibility have suggested that cause-related marketing (CRM) can provide firms with opportunities for managing their community relationships and for enhancing their...
Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility.
Sam Virtue, Kasparas Petkevicius, José Maria Moreno-Navarrete, Benjamin Jenkins, Daniel Hart, Martin Dale, Albert Koulman, José Manuel Fernández-Real, Antonio Vidal-Puig
Nov 05, 2018
One understudied function of white adipose tissue (AT) is its role in postprandial lipid buffering. In this study, we demonstrate that mice lacking the adipose tissue-specific transcription factor peroxisome...
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