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A quick guide to survey research.
Questionnaires are a very useful survey tool that allow large populations to be assessed with relative ease. Despite a widespread perception that surveys are easy to conduct, in order to yield meaningful results, a survey needs...
Some statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the Drosophila genome
Algorithms Amino Acid Motifs Animals Base Sequence Binding Sites Cell Nucleus Chromatin Cluster Analysis Computational Biology DNA Databases Genetic Drosophila melanogaster Genes Insect Genes Regulator Genome Genomics Models Statistical Molecular Sequence Data Sequence Analysis DNA Transcription Genetic
Challenges of the Fourth Industrial Revolution in HRM
As a result of the changes caused by Industry 4.0 and Industry 5.0, unknown or less prominent challenges will be the focus of the operation of organizations and will essentially transform current human resource management (HRM)...
Published by: IGI Global Scientific Publishing
Light-driven peristaltic pumping by an actuating splay-bend strip.
Klaudia Dradrach, Michał Zmyślony, Zixuan Deng, Arri Priimagi, John Biggins, Piotr Wasylczyk
Apr 17, 2023
Despite spectacular progress in microfluidics, small-scale liquid manipulation, with few exceptions, is still driven by external pumps and controlled by large-scale valves, increasing cost and size and limiting complexity. By...
Published by: Nature Communications
Birds Drinking Alcohol
Piotr Tryjanowski, Mateusz Hetman, Paweł Czechowski, Grzegorz Grzywaczewski, Petr Sklenicka, Klaudia Ziemblińska, Tim H Sparks
Feb 10, 2020
Ethanol is a natural by-product of the fermentation process of fruit sugars and is occasionally consumed by fruit-eating and tree sap drinking birds. Information on this form of alcohol consumption features in the scientific...
The influence of rare variants in circulating metabolic biomarkers.
Fernando Riveros-McKay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, INTERVAL Study, Eleanor Wheeler, Eleftheria Zeggini, Adam S Butterworth, Inês Barroso
Jan 31, 2020
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy...
Groups with boundedly many commutator of maximal order
By a result of Cocke and Venkataraman we know that if G is a group with at most m elements of maximal order, then is m-bounded. In this paper we consider the following related setting. Suppose G is a group with at most m...
The influence of rare variants in circulating metabolic biomarkers.
Fernando Riveros-McKay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, Eleanor Wheeler, Eleftheria Zeggini, Adam S Butterworth, Inês Barroso
Apr 09, 2020
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy...
Published by: PLoS genetics
The influence of rare variants in circulating metabolic biomarkers
Fernando Riveros-McKay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H. Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, INTERVAL Study, Eleanor Wheeler, Eleftheria Zeggini, Adam S. Butterworth, Inês Barroso
Mar 31, 2020
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy...
Groups with boundedly many commutator of maximal order
By a result of Cocke and Venkataraman we know that if G is a group with at most m elements of maximal order, then is m-bounded. In this paper we consider the following related setting. Suppose G is a group with at most m...
An interactive genome browser of association results from the UK10K cohorts project.
Matthias Geihs, Ying Yan, Klaudia Walter, Jie Huang, Yasin Memari, Josine L Min, Daniel Mead, UK10K consortium, Tim J Hubbard, Nicholas J Timpson, Thomas A Down, Nicole Soranzo
Jun 25, 2018
UNLABELLED: High-throughput sequencing technologies survey genetic variation at genome scale and are increasingly used to study the contribution of rare and low-frequency genetic variants to human traits. As part of the Cohorts...
HPV Vaccination among Polish Adolescents-Results from POLKA 18 Study.
Michalina Drejza, Katarzyna Rylewicz, Maria Lewandowska, Katarzyna Gross-Tyrkin, Grzegorz Łopiński, Joanna Barwińska, Ewa Majcherek, Klaudia Szymuś, Patrycja Klein, Katarzyna Plagens-Rotman, Magdalena Pisarska-Krawczyk, Witold Kędzia, Grażyna Jarząbek-Bielecka
Jan 25, 2023
Human Papillomavirus (HPV) is the main cause of cervical cancer and genital warts and constitutes one of the most common sexually transmitted infections. Cervical cancer is the only reproductive cancer that has a primary...
Approaches and determinants to sustainably improve crop production
A Gojon, L Nussaume, DT Luu, EH Murchie, A Baekelandt, VL Rodrigues Saltenis, JP Cohan, T Desnos, D Inzé, JN Ferguson, E Guiderdonni, A Krapp, R Klein Lankhorst, C Maurel, H Rouached, MAJ Parry, M Pribil, LB Scharff, P Nacry
Jan 28, 2022
Abstract: Plant scientists and farmers are facing major challenges in providing food and nutritional security for a growing population, while preserving natural resources and biodiversity. Moreover, this should be done while...
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel.
Jie Huang, Bryan Howie, Shane McCarthy, Yasin Memari, Klaudia Walter, Josine L Min, Petr Danecek, Giovanni Malerba, Elisabetta Trabetti, Hou-Feng Zheng, UK10K consortium, Giovanni Gambaro, J Brent Richards, Richard Durbin, Nicholas J Timpson, Jonathan Marchini, Nicole Soranzo
Jun 25, 2018
Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts...
Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people.
Micro-Hotspots of Risk in Urban Cholera Epidemics.
Andrew S Azman, Francisco J Luquero, Henrik Salje, Nathan Naibei Mbaïbardoum, Ngandwe Adalbert, Mohammad Ali, Enrico Bertuzzo, Flavio Finger, Brahima Toure, Louis Albert Massing, Romain Ramazani, Bansaga Saga, Maya Allan, David Olson, Jerome Leglise, Klaudia Porten, Justin Lessler
Feb 15, 2021
Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from urban epidemics in Chad and Democratic...
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.
Arthur Gilly, Daniel Suveges, Karoline Kuchenbaecker, Martin Pollard, Lorraine Southam, Konstantinos Hatzikotoulas, Aliki-Eleni Farmaki, Thea Bjornland, Ryan Waples, Emil VR Appel, Elisabetta Casalone, Giorgio Melloni, Britt Kilian, Nigel W Rayner, Ioanna Ntalla, Kousik Kundu, Klaudia Walter, John Danesh, Adam Butterworth, Inês Barroso, Emmanouil Tsafantakis, George Dedoussis, Ida Moltke, Eleftheria Zeggini
Feb 07, 2019
The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardiometabolic traits....
Effects of adiposity on the human plasma proteome
Lucy J Goudswaard, Joshua A Bell, David A Hughes, Laura J Corbin, Klaudia Walter, George Davey Smith, Nicole Soranzo, John Danesh, Emanuele Di Angelantonio, Willem H Ouwehand, Nicholas A Watkins, David J Roberts, Adam S Butterworth, Ingeborg Hers, Nicholas J Timpson
Sep 22, 2021
BACKGROUND: Variation in adiposity is associated with cardiometabolic disease outcomes, but mechanisms leading from this exposure to disease are unclear. This study aimed to estimate effects of body mass index (BMI) on an...
Integration of Machine Learning Methods to Dissect Genetically Imputed Transcriptomic Profiles in Alzheimer's Disease.
The UK10K project identifies rare variants in health and disease.
UK10K consortium, Klaudia Walter, Josine L Min, Jie Huang, Lucy Crooks, Yasin Memari, Shane McCarthy, John RB Perry, ChangJiang Xu, Marta Futema, Daniel Lawson, Valentina Iotchkova, Stephan Schiffels, Audrey E Hendricks, Petr Danecek, Rui Li, James Floyd, Louise V Wain, Inês Barroso, Steve E Humphries, Matthew E Hurles, Eleftheria Zeggini, Jeffrey C Barrett, Vincent Plagnol, J Brent Richards, Celia MT Greenwood, Nicholas J Timpson, Richard Durbin, Nicole Soranzo
Jun 25, 2018
The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes (high read depth, 80×) of nearly 10,000...
Adiponectin Alleles Cohort Studies Disease Exome Female Genetic Predisposition to Disease genetic variation Genetics Medical Genetics Population Genome Human Genome-Wide Association Study Genomics HEALTH Humans Lipid Metabolism Male Molecular Sequence Annotation Receptors LDL Reference Standards Sequence Analysis DNA Triglycerides United Kingdom
The management audit as a tool to foster corporate governance
Purpose – This paper aims to investigate management auditing, a thorough examination of an organization and the management in place, through an empirical research to gather data about how management audits are perceived and...
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