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Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3.
James E Collier, Byung-Gil Lee, Maurici Brunet Roig, Stanislav Yatskevich, Naomi J Petela, Jean Metson, Menelaos Voulgaris, Andres Gonzalez Llamazares, Jan Löwe, Kim A Nasmyth
Sep 16, 2020
In addition to extruding DNA loops, cohesin entraps within its SMC-kleisin ring (S-K) individual DNAs during G1 and sister DNAs during S-phase. All three activities require related hook-shaped proteins called Scc2 and Scc3....
Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes.
Naomi J Petela, Andres Gonzalez Llamazares, Sarah Dixon, Bin Hu, Byung-Gil Lee, Jean Metson, Heekyo Seo, Antonio Ferrer-Harding, Menelaos Voulgaris, Thomas Gligoris, James Collier, Byung-Ha Oh, Jan Löwe, Kim A Nasmyth
Jul 28, 2021
Cohesin's association with and translocation along chromosomal DNAs depend on an ATP hydrolysis cycle driving the association and subsequent release of DNA. This involves DNA being 'clamped' by Scc2 and ATP-dependent engagement...
S. cerevisiae Chromosomes cryo-EM Folding Gene Expression molecular biophysics sister chromatid cohesion structural biology Adenosine Triphosphatases Cell Cycle Proteins Chromatids Chromosomal Proteins Non-Histone Chromosomes Cryoelectron Microscopy DNA Dimerization Gene Expression Regulation Fungal Hydrolysis Protein Domains Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland.
BACKGROUND: This paper describes the derivation and characterization of a novel, conditionally immortal mammary epithelial cell line named KIM-2. These cells were derived from mid-pregnant mammary glands of a mouse harbouring...
Animals Antigens Viral Tumor Apoptosis Biomarkers Breast Caseins Cell Culture Techniques Cell Differentiation Cell Line Transformed Epithelium Female Gene Dosage Genetic Vectors Lactoglobulins Mice Mice Transgenic Milk Proteins Pregnancy Promoter Regions Genetic Recombinant Proteins Signal Transduction Simian virus 40 Transcriptional Activation
Top-down, bottom-up, or both? Toward an integrative perspective on operations strategy formation
Operations strategy is formed via complex processes that transpire in multiple directions at multiple organizational levels. While most previous studies focus on the “macro-level” process of strategy formation from the dominant...
Culture creation and change
This review presents comprehensive analyses of extant research on culture creation and change. We use the framework of culture creation and change (Kim & Toh, 2019), which consists of three unique perspectives, to understand...
Exploration of a panel of urine biomarkers of kidney disease in two paediatric cohorts with Type 1 diabetes mellitus of differing duration.
Letizia Zeni, Anthony GW Norden, Elena Prandi, Carolina Canepa, Keith Burling, Katherine Simpson, Barbara Felappi, Alessandro Plebani, Giovanni Cancarini, Pietro Manuel Ferraro, Donald Fraser, Robert J Unwin
Jun 13, 2022
BACKGROUND: The pathogenesis of diabetic kidney disease (DKD) is complex and involves both glomerular and tubular dysfunction. A global assessment of kidney function is necessary to stage DKD, a progressive kidney disease that...
Dietary energy density in relation to subsequent changes of weight and waist circumference in European men and women.
Huaidong Du, Daphne L van der A, Vanessa Ginder, Susan A Jebb, Nita G Forouhi, Nicholas J Wareham, Jytte Halkjaer, Anne Tjønneland, Kim Overvad, Marianne Uhre Jakobsen, Brian Buijsse, Annika Steffen, Domenico Palli, Giovanna Masala, Wim HM Saris, Thorkild IA Sørensen, Edith JM Feskens
Mar 21, 2018
BACKGROUND: Experimental studies show that a reduction in dietary energy density (ED) is associated with reduced energy intake and body weight. However, few observational studies have investigated the role of ED on long-term...
Exploration of a panel of urine biomarkers of kidney disease in two paediatric cohorts with Type 1 diabetes mellitus of differing duration.
Letizia Zeni, Anthony GW Norden, Elena Prandi, Carolina Canepa, Keith Burling, Katherine Simpson, Barbara Felappi, Alessandro Plebani, Giovanni Cancarini, Pietro Manuel Ferraro, Donald Fraser, Robert J Unwin
May 12, 2022
BACKGROUND: The pathogenesis of diabetic kidney disease (DKD) is complex and involves both glomerular and tubular dysfunction. A global assessment of kidney function is necessary to stage DKD, a progressive kidney disease that...
Genomic survey of Clostridium difficile reservoirs in the East of England implicates environmental contamination of wastewater treatment plants by clinical lineages.
Danesh Moradigaravand, Theodore Gouliouris, Catherine Ludden, Sandra Reuter, Dorota Jamrozy, Beth Blane, Plamena Naydenova, Kim Judge, Sani H Aliyu, Nazreen F Hadjirin, Mark A Holmes, Estée Török, Nicholas M Brown, Julian Parkhill, Sharon Peacock
May 22, 2018
There is growing evidence that patients with Clostridiumdifficile-associated diarrhoea often acquire their infecting strain before hospital admission. Wastewater is known to be a potential source of surface water that is...
Clostridium difficile One Health genomic epidemiology wastewater treatment plants Bayes Theorem Clostridioides difficile Cross-Sectional Studies DNA Bacterial Diarrhea England Genome Bacterial Genomics Humans Multilocus Sequence Typing Retrospective Studies Sequence Analysis DNA Waste Management Wastewater
To add or not to add a new treatment arm to a multiarm study
Multiarm clinical trials, which compare several experimental treatments against control, are frequently recommended due to their efficiency gain. In practise, all potential treatments may not be ready to be tested in a phase...
Charlotte Author Will Speak on Midlife Reinventions on Oct. 6
Winthrop University
Jan 01, 0001
Kim Wright is the guest speaker at the 6 p.m. dinner meeting Oct. 6 of the Friends of Dacus Library in Tuttle Dining Room, McBryde Hall. The Friends of Dacus meeting is free to members and open to non-members for $18 per ticket.
Published by: Winthrop University
Differentiated function and localisation of SPO11-1 and PRD3 on the chromosome axis during meiotic DSB formation in Arabidopsis thaliana.
Christophe Lambing, Pallas Kuo, Jaeil Kim, Kim Osman, Amy Leanne Whitbread, Jianhua Yang, Kyuha Choi, F Chris H Franklin, Ian R Henderson
Aug 19, 2022
During meiosis, DNA double-strand breaks (DSBs) occur throughout the genome, a subset of which are repaired to form reciprocal crossovers between chromosomes. Crossovers are essential to ensure balanced chromosome segregation...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Complex response of a bistable laminated plate
The use of bistable laminates is a potential approach to realize more broadband piezoelectric based energy harvesting systems. Based on the experimental time series of a bistable laminate plate we have examined its dynamic...
Biomarker panels associated with progression of renal disease in type 1 diabetes
Marco Colombo, Erkka Valo, Stuart J. McGurnaghan, Niina Sandholm, Luke A. K. Blackbourn, R. Neil Dalton, David Dunger, Per-Henrik Groop, Paul M. McKeigue, Carol Forsblom, Helen M. Colhoun
Jun 19, 2020
Abstract: Aims/hypothesis: We aimed to identify a sparse panel of biomarkers for improving the prediction of renal disease progression in type 1 diabetes. Methods: We considered 859 individuals recruited from the Scottish...
Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.
Judit Espana-Agusti, Xiangang Zou, Kim Wong, Beiyuan Fu, Fengtang Yang, David A Tuveson, David J Adams, Athena Matakidou
Feb 09, 2016
Animals Chromosomes Artificial Bacterial Epithelial Cells Estrogen Receptor alpha Female Gene Deletion Gene Knock-In Techniques Genotype Hypoxia Immunohistochemistry In Situ Hybridization Fluorescence Integrases Kidney Tubules Male Mice Mice Inbred C57BL Mice Transgenic Organic Anion Transport Protein 1 PAX8 Transcription Factor Paired Box Transcription Factors Sequence Analysis DNA Tamoxifen Transgenes
Differentiated function and localisation of SPO11-1 and PRD3 on the chromosome axis during meiotic DSB formation in Arabidopsis thaliana.
Christophe Lambing, Pallas Kuo, Jaeil Kim, Kim Osman, Amy Leanne Whitbread, Jianhua Yang, Kyuha Choi, F Chris H Franklin, Ian Henderson
Aug 01, 2022
During meiosis, DNA double-strand breaks (DSBs) occur throughout the genome, a subset of which are repaired to form reciprocal crossovers between chromosomes. Crossovers are essential to ensure balanced chromosome segregation...
Complex response of a bistable laminated plate
The use of bistable laminates is a potential approach to realize more broadband piezoelectric based energy harvesting systems. Based on the experimental time series of a bistable laminate plate we have examined its dynamic...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
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