Search
Results: 321
On Russian Roulette Estimates for Bayesian Inference with Doubly-Intractable Likelihoods
A large number of statistical models are "doubly-intractable": the likelihood normalising term, which is a function of the model parameters, is intractable, as well as the marginal likelihood (model evidence). This means that...
The Grizzly, March 3, 2005
Lauren A. Perotti, Lindsey Fund, Megan Helzner, Jaclyn Partyka, '06, Toyna Towles, Defne Sarsilmaz, Katy Diana, Jonathan Gagas, Dave Marcheskie, Matthew Pastor, Joseph Davido, Kevin Murphy
Jan 01, 0001
Students Connect at the Job and Internship Fair Who's Teaching Your Class Today? Jet Heiko of Turn Your Back on Bush Visits UC Davis Lecturer Stresses Oral Tradition "The Stories of Our Lives": Presentation by Reverend...
Ursinus College Collegeville Pennsylvania newspaper Basketball lacrosse theater Claudia Highbaugh job fair Jet Heiko adjunct professors cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Extending the Base-of-the-Pyramid Concept
The base-of-the-pyramid (BoP) concept plays a prominent role among the market-based perspectives for poverty alleviation. Previous literature reviews discuss the evolution of the BoP concept as a research domain, but...
Simon Joncourt, Heiko Gebauer, Javier Reynoso, Karla Cabrera, Ana Valdes, Katharina Greve
Dec 11, 2019
On Russian Roulette Estimates for Bayesian Inference with Doubly-Intractable Likelihoods
A large number of statistical models are "doubly-intractable": the likelihood normalising term, which is a function of the model parameters, is intractable, as well as the marginal likelihood (model evidence). This means that...
Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster.
Heiko Meyer, Annika Buhr, Patrick Callaerts, Ronja Schiemann, Mariana F Wolfner, Steven J Marygold
Jul 08, 2021
The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is...
Published by: MicroPubl Biol
Ventral Striatal D2/3 Receptor Availability Is Associated with Impulsive Choice Behavior As Well As Limbic Corticostriatal Connectivity.
Rebecca L Barlow, Martin Gorges, Alfie Wearn, Heiko G Niessen, Jan Kassubek, Jeffrey W Dalley, Anton Pekcec
Jun 05, 2018
BACKGROUND: Low dopamine D2/3 receptor availability in the nucleus accumbens shell is associated with highly impulsive behavior in rats as measured by premature responses in a cued attentional task. However, it is unclear...
Robust group sequential designs for trials with survival endpoints and delayed response
Pranab Ghosh, Robin Ristl, Franz König, Martin Posch, Christopher Jennison, Heiko Götte, Armin Schüler, Cyrus Mehta
Feb 28, 2022
Randomized clinical trials in oncology typically utilize time-to-event endpoints such as progression-free survival or overall survival as their primary efficacy endpoints, and the most commonly used statistical test to...
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.
Kimberley A Roper, Heiko Lange, Anastasios Polyzos, Malcolm B Berry, Ian R Baxendale, Steven V Ley
Jun 17, 2021
Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no...
Robust group sequential designs for trials with survival endpoints and delayed response
Pranab Ghosh, Robin Ristl, Franz König, Martin Posch, Christopher Jennison, Heiko Götte, Armin Schüler, Cyrus Mehta
Feb 28, 2022
Randomized clinical trials in oncology typically utilize time-to-event endpoints such as progression-free survival or overall survival as their primary efficacy endpoints, and the most commonly used statistical test to...
Genetic associations of protein-coding variants in human disease.
Benjamin B Sun, Mitja I Kurki, Christopher N Foley, Asma Mechakra, Chia-Yen Chen, Eric Marshall, Jemma B Wilk, Biogen Biobank Team, Mohamed Chahine, Philippe Chevalier, Georges Christé, FinnGen, Aarno Palotie, Mark J Daly, Heiko Runz
Mar 02, 2022
Genome-wide association studies (GWAS) have identified thousands of genetic variants linked to the risk of human disease. However, GWAS have so far remained largely underpowered in relation to identifying associations in the...
Design and rationale of the EMPA-VISION trial
A method for increasing expressivity of Gene Ontology annotations using a compositional approach.
Rachael P Huntley, Midori A Harris, Yasmin Alam-Faruque, Judith A Blake, Seth Carbon, Heiko Dietze, Emily C Dimmer, Rebecca E Foulger, David P Hill, Varsha K Khodiyar, Antonia Lock, Jane Lomax, Ruth C Lovering, Prudence Mutowo-Meullenet, Tony Sawford, Kimberly Van Auken, Valerie Wood, Christopher J Mungall
May 06, 2020
BACKGROUND: The Gene Ontology project integrates data about the function of gene products across a diverse range of organisms, allowing the transfer of knowledge from model organisms to humans, and enabling computational...
Dovetailing biology and chemistry
David P Hill, Nico Adams, Mike Bada, Colin Batchelor, Tanya Z Berardini, Heiko Dietze, Harold J Drabkin, Marcus Ennis, Rebecca E Foulger, Midori A Harris, Janna Hastings, Namrata S Kale, Paula de Matos, Christopher J Mungall, Gareth Owen, Paola Roncaglia, Christoph Steinbeck, Steve Turner, Jane Lomax
May 06, 2020
BACKGROUND: The Gene Ontology (GO) facilitates the description of the action of gene products in a biological context. Many GO terms refer to chemical entities that participate in biological processes. To facilitate accurate and...
Impacts of abiotic and biotic factors on terrestrial leeches in Indonesian Borneo
Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.
Kornelia Johann, Anna Lena Cremer, Alexander W Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel López, Joerg Heeren, Jeffrey W Dalley, Heiko Backes, Jens Mittag
Oct 09, 2020
Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and...
beige adipose tissue beta3-adrenergic receptor Body Temperature brown adipose tissue glucose tolerance hyperthermia metabolism Norepinephrine pyrexia sympathetic nervous system thyroid hormone receptor Uncoupling Protein 1 Adipose Tissue Beige Adipose Tissue Brown Adipose Tissue White Animals Glucose Male Mice Mice Inbred C57BL Muscle Skeletal Receptors Adrenergic beta-3 Thermogenesis Thyroid Hormones Uncoupling Protein 1
Genetic map of regional sulcal morphology in the human brain from UK biobank data.
Benjamin B Sun, Stephanie J Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N Painter, Christopher N Foley, Biogen Biobank Team, Megan E Jensen, Donald G McLaren, Sai Spandana Chintapalli, Alyssa H Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E Medland, Paul M Thompson, Neda Jahanshad, Christopher D Whelan
Oct 14, 2022
Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted...
An astronomically dated record of Earth's climate and its predictability over the last 66 million years.
Thomas Westerhold, Norbert Marwan, Anna Joy Drury, Diederik Liebrand, Claudia Agnini, Eleni Anagnostou, James SK Barnet, Steven M Bohaty, David De Vleeschouwer, Fabio Florindo, Thomas Frederichs, David A Hodell, Ann E Holbourn, Dick Kroon, Vittoria Lauretano, Kate Littler, Lucas J Lourens, Mitchell Lyle, Heiko Pälike, Ursula Röhl, Jun Tian, Roy H Wilkens, Paul A Wilson, James C Zachos
Oct 06, 2020
Much of our understanding of Earth's past climate comes from the measurement of oxygen and carbon isotope variations in deep-sea benthic foraminifera. Yet, long intervals in existing records lack the temporal resolution and age...
Genetic map of regional sulcal morphology in the human brain from UK biobank data.
Benjamin B Sun, Stephanie J Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N Painter, Christopher N Foley, Biogen Biobank Team, Megan E Jensen, Donald G McLaren, Sai Spandana Chintapalli, Alyssa H Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E Medland, Paul M Thompson, Neda Jahanshad, Christopher D Whelan
Nov 16, 2022
Genetic associations with macroscopic brain structure can provide insights into brain function and disease. However, specific associations with measures of local brain folding are largely under-explored. Here, we conducted...
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.
Chen Yao, George Chen, Ci Song, Joshua Keefe, Michael Mendelson, Tianxiao Huan, Benjamin B Sun, Annika Laser, Joseph C Maranville, Hongsheng Wu, Jennifer E Ho, Paul Courchesne, Asya Lyass, Martin G Larson, Christian Gieger, Johannes Graumann, Andrew D Johnson, John Danesh, Heiko Runz, Shih-Jen Hwang, Chunyu Liu, Adam S Butterworth, Karsten Suhre, Daniel Levy
Nov 12, 2018
Identifying genetic variants associated with circulating protein concentrations (protein quantitative trait loci; pQTLs) and integrating them with variants from genome-wide association studies (GWAS) may illuminate the...
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Jie Zheng, Valeriia Haberland, Denis Baird, Venexia Walker, Philip C Haycock, Mark R Hurle, Alex Gutteridge, Pau Erola, Yi Liu, Shan Luo, Jamie Robinson, Tom G Richardson, James R Staley, Benjamin Elsworth, Stephen Burgess, Benjamin B Sun, John Danesh, Heiko Runz, Joseph C Maranville, Hannah M Martin, James Yarmolinsky, Charles Laurin, Michael V Holmes, Jimmy Z Liu, Karol Estrada, Rita Santos, Linda McCarthy, Dawn Waterworth, Matthew R Nelson, George Davey Smith, Adam S Butterworth, Gibran Hemani, Robert A Scott, Tom R Gaunt
Jun 17, 2020
Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable.
Carla Mavian, Sergei Kosakovsky Pond, Simone Marini, Brittany Rife Magalis, Anne-Mieke Vandamme, Simon Dellicour, Samuel V Scarpino, Charlotte Houldcroft, Julian Villabona-Arenas, Taylor K Paisie, Nídia S Trovão, Christina Boucher, Yun Zhang, Richard H Scheuermann, Olivier Gascuel, Tommy Tsan-Yuk Lam, Marc A Suchard, Ana Abecasis, Eduan Wilkinson, Tulio de Oliveira, Ana I Bento, Heiko A Schmidt, Darren Martin, James Hadfield, Nuno Faria, Nathan D Grubaugh, Richard A Neher, Guy Baele, Philippe Lemey, Tanja Stadler, Jan Albert, Keith A Crandall, Thomas Leitner, Alexandros Stamatakis, Mattia Prosperi, Marco Salemi
Apr 30, 2020
PredictCBC-2.0
Daniele Giardiello, Maartje J Hooning, Michael Hauptmann, Renske Keeman, BAM Heemskerk-Gerritsen, Heiko Becher, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Nicola J Camp, Kamila Czene, Peter Devilee, Diana M Eccles, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Montserrat García-Closas, Christopher A Haiman, Ute Hamann, John L Hopper, Anna Jakubowska, Floor E Leeuwen, Annika Lindblom, Jan Lubiński, Sara Margolin, Maria Elena Martinez, Heli Nevanlinna, Ines Nevelsteen, Saskia Pelders, Paul DP Pharoah, Sabine Siesling, Melissa C Southey, Annemieke H van der Hout, Liselotte P van Hest, Jenny Chang-Claude, Per Hall, Douglas F Easton, Ewout W Steyerberg, Marjanka K Schmidt
Dec 08, 2022
BACKGROUND: Prediction of contralateral breast cancer (CBC) risk is challenging due to moderate performances of the known risk factors. We aimed to improve our previous risk prediction model (PredictCBC) by updated follow-up and...
Bcac Breast Cancer Association Consortium Breast Cancer Genetic Predisposition Clinical Decision-Making Contralateral breast cancer Contralateral Preventive Mastectomy polygenic risk score Prediction Performance Risk prediction Humans Female Breast Neoplasms Mastectomy Prophylactic Mastectomy Germ-Line Mutation Risk Factors
Standards for plant synthetic biology
Nicola J Patron, Diego Orzaez, Sylvestre Marillonnet, Heribert Warzecha, Colette Matthewman, Mark Youles, Oleg Raitskin, Aymeric Leveau, Gemma Farré, Christian Rogers, Alison Smith, Julian Hibberd, Alex AR Webb, James Locke, Sebastian Schornack, Jim Ajioka, David C Baulcombe, Cyril Zipfel, Sophien Kamoun, Jonathan DG Jones, Hannah Kuhn, Silke Robatzek, H Peter van Esse, Dale Sanders, Giles Oldroyd, Cathie Martin, Rob Field, Sarah O'Connor, Samantha Fox, Brande Wulff, Ben Miller, Andy Breakspear, Guru Radhakrishnan, Pierre-Marc Delaux, Dominique Loqué, Antonio Granell, Alain Tissier, Patrick Shih, Thomas P Brutnell, W Paul Quick, Heiko Rischer, Paul D Fraser, Asaph Aharoni, Christine Raines, Paul F South, Jean-Michel Ané, Björn R Hamberger, Jane Langdale, Jens Stougaard, Harro Bouwmeester, Michael Udvardi, James AH Murray, Vardis Ntoukakis, Patrick Schäfer, Katherine Denby, Keith J Edwards, Anne Osbourn, Jim Haseloff
Jun 13, 2019
DNA assembly GoldenGate Type IIS restriction endonucleases Cloning genetic syntax synthetic biology Botany Cloning Molecular DNA Deoxyribonucleases Type II Site-Specific Eukaryota Genetic Engineering Plants Plants Genetically Modified Plasmids Reference Standards synthetic biology Transcription Genetic
PredictCBC-2.0
Daniele Giardiello, Maartje J Hooning, Michael Hauptmann, Renske Keeman, BAM Heemskerk-Gerritsen, Heiko Becher, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Nicola J Camp, Kamila Czene, Peter Devilee, Diana M Eccles, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Montserrat García-Closas, Christopher A Haiman, Ute Hamann, John L Hopper, Anna Jakubowska, Floor E Leeuwen, Annika Lindblom, Jan Lubiński, Sara Margolin, Maria Elena Martinez, Heli Nevanlinna, Ines Nevelsteen, Saskia Pelders, Paul DP Pharoah, Sabine Siesling, Melissa C Southey, Annemieke H van der Hout, Liselotte P van Hest, Jenny Chang-Claude, Per Hall, Douglas F Easton, Ewout W Steyerberg, Marjanka K Schmidt
Oct 24, 2022
BACKGROUND: Prediction of contralateral breast cancer (CBC) risk is challenging due to moderate performances of the known risk factors. We aimed to improve our previous risk prediction model (PredictCBC) by updated follow-up and...
|
|< |
< |
1 |