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Results: 28
Improving the lateral load resistance of vernacular masonry walls subject to flooding
Shawn Platt, Indunil Erandi, Chintha Jayasinghe, Thishan Jayasinghe, Dan Maskell, Gihan Ranasinghe, Pete Walker
May 31, 2023
Low rise vernacular masonry buildings are vulnerable to damage from extreme flooding. This paper presents findings from a study based in Sri Lanka assessing the structural resilience of non-engineered single storey houses...
Improving the lateral load resistance of vernacular masonry walls subject to flooding
Shawn Platt, Indunil Erandi, Chintha Jayasinghe, Thishan Jayasinghe, Dan Maskell, Gihan Ranasinghe, Pete Walker
May 31, 2023
Low rise vernacular masonry buildings are vulnerable to damage from extreme flooding. This paper presents findings from a study based in Sri Lanka assessing the structural resilience of non-engineered single storey houses...
Retrofitting and Rehabilitation of Vernacular housing in Flood Prone Areas in Sri Lanka
Shawn Platt, Gihan Ranasinghe, Gaindu Saranga Jayathilaka, Chintha Jayasinghe, Thishan Jayasinghe, Pete Walker, Dan Maskell
Sep 30, 2021
This paper presents findings from an investigation into applications to improve the structural resilience and safety of low-rise vernacular masonry homes when subject to extreme flooding. In 2016 and 2017 flooding brought...
Retrofitting and Rehabilitation of Vernacular housing in Flood Prone Areas in Sri Lanka
Shawn Platt, Gihan Ranasinghe, Gaindu Saranga Jayathilaka, Chintha Jayasinghe, Thishan Jayasinghe, Pete Walker, Dan Maskell
Sep 30, 2021
This paper presents findings from an investigation into applications to improve the structural resilience and safety of low-rise vernacular masonry homes when subject to extreme flooding. In 2016 and 2017 flooding brought...
The Role of Assessment in Driving Continuous School Improvement
Assessment plays a pivotal role in the school improvement in ensuring its effectiveness, continuity, and impact. Equally important is the utilization of reliable data that enables schools to identify, address and achieve desired...
Educational Technologies Education Educational Technologies Computer Science and Information Technology Library and Information Science
Published by: IGI Global Scientific Publishing
Electrophysiology of Endolysosomal Two-Pore Channels
Sandip Patel, Yu Yuan, Cheng-Chang Chen, Dawid Jaślan, Gihan Gunaratne, Christian Grimm, Taufiq Rahman, Jonathan S Marchant
Aug 04, 2022
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels. Direct macroscopic recordings of...
Tourism-Driven Mobilities
Mobilities discourse, regardless of its vital significance in day-to-day life, is under examined. It draws researchers' attention at theoretical level showing significant absence of empirical studies. The absence of a scale to...
Published by: IGI Global Scientific Publishing
Electrophysiology of Endolysosomal Two-Pore Channels
Sandip Patel, Yu Yuan, Cheng-Chang Chen, Dawid Jaślan, Gihan Gunaratne, Christian Grimm, Taufiq Rahman, Jonathan S Marchant
Sep 11, 2022
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels. Direct macroscopic recordings of...
Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells.
Jason C Sang, Eric Hidari, Georg Meisl, Rohan T Ranasinghe, Maria Grazia Spillantini, David Klenerman
Jun 22, 2021
Aggregation of α-synuclein (α-syn) is closely linked to Parkinson's disease (PD) and the related synucleinopathies. Aggregates spread through the brain during the progression of PD, but the mechanism by which this occurs is...
Published by: Communications biology
Laboratory investigation of the Bruun Rule and beach response to sea level rise
Alexander L. Atkinson, Tom E. Baldock, Florent Birrien, David P. Callaghan, Peter Nielsen, Tomas Beuzen, Ian L. Turner, Chris E. Blenkinsopp, Roshanka Ranasinghe
Jun 01, 2018
Rising sea levels are expected to cause widespread coastal recession over the course of the next century. In this work, new insight into the response of sandy beaches to sea level rise is obtained through a series of...
Laboratory investigation of the Bruun Rule and beach response to sea level rise
Alexander L. Atkinson, Tom E. Baldock, Florent Birrien, David P. Callaghan, Peter Nielsen, Tomas Beuzen, Ian L. Turner, Chris E. Blenkinsopp, Roshanka Ranasinghe
Jun 01, 2018
Rising sea levels are expected to cause widespread coastal recession over the course of the next century. In this work, new insight into the response of sandy beaches to sea level rise is obtained through a series of...
Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).
Detecting RNA base methylations in single cells by in situ hybridization.
Rohan T Ranasinghe, Martin R Challand, Kristina A Ganzinger, Benjamin W Lewis, Charlotte Softley, Wolfgang H Schmied, Mathew H Horrocks, Nadia Shivji, Jason W Chin, James Spencer, David Klenerman
Feb 16, 2018
Methylated bases in tRNA, rRNA and mRNA control a variety of cellular processes, including protein synthesis, antimicrobial resistance and gene expression. Currently, bulk methods that report the average methylation state of...
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
Derya Emin, Yu P Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I Sideris, Jeff YL Lam, Rohan T Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas PJ Knowles, Michele Vendruscolo, Francesco S Ruggeri, Franklin I Aigbirhio, Caroline H Williams-Gray, David Klenerman
Sep 20, 2022
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
Daniel R Whiten, Yukun Zuo, Laura Calo, Minee-Liane Choi, Suman De, Patrick Flagmeier, David C Wirthensohn, Franziska Kundel, Rohan T Ranasinghe, Santiago E Sanchez, Dilan Athauda, Steven F Lee, Christopher M Dobson, Sonia Gandhi, Maria-Grazia Spillantini, David Klenerman, Mathew H Horrocks
Sep 05, 2018
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
Derya Emin, Yu P Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I Sideris, Jeff YL Lam, Rohan T Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas PJ Knowles, Michele Vendruscolo, Francesco S Ruggeri, Franklin I Aigbirhio, Caroline H Williams-Gray, David Klenerman
Oct 24, 2022
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Marthe HR Ludtmann, Plamena R Angelova, Mathew H Horrocks, Minee L Choi, Margarida Rodrigues, Artyom Y Baev, Alexey V Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T Ranasinghe, Daniel R Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov, Sonia Gandhi
Oct 10, 2018
Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that...
Animals Coculture Techniques Embryonic Stem Cells Humans Induced Pluripotent Stem Cells Lipid Peroxidation Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Permeability Transition Pore Mitochondrial Proton-Translocating ATPases Neurons Oxidation-Reduction Parkinson Disease Patch-Clamp Techniques Permeability Proteomics Rats Rats Sprague-Dawley Reactive Oxygen Species ALPHA-SYNUCLEIN
Worldwide surveillance of self-reported sitting time
M. Mclaughlin, A. J. Atkin, L. Starr, A. Hall, L. Wolfenden, R. Sutherland, J. Wiggers, A. Ramirez, P. Hallal, M. Pratt, B. M. Lynch, K. Wijndaele, Saiful Adli, Paul A. Gardiner, Ciaran B. Doyle, Angela Meadows, Ruth M. Mabry, Alberto Florez Pregonero, Kabir P. Sadarangani, Nyssa T. Hadgraft, Terry Boyle, Nicolas Aguilar Farias, Jacqueline L. Mair, Siosaia F. Hafoka, Gregore Iven Mielke, Selina Khoo Phaik Lin, Vienna R. McLeod, Chathuranga Ranasinghe, Paul C. Storning, Ing-Mari Dohrn, Falk Müller-Riemenschnieder, Lyutha Al Subhi, Anne Chu Hin Yee, Mayuri Gad, Adilson Marques, Elli Kontostoli
Sep 03, 2020
Abstract: Background: Prolonged sitting time is a risk factor for chronic disease, yet recent global surveillance is not well described. The aims were to clarify: (i) the countries that have collected country-level data on...
World Health Organization 2020 guidelines on physical activity and sedentary behaviour
Fiona C Bull, Salih S Al-Ansari, Stuart Biddle, Katja Borodulin, Matthew P Buman, Greet Cardon, Catherine Carty, Jean-Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C Dempsey, Loretta DiPietro, Ulf Ekelund, Joseph Firth, Christine M Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P Troiano, Hidde P van der Ploeg, Vicky Wari, Juana F Willumsen
Nov 16, 2020
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