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SARS-CoV-2 B.1.617 Mutations L452R and E484Q Are Not Synergistic for Antibody Evasion.
Isabella ATM Ferreira, Steven A Kemp, Rawlings Datir, Akatsuki Saito, Bo Meng, Partha Rakshit, Akifumi Takaori-Kondo, Yusuke Kosugi, Keiya Uriu, Izumi Kimura, Kotaro Shirakawa, Adam Abdullahi, Anurag Agarwal, Seiya Ozono, Kenzo Tokunaga, Kei Sato, Ravindra K Gupta, Indian SARS-CoV-2 Genomics Consortium CITIID-NIHR BioResource COVID-19 Collaboration, Genotype to Phenotype Japan (G2P-Japan) Consortium
Jul 29, 2021
The SARS-CoV-2 B.1.617 variant emerged in the Indian state of Maharashtra in late 2020. There have been fears that 2 key mutations seen in the receptor-binding domain, L452R and E484Q, would have additive effects on evasion of...
B.1.617 covid-19 Indian variant SARS-CoV-2 Antibody Escape evasion FITNESS infectivity neutralizing antibodies resistance spike mutation Angiotensin-Converting Enzyme 2 Animals Antibodies Neutralizing Antibodies Viral BNT162 Vaccine covid-19 COVID-19 Vaccines Chlorocebus aethiops HEK293 Cells Humans Immune Evasion india Mutation Protein Binding SARS-CoV-2 Serine Endopeptidases Spike Glycoprotein Coronavirus Vero Cells
An integrated national scale SARS-CoV-2 genomic surveillance network.
The Coronavirus Disease 2019 (COVID-19) Genomics UK Consortium (COG-UK) was launched in March, 2020, with £20 million support from UK Research and Innovation, the UK Department of Health and Social Care, and Wellcome Trust. The...
Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers
Daniel James Cooper, Sara Lear, Nyarie Sithole, Ashley Shaw, Hannah Stark, Mark Ferris, CITIID-NIHR BioResource COVID-19 collaboration consortium, John Bradley, Patrick Maxwell, Ian Goodfellow, Michael P Weekes, Shaun Seaman, Stephen Baker
Dec 09, 2022
OBJECTIVE: Healthcare workers (HCWs) are at higher risk of SARS-CoV-2 infection than the general population. This group is pivotal to healthcare system resilience during the COVID-19, and future, pandemics. We investigated...
SARS-CoV-2 variant biology
Alessandro M Carabelli, Thomas P Peacock, Lucy G Thorne, William T Harvey, Joseph Hughes, COVID-19 Genomics UK Consortium, Sharon J Peacock, Wendy S Barclay, Thushan I de Silva, Greg J Towers, David L Robertson
Feb 18, 2023
In late 2020, after circulating for almost a year in the human population, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its adaptation to humans. These highly mutated forms of...
Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID.
Benjamin A Krishna, Eleanor Y Lim, Lenette Mactavous, NIHR BioResource Team, Paul A Lyons, Rainer Doffinger, John R Bradley, Kenneth GC Smith, John Sinclair, Nicholas J Matheson, Paul J Lehner, Mark R Wills, Nyaradzai Sithole
Aug 01, 2022
BACKGROUND: There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. The diagnostic complexity of Long COVID is compounded in many patients who were or might have been infected...
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7)
Katherine RW Emary, Tanya Golubchik, Parvinder K Aley, Cristina V Ariani, Brian Angus, Sagida Bibi, Beth Blane, David Bonsall, Paola Cicconi, Sue Charlton, Elizabeth A Clutterbuck, Andrea M Collins, Tony Cox, Thomas C Darton, Christina Dold, Alexander D Douglas, Christopher JA Duncan, Katie J Ewer, Amy L Flaxman, Saul N Faust, Daniela M Ferreira, Shuo Feng, Adam Finn, Pedro M Folegatti, Michelle Fuskova, Eva Galiza, Anna L Goodman, Catherine M Green, Christopher A Green, Melanie Greenland, Bassam Hallis, Paul T Heath, Jodie Hay, Helen C Hill, Daniel Jenkin, Simon Kerridge, Rajeka Lazarus, Vincenzo Libri, Patrick J Lillie, Catherine Ludden, Natalie G Marchevsky, Angela M Minassian, Alastair C McGregor, Yama F Mujadidi, Daniel J Phillips, Emma Plested, Katrina M Pollock, Hannah Robinson, Andrew Smith, Rinn Song, Matthew D Snape, Rebecca K Sutherland, Emma C Thomson, Mark Toshner, David PJ Turner, Johan Vekemans, Tonya L Villafana, Christopher J Williams, Adrian VS Hill, Teresa Lambe, Sarah C Gilbert, Merryn Voysey, Maheshi N Ramasamy, Andrew J Pollard, COVID-19 Genomics UK Consortium, AMPHEUS Project, Oxford COVID-19 Vaccine Trial Group
May 06, 2021
BACKGROUND: A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19...
Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19.
Nick K Jones, Lucy Rivett, Dominic Sparkes, Sally Forrest, Sushmita Sridhar, Jamie Young, Joana Pereira-Dias, Claire Cormie, Harmeet Gill, Nicola Reynolds, Michelle Wantoch, Matthew Routledge, Ben Warne, Jack Levy, William David Córdova Jiménez, Fathima Nisha Begum Samad, Chris McNicholas, Mark Ferris, Jane Gray, Michael Gill, CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, John R Bradley, Gregory J Hannon, Ian G Goodfellow, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Giles Wright, Nicholas J Matheson, Stephen Baker, Michael P Weekes
Jun 24, 2020
Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus...
covid-19 SARS-CoV-2 emerging pathogens EPIDEMIOLOGY Global Health human human biology infectious disease Medicine Occupational health Virology Adult Asymptomatic Diseases Betacoronavirus covid-19 COVID-19 Testing Clinical Laboratory Techniques Community-Acquired Infections Contact Tracing Coronavirus Infections Disease Transmission Infectious England Family Characteristics Female Health Personnel Hospital Units Hospitals Teaching Hospitals University Humans infection control Infectious Disease Transmission Patient-to-Professional Male Mass Screening Middle Aged nasopharynx Occupational Diseases Pandemics Patient Admission Pneumonia Viral prevalence Program Evaluation Real-Time Polymerase Chain Reaction SARS-CoV-2 Symptom Assessment
A thermostable, closed SARS-CoV-2 spike protein trimer.
Xiaoli Xiong, Kun Qu, Katarzyna A Ciazynska, Myra Hosmillo, Andrew P Carter, Soraya Ebrahimi, Zunlong Ke, Sjors HW Scheres, Laura Bergamaschi, Guinevere L Grice, Ying Zhang, CITIID-NIHR COVID-19 BioResource Collaboration, James A Nathan, Stephen Baker, Leo C James, Helen E Baxendale, Ian Goodfellow, Rainer Doffinger, John AG Briggs
Oct 21, 2020
The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. It exhibits substantial conformational flexibility. It transitions from closed to open conformations...
Betacoronavirus COVID-19 Testing Clinical Laboratory Techniques Coronavirus Infections Cryoelectron Microscopy Disulfides Enzyme-Linked Immunosorbent Assay Flow Cytometry Humans Immunoglobulin G Models Molecular Mutation Protein Conformation Protein Engineering Protein Multimerization Protein Stability SARS-CoV-2 Spike Glycoprotein Coronavirus Temperature
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Petra Mlcochova, Steven A Kemp, Mahesh Shanker Dhar, Guido Papa, Bo Meng, Isabella ATM Ferreira, Rawlings Datir, Dami A Collier, Anna Albecka, Sujeet Singh, Rajesh Pandey, Jonathan Brown, Jie Zhou, Niluka Goonawardane, Swapnil Mishra, Charles Whittaker, Thomas Mellan, Robin Marwal, Meena Datta, Shantanu Sengupta, Kalaiarasan Ponnusamy, Venkatraman Srinivasan Radhakrishnan, Adam Abdullahi, Oscar Charles, Partha Chattopadhyay, Priti Devi, Daniela Caputo, Tom Peacock, Chand Wattal, Neeraj Goel, Ambrish Satwik, Raju Vaishya, Meenakshi Agarwal, Indian SARS-CoV-2 Genomics Consortium (INSACOG), Genotype to Phenotype Japan (G2P-Japan) Consortium, CITIID-NIHR BioResource COVID-19 Collaboration, Antranik Mavousian, Joo Hyeon Lee, Jessica Bassi, Chiara Silacci-Fegni, Christian Saliba, Dora Pinto, Takashi Irie, Isao Yoshida, William L Hamilton, Kei Sato, Samir Bhatt, Seth Flaxman, Leo C James, Davide Corti, Luca Piccoli, Wendy S Barclay, Partha Rakshit, Anurag Agrawal, Ravindra K Gupta
Sep 10, 2021
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages...
Mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative
Jan 05, 2022
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of...
Autoimmunity Body Mass Index covid-19 Critical Illness Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Geographic Mapping Hospitalization Host-Pathogen Interactions Humans Inflammation Information Dissemination Male Multifactorial Inheritance Racial Groups SARS-CoV-2 Smoking
SARS-CoV-2 (COVID-19)
Nisha S Mehta, Oliver T Mytton, Edward WS Mullins, Tom A Fowler, Catherine L Falconer, Orla B Murphy, Claudia Langenberg, Wikum JP Jayatunga, Danielle H Eddy, Jonathan S Nguyen-Van-Tam
May 20, 2020
BACKGROUND: Few pediatric cases of coronavirus disease 2019 (COVID-19) have been reported and we know little about the epidemiology in children, although more is known about other coronaviruses. We aimed to understand the...
Detecting SARS-CoV-2 variants with SNP genotyping.
Helen Harper, Amanda Burridge, Mark Winfield, Adam Finn, Andrew Davidson, David Matthews, Stephanie Hutchings, Barry Vipond, Nisha Jain, COVID-19 Genomics UK (COG-UK) Consortium, Keith Edwards, Gary Barker
Mar 01, 2021
Tracking genetic variations from positive SARS-CoV-2 samples yields crucial information about the number of variants circulating in an outbreak and the possible lines of transmission but sequencing every positive SARS-CoV-2...
Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection.
Nick K Jones, Lucy Rivett, Shaun Seaman, Richard J Samworth, Ben Warne, Chris Workman, Mark Ferris, Jo Wright, Natalie Quinnell, Ashley Shaw, Cambridge COVID-19 Collaboration, Ian G Goodfellow, Paul J Lehner, Rob Howes, Giles Wright, Nicholas J Matheson, Michael P Weekes
Apr 09, 2021
The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection against symptomatic disease has encouraged some countries to opt for...
Genomic reconstruction of the SARS-CoV-2 epidemic in England.
Harald S Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio, Thuy Nguyen, Richard Goater, Frank Schwach, Ian Harrison, Joel Hellewell, Cristina V Ariani, Sonia Gonçalves, David K Jackson, Ian Johnston, Alexander W Jung, Callum Saint, John Sillitoe, Maria Suciu, Nick Goldman, Jasmina Panovska-Griffiths, Wellcome Sanger Institute COVID-19 Surveillance Team, COVID-19 Genomics UK (COG-UK) Consortium*, Ewan Birney, Erik Volz, Sebastian Funk, Dominic Kwiatkowski, Meera Chand, Inigo Martincorena, Jeffrey C Barrett, Moritz Gerstung
Jan 05, 2022
The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the...
Genomic reconstruction of the SARS-CoV-2 epidemic in England.
Harald S Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio, Thuy Nguyen, Richard Goater, Frank Schwach, Ian Harrison, Joel Hellewell, Cristina V Ariani, Sonia Gonçalves, David K Jackson, Ian Johnston, Alexander W Jung, Callum Saint, John Sillitoe, Maria Suciu, Nick Goldman, Jasmina Panovska-Griffiths, Wellcome Sanger Institute COVID-19 Surveillance Team, COVID-19 Genomics UK (COG-UK) Consortium*, Ewan Birney, Erik Volz, Sebastian Funk, Dominic Kwiatkowski, Meera Chand, Inigo Martincorena, Jeffrey C Barrett, Moritz Gerstung
Nov 23, 2021
The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the...
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.
Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C James, Katarzyna A Ciazynska, Xiaoli Xiong, John AG Briggs, James A Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A Lyons, John Bradley, Steven Baker, Jean Pierre Allain, Kenneth GC Smith, Rachel Bousfield, Michael Wilson, Dominic Sparkes, Glenn Amoroso, Effrosyni Gkrania-Klotsas, Susie Hardwick, Adrian Boyle, Ian Goodfellow, Ravindra K Gupta, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration
Sep 29, 2020
Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%-50% of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (NAAT). Furthermore, the D614G spike mutant...
covid-19 D614G SARS-CoV-2 point of care testing rapid diagnoses Aged Aged 80 and over Antibodies Viral covid-19 COVID-19 Testing Female Humans Immunoassay Male Middle Aged Neutralization Tests Nucleic Acid Amplification Techniques Point-of-care testing SARS-CoV-2 Sensitivity and Specificity Spike Glycoprotein Coronavirus
SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies.
MacGregor Cox, Thomas P Peacock, William T Harvey, Joseph Hughes, Derek W Wright, COVID-19 Genomics UK (COG-UK) Consortium, Brian J Willett, Emma Thomson, Ravindra K Gupta, Sharon J Peacock, David L Robertson, Alessandro M Carabelli
Nov 28, 2022
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19 and are especially important in high-risk individuals where vaccination is not an option. Given the importance of understanding the...
Detection of SARS-CoV-2 in respiratory samples from cats in the UK associated with human-to-cat transmission.
Margaret J Hosie, Ilaria Epifano, Vanessa Herder, Richard J Orton, Andrew Stevenson, Natasha Johnson, Emma MacDonald, Dawn Dunbar, Michael McDonald, Fiona Howie, Bryn Tennant, Darcy Herrity, Ana da Silva Filipe, Daniel G Streicker, COVID-19 Genomics UK (COG-UK) Consortium, Brian J Willett, Pablo R Murcia, Ruth F Jarrett, David L Robertson, William Weir
Feb 25, 2021
OBJECTIVES: The aim of the study was to find evidence of SARS-CoV-2 infection in UK cats. DESIGN: Tissue samples were tested for SARS-CoV-2 antigen using immunofluorescence and for viral RNA by in situ hybridisation. A set of...
The COVID-19 Data Portal
Peter W Harrison, Rodrigo Lopez, Nadim Rahman, Stefan Gutnick Allen, Raheela Aslam, Nicola Buso, Carla Cummins, Yasmin Fathy, Eloy Felix, Mihai Glont, Suran Jayathilaka, Sandeep Kadam, Manish Kumar, Katharina B Lauer, Geetika Malhotra, Abayomi Mosaku, Ossama Edbali, Young Mi Park, Andrew Parton, Matt Pearce, Jose Francisco Estrada Pena, Joseph Rossetto, Craig Russell, Sandeep Selvakumar, Xènia Pérez Sitjà, Alexey Sokolov, Ross Thorne, Marianna Ventouratou, Peter Walter, Galabina Yordanova, Amonida Zadissa, Guy Cochrane, Niklas Blomberg, Rolf Apweiler
Jul 29, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic will be remembered as one of the defining events of the 21st century. The rapid global outbreak has had significant impacts on human society and is...
Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation
Adrian M Shields, Sian E Faustini, Harriet J Hill, Saly Al-Taei, Chloe Tanner, Fiona Ashford, Sarita Workman, Fernando Moreira, Nisha Verma, Hollie Wagg, Gail Heritage, Naomi Campton, Zania Stamataki, Mark T Drayson, Paul Klenerman, James ED Thaventhiran, Shuayb Elkhalifa, Sarah Goddard, Sarah Johnston, Aarnoud Huissoon, Claire Bethune, Suzanne Elcombe, David M Lowe, Smita Y Patel, Sinisa Savic, Alex G Richter, Siobhan O Burns, COV-AD consortium
Jun 16, 2022
BACKGROUND: Patients with primary and secondary antibody deficiency are vulnerable to COVID-19 and demonstrate diminished responses following two-dose SARS-CoV-2 vaccine schedules. Third primary vaccinations have been deployed...
Chronic neuropsychiatric sequelae of SARS‐CoV‐2
Gabriel A de Erausquin, Heather Snyder, Traolach S Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, Charlotte Teunissen, Krister Håkanson, Rufus Akinyemi, Kameshwar Prasad, Giovanni D'Avossa, Gabriela Gonzalez‐Aleman, Akram Hosseini, George D Vavougios, Perminder Sachdev, John Bankart, Niels Peter Ole Mors, Richard Lipton, Mindy Katz, Peter T Fox, Mohammad Zia Katshu, M Sriram Iyengar, Galit Weinstein, Hamid R Sohrabi, Rachel Jenkins, Dan J Stein, Jacques Hugon, Venetsanos Mavreas, John Blangero, Carlos Cruchaga, Murali Krishna, Ovais Wadoo, Rodrigo Becerra, Igor Zwir, William T Longstreth, Golo Kroenenberg, Paul Edison, Elizabeta Mukaetova‐Ladinska, Ekkehart Staufenberg, Mariana Figueredo‐Aguiar, Agustín Yécora, Fabiana Vaca, Hernan P Zamponi, Vincenzina Lo Re, Abdul Majid, Jonas Sundarakumar, Hector M Gonzalez, Mirjam I Geerlings, Ingmar Skoog, Alberto Salmoiraghi, Filippo Martinelli Boneschi, Vibuthi N Patel, Juan M Santos, Guillermo Rivera Arroyo, Antonio Caballero Moreno, Pascal Felix, Carla Gallo, Hidenori Arai, Masahito Yamada, Takeshi Iwatsubo, Malveeka Sharma, Nandini Chakraborty, Catterina Ferreccio, Dickens Akena, Carol Brayne, Gladys Maestre, Sarah Williams Blangero, Luis I Brusco, Prabha Siddarth, Timothy M Hughes, Alfredo Ramírez Zuñiga, Joseph Kambeitz, Agustin Ruiz Laza, Norrina Allen, Stella Panos, David Merrill, Agustín Ibáñez, Debby Tsuang, Nino Valishvili, Srishti Shrestha, Sophia Wang, Vasantha Padma, Kaarin J Anstey, Vijayalakshmi Ravindrdanath, Kaj Blennow, Paul Mullins, Emilia Łojek, Anand Pria, Thomas H Mosley, Penny Gowland, Timothy D Girard, Richard Bowtell, Farhaan S Vahidy
Sep 22, 2022
Abstract: Introduction: Coronavirus disease 2019 (COVID‐19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic....
A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital.
Daniel J Cooper, Sara Lear, Laura Watson, Ashley Shaw, Mark Ferris, Rainer Doffinger, Rachel Bousfield, Katherine Sharrocks, Michael P Weekes, Ben Warne, Dominic Sparkes, Nick K Jones, Lucy Rivett, Matthew Routledge, Afzal Chaudhry, Katherine Dempsey, Montgomery Matson, Adil Lakha, George Gathercole, Olivia O'Connor, Emily Wilson, Orthi Shahzad, Kieran Toms, Rachel Thompson, Ian Halsall, David Halsall, Sally Houghton, Sofia Papadia, Nathalie Kingston, Kathleen E Stirrups, Barbara Graves, Paul Townsend, Neil Walker, Hannah Stark, CITIID-NIHR BioResource COVID-19 Collaboration, Daniela De Angelis, Shaun Seaman, Gordon Dougan, John R Bradley, M Estée Török, Ian Goodfellow, Stephen Baker
Oct 05, 2022
OBJECTIVES: To describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs). METHODS: We conducted a prospective sero-epidemiological study of HCWs at a major UK teaching hospital using a SARS-CoV-2...
SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency
Adrian M Shields, Sian E Faustini, Harriet J Hill, Saly Al-Taei, Chloe Tanner, Fiona Ashford, Sarita Workman, Fernando Moreira, Nisha Verma, Hollie Wagg, Gail Heritage, Naomi Campton, Zania Stamataki, Paul Klenerman, James ED Thaventhiran, Sarah Goddard, Sarah Johnston, Aarnoud Huissoon, Claire Bethune, Suzanne Elcombe, David M Lowe, Smita Y Patel, Sinisa Savic, Siobhan O Burns, Alex G Richter, COV-AD consortium
Aug 25, 2022
BACKGROUND: Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity and efficacy of SARS-CoV-2 vaccines in patients with antibody deficiency is poorly understood....
Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients
Dami A Collier, Sonny M Assennato, Ben Warne, Nyarie Sithole, Katherine Sharrocks, Allyson Ritchie, Pooja Ravji, Matthew Routledge, Dominic Sparkes, Jordan Skittrall, Anna Smielewska, Isobel Ramsey, Neha Goel, Martin Curran, David Enoch, Rhys Tassell, Michelle Lineham, Devan Vaghela, Clare Leong, Hoi Ping Mok, John Bradley, Kenneth GC Smith, Vivienne Mendoza, Nikos Demiris, Martin Besser, Gordon Dougan, Paul J Lehner, Mark J Siedner, Hongyi Zhang, Claire S Waddington, Helen Lee, Ravindra K Gupta, CITIID-NIHR COVID BioResource Collaboration
Aug 10, 2020
There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined...
Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers
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