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On Russian Roulette Estimates for Bayesian Inference with Doubly-Intractable Likelihoods
A large number of statistical models are "doubly-intractable": the likelihood normalising term, which is a function of the model parameters, is intractable, as well as the marginal likelihood (model evidence). This means that...
Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.
Kornelia Johann, Anna Lena Cremer, Alexander W Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel López, Joerg Heeren, Jeffrey W Dalley, Heiko Backes, Jens Mittag
Oct 09, 2020
Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and...
beige adipose tissue beta3-adrenergic receptor Body Temperature brown adipose tissue glucose tolerance hyperthermia metabolism Norepinephrine pyrexia sympathetic nervous system thyroid hormone receptor Uncoupling Protein 1 Adipose Tissue Beige Adipose Tissue Brown Adipose Tissue White Animals Glucose Male Mice Mice Inbred C57BL Muscle Skeletal Receptors Adrenergic beta-3 Thermogenesis Thyroid Hormones Uncoupling Protein 1
The Grizzly, March 3, 2005
Lauren A. Perotti, Lindsey Fund, Megan Helzner, Jaclyn Partyka, '06, Toyna Towles, Defne Sarsilmaz, Katy Diana, Jonathan Gagas, Dave Marcheskie, Matthew Pastor, Joseph Davido, Kevin Murphy
Jan 01, 0001
Students Connect at the Job and Internship Fair Who's Teaching Your Class Today? Jet Heiko of Turn Your Back on Bush Visits UC Davis Lecturer Stresses Oral Tradition "The Stories of Our Lives": Presentation by Reverend...
Ursinus College Collegeville Pennsylvania newspaper Basketball lacrosse theater Claudia Highbaugh job fair Jet Heiko adjunct professors cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Extending the Base-of-the-Pyramid Concept
The base-of-the-pyramid (BoP) concept plays a prominent role among the market-based perspectives for poverty alleviation. Previous literature reviews discuss the evolution of the BoP concept as a research domain, but...
Simon Joncourt, Heiko Gebauer, Javier Reynoso, Karla Cabrera, Ana Valdes, Katharina Greve
Dec 11, 2019
On Russian Roulette Estimates for Bayesian Inference with Doubly-Intractable Likelihoods
A large number of statistical models are "doubly-intractable": the likelihood normalising term, which is a function of the model parameters, is intractable, as well as the marginal likelihood (model evidence). This means that...
Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster.
Heiko Meyer, Annika Buhr, Patrick Callaerts, Ronja Schiemann, Mariana F Wolfner, Steven J Marygold
Jul 08, 2021
The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is...
Published by: MicroPubl Biol
Ventral Striatal D2/3 Receptor Availability Is Associated with Impulsive Choice Behavior As Well As Limbic Corticostriatal Connectivity.
Rebecca L Barlow, Martin Gorges, Alfie Wearn, Heiko G Niessen, Jan Kassubek, Jeffrey W Dalley, Anton Pekcec
Jun 05, 2018
BACKGROUND: Low dopamine D2/3 receptor availability in the nucleus accumbens shell is associated with highly impulsive behavior in rats as measured by premature responses in a cued attentional task. However, it is unclear...
Robust group sequential designs for trials with survival endpoints and delayed response
Pranab Ghosh, Robin Ristl, Franz König, Martin Posch, Christopher Jennison, Heiko Götte, Armin Schüler, Cyrus Mehta
Feb 28, 2022
Randomized clinical trials in oncology typically utilize time-to-event endpoints such as progression-free survival or overall survival as their primary efficacy endpoints, and the most commonly used statistical test to...
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.
Kimberley A Roper, Heiko Lange, Anastasios Polyzos, Malcolm B Berry, Ian R Baxendale, Steven V Ley
Jun 17, 2021
Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no...
Robust group sequential designs for trials with survival endpoints and delayed response
Pranab Ghosh, Robin Ristl, Franz König, Martin Posch, Christopher Jennison, Heiko Götte, Armin Schüler, Cyrus Mehta
Feb 28, 2022
Randomized clinical trials in oncology typically utilize time-to-event endpoints such as progression-free survival or overall survival as their primary efficacy endpoints, and the most commonly used statistical test to...
Understanding the Photoluminescence Quenching of Liquid Exfoliated WS<sub>2</sub> Monolayers.
Zhaojun Li, Farnia Rashvand, Hope Bretscher, Beata M Szydłowska, James Xiao, Claudia Backes, Akshay Rao
Feb 09, 2023
Monolayer transition metal dichalcogenides (TMDs) are being investigated as active materials in optoelectronic devices due to their strong excitonic effects. While mechanical exfoliation (ME) of monolayer TMDs is limited to...
Understanding the Photoluminescence Quenching of Liquid Exfoliated WS<sub>2</sub> Monolayers
Zhaojun Li, Farnia Rashvand, Hope Bretscher, Beata M Szydłowska, James Xiao, Claudia Backes, Akshay Rao
Jan 04, 2023
Monolayer transition metal dichalcogenides (TMDs) are being investigated as active materials in optoelectronic devices due to their strong excitonic effects. While mechanical exfoliation (ME) of monolayer TMDs is limited to...
Magnetisation configuration in arrays of permalloy rectangles and its impact on magnetisation reversal
P J Newton, N B Devlin, S M Masur, M Ghidini, D Backes, F Maccherozzi, A A Pacheco-Pumaleque, M A González Esqueche, C H W Barnes
Sep 15, 2021
Abstract: The remanent domain structures of composite element magnetic barcodes have been imaged using photo-emission electron microscopy with contrast from x-ray magnetic circular dichroism (XMCD-PEEM) and analysed with...
The role of structural order in heterogeneous ice nucleation.
Gabriele C Sosso, Prerna Sudera, Anna T Backes, Thomas F Whale, Janine Fröhlich-Nowoisky, Mischa Bonn, Angelos Michaelides, Ellen HG Backus
Jul 03, 2022
The freezing of water into ice is a key process that is still not fully understood. It generally requires an impurity of some description to initiate the heterogeneous nucleation of the ice crystals. The molecular structure, as...
Magnetisation configuration in arrays of permalloy rectangles and its impact on magnetisation reversal
P J Newton, N B Devlin, S M Masur, M Ghidini, D Backes, F Maccherozzi, A A Pacheco-Pumaleque, M A González Esqueche, C H W Barnes
Sep 15, 2021
Abstract: The remanent domain structures of composite element magnetic barcodes have been imaged using photo-emission electron microscopy with contrast from x-ray magnetic circular dichroism (XMCD-PEEM) and analysed with...
Genetic associations of protein-coding variants in human disease.
Benjamin B Sun, Mitja I Kurki, Christopher N Foley, Asma Mechakra, Chia-Yen Chen, Eric Marshall, Jemma B Wilk, Biogen Biobank Team, Mohamed Chahine, Philippe Chevalier, Georges Christé, FinnGen, Aarno Palotie, Mark J Daly, Heiko Runz
Mar 02, 2022
Genome-wide association studies (GWAS) have identified thousands of genetic variants linked to the risk of human disease. However, GWAS have so far remained largely underpowered in relation to identifying associations in the...
Design and rationale of the EMPA-VISION trial
Transcription Factors Evolve Faster Than Their Structural Gene Targets in the Flavonoid Pigment Pathway.
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