A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Connor A. Emdin,
Mary E. Haas,
Amit V. Khera,
Krishna Aragam,
Mark Chaffin,
Derek Klarin,
George Hindy,
Lan Jiang,
Wei-Qi Wei,
Qiping Feng,
Juha Karjalainen,
Aki Havulinna,
Tuomo Kiiskinen,
Alexander Bick,
Diego Ardissino,
James G. Wilson,
Heribert Schunkert,
Ruth McPherson,
Hugh Watkins,
Roberto Elosua,
Matthew J. Bown,
Nilesh J. Samani,
Usman Baber,
Jeanette Erdmann,
Namrata Gupta,
John Danesh,
Danish Saleheen,
Kyong-Mi Chang,
Marijana Vujkovic,
Ben Voight,
Scott Damrauer,
Julie Lynch,
David Kaplan,
Marina Serper,
Philip Tsao,
Million Veteran Program,
Josep Mercader,
Craig Hanis,
Mark Daly,
Joshua Denny,
Stacey Gabriel,
Sekar Kathiresan
May 05, 2020
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection...