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Are donor lymphocytes a barrier to transplantation tolerance?
PURPOSE OF REVIEW: Following solid organ transplantation (SOT), populations of donor lymphocytes are frequently found in the recipient circulation. Their impact on host alloimmunity has long been debated but remains unclear, and...
Spoiling for a Fight
Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from canonical secondary lymphoid organs (SLOs), in...
Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury.
Manu Chhabra, Jawaher Alsughayyir, M Saeed Qureshi, Mekhola Mallik, Jason M Ali, Ivonne Gamper, Ellen L Moseley, Sarah Peacock, Vasilis Kosmoliaptsis, Martin J Goddard, Michelle A Linterman, Reza Motallebzadeh, Gavin J Pettigrew
Feb 19, 2019
Different profiles of alloantibody responses are observed in the clinic, with those that persist, often despite targeted treatment, associated with poorer long-term transplant outcomes. Although such responses would suggest an...
allograft extrafollicular B cell response germinal center (GC) humoral allograft rejection Transplantation Allografts Animals Chronic Disease Disease Models Animal Disease Progression Germinal Center Graft Rejection Heart Transplantation Humans Immunity Humoral Isoantibodies Isoantigens Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Myocardium Receptors Antigen T-Cell alpha-beta Signaling Lymphocytic Activation Molecule Associated Protein Transplantation Homologous
Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection.
Jawaher Alsughayyir, Manu Chhabra, M Saeed Qureshi, Mekhola Mallik, Jason M Ali, Ivonne Gamper, Ellen L Moseley, Sarah Peacock, Vasilis Kosmoliaptsis, Martin J Goddard, Michelle A Linterman, Reza Motallebzadeh, Gavin J Pettigrew
Feb 12, 2019
Humoral alloimmunity is now recognized as a major determinant of transplant outcome. MHC glycoprotein is considered a typical T-dependent antigen, but the nature of the T cell alloresponse that underpins alloantibody generation...
allograft extrafollicular B cell response germinal center (GC) humoral alloimmunity Transplantation vasculopathy Adoptive Transfer Allografts Animals B-Lymphocytes DNA-Binding Proteins Disease Models Animal Disease Progression Graft Rejection Heart Transplantation Humans Isoantibodies Isoantigens Lymphocyte Count Mice Mice Inbred BALB C Mice Inbred C57BL Mice Knockout Myocardium Receptors Antigen T-Cell alpha-beta Signaling Lymphocytic Activation Molecule Associated Protein T-Lymphocytes Helper-Inducer Transplantation Homologous
Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant.
Ines G Harper, Jason M Ali, Simon JF Harper, Elizabeth Wlodek, Jawaher Alsughayyir, Margaret C Negus, M Saeed Qureshi, Reza Motalleb-Zadeh, Kourosh Saeb-Parsy, Eleanor M Bolton, J Andrew Bradley, Menna R Clatworthy, Thomas M Conlon, Gavin J Pettigrew
Mar 18, 2016
Adaptive Immunity Allografts Animals Autoantibodies B-Lymphocytes CD4-Positive T-Lymphocytes Cell Differentiation Graft Rejection Graft vs Host Disease Histocompatibility Antigens Class I Histocompatibility Antigens Class II Immunity Humoral Killer Cells Natural Mice Inbred BALB C Models Immunological Peptides Plasma Cells Receptors Antigen B-Cell Tissue Donors Transplantation Homologous