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Helmuth Plessner and <i>The Delayed Nation</i>
Helmuth Plessner’s The Delayed Nation was a key text in the Sonderweg narrative that dominated the writing of German history from the later 1950s to the mid-1980s: the idea that the disaster of the Third Reich and the...
Joachim Whaley
Nov 18, 2019
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.
Ary Marsee, Floris JM Roos, Monique MA Verstegen, HPB Organoid Consortium, Helmuth Gehart, Eelco de Koning, Frédéric Lemaigre, Stuart J Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc JW van der Laan, Bart Spee
May 26, 2021
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also...
Random Spanning Forests and Hyperbolic Symmetry
Abstract: We study (unrooted) random forests on a graph where the probability of a forest is multiplicatively weighted by a parameter β>0 per edge. This is called the arboreal gas model, and the special case when β=1 is the...
Thrombomodulin in patients with mild to moderate bleeding tendency.
Dino Mehic, Alexander Tolios, Stefanie Hofer, Cihan Ay, Helmuth Haslacher, Kate Downes, Matthias Haimel, Ingrid Pabinger, Johanna Gebhart
Oct 10, 2021
INTRODUCTION: A massive increase of soluble thrombomodulin (sTM) due to variants in the thrombomodulin gene (THBD) has recently been identified as a novel bleeding disorder. AIM: To investigate sTM levels and underlying genetic...
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl, Monique MA Verstegen, Ewa Ellis, Martien van Wenum, Sabine A Fuchs, Joep de Ligt, Marc van de Wetering, Nobuo Sasaki, Susanne J Boers, Hans Kemperman, Jeroen de Jonge, Jan NM Ijzermans, Edward ES Nieuwenhuis, Ruurdtje Hoekstra, Stephen Strom, Robert RG Vries, Luc JW van der Laan, Edwin Cuppen, Hans Clevers
Feb 11, 2015
A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke.
Alexandra Lucaciu, Hannah Kuhn, Sandra Trautmann, Nerea Ferreirós, Helmuth Steinmetz, Josef Pfeilschifter, Robert Brunkhorst, Waltraud Pfeilschifter, Julien Subburayalu, Rajkumar Vutukuri
Aug 29, 2020
Emerging evidence suggests a complex relationship between sphingosine 1-phosphate (S1P) signaling and stroke. Here, we show the kinetics of S1P in the acute phase of ischemic stroke and highlight accompanying changes in immune...
Ceramides fingolimod regulatory T helper cells sphingosine 1-phosphate sphingosine 1-phosphate receptor sphingosine kinase stroke Animals Brain Disease Models Animal ischemic stroke Lysophospholipids Male Mice Mice Inbred C57BL Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors Spleen T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Jul 30, 2021
Abstract: The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development...
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E Koromilas
Aug 31, 2021
The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most...
adenine Adenocarcinoma Animals Carcinogenesis Cell Line Tumor Dual Specificity Phosphatase 6 Eukaryotic Initiation Factor-2 Female Humans Indoles Kaplan-Meier Estimate Lung Neoplasms Male Mice Nude Mitogen-Activated Protein Kinases Phosphorylation Proto-Oncogene Proteins p21(ras) Stress Physiological Xenograft Model Antitumor Assays
Carotid intima-media thickness progression and risk of vascular events in people with diabetes
Matthias W Lorenz, Jackie F Price, Christine Robertson, Michiel L Bots, Joseph F Polak, Holger Poppert, Maryam Kavousi, Marcus Dörr, Eva Stensland, Pierre Ducimetiere, Kimmo Ronkainen, Stefan Kiechl, Matthias Sitzer, Tatjana Rundek, Lars Lind, Jing Liu, Göran Bergström, Liliana Grigore, Lena Bokemark, Alfonsa Friera, David Yanez, Horst Bickel, M Arfan Ikram, Henry Völzke, Stein Harald Johnsen, Jean Philippe Empana, Tomi-Pekka Tuomainen, Peter Willeit, Helmuth Steinmetz, Moise Desvarieux, Wuxiang Xie, Caroline Schmidt, Giuseppe D Norata, Carmen Suarez, Dirk Sander, Albert Hofman, Ulf Schminke, Ellisiv Mathiesen, Matthieu Plichart, Jussi Kauhanen, Johann Willeit, Ralph L Sacco, Stela McLachlan, Dong Zhao, Björn Fagerberg, Alberico L Catapano, Rafael Gabriel, Oscar H Franco, Alpaslan Bülbül, Frank Scheckenbach, Anja Pflug, Lu Gao, Simon G Thompson
Jun 05, 2019
OBJECTIVE: Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with...
Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.
Matthias W Lorenz, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, Mauro Amato, Ulf Schminke, Sathanur R Srinivasan, Lars Lind, Shuhei Okazaki, Coen DA Stehouwer, Peter Willeit, Joseph F Polak, Helmuth Steinmetz, Dirk Sander, Holger Poppert, Moise Desvarieux, M Arfan Ikram, Stein Harald Johnsen, Daniel Staub, Cesare R Sirtori, Bernhard Iglseder, Oscar Beloqui, Gunnar Engström, Alfonso Friera, Francesco Rozza, Wuxiang Xie, Grace Parraga, Liliana Grigore, Matthieu Plichart, Stefan Blankenberg, Ta-Chen Su, Caroline Schmidt, Tomi-Pekka Tuomainen, Fabrizio Veglia, Henry Völzke, Giel Nijpels, Johann Willeit, Ralph L Sacco, Oscar H Franco, Heiko Uthoff, Bo Hedblad, Carmen Suarez, Raffaele Izzo, Dong Zhao, Thapat Wannarong, Alberico Catapano, Pierre Ducimetiere, Christine Espinola-Klein, Kuo-Liong Chien, Jackie F Price, Göran Bergström, Jussi Kauhanen, Elena Tremoli, Marcus Dörr, Gerald Berenson, Kazuo Kitagawa, Jacqueline M Dekker, Stefan Kiechl, Matthias Sitzer, Horst Bickel, Tatjana Rundek, Albert Hofman, Ellisiv B Mathiesen, Samuela Castelnuovo, Manuel F Landecho, Maria Rosvall, Rafael Gabriel, Nicola de Luca, Jing Liu, Damiano Baldassarre, Maryam Kavousi, Eric de Groot, Michiel L Bots, David N Yanez, Simon G Thompson, PROG-IMT Study Group
Jun 19, 2018
AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular...