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Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens
Background: Photorhabdus are Gram negative entomopathogenic bacteria that also have a mutualistic association with nematodes from the family Heterorhabditis. An essential part of this symbiosis is the ability of the bacterium to...
Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens
Background: Photorhabdus are Gram negative entomopathogenic bacteria that also have a mutualistic association with nematodes from the family Heterorhabditis. An essential part of this symbiosis is the ability of the bacterium to...
Recruiting patients with advanced malignant and non-malignant disease
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...
HPV16 oncogene expression levels during early cervical carcinogenesis are determined by the balance of epigenetic chromatin modifications at the integrated virus genome.
Cell Line Tumor Chromatin Chromatin Assembly and Disassembly Cyclin-Dependent Kinase 9 Epigenesis Genetic Female Gene Expression Regulation Neoplastic Gene Expression Regulation Viral Genome Viral Human papillomavirus 16 Humans Oncogene Proteins Viral Papillomavirus E7 Proteins Repressor Proteins Uterine Cervical Neoplasms Virus Integration
What influenced people with chronic or refractory breathlessness and advanced disease to take part and remain in a drug trial? A qualitative study.
BACKGROUND: Recruitment and retention in clinical trials remains an important challenge, particularly in the context of advanced disease. It is important to understand what affects retention to improve trial quality, minimise...
breathlessness Palliative Care person-centred care Qualitative randomised controlled trial Recruitment Retention Aged Aged 80 and over Chronic Disease Double-Blind Method Dyspnea Feasibility Studies Female Heart Failure Humans Lung Diseases Interstitial Male Middle Aged motivation Neoplasms Patient Participation Pulmonary Disease Chronic Obstructive qualitative research Quality of life Severity of Illness Index Surveys and Questionnaires United Kingdom
INTERFEROME
INTERFEROME is an open access database of types I, II and III Interferon regulated genes (http://www.interferome.org) collected from analysing expression data sets of cells treated with IFNs. This database of interferon...
High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors.
BACKGROUND: Morphine and its derivatives are key drugs in pain control. Despite its well-known analgesic properties morphine at high concentrations may be proalgesic. Particularly, short-lasting painful sensations have been...
Acrolein Animals Bradykinin Calcitonin Gene-Related Peptide Calcium Signaling Capsaicin Dose-Response Relationship Drug Extremities Ganglia Spinal Hot Temperature Humans Ion Channel Gating Mice Morphine Naloxone Neurons Skin TRPA1 Cation Channel TRPV Cation Channels Transient Receptor Potential Channels
How many people will need palliative care in 2040? Past trends, future projections and implications for services.
BACKGROUND: Current estimates suggest that approximately 75% of people approaching the end-of-life may benefit from palliative care. The growing numbers of older people and increasing prevalence of chronic illness in many...
Chronic Disease Comorbidity Forecasting Health Services Needs and Demand Mortality Needs Assessment Palliative Care Adolescent Adult Aged Aged 80 and over Child Child Preschool Chronic Disease Delivery of Health Care Dementia England Female Forecasting Humans Infant Infant Newborn Male Middle Aged Palliative Care Population Growth prevalence Wales Young Adult
Innovation in low carbon construction technologies
Purpose – The purpose of this paper is to evaluate the risks of building defects associated with rapid advancement of “green” construction technologies. It identifies the methods adopted by the sector for the determination of...
Diagnosing cancer in patients with 'non-alarm' symptoms
Efforts to improve cancer outcomes have led to the introduction of policies to enable ‘fast-track’ referrals from primary to secondary care for patients with possible cancer. Although these schemes, also known as ‘two-week-wait’...
Mysterious inhibitory cell regulator investigated and found likely to be secretogranin II related
In the context of a hunt for a postulated hormone that is tissue-mass inhibiting and reproductively associated there is described probable relatedness to a granin protein. A 7-8 kDa polypeptide candidate (gels/MS) appeared in a...
Stage IV Colorectal Cancer Patients with High Risk Mutation Profiles Survived 16 Months Longer with Individualized Therapies.
Alexander Hendricks, Anu Amallraja, Tobias Meißner, Peter Forster, Philip Rosenstiel, Greta Burmeister, Clemens Schafmayer, Andre Franke, Sebastian Hinz, Michael Forster, Casey B Williams
Feb 09, 2020
Personalized treatment vs. standard of care is much debated, especially in clinical practice. Here we investigated whether overall survival differences in metastatic colorectal cancer patients are explained by tumor mutation...
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