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The ‘Yew Chung model’ of international education
Tristan Bunnell
Dec 01, 2015
The Yew Chung Educational Foundation operates a network of five International Schools in China, plus one in California, serving in total 5,500 children. This paper investigates the aims and philosophy of a ‘model’ of...
The ‘Yew Chung model’ of international education
Tristan Bunnell
Dec 01, 2015
The Yew Chung Educational Foundation operates a network of five International Schools in China, plus one in California, serving in total 5,500 children. This paper investigates the aims and philosophy of a ‘model’ of...
Cork-in-bottle mechanism of inhibitor binding to mammalian complex I.
Injae Chung, Riccardo Serreli, Jason B Cross, M Emilia Di Francesco, Joseph R Marszalek, Judy Hirst
Jun 17, 2021
Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a major contributor of free energy for oxidative phosphorylation, is increasingly recognized as a promising drug target for ischemia-reperfusion injury, metabolic...
Published by: Science advances
Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System.
Respiratory complex I is an essential metabolic enzyme that uses the energy from NADH oxidation and ubiquinone reduction to translocate protons across an energy transducing membrane and generate the proton motive force for ATP...
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
The molecular mode of action of biguanides, including the drug metformin, which is widely used in the treatment of diabetes, is incompletely characterized. Here, we define the inhibitory drug-target interaction(s) of a model...
Cork-in-bottle mechanism of inhibitor binding to mammalian complex I.
Injae Chung, Riccardo Serreli, Jason B Cross, M Emilia Di Francesco, Joseph R Marszalek, Judy Hirst
Jun 17, 2021
Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a major contributor of free energy for oxidative phosphorylation, is increasingly recognized as a promising drug target for ischemia-reperfusion injury, metabolic...
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis
Jun 26, 2020
Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial...
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I.
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis
Jun 04, 2020
Biochemistry cancer biology cardiac liability chemical biology human Mitochondria toxicophore Adenosine Triphosphate Antineoplastic Agents Cell Death Cell Line Cell Proliferation Electron Transport Complex I Gene Expression Regulation Humans Mitochondria Mitochondria Heart Myocytes Cardiac Oxazoles Oxidative Phosphorylation Protein Binding Receptor ErbB-2 Triazoles
New Sports Course Gives Students Once-in-a-Lifetime Opportunity to Tour South Korea
Winthrop University
Jan 01, 0001
In this new course, students will travel will COE faculty Jason Chung and Seth Jenny to South Korea for two weeks. The cost of the trip is still being finalized.
Published by: Winthrop University
Winter Olympics Puts Professor's Home Country in the Spotlight
Winthrop University
Jan 01, 0001
Quick Facts
South Korea is only the fifth country to host four major international sporting events. Chung is from Seoul, South Korea, the country's capital.
Published by: Winthrop University
Diagnosing the
<scp>UK</scp>
productivity slowdown
This paper explores the slowdown in labour productivity growth in the UK and other advanced economies by decomposing its growth into contributions from different sectors of the economy, looking at both within‐industry...
Long-term effects of discontinuation from antipsychotic maintenance following first-episode schizophrenia and related disorders
Christy LM Hui, William G Honer, Edwin HM Lee, Wing Chung Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, Wai Song Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen
May 03, 2018
BACKGROUND: The long-term consequences of discontinuing antipsychotic medication after successful treatment of first-episode psychosis are not well studied. We assess the relation between early maintenance therapy decisions in...
Efficient learning methods for large-scale optimal inversion design
In this work, we investigate various approaches that use learning from training data to solve inverse problems, following a bi-level learning approach. We consider a general framework for optimal inversion design, where...
Efficient learning methods for large-scale optimal inversion design
In this work, we investigate various approaches that use learning from training data to solve inverse problems, following a bi-level learning approach. We consider a general framework for optimal inversion design, where...
Analysis of the Establishment and Closure of the Ta Teh Institute in British Hong Kong during the Chinese Civil War
Chung Fun Steven Hung
Aug 25, 2016
The Ta Teh Institute was a prominent and important higher learning institute that existed in Hong Kong during the period of the Chinese Civil War, after the Second World War. The institute was founded in October, 1946 and then...
Recent insights into Shigella.
PURPOSE OF REVIEW: Diarrhoea is a major global health problem, and recent studies have confirmed Shigella as a major contributor to this burden. Here, we review recent advances in Shigella research; focusing on their...
Structural flood damage and the efficacy of property-level flood protection
Purpose: The purpose of this paper is twofold: first, to investigate the flood impact on a detached dwelling based on physical attributes related to the positioning, form and orientation of the house, and second, to...
Computational methods for large-scale inverse problems
This paper surveys animportant class of methods that combine iterative projection methods and variational regularization methods for large-scale inverse problems. Iterative methods such as Krylov subspace methods are invaluable...
Molecular Genetic Analysis of Rodent Non-Insulin Dependent Diabetes Mellitus
Wendy Chung
Jan 01, 0001
Non-insulin dependent diabetes mellitus (NIDDM) is perhaps the most common metabolic disorder in humans. In its essence, NIDDM is a disorder of glucose homeostasis which results from a relative deficiency of circulating...
Published by: Rockefeller University
Effects of DNA Interactions on the Stability of Oligonucleotide-Lipid Micelles
Cianna Chung
Jan 01, 0001
Lipids, due to their amphipathic makeup, self-assemble into small, nearly identical vesicles called micelles. Because these micelles have a hydrophobic core, they can hold therapeutics that are hydrophobic in nature. Their...
Published by: Ursinus College
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