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Contact line dynamics of gravity driven spreading of liquids
Abstract
The spreading dynamics of the gravity-driven liquid motion on an inclined solid surface was studied by considering two fundamental physical models: the molecular kinetic...
Histone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin.
The eukaryotic replisome disassembles parental chromatin at DNA replication forks, but then plays a poorly understood role in the re-deposition of the displaced histone complexes onto nascent DNA. Here, we show that yeast DNA...
Contact line dynamics of gravity driven spreading of liquids
Abstract
The spreading dynamics of the gravity-driven liquid motion on an inclined solid surface was studied by considering two fundamental physical models: the molecular kinetic...
Contact line dynamics of gravity driven spreading of liquids
Abstract: The spreading dynamics of the gravity-driven liquid motion on an inclined solid surface was studied by considering two fundamental physical models: the molecular kinetic theory and the hydrodynamic theory (HDT). The...
Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Yuteng Wu, Fabrizio Villa, Joseph Maman, Yu Heng Lau, Lina Dobnikar, Aline C Simon, Karim Labib, David R Spring, Luca Pellegrini
Apr 26, 2018
The exploitation of synthetic lethality by small-molecule targeting of pathways that maintain genomic stability is an attractive chemotherapeutic approach. The Ctf4/AND-1 protein hub, which links DNA replication, repair, and...
Ctf4 protein chemical biology chromosome stability protein-protein interactions stapled peptides Amino Acid Motifs Binding Sites Crystallography X-Ray DNA Polymerase I DNA-Binding Proteins Diazonium Compounds Fluorescence Polarization Genomic Instability Humans Molecular Dynamics Simulation Peptides Protein Interaction Domains and Motifs Protein Structure Tertiary Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
A conserved mechanism for regulating replisome disassembly in eukaryotes.
Michael Jenkyn-Bedford, Morgan L Jones, Yasemin Baris, Karim PM Labib, Giuseppe Cannone, Joseph TP Yeeles, Tom D Deegan
Jan 05, 2022
Replisome disassembly is the final step of eukaryotic DNA replication and is triggered by ubiquitylation of the CDC45-MCM-GINS (CMG) replicative helicase1-3. Despite being driven by evolutionarily diverse E3 ubiquitin ligases in...
Noncommunicable Diseases, Park Prescriptions, and Urban Green Space Use Patterns in a Global South Context
Urban green space use is often associated with improved physical and mental health and lower noncommunicable disease (NCDs) burdens. Factors that influence green space visits have been documented in cities of the Global North...
Global South Developing Countries Health Promotion nature prescriptions Noncommunicable Diseases park prescriptions urban green space Urban Health urban parks Adult Bangladesh Cities Environment Design Exercise Female Humans Male Middle Aged Noncommunicable Diseases Residence Characteristics Urban Population
Local mixture models of exponential families
Exponential families are the workhorses of parametric modelling theory. One reason for their popularity is their associated inference theory, which is very clean, both from a theoretical and a computational point of view. One...
Spatial dimensions of the influence of urban green-blue spaces on human health
BACKGROUND: There is an increasing volume of literature investigating the links between urban environments and human health, much of which involves spatial conceptualisations and research designs involving various aspects of...
Infrapatellar fat pad adipose-derived stem cells co-cultured with articular chondrocytes from osteoarthritis patients exhibit increased chondrogenic gene expression.
AIM: The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesions. We sought...
Anticlockwise or clockwise?
Reviewing the relevant literature in visual psychophysics and visual neuroscience we propose a three-stage model of directionality bias in visuospatial functioning. We call this model the 'Perception-Action-Laterality' (PAL)...
Iatrogenic antibody deficiency from B-cell targeted therapies in autoimmune rheumatic diseases.
B-cell targeted therapies (BCTT) are now widely used in autoimmune rheumatic diseases, including SLE, antineutrophil cytoplasmic antibody-associated vasculitis and rheumatoid arthritis. Early studies suggested that rituximab did...
Anticlockwise or clockwise?
Reviewing the relevant literature in visual psychophysics and visual neuroscience we propose a three-stage model of directionality bias in visuospatial functioning. We call this model the 'Perception-Action-Laterality' (PAL)...
Orthogonal simple component analysis
Combining principles with pragmatism, a new approach and accompanying algorithm are presented to a longstanding problem in applied statistics: the interpretation of principal components. Following Rousson and Gasser "the...
Local mixture models of exponential families
Exponential families are the workhorses of parametric modelling theory. One reason for their popularity is their associated inference theory, which is very clean, both from a theoretical and a computational point of view. One...
Walkability and Greenness Do Not Walk Together
Background: The existing environment literature separately emphasizes the importance of neighborhood walkability and greenness in enhancing health and wellbeing. Thus, a desirable neighborhood should ideally be green and...
Managing the surge in demand for blood following mass casualty events. Early automatic restocking may preserve red cell supply
Background: Traumatic hemorrhage is a leading preventable cause of mortality following mass casualty events (MCEs). Improving outcomes requires adequate in-hospital provision of high volume red blood cell (RBC) transfusions....
Managing the surge in demand for blood following mass casualty events. Early automatic restocking may preserve red cell supply
Background: Traumatic hemorrhage is a leading preventable cause of mortality following mass casualty events (MCEs). Improving outcomes requires adequate in-hospital provision of high volume red blood cell (RBC) transfusions....
Modelling and mapping eye-level greenness visibility exposure using multi-source data at high spatial resolutions.
The visibility of natural greenness is associated with several health benefits along multiple pathways, including stress recovery and attention restoration mechanisms. However, existing methodologies are inadequate for capturing...
Walkability and Greenness Do Not Walk Together
BACKGROUND: The existing environment literature separately emphasizes the importance of neighborhood walkability and greenness in enhancing health and wellbeing. Thus, a desirable neighborhood should ideally be green and...
Estimating multiple greenspace exposure types and their associations with neighbourhood premature mortality
BACKGROUND: Greenspace exposures are often measured using single exposure metrics, which can lead to conflicting results. Existing methodologies are limited in their ability to estimate greenspace exposure comprehensively. We...
Impact of blood pressure and hypertension in the risk assessment of heart diseases among young people
Introduction: Hypertension is a significant public health problem, with a worldwide prevalence of 40.8% and a control rate of 32.3. Hypertension is a noteworthy hazard factor for various genuine health conditions, including...
Published by: IJHS Medical Association
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