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Standardization and the European standards organisations
Standardization is a relatively neglected aspect of the EU regulatory process and yet it is fundamental to that process and arguably has recently been the key vehicle in making the single market an economic reality. Yet the key...
Standardization and the European standards organisations
Standardization is a relatively neglected aspect of the EU regulatory process and yet it is fundamental to that process and arguably has recently been the key vehicle in making the single market an economic reality. Yet the key...
Gold(I) and Silver(I) π-Complexes with Unsaturated Hydrocarbons.
Gold π-complexes have been studied largely in the past 2 decades because of their role in gold-catalyzed reactions. We report an experimental and theoretical investigation of the interaction between a wide range of unsaturated...
A comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformations
Anuradha R. Pallipurath, Francesco Civati, Juraj Sibik, Clare Crowley, J. Axel Zeitler, Patrick McArdle, Andrea Erxleben
Aug 01, 2017
Understanding phase transitions in pharmaceutical materials is of vital importance for drug manufacturing, processing and storage. In this paper we have carried out comprehensive high-resolution spectroscopic studies on the...
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
Juraj Konč, Libby Brown, Daniel R. Whiten, Yukun Zuo, Peter Ravn, David Klenerman, Gonçalo J. L. Bernardes
Nov 03, 2021
Abstract: Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site‐specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for...
RESEARCH ARTICLE RESEARCH ARTICLES Antibodies bioconjugation Imaging Mass Spectrometry Nucleic Acids
Published by: Angewandte Chemie International Edition
Proteomic analysis of meiosis and characterization of novel short open reading frames in the fission yeast Schizosaccharomyces pombe.
Barbora Huraiova, Judit Kanovits, Silvia Bagelova Polakova, Lubos Cipak, Zsigmond Benko, Andrea Sevcovicova, Dorothea Anrather, Gustav Ammerer, Caia DS Duncan, Juan Mata, Juraj Gregan
Jun 10, 2020
Meiosis is the process by which haploid gametes are produced from diploid precursor cells. We used stable isotope labeling by amino acids in cell culture (SILAC) to characterize the meiotic proteome in the fission yeast...
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
Juraj Konč, Libby Brown, Daniel R Whiten, Yukun Zuo, Peter Ravn, David Klenerman, Gonçalo JL Bernardes
Nov 24, 2021
Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site-specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for biological...
A comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformations
Anuradha R. Pallipurath, Francesco Civati, Juraj Sibik, Clare Crowley, J. Axel Zeitler, Patrick McArdle, Andrea Erxleben
Aug 01, 2017
Understanding phase transitions in pharmaceutical materials is of vital importance for drug manufacturing, processing and storage. In this paper we have carried out comprehensive high-resolution spectroscopic studies on the...
Quantification of cation-anion interactions in crystalline monopotassium and monosodium glutamate salts.
Crystalline salt compounds composed of metal cations and organic anions are becoming increasingly popular in a number of fields, including the pharmaceutical and food industries, where such formulations can lead to increased...
A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides.
Juraj Konč, Libby Brown, Daniel R Whiten, Yukun Zuo, Peter Ravn, David Klenerman, Gonçalo JL Bernardes
Sep 28, 2021
Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site-specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for biological...
The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1
Samy Yassin, Daniel J Goodwin, Andrew Anderson, Juraj Sibik, D Ian Wilson, Lynn F Gladden, J Axel Zeitler
Jun 17, 2015
formulation polymeric drug delivery systems Porosity solid dosage forms structure-transport relationship superdisintegrants swelling terahertz pulsed imaging Algorithms Cellulose Chemistry Pharmaceutical Dosage Forms Drug Delivery Systems excipients Kinetics Models Theoretical Porosity Solubility Tablets Temperature
Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging.
Juraj Konč, Valerio Sabatino, Ester Jiménez-Moreno, Eloah Latocheski, Laura Rodríguez Pérez, Jason Day, Josiel B Domingos, Gonçalo JL Bernardes
Nov 09, 2021
Owing to their bioorthogonality, transition metals have become very popular in the development of biocompatible bond-cleavage reactions. However, many approaches require design and synthesis of complex ligands or formulation of...
Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors.
Cheryl A Brighton, Juraj Rievaj, Rune E Kuhre, Leslie L Glass, Kristina Schoonjans, Jens J Holst, Fiona M Gribble, Frank Reimann
Aug 20, 2015
Animals Bile Acids and Salts Calcium Cells Cultured Cyclic AMP Enteroendocrine Cells Glucagon-Like Peptide 1 Intestine Small Intracellular Space Male Mice Knockout Mice Transgenic Microscopy Fluorescence Rats Wistar Receptors G-Protein-Coupled Taurodeoxycholic Acid Taurolithocholic Acid Tissue Culture Techniques
The significance of the amorphous potential energy landscape for dictating glassy dynamics and driving solid-state crystallisation.
Michael T Ruggiero, Marcin Krynski, Eric Ofosu Kissi, Juraj Sibik, Daniel Markl, Nicholas Y Tan, Denis Arslanov, Wim van der Zande, Britta Redlich, Timothy M Korter, Holger Grohganz, Korbinian Löbmann, Thomas Rades, Stephen R Elliott, J Axel Zeitler
Jun 04, 2018
The fundamental origins surrounding the dynamics of disordered solids near their characteristic glass transitions continue to be fiercely debated, even though a vast number of materials can form amorphous solids, including...
Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.
Van B Lu, Juraj Rievaj, Elisabeth A O'Flaherty, Christopher A Smith, Ramona Pais, Luke A Pattison, Gwen Tolhurst, Andrew B Leiter, David C Bulmer, Fiona M Gribble, Frank Reimann
Feb 12, 2019
Adenosine Triphosphate Afferent Pathways Animals Cell Line Eating Enterocytes Enteroendocrine Cells Female Ganglion Cysts Glucagon-Like Peptide 1 Incretins Intestinal Mucosa Intestines Male Mice Mice Inbred C57BL Neurons Neurons Afferent nodose ganglion Peptide YY Receptors Purinergic P2X2 Receptors Purinergic P2X3 Vagus Nerve
Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes.
Gerardo Calderon, Alison McRae, Juraj Rievaj, Judith Davis, Inuk Zandvakili, Sara Linker-Nord, Duane Burton, Geoffrey Roberts, Frank Reimann, Bronislava Gedulin, Adrian Vella, Nicholas F LaRusso, Michael Camilleri, Fiona M Gribble, Andres Acosta
May 01, 2020
BACKGROUND: The bile acid (BA) pathway plays a role in regulation of food intake and glucose metabolism, based mainly on findings in animal models. Our aim was to determine whether the BA pathway is altered and correctable in...
Administration Oral Bile Acids and Salts Biological Transport Blood Glucose Capsules Cell Line Cholestenones Colon Diabetes mellitus Type 2 Diffusion Chambers Culture Enteroendocrine Cells Fasting Fibroblast Growth Factors Fructosamine Gene Expression Glucagon-Like Peptide 1 Homeostasis Humans Ileum Insulin obesity Postprandial Period Primary Cell Culture Receptors G-Protein-Coupled
Characterisation of proguanylin expressing cells in the intestine – evidence for constitutive luminal secretion
Florent Serge Dye, Pierre Larraufie, Richard Kay, Tamana Darwish, Juraj Rievaj, Deborah A. Goldspink, Claire L. Meek, Stephen J. Middleton, Richard H. Hardwick, Geoffrey P. Roberts, Jennifer L. Percival-Alwyn, Tris Vaughan, Franco Ferraro, Benjamin G. Challis, Stephen O’Rahilly, Maria Groves, Fiona M. Gribble, Frank Reimann
Oct 29, 2020
Abstract: Guanylin, a peptide implicated in regulation of intestinal fluid secretion, is expressed in the mucosa, but the exact cellular origin remains controversial. In a new transgenic mouse model fluorescent reporter protein...
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