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Results: 84
Truss geometry and topology optimization with global stability constraints
Alemseged Weldeyesus, Jacek Gondzio, Linwei He, Matthew Gilbert, Paul Shepherd, Andy Tyas
Oct 31, 2020
In this paper, we introduce geometry optimization into an existing topology optimization workflow for truss structures with global stability constraints, assuming a linear buckling analysis. The design variables are the...
Metadata requirements for digital museum environments
Manjula Patel, Martin White, Nikolaos Mourkoussis, Krzysztof Walczak, Rafal Wojciechowski, Jacek Chmielewski
May 01, 2005
We describe a system which addresses all the processes involved in digitally acquiring, modelling, storing, manipulating and creating virtual exhibitions from 3D museum artefacts. More specifically, we examine the significance...
Online or Offline Services for Urban Neighbourhoods?
Services originally developed as natural concentrations of human activity, reflecting the Christallerian hierarchy of central places. Today, those natural mechanisms are challenged by strong competition from online facilities....
Published by: IGI Global Scientific Publishing
Metadata requirements for digital museum environments
Manjula Patel, Martin White, Nikolaos Mourkoussis, Krzysztof Walczak, Rafal Wojciechowski, Jacek Chmielewski
May 01, 2005
We describe a system which addresses all the processes involved in digitally acquiring, modelling, storing, manipulating and creating virtual exhibitions from 3D museum artefacts. More specifically, we examine the significance...
Truss geometry and topology optimization with global stability constraints
Alemseged Weldeyesus, Jacek Gondzio, Linwei He, Matthew Gilbert, Paul Shepherd, Andy Tyas
Oct 31, 2020
In this paper, we introduce geometry optimization into an existing topology optimization workflow for truss structures with global stability constraints, assuming a linear buckling analysis. The design variables are the...
The size and shape of parasitic larvae of naiads (Unionidae) are not dependent on female size.
Adam M Ćmiel, Jacek Dołęga, David C Aldridge, Anna Lipińska, Feng Tang, Katarzyna Zając, Manuel Lopes-Lima, Tadeusz Zając
Jan 04, 2022
The naiads, large freshwater mussels (Unionida), have very long life spans, are large-bodied, and produce thousands to millions of larvae (glochidia) which typically must attach to host fish tissues to metamorphose into a...
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling
Anindya Roy Chowdhury, Jacek Zielonka, Balaraman Kalyanaraman, Richard C Hartley, Michael P Murphy, Narayan G Avadhani
Jul 06, 2020
The mitochondrial electron transport chain is a major source of reactive oxygen species (ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia-inducible factor (HIF) and induction of the AMPK...
The unquantified mass loss of Northern Hemisphere marine-terminating glaciers from 2000-2020.
Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer
Honglin Song, Ed M Dicks, Jonathan Tyrer, Maria Intermaggio, Georgia Chenevix-Trench, David D Bowtell, Nadia Traficante, Aocs Group, James Brenton, Teodora Goranova, Karen Hosking, Anna Piskorz, Elke van Oudenhove, Jen Doherty, Holly R Harris, Mary Anne Rossing, Matthias Duerst, Thilo Dork, Natalia V Bogdanova, Francesmary Modugno, Kirsten Moysich, Kunle Odunsi, Roberta Ness, Beth Y Karlan, Jenny Lester, Allan Jensen, Susanne Krüger Kjaer, Estrid Høgdall, Ian G Campbell, Conxi Lázaro, Miguel Angel Pujara, Julie Cunningham, Robert Vierkant, Stacey J Winham, Michelle Hildebrandt, Chad Huff, Donghui Li, Xifeng Wu, Yao Yu, Jennifer B Permuth, Douglas A Levine, Joellen M Schildkraut, Marjorie J Riggan, Andrew Berchuck, Penelope M Webb, Opal Study Group, Cezary Cybulski, Jacek Gronwald, Anna Jakubowska, Jan Lubinski, Jennifer Alsop, Patricia Harrington, Isaac Chan, Usha Menon, Celeste L Pearce, Anna H Wu, Anna de Fazio, Catherine J Kennedy, Ellen Goode, Susan Ramus, Simon Gayther, Paul Pharoah
Jun 17, 2020
Purpose: The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate...
Population-based targeted sequencing of 54 candidate genes identifies PALB2 as a susceptibility gene for high-grade serous ovarian cancer.
Honglin Song, Ed M Dicks, Jonathan Tyrer, Maria Intermaggio, Georgia Chenevix-Trench, David D Bowtell, Nadia Traficante, Aocs Group, James Brenton, Teodora Goranova, Karen Hosking, Anna Piskorz, Elke van Oudenhove, Jen Doherty, Holly R Harris, Mary Anne Rossing, Matthias Duerst, Thilo Dork, Natalia V Bogdanova, Francesmary Modugno, Kirsten Moysich, Kunle Odunsi, Roberta Ness, Beth Y Karlan, Jenny Lester, Allan Jensen, Susanne Krüger Kjaer, Estrid Høgdall, Ian G Campbell, Conxi Lázaro, Miguel Angel Pujara, Julie Cunningham, Robert Vierkant, Stacey J Winham, Michelle Hildebrandt, Chad Huff, Donghui Li, Xifeng Wu, Yao Yu, Jennifer B Permuth, Douglas A Levine, Joellen M Schildkraut, Marjorie J Riggan, Andrew Berchuck, Penelope M Webb, Opal Study Group, Cezary Cybulski, Jacek Gronwald, Anna Jakubowska, Jan Lubinski, Jennifer Alsop, Patricia Harrington, Isaac Chan, Usha Menon, Celeste L Pearce, Anna H Wu, Anna de Fazio, Catherine J Kennedy, Ellen Goode, Susan Ramus, Simon Gayther, Paul Pharoah
May 13, 2020
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.
Luca A Lotta, Jacek Mokrosiński, Edson Mendes de Oliveira, Chen Li, Stephen J Sharp, Jian'an Luan, Bas Brouwers, Vikram Ayinampudi, Nicholas Bowker, Nicola Kerrison, Vasileios Kaimakis, Diana Hoult, Isobel D Stewart, Eleanor Wheeler, Felix R Day, John RB Perry, Claudia Langenberg, Nicholas J Wareham, I Sadaf Farooqi
Apr 12, 2019
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their associations...
GPCRs MC4R UK Biobank biased signaling Genetics melanocortin obesity β-Arrestin Adult Aged Body Mass Index Coronary Artery Disease Cyclic AMP Databases Factual Diabetes mellitus Type 2 Female GTP-Binding Protein alpha Subunits Gs Gain of Function Mutation Genetic Predisposition to Disease Genotype Humans Male Middle Aged obesity Polymorphism Single Nucleotide Receptor Melanocortin Type 4 Signal Transduction beta-Arrestins
Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.
Kaitlin H Wade, Brian YH Lam, Audrey Melvin, Warren Pan, Laura J Corbin, David A Hughes, Kara Rainbow, Jian-Hua Chen, Katie Duckett, Xiaoming Liu, Jacek Mokrosiński, Alexander Mörseburg, Sam Neaves, Alice Williamson, Chen Zhang, I Sadaf Farooqi, Giles SH Yeo, Nicholas J Timpson, Stephen O'Rahilly
Apr 19, 2021
Mutations in the melanocortin 4 receptor gene (MC4R) are associated with obesity but little is known about the prevalence and impact of such mutations throughout human growth and development. We examined the MC4R coding sequence...
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Bas Brouwers, Edson Mendes de Oliveira, Maria Marti-Solano, Fabiola BF Monteiro, Suli-Anne Laurin, Julia M Keogh, Elana Henning, Rebecca Bounds, Carole A Daly, Shane Houston, Vikram Ayinampudi, Natalia Wasiluk, David Clarke, Bianca Plouffe, Michel Bouvier, M Madan Babu, I Sadaf Farooqi, Jacek Mokrosiński
Apr 14, 2021
The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate MC4R function. Most...
GPCRs Gα(s) MC4R MSH melanocortin obesity Therapy Weight Loss β-Arrestin Animals Body Weight COS Cells Cell Membrane Chlorocebus aethiops Cyclic AMP Endocytosis Extracellular Signal-Regulated MAP Kinases GTP-Binding Protein alpha Subunits Gs genetic variation HEK293 Cells Humans Models Biological Mutant Proteins Mutation Phosphorylation Protein Multimerization Receptor Melanocortin Type 4 Signal Transduction beta-Arrestins
Printable Perovskite Diodes for Broad-Spectrum Multienergy X-Ray Detection.
Babar Shabbir, Jae Choul Yu, Tharindu Warnakula, RAW Ayyubi, James A Pollock, M Mosarof Hossain, Jueng-Eun Kim, Nasiruddin Macadam, Leonard WT Ng, Tawfique Hasan, Doojin Vak, Marcus J Kitchen, Jacek J Jasieniak
Mar 30, 2023
Multienergy X-ray detection is critical to effectively differentiate materials in a variety of diagnostic radiology and nondestructive testing applications. Silicon and selenium X-ray detectors are the most common for...
The unquantified mass loss of Northern Hemisphere marine-terminating glaciers from 2000-2020.
William Kochtitzky, Luke Copland, Wesley Van Wychen, Romain Hugonnet, Regine Hock, Julian A Dowdeswell, Toby Benham, Tazio Strozzi, Andrey Glazovsky, Ivan Lavrentiev, David R Rounce, Romain Millan, Alison Cook, Abigail Dalton, Hester Jiskoot, Jade Cooley, Jacek Jania, Francisco Navarro
Nov 15, 2022
In the Northern Hemisphere, ~1500 glaciers, accounting for 28% of glacierized area outside the Greenland Ice Sheet, terminate in the ocean. Glacier mass loss at their ice-ocean interface, known as frontal ablation, has not yet...
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
Ismail Syed, Jennifer Lee, Pedro M Moraes-Vieira, Cynthia J Donaldson, Alexandra Sontheimer, Pratik Aryal, Kerry Wellenstein, Matthew J Kolar, Andrew T Nelson, Dionicio Siegel, Jacek Mokrosinski, I Sadaf Farooqi, Juan Juan Zhao, Mark M Yore, Odile D Peroni, Alan Saghatelian, Barbara B Kahn
Aug 08, 2019
FAHFA GLP-1 receptor GPR40 glucose-insulin homeostasis human islets Insulin Secretion palmitic acid hydroxystearic acid Type 2 diabetes Adiposity Animals Eating Glucose HEK293 Cells Homeostasis Humans Inflammation Insulin Resistance Mice Inbred C57BL Palmitic Acid Receptors G-Protein-Coupled Stearic Acids
A rare human variant that disrupts GPR10 signalling causes weight gain in mice.
Fleur Talbot, Claire H Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles SH Yeo, Philippe Froguel, David A Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M Luckman, I Sadaf Farooqi
Mar 15, 2023
A rare human variant that disrupts GPR10 signalling causes weight gain in mice.
Fleur Talbot, Claire H Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S H Yeo, Philippe Froguel, David A Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M Luckman, I Sadaf Farooqi
Apr 15, 2023
Animals Mice Transgenic Humans Mice obesity Weight Gain Receptors G-Protein-Coupled Signal Transduction Energy Metabolism
Published by: Nature Communications
Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D.
Xin Yang, Honglin Song, Goska Leslie, Christoph Engel, Eric Hahnen, Bernd Auber, Judit Horváth, Karin Kast, Dieter Niederacher, Clare Turnbull, Richard Houlston, Helen Hanson, Chey Loveday, Jill S Dolinsky, Holly LaDuca, Susan J Ramus, Usha Menon, Adam N Rosenthal, Ian Jacobs, Simon A Gayther, Ed Dicks, Heli Nevanlinna, Kristiina Aittomäki, Liisa M Pelttari, Hans Ehrencrona, Åke Borg, Anders Kvist, Barbara Rivera, Thomas vO Hansen, Malene Djursby, Andrew Lee, Joe Dennis, David D Bowtell, Nadia Traficante, Orland Diez, Judith Balmaña, Stephen B Gruber, Georgia Chenevix-Trench, KConFaB Investigators, Allan Jensen, Susanne K Kjaer, Estrid Høgdall, Laurent Castéra, Judy Garber, Ramunas Janavicius, Ana Osorio, Lisa Golmard, Ana Vega, Fergus J Couch, Mark Robson, Jacek Gronwald, Susan M Domchek, Julie O Culver, Miguel de la Hoya, Douglas F Easton, William D Foulkes, Marc Tischkowitz, Alfons Meindl, Rita K Schmutzler, Paul DP Pharoah, Antonis C Antoniou
Feb 20, 2020
BACKGROUND: The purpose of this study was to estimate precise age-specific tubo-ovarian carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C and RAD51D. METHODS: We analyzed data from 6178...
Pro-fluorescent mitochondria-targeted real-time responsive redox probes synthesised from carboxy isoindoline nitroxides
Kok Leong Chong, Benjamin A Chalmers, Jason K Cullen, Amandeep Kaur, Jacek L Kolanowski, Benjamin J Morrow, Kathryn E Fairfull-Smith, Martin J Lavin, Nigel L Barnett, Elizabeth J New, Michael P Murphy, Steven E Bottle
Jun 18, 2018
Here we describe new fluorescent probes based on fluorescein and rhodamine that provide reversible, real-time insight into cellular redox status. The new probes incorporate bio-imaging relevant fluorophores derived from...
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.
Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes de Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooqi
Jan 22, 2023
Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation.
Jacek Kwiecinski, Evangelos Tzolos, Timothy RG Cartlidge, Alexander Fletcher, Mhairi K Doris, Rong Bing, Jason M Tarkin, Michael A Seidman, Gaurav S Gulsin, Nicholas L Cruden, Anna K Barton, Neal G Uren, Michelle C Williams, Edwin JR van Beek, Jonathon Leipsic, Damini Dey, Raj R Makkar, Piotr J Slomka, James HF Rudd, David E Newby, Stephanie L Sellers, Daniel S Berman, Marc R Dweck
Sep 15, 2021
BACKGROUND: Major uncertainties remain regarding disease activity within the retained native aortic valve, and regarding bioprosthetic valve durability, after transcatheter aortic valve implantation (TAVI). We aimed to assess...
18F-sodium fluoride Aortic Valve Positron Emission Tomography Computed Tomography transcatheter aortic valve implantation Aged Aged 80 and over aortic valve disease Cohort Studies Cross-Sectional Studies Disease Progression Female Heart valve prosthesis Humans Male transcatheter aortic valve replacement
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