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Immune cells lacking Y chromosome show dysregulation of autosomal gene expression.
Jan P Dumanski, Jonatan Halvardson, Hanna Davies, Edyta Rychlicka-Buniowska, Jonas Mattisson, Behrooz Torabi Moghadam, Noemi Nagy, Kazimierz Węglarczyk, Karolina Bukowska-Strakova, Marcus Danielsson, Paweł Olszewski, Arkadiusz Piotrowski, Erin Oerton, Aleksandra Ambicka, Marcin Przewoźnik, Łukasz Bełch, Tomasz Grodzicki, Piotr L Chłosta, Stefan Imreh, Vilmantas Giedraitis, Lena Kilander, Jessica Nordlund, Adam Ameur, Ulf Gyllensten, Åsa Johansson, Alicja Józkowicz, Maciej Siedlar, Alicja Klich-Rączka, Janusz Jaszczyński, Stefan Enroth, Jarosław Baran, Martin Ingelsson, John RB Perry, Janusz Ryś, Lars A Forsberg
Apr 26, 2021
Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes is associated with earlier mortality and morbidity from many diseases in men. LOY is the most common acquired mutation and is associated...
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
Jan P. Dumanski, Jonatan Halvardson, Hanna Davies, Edyta Rychlicka-Buniowska, Jonas Mattisson, Behrooz Torabi Moghadam, Noemi Nagy, Kazimierz Węglarczyk, Karolina Bukowska-Strakova, Marcus Danielsson, Paweł Olszewski, Arkadiusz Piotrowski, Erin Oerton, Aleksandra Ambicka, Marcin Przewoźnik, Łukasz Bełch, Tomasz Grodzicki, Piotr L. Chłosta, Stefan Imreh, Vilmantas Giedraitis, Lena Kilander, Jessica Nordlund, Adam Ameur, Ulf Gyllensten, Åsa Johansson, Alicja Józkowicz, Maciej Siedlar, Alicja Klich-Rączka, Janusz Jaszczyński, Stefan Enroth, Jarosław Baran, Martin Ingelsson, John R. B. Perry, Janusz Ryś, Lars A. Forsberg
May 08, 2021
Brown Adipose Tissue Volume and Fat Content Are Positively Associated With Whole-Body Adiposity in Young Men-Not in Women.
Guillermo Sanchez-Delgado, Borja Martinez-Tellez, Francisco M Acosta, Samuel Virtue, Antonio Vidal-Puig, Angel Gil, Jose M Llamas-Elvira, Jonatan R Ruiz
Apr 23, 2021
Human brown adipose tissue (BAT) volume has consistently been claimed to be inversely associated with whole-body adiposity. However, recent advances in the assessment of human BAT suggest that previously reported associations...
Genetic predisposition to mosaic Y chromosome loss in blood.
Deborah J Thompson, Giulio Genovese, Jonatan Halvardson, Jacob C Ulirsch, Daniel J Wright, Chikashi Terao, Olafur B Davidsson, Felix R Day, Patrick Sulem, Yunxuan Jiang, Marcus Danielsson, Hanna Davies, Joe Dennis, Malcolm G Dunlop, Douglas F Easton, Victoria A Fisher, Florian Zink, Richard S Houlston, Martin Ingelsson, Siddhartha Kar, Nicola D Kerrison, Ben Kinnersley, Ragnar P Kristjansson, Philip J Law, Rong Li, Chey Loveday, Jonas Mattisson, Steven A McCarroll, Yoshinori Murakami, Anna Murray, Pawel Olszewski, Edyta Rychlicka-Buniowska, Robert A Scott, Unnur Thorsteinsdottir, Ian Tomlinson, Behrooz Torabi Moghadam, Clare Turnbull, Nicholas J Wareham, Daniel F Gudbjartsson, International Lung Cancer Consortium (INTEGRAL-ILCCO), Breast Cancer Association Consortium, Consortium of Investigators of Modifiers of BRCA1/2, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium, Kidney Cancer GWAS Meta-Analysis Project, eQTLGen Consortium, Biobank-based Integrative Omics Study (BIOS) Consortium, 23andMe Research Team, Yoichiro Kamatani, Eva R Hoffmann, Steve P Jackson, Kari Stefansson, Adam Auton, Ken K Ong, Mitchell J Machiela, Po-Ru Loh, Jan P Dumanski, Stephen J Chanock, Lars A Forsberg, John RB Perry
Aug 06, 2019
Identification of an algal xylan synthase indicates that there is functional orthology between algal and plant cell wall biosynthesis.
Jacob Krüger Jensen, Marta Busse-Wicher, Christian Peter Poulsen, Jonatan Ulrik Fangel, Peter James Smith, Jeong-Yeh Yang, Maria-Jesus Peña, Malene Hessellund Dinesen, Helle Juel Martens, Michael Melkonian, Gane Ka-Shu Wong, Kelley W Moremen, Curtis Gene Wilkerson, Henrik Vibe Scheller, Paul Dupree, Peter Ulvskov, Breeanna Rae Urbanowicz, Jesper Harholt
Nov 05, 2018
Insights into the evolution of plant cell walls have important implications for comprehending these diverse and abundant biological structures. In order to understand the evolving structure-function relationships of the plant...
Variations in accelerometry measured physical activity and sedentary time across Europe - harmonized analyses of 47,497 children and adolescents.
Jostein Steene-Johannessen, Bjørge Herman Hansen, Knut Eirik Dalene, Elin Kolle, Kate Northstone, Niels Christian Møller, Anders Grøntved, Niels Wedderkopp, Susi Kriemler, Angie S Page, Jardena J Puder, John J Reilly, Luis B Sardinha, Esther M F van Sluijs, Lars Bo Andersen, Hidde van der Ploeg, Wolfgang Ahrens, Claudia Flexeder, Marie Standl, Holger Shculz, Luis A Moreno, Stefaan De Henauw, Nathalie Michels, Greet Cardon, Francisco B Ortega, Jonatan Ruiz, Susana Aznar, Mikael Fogelholm, Andrew Decelis, Line Grønholt Olesen, Mads Fiil Hjorth, Rute Santos, Susana Vale, Lars Breum Christiansen, Russ Jago, Laura Basterfield, Christopher G Owen, Claire M Nightingale, Gabriele Eiben, Angela Polito, Fabio Lauria, Jeremy Vanhelst, Charalambos Hadjigeorgiou, Kenn Konstabel, Dénes Molnár, Ole Sprengeler, Yannis Manios, Jaanus Harro, Anthony Kafatos, Sigmund Alfred Anderssen, Ulf Ekelund
Apr 19, 2020
BACKGROUND:Levels of physical activity and variation in physical activity and sedentary time by place and person in European children and adolescents are largely unknown. The objective of the study was to assess the variations...
Variations in accelerometry measured physical activity and sedentary time across Europe - harmonized analyses of 47,497 children and adolescents.
Jostein Steene-Johannessen, Bjørge Herman Hansen, Knut Eirik Dalene, Elin Kolle, Kate Northstone, Niels Christian Møller, Anders Grøntved, Niels Wedderkopp, Susi Kriemler, Angie S Page, Jardena J Puder, John J Reilly, Luis B Sardinha, Esther Mf van Sluijs, Lars Bo Andersen, Hidde van der Ploeg, Wolfgang Ahrens, Claudia Flexeder, Marie Standl, Holger Shculz, Luis A Moreno, Stefaan De Henauw, Nathalie Michels, Greet Cardon, Francisco B Ortega, Jonatan Ruiz, Susana Aznar, Mikael Fogelholm, Andrew Decelis, Line Grønholt Olesen, Mads Fiil Hjorth, Rute Santos, Susana Vale, Lars Breum Christiansen, Russ Jago, Laura Basterfield, Christopher G Owen, Claire M Nightingale, Gabriele Eiben, Angela Polito, Fabio Lauria, Jeremy Vanhelst, Charalambos Hadjigeorgiou, Kenn Konstabel, Dénes Molnár, Ole Sprengeler, Yannis Manios, Jaanus Harro, Anthony Kafatos, Sigmund Alfred Anderssen, Ulf Ekelund, Determinants of Diet and Physical Activity knowledge hub (DEDIPAC)
Jan 14, 2021
BACKGROUND: Levels of physical activity and variation in physical activity and sedentary time by place and person in European children and adolescents are largely unknown. The objective of the study was to assess the variations...
Variations in accelerometry measured physical activity and sedentary time across Europe – harmonized analyses of 47,497 children and adolescents
Jostein Steene-Johannessen, Bjørge Herman Hansen, Knut Eirik Dalene, Elin Kolle, Kate Northstone, Niels Christian Møller, Anders Grøntved, Niels Wedderkopp, Susi Kriemler, Angie S. Page, Jardena J. Puder, John J. Reilly, Luis B. Sardinha, Esther M. F. van Sluijs, Lars Bo Andersen, Hidde van der Ploeg, Wolfgang Ahrens, Claudia Flexeder, Marie Standl, Holger Shculz, Luis A. Moreno, Stefaan De Henauw, Nathalie Michels, Greet Cardon, Francisco B. Ortega, Jonatan Ruiz, Susana Aznar, Mikael Fogelholm, Andrew Decelis, Line Grønholt Olesen, Mads Fiil Hjorth, Rute Santos, Susana Vale, Lars Breum Christiansen, Russ Jago, Laura Basterfield, Christopher G. Owen, Claire M. Nightingale, Gabriele Eiben, Angela Polito, Fabio Lauria, Jeremy Vanhelst, Charalambos Hadjigeorgiou, Kenn Konstabel, Dénes Molnár, Ole Sprengeler, Yannis Manios, Jaanus Harro, Anthony Kafatos, Sigmund Alfred Anderssen, Ulf Ekelund, L. B. Andersen, S. Anderssen, A. J. Atkin, G. Cardon, R. Davey, U. Ekelund, D. W. Esliger, P. Hallal, B. H. Hansen, K. F. Janz, S. Kriemler, N. Møller, K. Northstone, R. Pate, J. J. Puder, J. Reilly, J. Salmon, L. B. Sardinha, L. B. Sherar, E. M. F. van Sluijs
Jun 06, 2020
Variations in accelerometry measured physical activity and sedentary time across Europe – harmonized analyses of 47,497 children and adolescents
Jostein Steene-Johannessen, Bjørge Herman Hansen, Knut Eirik Dalene, Elin Kolle, Kate Northstone, Niels Christian Møller, Anders Grøntved, Niels Wedderkopp, Susi Kriemler, Angie S. Page, Jardena J. Puder, John J. Reilly, Luis B. Sardinha, Esther M. F. van Sluijs, Lars Bo Andersen, Hidde van der Ploeg, Wolfgang Ahrens, Claudia Flexeder, Marie Standl, Holger Shculz, Luis A. Moreno, Stefaan De Henauw, Nathalie Michels, Greet Cardon, Francisco B. Ortega, Jonatan Ruiz, Susana Aznar, Mikael Fogelholm, Andrew Decelis, Line Grønholt Olesen, Mads Fiil Hjorth, Rute Santos, Susana Vale, Lars Breum Christiansen, Russ Jago, Laura Basterfield, Christopher G. Owen, Claire M. Nightingale, Gabriele Eiben, Angela Polito, Fabio Lauria, Jeremy Vanhelst, Charalambos Hadjigeorgiou, Kenn Konstabel, Dénes Molnár, Ole Sprengeler, Yannis Manios, Jaanus Harro, Anthony Kafatos, Sigmund Alfred Anderssen, Ulf Ekelund, L. B. Andersen, S. Anderssen, A. J. Atkin, G. Cardon, R. Davey, U. Ekelund, D. W. Esliger, P. Hallal, B. H. Hansen, K. F. Janz, S. Kriemler, N. Møller, K. Northstone, R. Pate, J. J. Puder, J. Reilly, J. Salmon, L. B. Sardinha, L. B. Sherar, E. M. F. van Sluijs
Mar 18, 2021
Physical activity attenuates the influence of FTO variants on obesity risk
Tuomas O Kilpeläinen, Lu Qi, Soren Brage, Stephen J Sharp, Emily Sonestedt, Ellen Demerath, Tariq Ahmad, Samia Mora, Marika Kaakinen, Camilla Helene Sandholt, Christina Holzapfel, Christine S Autenrieth, Elina Hyppönen, Stéphane Cauchi, Meian He, Zoltan Kutalik, Meena Kumari, Alena Stančáková, Karina Meidtner, Beverley Balkau, Jonathan T Tan, Massimo Mangino, Nicholas J Timpson, Yiqing Song, M Carola Zillikens, Kathleen A Jablonski, Melissa E Garcia, Stefan Johansson, Jennifer L Bragg-Gresham, Ying Wu, Jana V van Vliet-Ostaptchouk, N Charlotte Onland-Moret, Esther Zimmermann, Natalia V Rivera, Toshiko Tanaka, Heather M Stringham, Günther Silbernagel, Stavroula Kanoni, Mary F Feitosa, Soren Snitker, Jonatan R Ruiz, Jeffery Metter, Maria Teresa Martinez Larrad, Mustafa Atalay, Maarit Hakanen, Najaf Amin, Christine Cavalcanti-Proença, Anders Grøntved, Göran Hallmans, John-Olov Jansson, Johanna Kuusisto, Mika Kähönen, Pamela L Lutsey, John J Nolan, Luigi Palla, Oluf Pedersen, Louis Pérusse, Frida Renström, Robert A Scott, Dmitry Shungin, Ulla Sovio, Tuija H Tammelin, Tapani Rönnemaa, Timo A Lakka, Matti Uusitupa, Manuel Serrano Rios, Luigi Ferrucci, Claude Bouchard, Aline Meirhaeghe, Mao Fu, Mark Walker, Ingrid B Borecki, George V Dedoussis, Andreas Fritsche, Claes Ohlsson, Michael Boehnke, Stefania Bandinelli, Cornelia M van Duijn, Shah Ebrahim, Debbie A Lawlor, Vilmundur Gudnason, Tamara B Harris, Thorkild IA Sørensen, Karen L Mohlke, Albert Hofman, André G Uitterlinden, Jaakko Tuomilehto, Terho Lehtimäki, Olli Raitakari, Bo Isomaa, Pål R Njølstad, Jose C Florez, Simin Liu, Andy Ness, Timothy D Spector, E Shyong Tai, Philippe Froguel, Heiner Boeing, Markku Laakso, Michael Marmot, Sven Bergmann, Chris Power, Kay-Tee Khaw, Daniel Chasman, Paul Ridker, Torben Hansen, Keri L Monda, Thomas Illig, Marjo-Riitta Järvelin, Nicholas J Wareham, Frank B Hu, Leif C Groop, Marju Orho-Melander, Ulf Ekelund, Paul W Franks, Ruth JF Loos
Nov 16, 2017
BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have...