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The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins.
Christian Edlich-Muth, Jean-Baptiste Artero, Phil Callow, Marcin R Przewloka, Aleksandra A Watson, Wei Zhang, David M Glover, Janusz Debski, Michal Dadlez, Adam R Round, V Trevor Forsyth, Ernest D Laue
May 21, 2015
FKBP NMR histone chaperone nucleoplasmin structure determination Amino Acid Sequence Animals Arabidopsis Chromatin Cross-Linking Reagents Crystallography X-Ray Drosophila Proteins Drosophila melanogaster Histone Chaperones Histone Deacetylase 2 Histones Immunoprecipitation Models Molecular Molecular Sequence Data Nucleoplasmins Phylogeny Protein Binding Protein Conformation Protein Structure Tertiary Recombinant Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Sequence Homology Amino Acid Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Structure-Activity Relationship Tacrolimus Binding Proteins
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.
Nikola S Dzhindzhev, George Tzolovsky, Zoltan Lipinszki, Mohammed Abdelaziz, Janus Debski, Michal Dadlez, David M Glover
Apr 20, 2018
The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL...
Post-COVID-19 syndrome risk factors and further use of health services in East England.
Maciej Debski, Vasiliki Tsampasian, Shawn Haney, Katy Blakely, Samantha Weston, Eleana Ntatsaki, Mark Lim, Susan Madden, Aris Perperoglou, Vassilios S Vassiliou
Apr 17, 2023
Post-COVID syndrome, defined as symptoms persisting for more than twelve weeks after the diagnosis of COVID-19, has been recognised as a new clinical entity in the context of SARS-CoV-2 infection. This study was conducted to...
Published by: PLOS global public health
From a Well-Defined Organozinc Precursor to Diverse Luminescent Coordination Polymers Based on Zn(II)-Quinolinate Building Units Interconnected by Mixed Ligand Systems.
Katarzyna Sołtys-Brzostek, Kamil Sokołowski, Iwona Justyniak, Michał K Leszczyński, Natalia Olejnik-Fehér, Janusz Lewiński
Dec 24, 2021
Introduction of photoactive building blocks into mixed-ligand coordination polymers appears to be a promising way to produce new advanced luminescent materials. However, rational design and self-assembly of the multi-component...
The Role of SGLT2 Inhibitors in Heart Failure
Vasiliki Tsampasian, Ranu Baral, Rahul Chattopadhyay, Maciej Debski, Shruti S Joshi, Johannes Reinhold, Marc R Dweck, Pankaj Garg, Vassilios S Vassiliou
Aug 27, 2021
Aims. Recent randomised controlled trials (RCTs) have shown a significant prognostic benefit of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the cardiovascular (CV) profile of patients with diabetes. This systematic...
Post-COVID-19 syndrome risk factors and further use of health services in East England.
Maciej Debski, Vasiliki Tsampasian, Shawn Haney, Katy Blakely, Samantha Weston, Eleana Ntatsaki, Mark Lim, Susan Madden, Aris Perperoglou, Vassilios S Vassiliou
Nov 30, 2022
Post-COVID syndrome, defined as symptoms persisting for more than twelve weeks after the diagnosis of COVID-19, has been recognised as a new clinical entity in the context of SARS-CoV-2 infection. This study was conducted to...
The Role of SGLT2 Inhibitors in Heart Failure
Vasiliki Tsampasian, Ranu Baral, Rahul Chattopadhyay, Maciej Debski, Shruti S Joshi, Johannes Reinhold, Marc R Dweck, Pankaj Garg, Vassilios S Vassiliou
Oct 01, 2021
AIMS: Recent randomised controlled trials (RCTs) have shown a significant prognostic benefit of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the cardiovascular (CV) profile of patients with diabetes. This systematic...
Dancing sprites
Serge Soula, Janusz Mlynarczyk, Martin Füllekrug, Nicolau Pineda, Jean François Georgis, Oscar van der Velde, Joan Montanyà, Ferran Fabró
Mar 16, 2017
On 29-30 October 2013, a low-light video camera installed at Pic du Midi (2877m), recorded transient luminous events above a very active storm over the Mediterranean Sea. The minimum cloud top temperature reached -73°C, while...
Dancing sprites
Serge Soula, Janusz Mlynarczyk, Martin Füllekrug, Nicolau Pineda, Jean François Georgis, Oscar van der Velde, Joan Montanyà, Ferran Fabró
Mar 16, 2017
On 29-30 October 2013, a low-light video camera installed at Pic du Midi (2877m), recorded transient luminous events above a very active storm over the Mediterranean Sea. The minimum cloud top temperature reached -73°C, while...
A systematic literature review of reviews on techniques for physical activity measurement in adults
Kieran P Dowd, Robert Szeklicki, Marco Alessandro Minetto, Marie H Murphy, Angela Polito, Ezio Ghigo, Hidde van der Ploeg, Ulf Ekelund, Janusz Maciaszek, Rafal Stemplewski, Maciej Tomczak, Alan E Donnelly
May 24, 2018
The links between increased participation in Physical Activity (PA) and improvements in health are well established. As this body of evidence has grown, so too has the search for measures of PA with high levels of methodological...
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression.
Jan P Dumanski, Jonatan Halvardson, Hanna Davies, Edyta Rychlicka-Buniowska, Jonas Mattisson, Behrooz Torabi Moghadam, Noemi Nagy, Kazimierz Węglarczyk, Karolina Bukowska-Strakova, Marcus Danielsson, Paweł Olszewski, Arkadiusz Piotrowski, Erin Oerton, Aleksandra Ambicka, Marcin Przewoźnik, Łukasz Bełch, Tomasz Grodzicki, Piotr L Chłosta, Stefan Imreh, Vilmantas Giedraitis, Lena Kilander, Jessica Nordlund, Adam Ameur, Ulf Gyllensten, Åsa Johansson, Alicja Józkowicz, Maciej Siedlar, Alicja Klich-Rączka, Janusz Jaszczyński, Stefan Enroth, Jarosław Baran, Martin Ingelsson, John RB Perry, Janusz Ryś, Lars A Forsberg
Apr 26, 2021
Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes is associated with earlier mortality and morbidity from many diseases in men. LOY is the most common acquired mutation and is associated...
Halide Mixing and Phase Segregation in Cs2AgBiX6 (X=Cl, Br, I) Double Perovskites from Cesium-133 Solid-State NMR and Optical Spectroscopy
Dominik J Kubicki, Marcin Saski, Stuart Macpherson, Krzysztof Galkowski, Janusz Lewiński, Daniel Prochowicz, Jeremy J Titman, Samuel D Stranks
Sep 29, 2020
All-inorganic double perovskites (elpasolites) are a promising potential alternative to lead halide perovskite in optoelectronic applications. While halide mixing is a well-established strategy for band gap tuning, little is...
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
Jan P. Dumanski, Jonatan Halvardson, Hanna Davies, Edyta Rychlicka-Buniowska, Jonas Mattisson, Behrooz Torabi Moghadam, Noemi Nagy, Kazimierz Węglarczyk, Karolina Bukowska-Strakova, Marcus Danielsson, Paweł Olszewski, Arkadiusz Piotrowski, Erin Oerton, Aleksandra Ambicka, Marcin Przewoźnik, Łukasz Bełch, Tomasz Grodzicki, Piotr L. Chłosta, Stefan Imreh, Vilmantas Giedraitis, Lena Kilander, Jessica Nordlund, Adam Ameur, Ulf Gyllensten, Åsa Johansson, Alicja Józkowicz, Maciej Siedlar, Alicja Klich-Rączka, Janusz Jaszczyński, Stefan Enroth, Jarosław Baran, Martin Ingelsson, John R. B. Perry, Janusz Ryś, Lars A. Forsberg
May 08, 2021
British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus.
Rebecca C Fitzgerald, Massimiliano di Pietro, Krish Ragunath, Yeng Ang, Jin-Yong Kang, Peter Watson, Nigel Trudgill, Praful Patel, Philip V Kaye, Scott Sanders, Maria O'Donovan, Elizabeth Bird-Lieberman, Pradeep Bhandari, Janusz A Jankowski, Stephen Attwood, Simon L Parsons, Duncan Loft, Jesper Lagergren, Paul Moayyedi, Georgios Lyratzopoulos, John de Caestecker, British Society of Gastroenterology
Sep 05, 2018
These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument...
BARRETT'S CARCINOMA BARRETT'S METAPLASIA BARRETT'S OESOPHAGUS gastroesophageal reflux disease OESOPHAGEAL CANCER Ablation Techniques Adenocarcinoma Barrett Esophagus Biopsy Cost-Benefit Analysis Decision Support Techniques Early Detection of Cancer Esophageal Neoplasms Esophagectomy Esophagoscopy esophagus Humans Risk Assessment Risk Factors United Kingdom United States
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases.
Jiyuan An, Puya Gharahkhani, Matthew H Law, Jue-Sheng Ong, Xikun Han, Catherine M Olsen, Rachel E Neale, John Lai, Tom L Vaughan, Ines Gockel, René Thieme, Anne C Böhmer, Janusz Jankowski, Rebecca C Fitzgerald, Johannes Schumacher, Claire Palles, BEACON, 23andMe Research Team, David C Whiteman, Stuart MacGregor
Oct 03, 2019
Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large...
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca 2+ flux to mitochondria
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Sep 13, 2021
Abstract: Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in...
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca<sup>2+</sup> flux to mitochondria.
Yibo Xue, Jordan L Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D Foulkes, Julien Prudent, Sidong Huang
Oct 18, 2021
Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in both cancers...
Published by: Nature Communications
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.
Yibo Xue, Jordan L Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D Foulkes, Julien Prudent, Sidong Huang
Jun 30, 2021
Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in both cancers...
Animals Antineoplastic Agents Apoptosis Calcium Cell Line Tumor DNA Helicases Gene Expression Profiling Gene Expression Regulation Neoplastic HEK293 Cells Humans Inositol 1 4 5-Trisphosphate Receptors Ion Transport Male Mice Inbred NOD Mice Knockout Mice SCID Mitochondria Mutation Neoplasms Nuclear Proteins Transcription Factors Xenograft Model Antitumor Assays
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Jue-Sheng Ong, Jiyuan An, Xikun Han, Matthew H Law, Priyanka Nandakumar, 23andMe Research Team, Esophageal Cancer Consortium, Johannes Schumacher, Ines Gockel, Anne Bohmer, Janusz Jankowski, Claire Palles, Catherine M Olsen, Rachel E Neale, Rebecca Fitzgerald, Aaron P Thrift, Thomas L Vaughan, Matthew F Buas, David A Hinds, Puya Gharahkhani, Bradley J Kendall, Stuart MacGregor
Jul 28, 2021
OBJECTIVE: Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based definitions. GERD genome-wide association studies (GWASs) have shown strong genetic overlaps with...
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.
Jue-Sheng Ong, Suzanne C Dixon-Suen, Xikun Han, Jiyuan An, Esophageal Cancer Consortium, 23 and Me Research Team, Upekha Liyanage, Jean-Cluade Dusingize, Johannes Schumacher, Ines Gockel, Anne Böhmer, Janusz Jankowski, Claire Palles, Tracy O'Mara, Amanda Spurdle, Matthew H Law, Mark M Iles, Paul Pharoah, Andrew Berchuck, Wei Zheng, Aaron P Thrift, Catherine Olsen, Rachel E Neale, Puya Gharahkhani, Penelope M Webb, Stuart MacGregor
Feb 01, 2021
Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal...
Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination.
Francisco J Rivera, Alerie G de la Fuente, Chao Zhao, Maria E Silva, Ginez A Gonzalez, Roman Wodnar, Martina Feichtner, Simona Lange, Oihana Errea, Eleni Priglinger, Anna O'Sullivan, Pasquale Romanelli, Janusz J Jadasz, Gabriele Brachtl, Richard Greil, Herbert Tempfer, Andreas Traweger, Luis F Bátiz, Patrick Küry, Sebastien Couillard-Despres, Robin Jm Franklin, Ludwig Aigner
Apr 16, 2019
CNS stem and progenitor cells aging Cell therapy Mesenchymal Stem Cells Multiple Sclerosis Oligodendrocytes remyelination aging Animals Cells Cultured Demyelinating Diseases Disease Models Animal Female Male Mesenchymal Stem Cells Oligodendroglia Rats Inbred F344 Rats Sprague-Dawley remyelination Tissue Culture Techniques
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca 2+ flux to mitochondria
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Mar 21, 2023
Published by: Nature Publishing Group UK
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