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Results: 42
Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease.
Luke Whiley, Katie E Chappell, Ellie D'Hondt, Matthew R Lewis, Beatriz Jiménez, Stuart G Snowden, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Jonathan R Swann, Abdul Hye, Simon Lovestone, Cristina Legido-Quigley, Elaine Holmes, AddNeuroMed consortium
Jan 09, 2021
A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis.
Nicola Voyle, Aoife Keohane, Stephen Newhouse, Katie Lunnon, Caroline Johnston, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Simon Lovestone, Angela Hodges, Steven Kiddle, Richard JB Dobson
Jun 11, 2018
BACKGROUND: Recent studies indicate that gene expression levels in blood may be able to differentiate subjects with Alzheimer's disease (AD) from normal elderly controls and mild cognitively impaired (MCI) subjects. However...
Pooling individual participant data from randomized controlled trials
Lennard L van Wanrooij, Marieke P Hoevenaar-Blom, Nicola Coley, Tiia Ngandu, Yannick Meiller, Juliette Guillemont, Anna Rosenberg, Cathrien RL Beishuizen, Eric P Moll van Charante, Hilkka Soininen, Carol Brayne, Sandrine Andrieu, Miia Kivipelto, Edo Richard
May 22, 2020
BACKGROUND: Pooling individual participant data to enable pooled analyses is often complicated by diversity in variables across available datasets. Therefore, recoding original variables is often necessary to build a pooled...
Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease
Petroula Proitsi, Michelle K Lupton, Latha Velayudhan, Stephen Newhouse, Isabella Fogh, Magda Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Alzheimer's Disease Neuroimaging Initiative, Julie Williams, GERAD1 Consortium, Robert Stewart, Pak Sham, Simon Lovestone, John F Powell
Nov 08, 2018
BACKGROUND: Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking...
Pooling individual participant data from randomized controlled trials
Lennard L. van Wanrooij, Marieke P. Hoevenaar-Blom, Nicola Coley, Tiia Ngandu, Yannick Meiller, Juliette Guillemont, Anna Rosenberg, Cathrien R. L. Beishuizen, Eric P. Moll van Charante, Hilkka Soininen, Carol Brayne, Sandrine Andrieu, Miia Kivipelto, Edo Richard
May 12, 2020
Background: Pooling individual participant data to enable pooled analyses is often complicated by diversity in variables across available datasets. Therefore, recoding original variables is often necessary to build a pooled...
The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER).
Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Bäckman, Tuomo Hänninen, Jaana Lindström, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Jul 15, 2022
Circulating Proteomic Signatures of Chronological Age.
Cristina Menni, Steven J Kiddle, Massimo Mangino, Ana Viñuela, Maria Psatha, Claire Steves, Martina Sattlecker, Alfonso Buil, Stephen Newhouse, Sally Nelson, Stephen Williams, Nicola Voyle, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Simon Lovestone, Tim D Spector, Richard Dobson, Ana M Valdes
Jun 11, 2018
To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent...
aging Aptamers. Blood biomarkers early development Nucleotide Proteomics Adult Aged Aged 80 and over aging Biomarkers Carrier Proteins Cohort Studies Cytokines Eye Proteins Female Humans Insulin-Like Growth Factor Binding Protein 6 Male Matrix Metalloproteinase 12 Middle Aged Nerve Tissue Proteins Phenotype Proteomics Registries Twins United Kingdom
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M Constable, Josie E Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R Barker, Sarah A Moore, Sonja Soininen, Eero A Haapala, Kate Westgate, Soren Brage, Ricardo R Agostinete, Romulo A Fernandes, Timo A Lakka
Jul 07, 2021
Purpose
Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The...
A Decision Support System for Diagnostics and Treatment Planning in Traumatic Brain Injury.
Adil Umer, Jussi Mattila, Hilkka Liedes, Juha Koikkalainen, Jyrki Lotjonen, Ari Katila, Janek Frantzen, Virginia Newcombe, Olli Tenovuo, David Menon, Mark van Gils
Sep 20, 2018
Traumatic brain injury (TBI) occurs when an external force causes functional or structural alterations in the brain. Clinical characteristics of TBI vary greatly from patient to patient, and a large amount of data is gathered...
Ecological networks of dissolved organic matter and microorganisms under global change.
Ang Hu, Mira Choi, Andrew J Tanentzap, Jinfu Liu, Kyoung-Soon Jang, Jay T Lennon, Yongqin Liu, Janne Soininen, Xiancai Lu, Yunlin Zhang, Ji Shen, Jianjun Wang
Jul 24, 2022
Microbes regulate the composition and turnover of organic matter. Here we developed a framework called Energy-Diversity-Trait integrative Analysis to quantify how dissolved organic matter and microbes interact along global...
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M. Constable, Josie E. Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R. Barker, Sarah A. Moore, Sonja Soininen, Eero A. Haapala, Kate Westgate, Soren Brage, Ricardo R. Agostinete, Romulo A. Fernandes, Timo A. Lakka
May 20, 2021
Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of...
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M Constable, Josie E Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R Barker, Sarah A Moore, Sonja Soininen, Eero A Haapala, Kate Westgate, Soren Brage, Ricardo R Agostinete, Romulo A Fernandes, Timo A Lakka
Jun 07, 2021
PURPOSE: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of...
Ecological networks of dissolved organic matter and microorganisms under global change.
Ang Hu, Mira Choi, Andrew Tanentzap, Jinfu Liu, Kyoung-Soon Jang, Jay T Lennon, Yongqin Liu, Janne Soininen, Xiancai Lu, Yunlin Zhang, Ji Shen, Jianjun Wang
Jun 29, 2022
Microbes regulate the composition and turnover of organic matter. Here we developed a framework called Energy-Diversity-Trait integrative Analysis to quantify how dissolved organic matter and microbes interact along global...
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury.
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury
Jussi P Posti, Iftakher Hossain, Riikka SK Takala, Hilkka Liedes, Virginia Newcombe, Joanne Outtrim, Ari J Katila, Janek Frantzen, Henna Ala-Seppala, Jonathan P Coles, Anna Kyllonen, Henna-Riikka Maanpaa, Jussi Tallus, Peter J Hutchinson, Mark van Gils, David K Menon, Olli Tenovuo, TBIcare Investigators
Aug 16, 2017
Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) have been studied as potential
biomarkers of mild traumatic brain injury (mTBI). We report the levels of GFAP and UCH-L1 in patients with...
The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children
Aino-Maija Eloranta, Taisa Sallinen, Anna Viitasalo, Niina Lintu, Juuso Väistö, Henna Jalkanen, Tuomo T. Tompuri, Sonja Soininen, Eero A. Haapala, Sanna Kiiskinen, Theresia M. Schnurr, Tuomas O. Kilpeläinen, Santtu Mikkonen, Kai Savonen, Mustafa Atalay, Soren Brage, David E. Laaksonen, Virpi Lindi, Jyrki Ågren, Ursula Schwab, Jarmo Jääskeläinen, Timo A. Lakka
Feb 06, 2021
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A. Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A. Haapala, Tuomo T. Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M. Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O. Kilpeläinen, Tomi Laitinen, David E. Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Aug 26, 2021
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins
SJ Kiddle, CJ Steves, M Mehta, A Simmons, X Xu, S Newhouse, M Sattlecker, NJ Ashton, C Bazenet, R Killick, J Adnan, E Westman, S Nelson, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas, C Curtis, G Breen, SCR Williams, S Lovestone, TD Spector, RJB Dobson
Jun 08, 2018
There is great interest in blood-based markers of Alzheimer's disease (AD), especially in its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential markers of...
The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children
Aino-Maija Eloranta, Taisa Sallinen, Anna Viitasalo, Niina Lintu, Juuso Väistö, Henna Jalkanen, Tuomo T. Tompuri, Sonja Soininen, Eero A. Haapala, Sanna Kiiskinen, Theresia M. Schnurr, Tuomas O. Kilpeläinen, Santtu Mikkonen, Kai Savonen, Mustafa Atalay, Soren Brage, David E. Laaksonen, Virpi Lindi, Jyrki Ågren, Ursula Schwab, Jarmo Jääskeläinen, Timo A. Lakka
May 04, 2021
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A Haapala, Tuomo T Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O Kilpeläinen, Tomi Laitinen, David E Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Oct 29, 2020
AIMS/HYPOTHESIS: We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly...
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury
Jussi P Posti, Riikka SK Takala, Hilkka Runtti, Virginia F Newcombe, Joanne Outtrim, Ari J Katila, Janek Frantzén, Henna Ala-Seppälä, Jonathan P Coles, Md Iftakher Hossain, Anna Kyllönen, Henna-Riikka Maanpää, Jussi Tallus, Peter J Hutchinson, Mark van Gils, David K Menon, Olli Tenovuo
May 24, 2019
BACKGROUND: Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) are promising biomarkers of traumatic brain injury (TBI). OBJECTIVE: We investigated the relation of the GFAP and UCH-L1 levels to...
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