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Dissection of the Polar and Non‐Polar Contributions to Aromatic Stacking Interactions in Solution
Abstract: Aromatic stacking interactions have been a matter of study and debate due to their crucial role in chemical and biological systems. The strong dependence on orientation and solvent together with the relatively small...
Keep nice and carry on
Olga Bialobrzeska, Justyna Baba, Sylwia Bedynska, Aleksandra Cichocka, Aleksandra Cislak, Magdalena Formanowicz, Gosia Goclowska, Zuzanna Jakubik, Karolina Kozakiewicz
Dec 31, 2023
Practicing acts of kindness is beneficial to one’s well-being, but is simply being nice to others also beneficial? In a correlational Study 1 (N=497), self-reported behavioral niceness was positively correlated with happiness...
Keep nice and carry on
Olga Bialobrzeska, Justyna Baba, Sylwia Bedynska, Aleksandra Cichocka, Aleksandra Cislak, Magdalena Formanowicz, Gosia Goclowska, Zuzanna Jakubik, Karolina Kozakiewicz
Dec 31, 2023
Practicing acts of kindness is beneficial to one’s well-being, but is simply being nice to others also beneficial? In a correlational Study 1 (N=497), self-reported behavioral niceness was positively correlated with happiness...
Dissection of the Polar and Non-Polar Contributions to Aromatic Stacking Interactions in Solution.
Aromatic stacking interactions have been a matter of study and debate due to their crucial role in chemical and biological systems. The strong dependence on orientation and solvent together with the relatively small interaction...
The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly.
Justyna Broniarczyk, David Pim, Paola Massimi, Martina Bergant, Anna Goździcka-Józefiak, Colin Crump, Lawrence Banks
Aug 15, 2018
Human Papillomavirus (HPV) infection involves multiple steps, from cell attachment, through endocytic trafficking towards the trans-Golgi network, and, ultimately, the entry into the nucleus during mitosis. An essential viral...
ATPases Associated with Diverse Cellular Activities Capsid Proteins Cell Line Cells Cultured Endosomal Sorting Complexes Required for Transport Humans Papillomaviridae Papillomavirus Infections Protein Binding Protein Transport Vacuolar Proton-Translocating ATPases Viral Proteins Virus Internalization Virus Uncoating
Genotype–phenotype correlation in two Polish neonates with alveolar capillary dysplasia
Zuzanna Kozłowska, Zuzanna Owsiańska, Joanna P. Wroblewska, Apolonia Kałużna, Andrzej Marszałek, Yogen Singh, Bartłomiej Mroziński, Qian Liu, Justyna A. Karolak, Paweł Stankiewicz, Gail Deutsch, Marta Szymankiewicz-Bręborowicz, Tomasz Szczapa
Jun 29, 2020
Abstract: Background: Alveolar capillary dysplasia (ACD) is a rare cause of severe pulmonary hypertension and respiratory failure in neonates. The onset of ACD is usually preceded by a short asymptomatic period. The condition is...
Physical Activity in the Prevention of Childhood Obesity
Justyna Wyszyńska, Susanne Ring-Dimitriou, David Thivel, Daniel Weghuber, Adamos Hadjipanayis, Zachi Grossman, Robert Ross-Russell, Katarzyna Dereń, Artur Mazur
Nov 19, 2020
Obesity affects an increasing number of children and adolescents. Physical activity (PA) is a significant factor in the prevention of excessive body mass in the pediatric population. A significant percentage of pediatric...
The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils.
Tomasz K Prajsnar, Justyna J Serba, Bernice M Dekker, Josie F Gibson, Samrah Masud, Angeleen Fleming, Simon A Johnston, Stephen A Renshaw, Annemarie H Meijer
Mar 30, 2020
Staphylococcus aureus is a major human pathogen causing multiple pathologies, from cutaneous lesions to life-threatening sepsis. Although neutrophils contribute to immunity against S. aureus, multiple lines of evidence suggest...
Autophagy NADPH oxidase ROS Staphylococcus aureus lc3-associated phagocytosis (LAP) neutrophil Zebrafish Animals Animals Genetically Modified Autophagy Intracellular Space Kinetics MACROPHAGES Microtubule-Associated Proteins NADPH Oxidases Neutrophils Phagocytosis Phagosomes Protein Aggregates Sequestosome-1 Protein Staphylococcus aureus Zebrafish Zebrafish Proteins
Model‐guided development of an evolutionarily stable yeast chassis
Filipa Pereira, Helder Lopes, Paulo Maia, Britta Meyer, Justyna Nocon, Paula Jouhten, Dimitrios Konstantinidis, Eleni Kafkia, Miguel Rocha, Peter Kötter, Isabel Rocha, Kiran R Patil
Jul 28, 2021
EMBO41 EMBO21 EMBO23 article ARTICLES adaptive laboratory evolution chassis cell Metabolic Engineering multi‐objective optimization Systems Biology
Published by: Molecular Systems Biology
Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma.
Justyna A Kucia-Tran, Valtteri Tulkki, Cinzia G Scarpini, Stephen Smith, Maja Wallberg, Marta Paez-Ribes, Angela M Araujo, Jan Botthoff, Maria Feeney, Katherine Hughes, Maria M Caffarel, Nicholas Coleman
Feb 13, 2018
The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the...
STAT3 cervix head and neck metastasis neutralizing antibodies oncostatin M receptor squamous cell carcinoma Animals Antineoplastic Agents Immunological Autocrine Communication Cell Line Tumor Female Gene Expression Regulation Neoplastic Head and Neck Neoplasms Humans Janus Kinase 2 Lung Neoplasms Mice Inbred NOD Mice SCID Oncostatin M Oncostatin M Receptor beta Subunit Phosphorylation STAT3 Transcription Factor Signal Transduction Squamous Cell Carcinoma of Head and Neck Suppressor of Cytokine Signaling 3 Protein Up-Regulation Uterine Cervical Neoplasms Xenograft Model Antitumor Assays
Model-guided development of an evolutionarily stable yeast chassis.
Filipa Pereira, Helder Lopes, Paulo Maia, Britta Meyer, Justyna Nocon, Paula Jouhten, Dimitrios Konstantinidis, Eleni Kafkia, Miguel Rocha, Peter Kötter, Isabel Rocha, Kiran R Patil
Sep 20, 2021
First-principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations. Yet, the theory of model-based chassis design has rarely been put to...
Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing.
Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane.
Vinaya Phatak, Yannick von Grabowiecki, Justyna Janus, Leah Officer, Caron Behan, Lydia Aschauer, Lucia Pinon, Hannah Mackay, Sara Zanivan, Jim C Norman, Michael Kelly, John Le Quesne, Patricia AJ Muller
Feb 24, 2021
TP53 is the most frequently mutated gene in cancers. Mutations lead to loss of p53 expression or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, but can also acquire novel functions in...
ATP Binding Cassette Transporter Subfamily B Adaptor Proteins Signal Transducing Animals Antineoplastic Agents Cell Membrane cisplatin Dose-Response Relationship Drug Drug Resistance Neoplasm Etoposide HCT116 Cells Humans Male Membrane Proteins Mice Inbred BALB C Mice Nude Mutation Neoplasms Tumor Burden Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays
An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor with an Important Role in Mouse Development.
Martha V Koerner, Kashyap Chhatbar, Shaun Webb, Justyna Cholewa-Waclaw, Jim Selfridge, Dina De Sousa, Bill Skarnes, Barry Rosen, Mark Thomas, Joanna Bottomley, Ramiro Ramires-Solis, Christopher Lelliott, David J Adams, Adrian Bird
Feb 08, 2021
Most human genes are associated with promoters embedded in non-methylated, G + C-rich CpG islands (CGIs). Not all CGIs are found at annotated promoters, however, raising the possibility that many serve as promoters for...
Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placenta.
Sungsam Gong, Michelle D Johnson, Justyna Dopierala, Francesca Gaccioli, Ulla Sovio, Miguel Constância, Gordon CS Smith, D Stephen Charnock-Jones
Mar 22, 2018
DNA methylation is an important regulator of gene function. Fetal sex is associated with the risk of several specific pregnancy complications related to placental function. However, the association between fetal sex and...
CSMD1 DNA Methylation RNA-sequencing differentially methylated region Placenta sex-specific methylation differences whole-genome oxidative bisulfite sequencing Chromosome Mapping Chromosomes Human X DNA Methylation Epigenesis Genetic Exons Female Genome Human Genomic Imprinting Humans Male Membrane Proteins Oxidative Stress Placenta Pregnancy Sequence Analysis RNA Sex Characteristics Tumor Suppressor Proteins whole genome sequencing
Genotype-phenotype correlation in two Polish neonates with alveolar capillary dysplasia.
Zuzanna Kozłowska, Zuzanna Owsiańska, Joanna P Wroblewska, Apolonia Kałużna, Andrzej Marszałek, Yogen Singh, Bartłomiej Mroziński, Qian Liu, Justyna A Karolak, Paweł Stankiewicz, Gail Deutsch, Marta Szymankiewicz-Bręborowicz, Tomasz Szczapa
Jun 29, 2021
BACKGROUND: Alveolar capillary dysplasia (ACD) is a rare cause of severe pulmonary hypertension and respiratory failure in neonates. The onset of ACD is usually preceded by a short asymptomatic period. The condition is...
Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells.
Justyna Ulanska-Poutanen, Jakub Mieczkowski, Chao Zhao, Katarzyna Konarzewska, Beata Kaza, Hartmut Bf Pohl, Lukasz Bugajski, Bozena Kaminska, Robin Jm Franklin, Malgorzata Zawadzka
Nov 19, 2018
Schwann Cells adult CNS progenitors neuroscience perivascular niche rat remyelination Animals Astrocytes Bone Morphogenetic Proteins Cell Differentiation Cellular Microenvironment Central Nervous System Demyelinating Diseases Endothelial Cells Gene Expression Regulation Ligands Oligodendroglia Peripheral Nervous System RNA Messenger Rats Stem Cell Niche Stem Cells Wnt Signaling Pathway Wounds and Injuries
Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.
Forager and farmer evolutionary adaptations to malaria evidenced by 7000 years of thalassemia in Southeast Asia.
Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis
Shikha Gupta, Oliver M Dovey, Ana Filipa Domingues, Oliwia W Cyran, Caitlin M Cash, George Giotopoulos, Justyna Rak, Jonathan Cooper, Malgorzata Gozdecka, Ryan J Asby, Noor Al-Jabery, Victor Hernandez-Hernandez, Sudhakaran Prabakaran, Brian J Huntly, George S Vassiliou, Cristina Pina
Sep 03, 2022
Transcriptional variability facilitates stochastic cell diversification and can in turn underpin adaptation to stress or injury. We hypothesize that it may analogously facilitate progression of premalignancy to cancer. To...
The RNA landscape of the human placenta in health and disease
Sungsam Gong, Francesca Gaccioli, Justyna Dopierala, Ulla Sovio, Emma Cook, Pieter-Jan Volders, Lennart Martens, Paul D. W. Kirk, Sylvia Richardson, Gordon C. S. Smith, D. Stephen Charnock-Jones
May 11, 2021
Abstract: The placenta is the interface between mother and fetus and inadequate function contributes to short and long-term ill-health. The placenta is absent from most large-scale RNA-Seq datasets. We therefore analyze long and...
The RNA landscape of the human placenta in health and disease.
Sungsam Gong, Francesca Gaccioli, Justyna Dopierala, Ulla Sovio, Emma Cook, Pieter-Jan Volders, Lennart Martens, Paul D W Kirk, Sylvia Richardson, Gordon C S Smith, D Stephen Charnock-Jones
Jun 12, 2021
Placenta Humans Fetal Growth Retardation pre-eclampsia Follistatin-Related Proteins RNA Biopsy Gene Expression Regulation Developmental Pregnancy Female Transcriptome Datasets as Topic RNA-seq
Published by: Nature Communications
Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation.
Olexandr Korchynskyi, Ken Yoshida, Nataliia Korchynska, Justyna Czarnik-Kwaśniak, Paul P Tak, Ger J M Pruijn, Takeo Isozaki, Jeffrey H Ruth, Phillip L Campbell, M Asif Amin, Alisa E Koch
Mar 14, 2023
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic agent for monocytes, primarily produced by macrophages and endothelial cells. Significantly elevated levels of MCP-1/CCL2 were found in synovial fluids of...
Glycosylation post-translational modifications monocyte chemoattractant protein-1 citrullination peptidylarginine deiminase partial degradation Endothelial Cells Animals Mammals Humans Arthritis Rheumatoid Citrulline Proteins Chemokine CCL2
Published by: International journal of molecular sciences
Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation.
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