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The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M Constable, Josie E Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R Barker, Sarah A Moore, Sonja Soininen, Eero A Haapala, Kate Westgate, Soren Brage, Ricardo R Agostinete, Romulo A Fernandes, Timo A Lakka
Jul 07, 2021
Purpose
Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The...
Inflammatory biomarkers in Alzheimer's disease plasma.
Angharad R Morgan, Samuel Touchard, Claire Leckey, Caroline O'Hagan, Alejo J Nevado-Holgado, NIMA Consortium, Frederik Barkhof, Lars Bertram, Olivier Blin, Isabelle Bos, Valerija Dobricic, Sebastiaan Engelborghs, Giovanni Frisoni, Lutz Frölich, Silvey Gabel, Peter Johannsen, Petronella Kettunen, Iwona Kłoszewska, Cristina Legido-Quigley, Alberto Lleó, Pablo Martinez-Lage, Patrizia Mecocci, Karen Meersmans, José Luis Molinuevo, Gwendoline Peyratout, Julius Popp, Jill Richardson, Isabel Sala, Philip Scheltens, Johannes Streffer, Hikka Soininen, Mikel Tainta-Cuezva, Charlotte Teunissen, Magda Tsolaki, Rik Vandenberghe, Pieter Jelle Visser, Stephanie Vos, Lars-Olof Wahlund, Anders Wallin, Sarah Westwood, Henrik Zetterberg, Simon Lovestone, B Paul Morgan, Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease
Jul 23, 2019
INTRODUCTION: Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers. METHODS: A hypothesis-led...
Ecological networks of dissolved organic matter and microorganisms under global change.
Ang Hu, Mira Choi, Andrew J Tanentzap, Jinfu Liu, Kyoung-Soon Jang, Jay T Lennon, Yongqin Liu, Janne Soininen, Xiancai Lu, Yunlin Zhang, Ji Shen, Jianjun Wang
Jul 24, 2022
Microbes regulate the composition and turnover of organic matter. Here we developed a framework called Energy-Diversity-Trait integrative Analysis to quantify how dissolved organic matter and microbes interact along global...
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M. Constable, Josie E. Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R. Barker, Sarah A. Moore, Sonja Soininen, Eero A. Haapala, Kate Westgate, Soren Brage, Ricardo R. Agostinete, Romulo A. Fernandes, Timo A. Lakka
May 20, 2021
Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of...
Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults
The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children
Annie M Constable, Josie E Porter, Danielle Benger, Dimitris Vlachopoulos, Alan R Barker, Sarah A Moore, Sonja Soininen, Eero A Haapala, Kate Westgate, Soren Brage, Ricardo R Agostinete, Romulo A Fernandes, Timo A Lakka
Jun 07, 2021
PURPOSE: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of...
Ecological networks of dissolved organic matter and microorganisms under global change.
Ang Hu, Mira Choi, Andrew Tanentzap, Jinfu Liu, Kyoung-Soon Jang, Jay T Lennon, Yongqin Liu, Janne Soininen, Xiancai Lu, Yunlin Zhang, Ji Shen, Jianjun Wang
Jun 29, 2022
Microbes regulate the composition and turnover of organic matter. Here we developed a framework called Energy-Diversity-Trait integrative Analysis to quantify how dissolved organic matter and microbes interact along global...
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease.
Luke Whiley, Katie E Chappell, Ellie D'Hondt, Matthew R Lewis, Beatriz Jiménez, Stuart G Snowden, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Jonathan R Swann, Abdul Hye, Simon Lovestone, Cristina Legido-Quigley, Elaine Holmes, AddNeuroMed consortium
Jan 09, 2021
A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis.
Nicola Voyle, Aoife Keohane, Stephen Newhouse, Katie Lunnon, Caroline Johnston, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Simon Lovestone, Angela Hodges, Steven Kiddle, Richard JB Dobson
Jun 11, 2018
BACKGROUND: Recent studies indicate that gene expression levels in blood may be able to differentiate subjects with Alzheimer's disease (AD) from normal elderly controls and mild cognitively impaired (MCI) subjects. However...
Pooling individual participant data from randomized controlled trials
Lennard L van Wanrooij, Marieke P Hoevenaar-Blom, Nicola Coley, Tiia Ngandu, Yannick Meiller, Juliette Guillemont, Anna Rosenberg, Cathrien RL Beishuizen, Eric P Moll van Charante, Hilkka Soininen, Carol Brayne, Sandrine Andrieu, Miia Kivipelto, Edo Richard
May 22, 2020
BACKGROUND: Pooling individual participant data to enable pooled analyses is often complicated by diversity in variables across available datasets. Therefore, recoding original variables is often necessary to build a pooled...
The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children
Aino-Maija Eloranta, Taisa Sallinen, Anna Viitasalo, Niina Lintu, Juuso Väistö, Henna Jalkanen, Tuomo T. Tompuri, Sonja Soininen, Eero A. Haapala, Sanna Kiiskinen, Theresia M. Schnurr, Tuomas O. Kilpeläinen, Santtu Mikkonen, Kai Savonen, Mustafa Atalay, Soren Brage, David E. Laaksonen, Virpi Lindi, Jyrki Ågren, Ursula Schwab, Jarmo Jääskeläinen, Timo A. Lakka
Feb 06, 2021
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A. Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A. Haapala, Tuomo T. Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M. Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O. Kilpeläinen, Tomi Laitinen, David E. Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Aug 26, 2021
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins
SJ Kiddle, CJ Steves, M Mehta, A Simmons, X Xu, S Newhouse, M Sattlecker, NJ Ashton, C Bazenet, R Killick, J Adnan, E Westman, S Nelson, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas, C Curtis, G Breen, SCR Williams, S Lovestone, TD Spector, RJB Dobson
Jun 08, 2018
There is great interest in blood-based markers of Alzheimer's disease (AD), especially in its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential markers of...
The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children
Aino-Maija Eloranta, Taisa Sallinen, Anna Viitasalo, Niina Lintu, Juuso Väistö, Henna Jalkanen, Tuomo T. Tompuri, Sonja Soininen, Eero A. Haapala, Sanna Kiiskinen, Theresia M. Schnurr, Tuomas O. Kilpeläinen, Santtu Mikkonen, Kai Savonen, Mustafa Atalay, Soren Brage, David E. Laaksonen, Virpi Lindi, Jyrki Ågren, Ursula Schwab, Jarmo Jääskeläinen, Timo A. Lakka
May 04, 2021
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A Haapala, Tuomo T Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O Kilpeläinen, Tomi Laitinen, David E Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Oct 29, 2020
AIMS/HYPOTHESIS: We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly...
Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease
Petroula Proitsi, Michelle K Lupton, Latha Velayudhan, Stephen Newhouse, Isabella Fogh, Magda Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Alzheimer's Disease Neuroimaging Initiative, Julie Williams, GERAD1 Consortium, Robert Stewart, Pak Sham, Simon Lovestone, John F Powell
Nov 08, 2018
BACKGROUND: Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking...
Pooling individual participant data from randomized controlled trials
Lennard L. van Wanrooij, Marieke P. Hoevenaar-Blom, Nicola Coley, Tiia Ngandu, Yannick Meiller, Juliette Guillemont, Anna Rosenberg, Cathrien R. L. Beishuizen, Eric P. Moll van Charante, Hilkka Soininen, Carol Brayne, Sandrine Andrieu, Miia Kivipelto, Edo Richard
May 12, 2020
Background: Pooling individual participant data to enable pooled analyses is often complicated by diversity in variables across available datasets. Therefore, recoding original variables is often necessary to build a pooled...
The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER).
Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Bäckman, Tuomo Hänninen, Jaana Lindström, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Jul 15, 2022
Circulating Proteomic Signatures of Chronological Age.
Cristina Menni, Steven J Kiddle, Massimo Mangino, Ana Viñuela, Maria Psatha, Claire Steves, Martina Sattlecker, Alfonso Buil, Stephen Newhouse, Sally Nelson, Stephen Williams, Nicola Voyle, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Simon Lovestone, Tim D Spector, Richard Dobson, Ana M Valdes
Jun 11, 2018
To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent...
aging Aptamers. Blood biomarkers early development Nucleotide Proteomics Adult Aged Aged 80 and over aging Biomarkers Carrier Proteins Cohort Studies Cytokines Eye Proteins Female Humans Insulin-Like Growth Factor Binding Protein 6 Male Matrix Metalloproteinase 12 Middle Aged Nerve Tissue Proteins Phenotype Proteomics Registries Twins United Kingdom
The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children
Aino-Maija Eloranta, Taisa Sallinen, Anna Viitasalo, Niina Lintu, Juuso Väistö, Henna Jalkanen, Tuomo T Tompuri, Sonja Soininen, Eero A Haapala, Sanna Kiiskinen, Theresia M Schnurr, Tuomas O Kilpeläinen, Santtu Mikkonen, Kai Savonen, Mustafa Atalay, Soren Brage, David E Laaksonen, Virpi Lindi, Jyrki Ågren, Ursula Schwab, Jarmo Jääskeläinen, Timo A Lakka
Jun 01, 2020
PURPOSE: We studied the effects of a physical activity and dietary intervention on plasma lipids in a general population of children. We also investigated how lifestyle changes contributed to the intervention effects. METHODS...
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children
Timo A. Lakka, Niina Lintu, Juuso Väistö, Anna Viitasalo, Taisa Sallinen, Eero A. Haapala, Tuomo T. Tompuri, Sonja Soininen, Panu Karjalainen, Theresia M. Schnurr, Santtu Mikkonen, Mustafa Atalay, Tuomas O. Kilpeläinen, Tomi Laitinen, David E. Laaksonen, Kai Savonen, Soren Brage, Ursula Schwab, Jarmo Jääskeläinen, Virpi Lindi, Aino-Maija Eloranta
Sep 30, 2020
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids.
Katherine E Beaney, Jackie A Cooper, Stela McLachlan, S Goya Wannamethee, Barbara J Jefferis, Peter Whincup, Yoav Ben-Shlomo, Jacqueline F Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Mika Kivimaki, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Fotios Drenos, Steve E Humphries, UCLEB Consortium
Sep 29, 2016
AIMS: An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between...
coronary heart disease genetic risk HDL-cholesterol Metabolomics Aged Amino Acids Biomarkers Cholesterol HDL Chromosomes Human Pair 1 Coronary Disease DNA Intergenic Diabetes mellitus Type 2 Down-Regulation Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease High-Throughput Screening Assays Humans Magnetic Resonance Spectroscopy Male Metabolomics Middle Aged Particle Size Phenotype Polymorphism Single Nucleotide Protective factors Risk Assessment Risk Factors
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