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Metabolic determinants of the immune modulatory function of neural stem cells.
Denise Drago, Veronica Basso, Edoardo Gaude, Giulio Volpe, Luca Peruzzotti-Jametti, Angela Bachi, Giovanna Musco, Annapaola Andolfo, Christian Frezza, Anna Mondino, Stefano Pluchino
Sep 09, 2016
Arginase I Immune modulation Lymph node cells Metabolomics Neural Stem Cells Animals Arginase Arginine Cell Proliferation Cells Cultured Coculture Techniques Colorimetry Cytokines Disease Models Animal Encephalomyelitis Autoimmune Experimental Female Immunologic Factors Lateral Ventricles Metabolomics Mice Neural Stem Cells Signal Transduction T-Lymphocytes
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.
Luca Peruzzotti-Jametti, Joshua D Bernstock, Nunzio Vicario, Ana SH Costa, Chee Keong Kwok, Tommaso Leonardi, Lee M Booty, Iacopo Bicci, Beatrice Balzarotti, Giulio Volpe, Giulia Mallucci, Giulia Manferrari, Matteo Donegà, Nunzio Iraci, Alice Braga, John M Hallenbeck, Michael P Murphy, Frank Edenhofer, Christian Frezza, Stefano Pluchino
Apr 23, 2018
Neural stem cell (NSC) transplantation can influence immune responses and suppress inflammation in the CNS. Metabolites, such as succinate, modulate the phenotype and function of immune cells, but whether and how NSCs are also...
cell metabolism experimental autoimmune encephalomyelitis Inflammation MACROPHAGES Microglia Multiple Sclerosis Neural Stem Cells Regenerative Medicine Stem Cells Succinate Animals Cell Line Central Nervous System Chronic Disease Dinoprostone Female Humans Inflammation MACROPHAGES Mice Inbred C57BL Neural Stem Cells Oxidative Phosphorylation Receptors G-Protein-Coupled Succinic Acid
Constructing differential categories and deconstructing categories of games
Differential categories were introduced by Blute, Cockett and Seely to axiomatize categorically Ehrhard and Regnierʼs syntactic differential operator. We present an abstract construction that takes a symmetric monoidal category...
Venture capital investments through the lens of network and functional data analysis
Abstract In this paper we characterize the performance of venture capital-backed firms based on their ability to attract investment. The aim of the study is to identify relevant predictors of...
Christian Esposito, Marco Gortan, Lorenzo Testa, Francesca Chiaromonte, Giorgio Fagiolo, Andrea Mina, Giulio Rossetti
Jun 29, 2022
Abstract Machines for Open Call-by-Value
The theory of the call-by-value λ-calculus relies on weak evaluation and closed terms, that are natural hypotheses in the study of programming languages. To model proof assistants, however, strong evaluation and open terms are...
Abstract Machines for Open Call-by-Value
The theory of the call-by-value λ-calculus relies on weak evaluation and closed terms, that are natural hypotheses in the study of programming languages. To model proof assistants, however, strong evaluation and open terms are...
The onset of penetrative convection in an inclined porous layer
In the present article, a model for penetrative convection in a fluid-saturated inclined porous medium is analyzed. Penetrative convection occurs when an unstably stratified fluid moves into a stably stratified region. In...
Safe human-robot interaction in medical robotics
This paper presents a safety analysis of a Robotic Fracture Surgery System using the Systems-Theoretic Process Analysis (STPA). It focuses particularly on hazards caused by the human in the loop. The robotic system and operating...
Quantum communication through devices with indefinite input-output direction
Abstract
Certain quantum devices, such as half-wave plates and quarter-wave plates in quantum optics, are bidirectional, meaning that the roles of their input and output ports can...
The onset of penetrative convection in an inclined porous layer
In the present article, a model for penetrative convection in a fluid-saturated inclined porous medium is analyzed. Penetrative convection occurs when an unstably stratified fluid moves into a stably stratified region. In...
Haven-Sent? Tax Havens, Corporate Social Irresponsibility and the Dark Side of Family Firm Internationalization
Family firms have been associated with an enhanced propensity for corporate social responsibility (CSR), but does this imply that family firms have a reduced propensity for corporate social irresponsibility (CSI)? Drawing on...
Robot-Assisted Fracture Surgery
The design of medical devices is a complex and crucial process to ensure patient safety. It has been shown that improperly designed devices lead to errors and associated accidents and costs. A key element for a successful design...
The Estrogen Receptor α Signaling Pathway Controls Alternative Splicing in the Absence of Ligands in Breast Cancer Cells.
BACKGROUND: The transcriptional activity of estrogen receptor α (ERα) in breast cancer (BC) is extensively characterized. Our group has previously shown that ERα controls the expression of a number of genes in its unliganded...
Robot-Assisted Fracture Surgery
The design of medical devices is a complex and crucial process to ensure patient safety. It has been shown that improperly designed devices lead to errors and associated accidents and costs. A key element for a successful design...
Docker4Circ
Giulio Ferrero, Nicola Licheri, Lucia Coscujuela Tarrero, Carlo De Intinis, Valentina Miano, Raffaele Adolfo Calogero, Francesca Cordero, Michele De Bortoli, Marco Beccuti
Mar 23, 2020
Recent improvements in cost-effectiveness of high-throughput technologies has allowed RNA sequencing of total transcriptomes suitable for evaluating the expression and regulation of circRNAs, a relatively novel class of...
Safe human-robot interaction in medical robotics
This paper presents a safety analysis of a Robotic Fracture Surgery System using the Systems-Theoretic Process Analysis (STPA). It focuses particularly on hazards caused by the human in the loop. The robotic system and operating...
Haven-Sent? Tax Havens, Corporate Social Irresponsibility and the Dark Side of Family Firm Internationalization
Family firms have been associated with an enhanced propensity for corporate social responsibility (CSR), but does this imply that family firms have a reduced propensity for corporate social irresponsibility (CSI)? Drawing on...
The Estrogen Receptor α Signaling Pathway Controls Alternative Splicing in the Absence of Ligands in Breast Cancer Cells.
BACKGROUND: The transcriptional activity of estrogen receptor α (ERα) in breast cancer (BC) is extensively characterized. Our group has previously shown that ERα controls the expression of a number of genes in its unliganded...
Constructing differential categories and deconstructing categories of games
Differential categories were introduced by Blute, Cockett and Seely to axiomatize categorically Ehrhard and Regnierʼs syntactic differential operator. We present an abstract construction that takes a symmetric monoidal category...
Connectometry evaluation in patients undergoing carotid endarterectomy
Michele Porcu, Davide Craboledda, Paolo Garofalo, Giulio Columbano, Luigi Barberini, Roberto Sanfilippo, Fulvio Zaccagna, Max Wintermark, Roberto Montisci, Luca Saba
Oct 02, 2019
This research investigated local brain connectivity changes following Carotid Endarterectomy (CEA) by connectometry. Seventeen subjects (15 males and 2 females, mean age 74.1 years), all eligible for CEA, were prospectively...
EEG functional connectivity metrics wPLI and wSMI account for distinct types of brain functional interactions.
Laura Sophie Imperatori, Monica Betta, Luca Cecchetti, Andrés Canales-Johnson, Emiliano Ricciardi, Francesca Siclari, Pietro Pietrini, Srivas Chennu, Giulio Bernardi
Sep 04, 2019
The weighted Phase Lag Index (wPLI) and the weighted Symbolic Mutual Information (wSMI) represent two robust and widely used methods for MEG/EEG functional connectivity estimation. Interestingly, both methods have been shown to...
Thermal Behavior of Iron Arsenides Under Non-Oxidizing Conditions.
Fe2As has been studied in situ by synchrotron powder X-ray diffraction (PXRD) over the range of temperatures 25-850 °C and under a neutral atmosphere to understand its thermal behavior, which is potentially important for gold...
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