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Black-necked spitting cobra (Naja nigricollis) phospholipases A2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket.
Andrea Martos-Esteban, Olivia JS Macleod, Isabella Maudlin, Konstantinos Kalogeropoulos, Jonas A Jürgensen, Mark Carrington, Andreas H Laustsen
May 18, 2022
African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome...
Black-necked spitting cobra ( Naja nigricollis) phospholipases A 2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket
Andrea Martos-Esteban, Olivia JS Macleod, Isabella Maudlin, Konstantinos Kalogeropoulos, Jonas A Jürgensen, Mark Carrington, Andreas H Laustsen
Apr 19, 2022
Abstract: African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African...
Toxin Neutralization Using Alternative Binding Proteins.
Timothy Patrick Jenkins, Thomas Fryer, Rasmus Ibsen Dehli, Jonas Arnold Jürgensen, Albert Fuglsang-Madsen, Sofie Føns, Andreas Hougaard Laustsen
Apr 09, 2019
Animal toxins present a major threat to human health worldwide, predominantly through snakebite envenomings, which are responsible for over 100,000 deaths each year. To date, the only available treatment against snakebite...
Counselors, Judges, or Executioners
Academic models grounded in market efficiency and reputational principles argue that market firms value suffer investors punishment as consequence of international bribery allegations. However, there are indicators of potential...
FCPA violations; capital markets reaction; revised analysts’ opinions; economic penalties; reputational penalties Accounting
Published by: Digital Commons @ Texas A&M University-San Antonio
Pros and cons of different therapeutic antibody formats for recombinant antivenom development.
Andreas H Laustsen, José María Gutiérrez, Cecilie Knudsen, Kristoffer H Johansen, Erick Bermúdez-Méndez, Felipe A Cerni, Jonas A Jürgensen, Line Ledsgaard, Andrea Martos-Esteban, Mia Øhlenschlæger, Urska Pus, Mikael R Andersen, Bruno Lomonte, Mikael Engmark, Manuela B Pucca
Jun 19, 2018
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being...
Adverse reactions Animal envenoming Antibodies Antibody expression Antivenom Antivenom design Biotechnology Immunogenicity Neglected tropical diseases pharmacodynamics Pharmacokinetics Recombinant antivenom Scorpion sting Snakebite Spider bite Venom Venom neutralization Animals Antibodies Antivenins Camelus Humans Recombinant Proteins Venoms
Counselors, Judges, or Executioners
Academic models grounded in market efficiency and reputational principles argue that market firms value suffer investors punishment as consequence of international bribery allegations. However, there are indicators of potential...
FCPA violations capital markets reaction revised analysts’ opinions economic penalties reputational penalties Accounting
Published by: Digital Commons @ Texas A&M University-San Antonio
Counselors, Judges, or Executioners
Academic models grounded in market efficiency and reputational principles argue that market firms value suffer investors punishment as consequence of international bribery allegations. However, there are indicators of potential...
FCPA violations capital markets reaction revised analysts’ opinions economic penalties reputational penalties Accounting
Published by: Digital Commons @ Texas A&M University-San Antonio
The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling.
Alice A Torres, Stephanie L Macilwee, Amir Rashid, Sarah E Cox, Jonas D Albarnaz, Claudio A Bonjardim, Geoffrey Smith
Feb 24, 2022
Cellular proteins often have multiple and diverse functions. This is illustrated with protein Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate immune signalling downstream of RNA sensing by...
Reference Values for DXA-Derived Visceral Adipose Tissue in Adults 40 Years and Older from a European Population
Marie W Lundblad, Bjarne K Jacobsen, Jonas Johansson, Emanuella De Lucia Rolfe, Sameline Grimsgaard, Laila A Hopstock
May 24, 2021
Background. Reference values for visceral adipose tissue (VAT) are needed and it has been advocated that body composition measures depend on both the technique and methods applied, as well as the population of interest. We aimed...
Mind Your Manners! A Dataset and A Continual Learning Approach for
Assessing Social Appropriateness of Robot Actions
To date, endowing robots with an ability to assess social appropriateness of
their actions has not been possible. This has been mainly due to (i) the lack
of relevant and labelled data, and (ii) the lack of formulations of this...
Introduction to the Special Issue on Individual Differences in Multisensory Perception
The world is full of objects that can be perceived through multiple different senses to create an integrated understanding of our environment. Since each of us has different biological and psychological characteristics...
Why Canada Did Not Go To War in Iraq
Jonas Holmlund
Dec 14, 2010
This essay discusses from a post-structuralist perspective why Canada did not participate in the United States-led war against Iraq in 2003 from a post-structuralist perspective. The essay argues that the question...
Published by: Memorial University of Newfoundland
Introduction to the Special Issue on Individual Differences in Multisensory Perception
The world is full of objects that can be perceived through multiple different senses to create an integrated understanding of our environment. Since each of us has different biological and psychological characteristics...
On PDF/A Conformance and Font Usage in PDF Documents Provided by Public Sector Organizations
The use of appropriate fonts and file formats for long-term maintenance of digital assets is a challenge for organizations in the public sector. The article reports from a study which investigated the PDF/A conformance and font...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
Achieving Conformance to Document Standards
In the context of long-term archival of digital assets, file formats that are standardized and designed for longevity such as PDF/A are preferred. However, due to the complexity of and ambiguities in PDF standards, it is far...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
Lingual Alveolar Soft Part Sarcoma in a 1-Year-Old Infant
Amy Ruffle, Malcolm Cameron, Nicolaas Jonas, Samantha Levine, Caroline Mills, C Elizabeth Hook, Matthew J Murray
Feb 15, 2019
Alveolar soft part sarcoma (ASPS) is an exceptionally rare non-rhabdomyosarcomatous soft tissue sarcoma (NRSTS), characterized by the translocation t(X;17) p(11.2;q25). This translocation results in the chimeric ASPSCR1-TFE3...
Coblation intracapsular tonsillectomy
Steven Powell, Daniel J Tweedie, Nicolaas E Jonas, Neil D Bateman, Kim Keltie, Andrew J Sims
Mar 28, 2022
OBJECTIVES: To identify paediatric intracapsular Coblation tonsillectomy procedures from routine administrative data in England, and determine their safety. DESIGN: Retrospective observational cohort study of four ENT centres...
Reference Values for DXA-Derived Visceral Adipose Tissue in Adults 40 Years and Older from a European Population
Marie W Lundblad, Bjarne K Jacobsen, Jonas Johansson, Emanuella De Lucia Rolfe, Sameline Grimsgaard, Laila A Hopstock
Jul 01, 2021
Background
Reference values for visceral adipose tissue (VAT) are needed and it has been advocated that body composition measures depend on both the technique and methods applied, as well as the population of interest....
Published by: Journal of Obesity
Why Canada Did Not Go To War in Iraq
Jonas Holmlund
Dec 14, 2010
This essay discusses from a post-structuralist perspective why Canada did not participate in the United States-led war against Iraq in 2003 from a post-structuralist perspective. The essay argues that the question...
Published by: Memorial University of Newfoundland
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Husserl und die „Philosophie der Philosophiegeschichte“
Peter Andras Varga
May 19, 2021
“Nichts lag Husserl ferner als Geschichte der Philosophie, denn die Wahrheit istnatürlich nicht interessiert an den Irrtümer der Vergangenheit“ – sagte HansJonas in einem Vortrag über Husserl und Heidegger. Jonas, der im SS 1921...
Published by: Memorial University of Newfoundland
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